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Inhibition of AKT phosphorylation in mouse BaF3 cells harboring L858R/C797S double mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of AKT phosphorylation in mouse BaF3 cells harboring De119/C797S mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis
Inhibition of AKT phosphorylation in mouse BaF3 cells harboring Del19 mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis
Inhibition of AKT phosphorylation in mouse BaF3 cells harboring L858R mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis
Activation of Akt phosphorylation in Swiss Webster mouse immature cerebrocortical neuron at 30 uM preincubated with TrkB receptor inhibitor K252a followed by compound addition and measured after 30 mins by western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Akt phosphorylation in Swiss Webster mouse immature cerebrocortical neuron at 30 uM preincubated with NMDAR antagonist MK-801 followed by compound addition and measured after 30 mins by western blot analysis
Activation of Akt phosphorylation in Swiss Webster mouse immature cerebrocortical neuron at 30 uM preincubated with VGSC blocker TTX followed by compound addition and measured after 30 mins by western blot analysis
Activation of Akt phosphorylation in Swiss Webster mouse immature cerebrocortical neuron at 30 uM preincubated with PI3 kinase inhibitor LY-294002 followed by compound addition and measured after 30 min by western blot analysis
Activation of Akt signalling pathway in Swiss Webster mouse immature cerebrocortical neuron assessed as increase in AKT phosphorylation of Ser473 by measuring fold change at 10 to 30 uM incubated for 24 hrs by western blot analysis
Inhibition of AKT in mouse 3T3-L1 cells assessed as reduction in AKT phosphorylation in maturation at 0.5 to 5 uM after 48 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of AKT in mouse 3T3-L1 cells assessed as reduction in AKT phosphorylation in early differentiation at 0.5 to 5 uM after 48 hrs by Western blot analysis
Inhibition of Akt phosphorylation in mouse BaF3 cells expressing EGFR del19/T790M/C797S triple mutant after 3 hrs by Western blot analysis
Inhibition of LPS-induced AKT activation in BSO-treated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at 10 uM preincubated for 1 hr followed by LPS-stimulation measured after 4 hrs by Western blot analysis
Inhibition of LPS-induced AKT activation in mouse RAW264.7 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysis
Activation of AKT in mouse C2C12 cells assessed as AKT phosphorylation at ser 308 residue at 1 uM after 6 hrs by Western blot analysis
Assay data:2 Tested
Effect on IFNgamma-stimulated AKT phosphorylation in mouse RAW264.7 cells harboring HA-empty vector assessed as phosphorylated AKT level at 40 nM preincubated for 2 hrs followed by IFNgamma-stimulation measured after 1 hr by Western blot analysis relative to GAPDH (Rvb = 4.3 +/- 0.1 No_unit)
Effect on IFNgamma-stimulated AKT phosphorylation in mouse RAW264.7 cells harboring HA-empty vector assessed as phosphorylated AKT level at 20 nM preincubated for 2 hrs followed by IFNgamma-stimulation measured after 1 hr by Western blot analysis relative to GAPDH (Rvb = 4.3 +/- 0.1 No_unit)
Effect on IFNgamma-stimulated AKT phosphorylation in mouse RAW264.7 cells harboring HA-empty vector assessed as phosphorylated AKT level at 10 nM preincubated for 2 hrs followed by IFNgamma-stimulation measured after 1 hr by Western blot analysis relative to GAPDH (Rvb = 4.3 +/- 0.1 No_unit)
Effect on IFNgamma-stimulated AKT phosphorylation in mouse RAW264.7 cells harboring HA-empty vector assessed as phosphorylated AKT level at 5 nM preincubated for 2 hrs followed by IFNgamma-stimulation measured after 1 hr by Western blot analysis relative to GAPDH (Rvb = 4.3 +/- 0.1 No_unit)
Inhibition of AKT phosphorylation in RANKL-induced ICR mouse bone marrow macrophages at 1 uM preincubated for 1 hr followed by RANKL-stimulation and measured after 5 to 30 mins by Western blot analysis
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