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Select item 105577441.

Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

Linda S. Rubio, Suman Mohajan, David S. Gross

Version 3. bioRxiv. Preprint. 2023 Sep 29 [revised 2024 Aug 17]. doi: 10.1101/2023.09.28.560064

Published in:: eLife. 2024; 12: RP92464.

PMCID:: PMC10557744

Abstract Article PDF–6.2M

Select item 105927362.

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype

Kirti Sad, Celina Y Jones, Dorelle V Fawwal, Emily J Hill, Katie Skinner, Severin Lustenberger, Richard S Lee, Satvick R Elayavalli, Jonathan Farhi, Laramie D Lemon, Milo B Fasken, Andrew L Hong, Steven A Sloan, Anita H Corbett, Jennifer M Spangle

Version 2. bioRxiv. Preprint. 2023 Oct 12 [revised 2024 Aug 1]. doi: 10.1101/2023.10.11.561775

PMCID:: PMC10592736

Abstract PDF–1.9M

Select item 109799893.

The Histone Chaperone Spn1 Preserves Chromatin Protections at Promoters and Nucleosome Positioning in Open Reading Frames

Andrew J. Tonsager, Alexis Zukowski, Catherine A. Radebaugh, Abigail Weirich, Laurie A. Stargell, Srinivas Ramachandran

Version 2. bioRxiv. Preprint. 2024 Mar 14 [revised 2024 Jul 29]. doi: 10.1101/2024.03.14.585010

PMCID:: PMC10979989

Abstract PDF–2.1M

Select item 102746744.

SMYD5 is a regulator of the mild hypothermia response

Salvor Rafnsdottir, Kijin Jang, Sara Tholl Halldorsdottir, Meghna Vinod, Arnhildur Tomasdottir, Katrin Möller, Katrin Halldorsdottir, Tinna Reynisdottir, Laufey Halla Atladottir, Kristin Elisabet Allison, Kevin Ostacolo, Jin He, Li Zhang, Frances J. Northington, Erna Magnusdottir, Raul Chavez-Valdez, Kimberley Jade Anderson, Hans Tomas Bjornsson

Version 3. bioRxiv. Preprint. NaN NaN [revised 2024 Jul 12]. doi: 10.1101/2023.05.11.540170

Published in:: Cell Rep. 2024 Aug 27; 43(8): 114554.

PMCID:: PMC10274674

Abstract Article PDF–1.7M

Select item 106808195.

Environment-independent distribution of mutational effects emerges from microscopic epistasis

Sarah Ardell, Alena Martsul, Milo S. Johnson, Sergey Kryazhimskiy

Version 3. bioRxiv. Preprint. 2023 Nov 18 [revised 2024 Jul 9]. doi: 10.1101/2023.11.18.567655

Published in:: Science. 2024 Oct 4; 386(6717): 87–92.

PMCID:: PMC10680819

Abstract Article PDF–25M

Select item 106347026.

Multilevel gene expression changes in lineages containing adaptive copy number variants

Pieter Spealman, Carolina de Santana, Titir De, David Gresham

Version 2. bioRxiv. Preprint. 2023 Oct 23 [revised 2024 Jul 9]. doi: 10.1101/2023.10.20.563336

PMCID:: PMC10634702

Abstract Article PDF–25M

Select item 106809157.

Trans-eQTL hotspots shape complex traits by modulating cellular states

Kaushik Renganaath, Frank W. Albert

Version 2. bioRxiv. Preprint. 2023 Nov 15 [revised 2024 Jul 8]. doi: 10.1101/2023.11.14.567054

PMCID:: PMC10680915

Abstract Article PDF–3.8M

Select item 109839318.

Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a Legionella pneumophila protein that impinges on a stress response pathway

Dar Hershkovitz, Emy J. Chen, Alexander W. Ensminger, Aisling S. Dugan, Kaleigh T. Conway, Alex C. Joyce, Gil Segal, Ralph R. Isberg

Version 3. bioRxiv. Preprint. NaN NaN [revised 2024 Jun 25]. doi: 10.1101/2024.03.17.585421

Published in:: mSphere. 2024 Sep; 9(9): e00222-24.

PMCID:: PMC10983931

Abstract Article PDF–3.1M

Select item 110145579.

Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG

Eri Hirata, Ken-taro Sakata, Grace I. Dearden, Faria Noor, Indu Menon, George N. Chiduza, Anant K. Menon

Version 2. bioRxiv. Preprint. 2024 Apr 3 [revised 2024 Jun 22]. doi: 10.1101/2024.04.03.587922

Published in:: J Biol Chem. 2024 Aug; 300(8): 107584.

PMCID:: PMC11014557

Abstract Article PDF–4.5M

Select item 1051580610.

Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation

Gabriela Giordano, Robin Buratowski, Célia Jeronimo, Christian Poitras, François Robert, Stephen Buratowski

Version 2. bioRxiv. Preprint. 2023 Sep 12 [revised 2024 Jun 13]. doi: 10.1101/2023.09.11.557269

PMCID:: PMC10515806

Abstract Article PDF–19M

Select item 1031274911.

A trade-off between proliferation and defense in the fungal pathogen Cryptococcus at alkaline pH is controlled by the transcription factor GAT201

Elizabeth S. Hughes, Laura R. Tuck, Zhenzhen He, Elizabeth R. Ballou, Edward W.J. Wallace

Version 3. bioRxiv. Preprint. 2023 Jun 14 [revised 2024 Jun 11]. doi: 10.1101/2023.06.14.543486

PMCID:: PMC10312749

Abstract Article PDF–2.9M

Select item 1088902112.

The budding yeast Fkh1 Forkhead associated (FHA) domain promoted a G1-chromatin state and the activity of chromosomal DNA replication origins

Timothy Hoggard, Erika Chacin, Allison J. Hollatz, Christoph F. Kurat, Catherine A. Fox

Version 2. bioRxiv. Preprint. 2024 Feb 17 [revised 2024 Jun 7]. doi: 10.1101/2024.02.16.580712

Published in:: PLoS Genet. 2024 Aug; 20(8): e1011366.

PMCID:: PMC10889021

Abstract Article PDF–6.7M

Select item 1034996913.

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects

Yevgeniy Plavskin, Maria Stella de Biase, Naomi Ziv, Libuše Janská, Yuan O Zhu, David W Hall, Roland F Schwarz, Daniel Tranchina, Mark L Siegal

Version 2. bioRxiv. Preprint. 2023 Jul 4 [revised 2024 Jun 2]. doi: 10.1101/2023.07.04.547687

Published in:: PLoS Biol. 2024 Jul; 22(7): e3002698.

PMCID:: PMC10349969

Abstract Article

Select item 1086285414.

Biogenesis of cytochromes c and c₁ in the electron transport chain of malaria parasites

Aldo E. García-Guerrero, Rebecca G. Marvin, Amanda Mixon Blackwell, Paul A. Sigala

Version 2. bioRxiv. Preprint. 2024 Feb 1 [revised 2024 Jun 1]. doi: 10.1101/2024.02.01.575742

PMCID:: PMC10862854

Abstract Article PDF–6.7M

Select item 1092514415.

Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

Marilina Raices, Fabiola Balmir, Nicola Silva, Wei Li, McKenzie K. Grundy, Dane K. Hoffman, Elisabeth Altendorfer, Carlos Jaime Camacho, Kara A. Bernstein, Monica P. Colaiácovo, Judith Yanowitz

Version 2. bioRxiv. Preprint. 2024 Feb 28 [revised 2024 May 30]. doi: 10.1101/2024.02.23.581796