Volume 7(5); 2024 May 10
Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.
Reviews
Role of the Gut
Microbiota–Brain Axis in Brain
Damage in Preterm Infants
Jie Xiao
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1197–1204. Published online 2024 Apr 26. doi: 10.1021/acsptsci.3c00369
- PMCID:
- PMC11091980
Currently embargoed: Free in PMC on Apr 26, 2025; PubMed
Glyphosate: Hepatotoxicity,
Nephrotoxicity, Hemotoxicity,
Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular,
and Pulmonary System Intoxication
Jarosław Mazuryk, Katarzyna Klepacka, Włodzimierz Kutner, Piyush Sindhu Sharma
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1205–1236. Published online 2024 Apr 8. doi: 10.1021/acsptsci.4c00046
- PMCID:
- PMC11092036
Currently embargoed: Free in PMC on Apr 8, 2025; PubMed
Articles
Opposing
Interplay between Nuclear Factor Erythroid
2-Related Factor 2 and Forkhead BoxO 1/3 is Responsible for
Sepantronium Bromide’s Poor Efficacy and Resistance in Cancer
cells: Opportunity for Combination Therapy in Triple Negative Breast
Cancer
Shaista Haider, Shayantani Chakraborty, Goutam Chowdhury, Anindita Chakrabarty
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1237–1251. Published online 2024 Apr 29. doi: 10.1021/acsptsci.3c00279
- PMCID:
- PMC11091984
Currently embargoed: Free in PMC on Apr 29, 2025; PubMed
Long-Circulating
Vasoactive 1,18-Octadecanedioic Acid–Terlipressin
Conjugate
Or Berger, Wonmin Choi, Caroline H. Ko, Matthew P. Thompson, Michael J. Avram, Daniel J. Scott, Bradley L. Hoare, Riley Cridge, Mark Wheatley, Ross A. D. Bathgate, Daniel Batlle, Nathan C. Gianneschi
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1252–1261. Published online 2024 Apr 30. doi: 10.1021/acsptsci.3c00305
- PMCID:
- PMC11092119
Currently embargoed: Free in PMC on Apr 30, 2025; PubMed
Association of
Oral Anticoagulant Therapy with the
Prevalence and Severity of Vascular Calcification among Patients with
Atrial Fibrillation: A Cohort Study
Tian Wu, Jun Huang, Xia Wang, Huilin Lian, Ren Guo, Can Shi
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1262–1269. Published online 2024 Apr 9. doi: 10.1021/acsptsci.3c00307
- PMCID:
- PMC11092121
Currently embargoed: Free in PMC on Apr 9, 2025; PubMed
Mangiferin, A Naturally
Occurring Glucosylxanthone,
Induces Apoptosis in Caco-2 Cells In Vitro and Exerts Protective Effects on Acetic Acid-Induced Ulcerative
Colitis in Mice through the Regulation of NLRP3
Gangappa Dharmapuri, Anil Kumar Kotha, Suresh K. Kalangi, Pallu Reddanna
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1270–1277. Published online 2024 Apr 29. doi: 10.1021/acsptsci.3c00323
- PMCID:
- PMC11091985
Currently embargoed: Free in PMC on Apr 29, 2025; PubMed
Coumarin–Furoxan
Hybrid Suppressed the Proliferation
and Metastasis of Triple-Negative Breast Cancer by Activating Mitochondrial
Stress and Cell Apoptosis
Mengru Li, Fan Cao, Weijie Wang, Yulei Ma, Zhihui Yu, Ke Wang, Ying Chen, Hongrui Liu
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1278–1290. Published online 2024 Apr 9. doi: 10.1021/acsptsci.3c00329
- PMCID:
- PMC11091983
Currently embargoed: Free in PMC on Apr 9, 2025; PubMed
Streamlined Generation of CRISPR/Cas9-Mediated Single-Cell
Knockout Clones in Murine Cell Lines
Tobias Hub, Alex Cornean, Kellen Round, Thomas Fleming, Marc Freichel, Rebekka Medert
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1291–1301. Published online 2024 May 2. doi: 10.1021/acsptsci.3c00338
