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Agonist activity at zebrafish GPR34 type b expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling treated at 24 hours post fertilization and measured after 6 hrs post dose by d2EGFP fluorescence based assay
Assay data:1 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Antagonist activity at zebrafish AhR2 expressed in COS7 cells transfected with ARNT-1c, Cyp1a-firefly luciferase and pRL-TK Renilla luciferase plasmids assessed as inhibition of AhR transcriptional activity administered at 5 hrs post-transfection treated with TCDD at 1 hr post-compound treatment and measured for 10 sec after a 3 sec delay at 18 hrs post-TCDD challenge by dual luciferase reporter gene assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DPN from zebrafish delta 1a opioid receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
Displacement of [3H]DPN from zebrafish mu opioid receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
Inhibition of zebrafish embryo tyrosinase assessed as melanin production after 48 hrs
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]-diprenorphine from zebrafish mu opioid receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
Assay data:3 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of tyrosinase in zebrafish assessed as reduction in pigmentation level at 10 uM
Assay data:2 Tested
Agonist activity at zebrafish GPR34 type b expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis relative to control
Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring reduction in ETSRP expression relative to control
Assay data:1 Active, 1 Tested
Inhibition of Dusp5 in Zebrafish 1-cell stage embryos assessed as rescue of Zebrafish dusp5-mediated suppression of sef expression at 5 uM
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of Dusp6 in Zebrafish 1-cell stage embryos assessed as rescue of Zebrafish dusp6-mediated suppression of sef expression at 5 uM
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP);ace mutant) transgenic Zebrafish assessed as activation of FGF signaling in mid-hindbrain boundary by d2EGFP fluorescence based assay
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling at 20 uM by d2EGFP fluorescence based assay
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling at 5 uM by d2EGFP fluorescence based assay
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in spry4 expression at 10 to 20 uM by semi-quantitative RT-PCR analysis
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in sef expression at 10 to 20 uM by semi-quantitative RT-PCR analysis
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in krox20 expression at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring expansion of rhombomere-4 and tail bud at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in eng3 expression at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay
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