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Enzyme Inhibition Assay from US Patent US10624871: "Bismuth(III) compounds and methods thereof"
Assay data:4 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
metallo-beta-lactamase inhibition assay from US Patent US11459296: "Antibacterial compounds"
Assay data:30 Active, 15 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Activity: Determination of IC50 from US Patent US11207312: "Metallo-beta-lactamase inhibitors and methods of use thereof"
Assay data:204 Active, 130 Activity ≤ 1 nM, 204 Activity ≤ 1 µM, 204 Tested
beta-lactamase assay from US Patent US10543221: "Beta-lactamase inhibitors, formulations, and uses thereof"
Assay data:6 Active, 1 Activity ≤ 1 µM, 13 Tested
Enzyme Activity from US Patent US10227331: "Metallo-beta-lactamase inhibitors"
Assay data:369 Active, 307 Activity ≤ 1 nM, 369 Activity ≤ 1 µM, 369 Tested
MBL Inhibitory Activity in Constructed E. coli Cells Expressing MBLs from US Patent US10227327: "Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety"
Assay data:11 Active, 9 Activity ≤ 1 µM, 11 Tested
BIOLOGICAL ASSAYS from US Patent US10221163: "Metallo-beta-lactamase inhibitors"
Assay data:492 Active, 462 Activity ≤ 1 nM, 492 Activity ≤ 1 µM, 492 Tested
Class B Enzyme Assay from US Patent US9708336: "Metallo-beta-lactamase inhibitors"
Assay data:825 Active, 169 Activity ≤ 1 nM, 823 Activity ≤ 1 µM, 825 Tested
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): primary screen against the NCATS Gemini Collection
Assay data:127 Activity ≤ 1 µM, 6933 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): Nitrocefin screen against the machine-based learning selections.
Assay data:6 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 2809 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay validation screen against the NCATS LOPAC Collection
Assay data:10 Active, 7 Activity ≤ 1 µM, 1248 Tested
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): Meropenem screen against the machine-based learning selections.
Assay data:1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2799 Tested
Inhibition of NDM-1 in Klebsiella pneumoniae using meropenem as substrate incubated for 0.5 hrs
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Synergistic Inhibition of beta lactamase NDM1 in Klebsiella pneumoniae K66-45 assessed colony formation by visual inspection in presence of 50 microM (5-((4-iodophenylsulfonamido)methyl)-1H-1,2,3-triazol-4-yl)methyl acetate incubated for 20 hrs by two-fold dilution method
Synergistic Inhibition of beta lactamase NDM1 in Klebsiella pneumoniae K66-45 assessed colony formation by visual inspection in presence of 125 microM N-((4-((adamantylamino)methyl)-1H-1,2,3-triazol-5-yl)methyl)-4-iodobenzenesulfonamide incubated for 20 hrs by two-fold dilution method
Synergistic Inhibition of beta lactamase NDM1 in Klebsiella pneumoniae K66-45 assessed colony formation by visual inspection in presence of 125 microM N-((4-((cyclohexylamino)methyl)-1H-1,2,3-triazol-5-yl)methyl)-4-iodobenzenesulfonamide incubated for 20 hrs by two-fold dilution method
Inhibition of beta lactamase NDM1 in Klebsiella pneumoniae K66-45 assessed colony formation by visual inspection incubated for 20 hrs by two-fold dilution method
Synergistic Inhibition of beta lactamase NDM1 in Klebsiella pneumoniae K66-45 assessed colony formation by visual inspection in presence of 50 microM 2,5-Dichloro-N-((4-((cyclohexylamino)methyl)-1H-1,2,3-triazol-5-yl)methyl)benzenesulfonamide incubated for 20 hrs by two-fold dilution method
Inhibition of Klebsiella pneumoniae NDM-1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of wild type N-terminal His6-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21 using nitrocefin as substrate measured after 30 mins
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