- PMCID:
- PMC11091971
Currently embargoed: Free in PMC on May 2, 2025; PubMed
Small Molecule
Functional Converter of B-Cell
Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis
Prasad
R. Kopparapu, Christiane V. Löhr, Martin C. Pearce, Shanthakumar Tyavanagimatt, Harikrishna Nakshatri, Siva K. Kolluri
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1302–1309. Published online 2024 May 1. doi: 10.1021/acsptsci.3c00360
- PMCID:
- PMC11091964
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Disease-Agnostic
Electronic Adherence Aid for Subcutaneous
at-Home and Self-Administration Devices—The Lowest Common Denominator
Based on a Cross-Indication Survey
Beate Bittner, Francisco Javier Munoz, James Odonoghue, Jose Manuel Ordonez, Johannes Schmidt, Kathrin Schmitt, Katja Stassen
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1310–1319. Published online 2024 Apr 26. doi: 10.1021/acsptsci.3c00377
- PMCID:
- PMC11091979
Currently embargoed: Free in PMC on Apr 26, 2025; PubMed
2,4′-Dihydroxybenzophenone:
A Promising Anti-Inflammatory
Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor
2-Mediated Mitochondrial Reactive Oxygen Species Production
during Lipopolysaccharide-Induced Systemic Inflammation
Mirissa
Hewage Dumindu Kavinda, Yung Hyun Choi, Chang-Hee Kang, Mi-Hwa Lee, Gi-Young Kim
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1320–1334. Published online 2024 Apr 27. doi: 10.1021/acsptsci.4c00003
- PMCID:
- PMC11092117
Currently embargoed: Free in PMC on Apr 27, 2025; PubMed
Preparation, Biological
Evaluation, and First-in-Human
Single-Photon Emission Computed Tomography (SPECT) Study of 99mTc-Labeled Prostate-Specific Membrane Antigen (PSMA)-Targeted Radiotracers Containing Triazole with
Reduced Kidneys Accumulation
Di Xiao, Peiwen Han, Yuhao Jiang, Xiaojiang Duan, Qing Ruan, Zhanbin Zhang, Xiaoliang Chen, Junbo Zhang
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1335–1347. Published online 2024 Apr 10. doi: 10.1021/acsptsci.4c00012
- PMCID:
- PMC11092200
Currently embargoed: Free in PMC on Apr 10, 2025; PubMed
Enantiomeric Agonists of the Type 2 Cannabinoid Receptor
Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit
Hyperactive Microglia In Vitro
Alexander P. Young, Anna-Maria Szczesniak, Karolynn Hsu, Melanie E.M. Kelly, Eileen M. Denovan-Wright
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1348–1363. Published online 2024 Apr 25. doi: 10.1021/acsptsci.4c00014
- PMCID:
- PMC11091991
Currently embargoed: Free in PMC on Apr 25, 2025; PubMed
Insights into Mechanisms and Promising Triple Negative
Breast Cancer Therapeutic Potential for a Water-Soluble Ruthenium
Compound
Nazia Nayeem, Sami Sauma, Afruja Ahad, Rachele Rameau, Sophia Kebadze, Mark Bazett, Brian J. Park, Patrizia Casaccia, Swayam Prabha, Karen Hubbard, Maria Contel
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1364–1376. Published online 2024 Apr 5. doi: 10.1021/acsptsci.4c00020
- PMCID:
- PMC11092013
Currently embargoed: Free in PMC on Apr 5, 2025; PubMed
Ethaverine and
Papaverine Target Cyclin-Dependent
Kinase 5 and Inhibit Lung Cancer Cell Proliferation and Migration
Arthur Laure, Chloé Royet, Frederic Bihel, Blandine Baratte, Stéphane Bach, Marion Peyressatre, May C. Morris
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1377–1385. Published online 2024 Apr 30. doi: 10.1021/acsptsci.4c00023
- PMCID:
- PMC11091981
