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Biochemical QPCT and QPCTL Activity Assay from US Patent US20240059675: "PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN"
Assay data:36 Active, 8 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
SummaryRelated BioAssays by Target
Inhibition of mouse glutaminyl cyclase
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of isoQC (unknown origin)
Inhibition of human glutaminyl cyclase using L-glutamine-7-amido-4-methylcoumarin as substrate incubated for 10 mins in presence of pyroglutamyl peptidase by fluorometry analysis
Assay data:35 Active, 35 Activity ≤ 1 µM, 35 Tested
Inhibition of QC (unknown origin)
Assay data:1 Active, 1 Tested
Binding affinity to human QC assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to QC (unknown origin) assessed as inhibition constant
Enzymatic Activity of Human Glutaminyl Cyclase In Vitro from US Patent US11845740: "Glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases"
Assay data:9 Active, 2 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Assay from US Patent US11834440: "Beta-lactam derivatives for the treatment of diseases"
Assay data:92 Active, 101 Activity ≤ 1 µM, 101 Tested
Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis
Assay data:32 Active, 20 Activity ≤ 1 µM, 69 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human isoQC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis
Assay data:21 Active, 18 Activity ≤ 1 µM, 24 Tested
Inhibition of mouse QPCT measured after 15 mins by fluorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry
Assay data:92 Active, 9 Activity ≤ 1 nM, 92 Activity ≤ 1 µM, 92 Tested
QC Inhibition Assay from US Patent US10584120: "Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease"
Assay data:58 Active, 55 Activity ≤ 1 µM, 58 Tested
Fluorometric Assays from US Patent US9512115: "Inhibitors"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitor Assay from US Patent US9512082: "Inhibitors of glutaminyl cyclase"
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
Spectrophotometric Assay from US Patent US9181233: "Inhibitors of glutaminyl cyclase"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Fluorometric Assay from US Patent US9126987: "Inhibitors of glutaminyl cyclase"
Assay data:21 Active, 7 Activity ≤ 1 µM, 25 Tested
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