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Binding affinity to FKBP52 (unknown origin) by competitive fluorescence polarization assay
Assay data:6 Tested
SummaryRelated BioAssays by Target
Binding affinity to FKBP52 (unknown origin)
Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested
NanoBRET assay (FKBP12-NLuc) (FKBP4)
Assay data:1 Tested
Competitive fluorescence polarization binding assay (FKBP4)
Displacement of fluorescent tracer 5-(3-(4-((1S,5S,6S)-10-(3,5-dichlorophenylsulfonyl)-2-oxo-3-(pyridin-3-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-5-yl)-1H-1,2,3-triazol-1-yl)propylcarbamoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)benzoate from recombinant full length C-terminal FLAG-tagged FKBP52 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by fluorescence polarisation competition binding assay
Assay data:11 Active, 2 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) at 10 uM by Dansyl fluorescence based assay
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) by Dansyl fluorescence based assay
Assay data:4 Tested
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) in PBS at 20 uM in presence of one equivalent FK506 by FRET assay
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) in PBS assessed as induction of blue shift by measuring emission wavelength at 10 to 20 uM by fluorimetric analysis (Rvb = 560 nm)
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) in PBS assessed as quenching of Trp emission at 10 to 20 uM by fluorimetric analysis
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) by isothermal calorimetric analysis
Assay data:9 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) in PBS by fluorescence spectroscopy
Assay data:1 Active, 1 Tested
Binding affinity to FKBP52 FK2 domain (167 to 253 residues) (unknown origin) in PBS at 10 uM by Dansyl fluorescence based assay relative to control
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) at 10 uM in presence of FK506 by Dansyl fluorescence based assay
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) assessed as increase in fluorescence at 10 uM by Dansyl fluorescence based assay relative to control
Binding affinity to FKBP52 FK1 domain (1 to 148 residues) (unknown origin) assessed as blue shift at 10 uM by Dansyl fluorescence based assay
Inhibition of human full length N-terminal His-tagged/C-terminal FLAG tagged FKBP52 expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by competitive fluorescence polarization assay
Assay data:16 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Displacement of 5-(3-(4-(((5S,6S)-10-(3,5-dichlorophenylsulfonyl)-2-oxo-5-vinyl-3,10-diazabicyclo[4.3.1]decan-3-yl)methyl)-1H-1,2,3-triazol-1-yl)propylcarbamoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3,10-dihydroanthracen-9-yl)benzoate from human FKBP52 after 30 mins by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to FKBP52 (1 to 140 amino acids) (unknown origin) up to 500 uM incubated for 30 mins using fluorescein-conjugated 2-(5-((2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetamido)methyl)-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid by competitive fluorescence polarization assay
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