Currently embargoed: Free in PMC on Apr 30, 2025; PubMed
Structure–Activity
Relationship Study of (E)-3-(6-Fluoro-1H-indol-3-Yl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
(FC116) Against Metastatic Colorectal Cancers Resistant to Oxaliplatin
Shuyu Wang, Qinghua Ge, Hui Cong, Wannian Zhang, Huanhai Liu, Zhuo Qu, Haihu Chen, Chunlin Zhuang
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1386–1394. Published online 2024 Apr 12. doi: 10.1021/acsptsci.4c00024
- PMCID:
- PMC11091977
Currently embargoed: Free in PMC on Apr 12, 2025; PubMed
Development of
Novel Bimodal Agents Based on Near-Infrared
BODIPY-Conjugated Hoechst Derivatives for Combined Use in Auger Electron
and Photodynamic Cancer Therapy
Ryotaro Onoue, Hiroyuki Watanabe, Masahiro Ono
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1395–1403. Published online 2024 Apr 29. doi: 10.1021/acsptsci.4c00035
- PMCID:
- PMC11091974
Currently embargoed: Free in PMC on Apr 29, 2025; PubMed
Development and
Preclinical Evaluation of a Copper-64-Labeled
Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated
Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Monireh Shojaei, Qihui Zhou, Giovanna Palumbo, Rebecca Schaefer, Janne Kaskinoro, Pirjo Vehmaan-Kreula, Peter Bartenstein, Matthias Brendel, Dieter Edbauer, Simon Lindner
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1404–1414. Published online 2024 Apr 25. doi: 10.1021/acsptsci.4c00037
- PMCID:
- PMC11091963
Currently embargoed: Free in PMC on Apr 25, 2025; PubMed
Structural Insights
into Partial Activation of the
Prototypic G Protein-Coupled Adenosine
A2A Receptor
Tobias Claff, Andhika B. Mahardhika, Victoria J. Vaaßen, Jonathan
G. Schlegel, Christin Vielmuth, Renato H. Weiße, Norbert Sträter, Christa E. Müller
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1415–1425. Published online 2024 Apr 29. doi: 10.1021/acsptsci.4c00051
- PMCID:
- PMC11091970
Currently embargoed: Free in PMC on Apr 29, 2025; PubMed
Site-Specifically
Modified Peptide Inhibitors of Protein
Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase
with Enhanced Stability and Improved In Vivo Long-Acting Activity
Chuanliang Zhang, Xianmin Yang, Lijuan Wu, Fei Liu, Kehong Dong, Chuanlong Guo, Liyan Gong, Guozhen Dong, Yiying Shi, Zongwen Gu, Xiaochun Liu, Shan Liu, Juan Wu, Feng Su
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1426–1437. Published online 2024 Apr 24. doi: 10.1021/acsptsci.4c00054
- PMCID:
- PMC11091969
Currently embargoed: Free in PMC on Apr 24, 2025; PubMed
Pharmacological
Analysis of NLRP3 Inflammasome Inhibitor
Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide
in Cellular and Mouse Models of Inflammation Provides a Translational
Framework
John R. Doedens, Pamela Smolak, MyTrang Nguyen, Heather Wescott, Christine Diamond, Ken Schooley, Andy Billinton, David Harrison, Beverly H. Koller, Alan P. Watt, Christopher A. Gabel
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1438–1456. Published online 2024 Apr 18. doi: 10.1021/acsptsci.4c00061
- PMCID:
- PMC11091978
Currently embargoed: Free in PMC on Apr 18, 2025; PubMed
Synthesis and Preclinical
Evaluation of Urea-Based
Prostate-Specific Membrane Antigen-Targeted
Conjugates Labeled with 177Lu
Aleksei E. Machulkin, Stanislav A. Petrov, Vitalina Bodenko, Mariia S. Larkina, Evgenii Plotnikov, Feruza Yuldasheva, Maria Tretyakova, Ekaterina Bezverkhniaia, Nikolay Yu. Zyk, Elena Stasyuk, Roman Zelchan, Alexander G. Majouga, Vladimir Tolmachev, Anna Orlova, Elena K. Beloglazkina, Mekhman S. Yusubov
