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Coupled Nucleotide Exchange Assay from US Patent US20240059703: "HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE"
Assay data:506 Active, 473 Activity ≤ 1 µM, 513 Tested
SummaryRelated BioAssays by Target
Determination of Related Protease Inhibition from US Patent US20240059691: "ENZYME INHIBITORS"
Assay data:279 Active, 16 Activity ≤ 1 nM, 253 Activity ≤ 1 µM, 299 Tested
Potentiator Assay from US Patent US20240058315: "Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
KRAS::SOS1 AlphaScreen Binding Assay from US Patent US20240051956: "SOS1 INHIBITORS AND USES THEREOF"
Assay data:85 Active, 87 Activity ≤ 1 µM, 87 Tested
Assay for Inhibition of MMP from US Patent US20240050571: "CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SOS-Catalyzed Nucleotide Exchange Assay from US Patent US20240043448: "Small Molecule Inhibitors of KRAS G12C Mutant"
Assay data:93 Active, 7 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 93 Tested
Cross screening panel
Assay data:1 Tested
Kallikrein Serine protease panel
Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
CDC42 SGC Tm panel (DSF)
CDC42BPA SGC Tm panel (DSF)
Transporter, Serotonin (5-Hydroxytryptamine) (SERT) Eurofins Panlabs panel
Panlabs assay PDE2A
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE2A)
RAF1 Invitrogen Lab (UK) kinase screen (BI)
SLC6A4/H Eurofins SafetyScreen44 (BI)
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