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Binding affinity to c-MYC (unknown origin) assessed as dissociation constant
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Myc/Max (unknown origin)
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of c-MYC (unknown origin)
Assay data:11 Active, 6 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Disruption of MKK3/MYC protein-protein interaction in human MDA-MB-468 cells assessed as decrease in PDL1 level at 1 to 20 uM measured by western blot assay
Disruption of MKK3/MYC protein-protein interaction in human MDA-MB-468 cells assessed as decrease in CDK4 level at 1 to 20 uM measured by western blot assay
Disruption of interaction between human recombinant GST-tagged MKK3/His-tagged MYC HLH LZ domain measured after 2 hrs by TR-FRET assay
Disruption of interaction between human recombinant GST-tagged MKK3 expressed in HEK293T cells/MYC in human HCT116 cells incubated for 30 mins by GST pull-down assay
Assay data:1 Tested
Disruption of interaction between human recombinant GST-tagged MAX/VF-tagged MYC expressed in HEK293T cells at 50 uM incubated for 30 mins by GST pull-down assay
Disruption of interaction between human recombinant GST-tagged MKK3/VF-tagged MYC expressed in HEK293T cells at 50 uM incubated for 30 mins by GST pull-down assay
Disruption of interaction between human recombinant GST-tagged MKK3/VF-tagged MYC expressed in HEK293T cells up to 100 uM measured after 2 hrs by TR-FRET assay
Assay data:2 Tested
Disruption of interaction between human recombinant GST-tagged MKK3/VF-tagged MYC expressed in HEK293T cells at 20 uM measured after 2 hrs by TR-FRET assay
Disruption of MKK3/MYC protein-protein interaction in human MDA-MB-468 cells transfected with VF-tagged MKK3 assessed as inhibition of MYC transcriptional activity measured after 12 hrs by Renilla luciferase based reporter assay
Disruption of MKK3/MYC protein-protein interaction in human HCT-116 cells transfected with VF-tagged MKK3 assessed as inhibition of MYC transcriptional activity at 0.5 to 2 uM measured after 12 hrs by Renilla luciferase based reporter assay
Disruption of MKK3/MYC protein-protein interaction in human MDA-MB-468 cells assessed as decrease in MYC level at 1 to 20 uM measured by western blot assay
Disruption of MKK3/MYC protein-protein interaction in human HCT-116 cells assessed as decrease in PDL1 level at 0.5 to 10 uM measured by western blot assay
Assay data:1 Active, 2 Tested
Disruption of MKK3/MYC protein-protein interaction in human HCT-116 cells assessed as decrease in CDK4 level at 0.5 to 10 uM measured by western blot assay
Disruption of MKK3/MYC protein-protein interaction in human HCT-116 cells assessed as decrease in MYC level at 0.5 to 10 uM measured by western blot assay
Disruption of interaction between human recombinant GST-tagged MKK3 (1 to 210 residues)/VF-tagged MYC expressed in HEK293T cells measured after 2 hrs by TR-FRET assay
Disruption of interaction between human recombinant GST-tagged MKK3/VF-tagged MYC expressed in HEK293T cells measured after 2 hrs by TR-FRET assay
Assay data:1 Active, 3 Tested
Inhibition of Nanoluc-tagged c-Myc/Halo-tagged MAX (unknown origin) interaction expressed in HEK293T cells assessed as degradation measured after 4 to 6 hrs by NanoBRET assay
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