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1457–1473. Published online 2024 May 1. doi: 10.1021/acsptsci.4c00070
- PMCID:
- PMC11092120
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Selective Detection
of Active Extracellular Granzyme
A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory
Diseases
Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A. Arias, Eva M. Galvez
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1474–1484. Published online 2024 Apr 22. doi: 10.1021/acsptsci.4c00065
- PMCID:
- PMC11092195
Currently embargoed: Free in PMC on Apr 22, 2025; PubMed
Structure-Based
Optimization of Pyrazinamide-Containing
Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors
to Overcome Clinical Mutations
Xuan Zheng, Zhiwen Chen, Ming Guo, Hong Liang, Xiaojuan Song, Yiling Liu, Zhenling Liao, Yan Zhang, Jing Guo, Yang Zhou, Zhi-min Zhang, Zhengchao Tu, Ye Zhang, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1485–1506. Published online 2024 Apr 11. doi: 10.1021/acsptsci.4c00071
- PMCID:
- PMC11092118
Currently embargoed: Free in PMC on Apr 11, 2025; PubMed
In Vitro Evaluation of Mangostanin
as an Antimicrobial and Biocompatible Topical Antiseptic for Skin
and Oral Tissues
Marta Munar-Bestard, Ana Rodríguez-Fernández, Joana Maria Ramis, Marta Monjo
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1507–1517. Published online 2024 Apr 19. doi: 10.1021/acsptsci.4c00082
- PMCID:
- PMC11091975
Currently embargoed: Free in PMC on Apr 19, 2025; PubMed
Energy Blocker
Lonidamine Reverses Nimustine Resistance
in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis
Disruption, and O6-Methylguanine-DNA
Methyltransferase Downregulation: In Vitro and In Vivo Validation
Yaxing Huang, Peng Wang, Tengjiao Fan, Na Zhang, Lijiao Zhao, Rugang Zhong, Guohui Sun
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1518–1532. Published online 2024 Apr 17. doi: 10.1021/acsptsci.4c00085
- PMCID:
- PMC11092191
Currently embargoed: Free in PMC on Apr 17, 2025; PubMed
Development of
a Fluorescent Ligand for the Intracellular
Allosteric Binding Site of the Neurotensin Receptor 1
Hannah Vogt, Patrick Shinkwin, Max E. Huber, Nico Staffen, Harald Hübner, Peter Gmeiner, Matthias Schiedel, Dorothee Weikert
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1533–1545. Published online 2024 Apr 18. doi: 10.1021/acsptsci.4c00086
- PMCID:
- PMC11092115
Currently embargoed: Free in PMC on Apr 18, 2025; PubMed
Concentration-Dependent Effects of Curcumin on Membrane
Permeability and Structure
Jamie Gudyka, Jasmin Ceja-Vega, Katherine Ivanchenko, Zachary Morocho, Micaela Panella, Alondra Gamez Hernandez, Colleen Clarke, Escarlin Perez, Shakinah Silverberg, Sunghee Lee
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1546–1556. Published online 2024 Apr 10. doi: 10.1021/acsptsci.4c00093
- PMCID:
- PMC11091966
Currently embargoed: Free in PMC on Apr 10, 2025; PubMed
Silicon-Rhodamine Functionalized Evocalcet Probes
Potently and Selectively Label Calcium Sensing Receptors In
Vitro, In Vivo, and Ex Vivo
Daniel Bátora, Jérôme
P. Fischer, Reto M. Kaderli, Máté Varga, Martin Lochner, Jürg Gertsch
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1557–1570. Published online 2024 Apr 25. doi: 10.1021/acsptsci.4c00096
- PMCID:
- PMC11091967
Currently embargoed: Free in PMC on Apr 25, 2025; PubMed
Hydroxytyrosol
