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Inhibition of recombinant CYP1A1 (unknown origin) assessed as decrease in EROD activity using 7-ethoxyresorufin as substrate upto 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:11 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 50 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 10 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:8 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 5 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:3 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:10 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.01 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH and CYP1A1 inhibitor, alpha-naphthoflavone addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Assay data:2 Tested
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with deuterated molecular ion at m/z 265.10940 at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by HDX LC/MS spectral analysis
Assay data:1 Active, 1 Tested
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with elution time of 5.02 min at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by HDX LC/MS spectral analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with elution time of 4.05 min at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by HDX LC/MS spectral analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with elution time of 4.03 min at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation by measuring increase in 16 Da molecular weight at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Assay data:2 Active, 2 Tested
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with elution time at 5.02 min at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with elution time at 4.05 min at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Inhibition of recombinant CYP1A1 (unknown origin) assessed as decrease in EROD activity using 7-ethoxyresorufin as substrate incubated for 15 mins by resorufin dye based spectrofluorimetry
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of CYP1A in human liver microsomes using probe substrate at 0.1 to 100 uM in presence of NADPH
Assay data:1 Tested
Time dependent inhibition of CYP450 (unknown origin) at 10 uM
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