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Inhibition of human TS
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryRelated BioAssays by Target
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Assay data:50 Active, 50 Activity ≤ 1 µM, 50 Tested
Inhibition of Thymidylate synthase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constant
Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:24 Active, 15 Activity ≤ 1 µM, 34 Tested
Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:22 Active, 12 Activity ≤ 1 µM, 34 Tested
Inhibition of Trypanosoma cruzi DHFR-TS in presence of NADPH by spectrophotometry
Inhibition of recombinant Trypanosoma cruzi DHFR-TS assessed as inhibition constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Trypanosoma cruzi DHFR-TS assessed as inhibition constant using DHF as substrate in presence of NADPH by spectrophotometry
Reduction in intracellular TS activity in human IGROV-1 cells assessed as residual activity measured at 5 uM by tritium release assay relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reduction in intracellular TS activity in human IGROV-1 cells measured at 2.5 uM by tritium release assay relative to control
Assay data:2 Tested
Reduction in intracellular TS activity in human IGROV-1 cells measured at 1.25 uM by tritium release assay relative to control
Mixed type inhibition of human TS assessed as inhibitor dissociation constant by measuring changes in slope of the double reciprocal plot using dTMP as substrate by UV-Vis spectroscopy based analysis
Non competitive type inhibition of human TS assessed as inhibition constant using varying levels of mTHF as substrate by UV-Vis spectroscopy based analysis
Inhibition Assay from US Patent US9422297: "Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof"
Assay data:13 Active, 6 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from Article 10.3109/14756360903179443: "Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms."
Assay data:13 Active, 11 Activity ≤ 1 µM, 21 Tested
Tritium Release Assay from Article 10.1111/j.1747-0285.2010.01010.x: "Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping."
Assay data:4 Active, 2 Activity ≤ 1 µM, 14 Tested
Inhibition Assay from Article 10.1016/j.chembiol.2003.11.012: "Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase."
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
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