Linoleoyl Ether Ameliorates Metabolic-Associated
Fatty Liver Disease Symptoms in Obese Zucker Rats
Rubén Tovar, Marialuisa de Ceglia, Miguel Rodríguez-Pozo, Antonio Vargas, Ana Gavito, Juan Suárez, Anna Boronat, Rafael de la Torre, Fernando Rodríguez de Fonseca, Elena Baixeras, Juan Decara
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1571–1583. Published online 2024 Apr 4. doi: 10.1021/acsptsci.4c00105
- PMCID:
- PMC11092116
Currently embargoed: Free in PMC on Apr 4, 2025; PubMed
Innovative Reversed-Phase
Chromatography Platform
Approach for the Fast and Accurate Characterization of Membrane Vesicles’
Protein Patterns
Luca Nompari, Salvatore Sanna Coccone, Gian Luca Sardone, Alessio Corrado, Stefania Berti, Massimiliano Biagini, Michele Rovini, Claudia Magagnoli, Simona Cianetti, Serena Orlandini, Sandra Furlanetto, Riccardo De Ricco
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1584–1594. Published online 2024 Apr 11. doi: 10.1021/acsptsci.4c00112
- PMCID:
- PMC11091982
Currently embargoed: Free in PMC on Apr 11, 2025; PubMed
Shorter Peptide
Nucleic Acid Probes Improve Affibody-Mediated
Peptide Nucleic Acid-Based Pretargeting
Kristina Westerlund, Maryam Oroujeni, Maxime Gestin, Jacob Clinton, Alia Hani Rosly, Hanna Tano, Anzhelika Vorobyeva, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1595–1611. Published online 2024 Apr 29. doi: 10.1021/acsptsci.4c00106
- PMCID:
- PMC11091976
Currently embargoed: Free in PMC on Apr 29, 2025; PubMed
Liposomes-Encapsulating
Double-Stranded Nucleic Acid
(Poly I:C) for Head and Neck Cancer Treatment
Vidit Singh, Anna Chernatynskaya, Lin Qi, Hsin-Yin Chuang, Tristan Cole, Vimalin Mani Jeyalatha, Lavanya Bhargava, W. Andrew Yeudall, Laszlo Farkas, Hu Yang
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1612–1623. Published online 2024 Apr 12. doi: 10.1021/acsptsci.4c00121
- PMCID:
- PMC11092114
Currently embargoed: Free in PMC on Apr 12, 2025; PubMed
Degradation of
the α-Carboxyl Terminus
11 Peptide: In Vivo and Ex Vivo Impacts
of Time, Temperature, Inhibitors, and Gender in Rat
Yagmur Tasdemiroglu, McAlister Council-Troche, Miao Chen, Benjamin Ledford, Russell A. Norris, Steven Poelzing, Robert G. Gourdie, Jia-Qiang He
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1624–1636. Published online 2024 Apr 22. doi: 10.1021/acsptsci.4c00120
- PMCID:
- PMC11091968
Currently embargoed: Free in PMC on Apr 22, 2025; PubMed
Cellular and Mitochondrial
Toxicity of Tolcapone,
Entacapone, and New Nitrocatechol Derivatives
Miguel Pinto, Tiago Barros Silva, Vilma A. Sardão, Rui Simões, Bárbara Albuquerque, Paulo J. Oliveira, Maria João Valente, Fernando Remião, Patrício Soares-da-Silva, Carlos Fernandes, Fernanda Borges
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1637–1649. Published online 2024 Apr 30. doi: 10.1021/acsptsci.4c00124
- PMCID:
- PMC11091965
Currently embargoed: Free in PMC on Apr 30, 2025; PubMed
GLP-1 Analogue-Loaded Glucose-Responsive Nanoparticles
as Allies of Stem Cell Therapies for the Treatment of Type I Diabetes
Joana
Moreira Marques, Rute Nunes, Ana Margarida Carvalho, Helena Florindo, Domingos Ferreira, Bruno Sarmento
ACS Pharmacol Transl Sci. 2024 May 10; 7(5): 1650–1663. Published online 2024 May 2. doi: 10.1021/acsptsci.4c00173
- PMCID:
- PMC11092009
Currently embargoed: Free in PMC on May 2, 2025; PubMed
Articles from ACS Pharmacology & Translational Science are provided here courtesy of American Chemical Society