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Select item 103710241.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

Kristel Martinez Lagunas, Deniz Pinar Savcigil, Matea Zrilic, Carlos Carvajal Fraile, Andrew Craxton, Emily Self, Iratxe Uranga-Murillo, Diego de Miguel, Maykel Arias, Sebastian Willenborg, Michael Piekarek, Marie Christine Albert, Kalvin Nugraha, Ina Lisewski, Erika Janakova, Natalia Igual, Wulf Tonnus, Ximena Hildebrandt, Mohammed Ibrahim, Marlies Ballegeer, Xavier Saelens, Andrew Kueh, Pascal Meier, Andreas Linkermann, Julian Pardo, Sabine Eming, Henning Walczak, Marion MacFarlane, Nieves Peltzer, Alessandro Annibaldi

Sci Adv. 2023 Jul; 9(30): eadg2829. Published online 2023 Jul 26. doi: 10.1126/sciadv.adg2829

PMCID:: PMC10371024

Abstract Article PDF–2.4M

Select item 84527652.

Oncogenic signaling inhibits c-FLIP_L expression and its non-apoptotic function during ECM-detachment

Matyas Abel Tsegaye, Jianping He, Kyle McGeehan, Ireland M. Murphy, Mati Nemera, Zachary T. Schafer

Sci Rep. 2021; 11: 18606. Published online 2021 Sep 20. doi: 10.1038/s41598-021-97715-4

PMCID:: PMC8452765

Abstract Article PDF–2.2M

Select item 77358623.

Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway

Ting Zhai, Wei Xu, Yayun Liu, Kun Qian, Yanling Xiong, Yong Chen

Oxid Med Cell Longev. 2020; 2020: 2313641. Published online 2020 Nov 27. doi: 10.1155/2020/2313641

PMCID:: PMC7735862

Abstract Article PDF–1.9M

Select item 54241154.

Constitutive expression of murine c-FLIP_R causes autoimmunity in aged mice

F Ewald, M Annemann, M C Pils, C Plaza-Sirvent, F Neff, C Erck, D Reinhold, I Schmitz

Cell Death Dis. 2014 Apr; 5(4): e1168. Published online 2014 Apr 10. doi: 10.1038/cddis.2014.138

PMCID:: PMC5424115

Abstract Article PDF–3.3M

Select item 45728615.

The endogenous caspase-8 inhibitor c-FLIP_L regulates ER morphology and crosstalk with mitochondria

E S Marini, C Giampietri, S Petrungaro, S Conti, A Filippini, L Scorrano, E Ziparo

Cell Death Differ. 2015 Jul; 22(7): 1131–1143. Published online 2014 Dec 12. doi: 10.1038/cdd.2014.197

PMCID:: PMC4572861

Abstract Article PDF–3.2M

Select item 44652946.

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

Xuehua Piao, Sachiko Komazawa-Sakon, Takashi Nishina, Masato Koike, Jiang-Hu Piao, Hanno Ehlken, Hidetake Kurihara, Mutsuko Hara, Nico Van Rooijen, Günther Schütz, Masaki Ohmuraya, Yasuo Uchiyama, Hideo Yagita, Ko Okumura, You-Wen He, Hiroyasu Nakano

Sci Signal. Author manuscript; available in PMC 2015 Jun 13.

Published in final edited form as: Sci Signal. 2012 Dec 18; 5(255): ra93. Published online 2012 Dec 18. doi: 10.1126/scisignal.2003558

PMCID:: PMC4465294

Abstract Article PDF–3.6M

Select item 43694107.

c- FLIP protects T lymphocyte from apoptosis in the intrinsic pathway

Ming-Xiao He, You-Wen He

J Immunol. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: J Immunol. 2015 Apr 1; 194(7): 3444–3451. Published online 2015 Feb 27. doi: 10.4049/jimmunol.1400469

PMCID:: PMC4369410

Abstract Article PDF–836K

Select item 35543408.

A role for c-FLIP_L in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes

M-X He, Y-W He

Cell Death Differ. 2013 Feb; 20(2): 188–197. Published online 2012 Nov 23. doi: 10.1038/cdd.2012.148

PMCID:: PMC3554340

Abstract Article PDF–3.1M

Select item 27566559.

c-FLIP_S reduces activation of caspase and NF-κB pathways and decreases T cell survival

Jennifer Hinshaw-Makepeace, Gail Huston, Karen A. Fortner, Jennifer Q. Russell, Daniel Holoch, Susan Swain, Ralph C. Budd

Eur J Immunol. Author manuscript; available in PMC 2009 Oct 5.

Published in final edited form as: Eur J Immunol. 2008 Jan; 38(1): 54–63. doi: 10.1002/eji.200636956

PMCID:: PMC2756655

Abstract Article PDF–1.5M

Select item 245308510.

Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1β Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis

Yujiang Fang, Helen Braley-Mullen

Endocrinology. 2008 Jul; 149(7): 3321–3329. Published online 2008 Mar 20. doi: 10.1210/en.2008-0080

PMCID:: PMC2453085

Abstract Article

Select item 1019323011.

Mechanisms regulating the loss of Tregs in HUPO mice that develop spontaneous inflammatory arthritis

Qi-Quan Huang, Yiwei Hang, Renee Doyle, Qinwen Mao, Deyu Fang, Richard M. Pope

iScience. 2023 May 19; 26(5): 106734. Published online 2023 Apr 25. doi: 10.1016/j.isci.2023.106734

PMCID:: PMC10193230

Abstract Article PDF–5.2M

Select item 872862712.

Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang

EMBO Rep. 2022 Jan 5; 23(1): e52702. Published online 2021 Oct 25. doi: 10.15252/embr.202152702

PMCID:: PMC8728627

Abstract Article PDF–2.2M

Select item 826680713.

c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability

Luana Tomaipitinca, Simonetta Petrungaro, Pasquale D’Acunzo, Angelo Facchiano, Amit Dubey, Salvatore Rizza, Federico Giulitti, Eugenio Gaudio, Antonio Filippini, Elio Ziparo, Francesco Cecconi, Claudia Giampietri

Cell Death Dis. 2021 Jul; 12(7): 686. Published online 2021 Jul 8. doi: 10.1038/s41419-021-03957-5

PMCID:: PMC8266807

Abstract Article PDF–2.1M

Select item 771787714.

hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages

Junxia Feng, Hongyan Li, Jingchun Li, Ping Meng, Lina Wang, Chunli Liu, Shili Zhao, Wei Sun, Yunfang Zhang

Redox Rep. 2020; 25(1): 104–111. Published online 2020 Dec 3. doi: 10.1080/13510002.2020.1857157

PMCID:: PMC7717877

Abstract Article PDF–1.2M

Select item 770065615.

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

Maria Feoktistova, Roman Makarov, Martin Leverkus, Amir S. Yazdi, Diana Panayotova-Dimitrova

Int J Mol Sci. 2020 Nov; 21(22): 8859. Published online 2020 Nov 23. doi: 10.3390/ijms21228859

PMCID:: PMC7700656

Abstract Article PDF–2.8M

Select item 594131016.

Deletion of c-FLIP from CD11b^hi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis

Alexandra L. McCubbrey, Lea Barthel, Michael P. Mohning, Elizabeth F. Redente, Kara J. Mould, Stacey M. Thomas, Sonia M. Leach, Thomas Danhorn, Sophie L. Gibbings, Claudia V. Jakubzick, Peter M. Henson, William J. Janssen

Am J Respir Cell Mol Biol. 2018 Jan; 58(1): 66–78. doi: 10.1165/rcmb.2017-0154OC

PMCID:: PMC5941310

Abstract Article PDF–1.7M

Select item 546090817.

Cellular FLICE-like Inhibitory Protein Deviates Myofibroblast Fas-Induced Apoptosis Toward Proliferation during Lung Fibrosis

Regina Golan-Gerstl, Shulamit B. Wallach-Dayan, Philip Zisman, Wellington V. Cardoso, Ronald H. Goldstein, Raphael Breuer

Am J Respir Cell Mol Biol. 2012 Sep; 47(3): 271–279. doi: 10.1165/rcmb.2010-0284RC

PMCID:: PMC5460908

Abstract Article PDF–1.0M

Select item 476083018.

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

Daniel R. Ram, Vladimir Ilyukha, Tatyana Volkova, Anton Buzdin, Albert Tai, Irina Smirnova, Alexander Poltorak

Proc Natl Acad Sci U S A. 2016 Feb 9; 113(6): 1606–1611. Published online 2016 Jan 21. doi: 10.1073/pnas.1517562113

PMCID:: PMC4760830

Abstract Article PDF–1.2M

Select item 439207919.

Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors

N Gehrke, D Garcia-Bardon, A Mann, A Schad, Y Alt, M A Wörns, M F Sprinzl, T Zimmermann, J Menke, A J Engstler, I Bergheim, Y-W He, P R Galle, M Schuchmann, J M Schattenberg

Cell Death Differ. 2015 Apr; 22(5): 826–837. Published online 2014 Oct 24. doi: 10.1038/cdd.2014.178

PMCID:: PMC4392079

Abstract Article PDF–5.0M

Select item 392159320.

Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

Y-H Wu, W-C Kuo, Y-J Wu, K-T Yang, S-T Chen, S-T Jiang, C Gordy, Y-W He, M-Z Lai

Cell Death Differ. 2014 Mar; 21(3): 451–461. Published online 2013 Nov 22. doi: 10.1038/cdd.2013.165

PMCID:: PMC3921593

Abstract Article PDF–2.7M

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