BioAssay by Target (List) for Gene (Select 10018) - PubChem BioAssay - NCBI

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Select item 19571621.

Inhibition of N-terminal GST-tagged human recombinant Mcl-1 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:26 Active, 17 Activity ≤ 1 µM, 29 Tested

AID:: 1957162

Summary Related BioAssays by Target

Select item 19571582.

Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 2

Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested

AID:: 1957158

Summary Related BioAssays by Target

Select item 19383343.

Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 1938334

Summary Related BioAssays by Target

Select item 19383334.

Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938333

Summary Related BioAssays by Target

Select item 19383325.

Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938332

Summary Related BioAssays by Target

Select item 19194876.

AlphaLISA Assay from US Patent US11667652: "MCL1 inhibitors"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:204 Active, 193 Activity ≤ 1 nM, 204 Activity ≤ 1 µM, 204 Tested

AID:: 1919487

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19194297.

AlphaLISA assay from US Patent US11643400: "MCL-1 inhibitors"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:443 Active, 402 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 443 Tested

AID:: 1919429

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18588288.

Inhibition of Mcl-1/Bim (unknown origin) by fluorescence polarisation assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1858828

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18588209.

Inhibition of Bcl-xL/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:2 Active, 3 Tested

AID:: 1858820

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 185881910.

Inhibition of GST-tagged Mcl-1/Bim (unknown origin) incubated for 15 mins followed by Bim addition measured after 2 hrs by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1858819

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185881811.

Inhibition of GST-tagged Bcl-xL/Bim (unknown origin) incubated for 15 mins followed by Bim addition measured after 2 hrs by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1858818

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185881712.

Inhibition of Bcl-2/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 2

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1858817

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185881613.

Inhibition of Mcl-1/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:6 Active, 3 Activity ≤ 1 µM, 7 Tested

AID:: 1858816

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185880614.

Binding affinity to Bcl-xL/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1858806

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185880315.

Binding affinity to GST-tagged Bcl-xL/5-FAM-tagged Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1858803

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184533716.

Inhibition of C-terminal His6-tagged recombinant human MCL-1 (171 to 327 residues/biotinylated Bim (51 to 76 residues) interaction incubated for 1 hrs followed by Bim addition and measured after 2 hrs by AlphaLISA assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1845337

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 181260217.

Inhibition of MCL1/Bim interaction in human MCF7 cells assessed as disruption of MCL1/Bim complex at 10 uM measured after 24 hrs by co-immunoprecipitation based western blot analysis relative to control

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:3 Tested

AID:: 1812602

Summary PubMed Citation Related BioAssays by Target

Select item 180660418.

Cell Free Mcl-1: Bim Affinity Assay (Mcl-1 HTRF) from US Patent US11364248: "Compounds that inhibit Mcl-1 protein"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:54 Active, 42 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested

AID:: 1806604

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180641119.

Cell Free Mcl-1:Bim Affinity Assay (Mcl-1 HTRF) from US Patent US11279712: "Macrocyclic compounds that inhibit MCL-1 protein"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:61 Active, 52 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 61 Tested

AID:: 1806411

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180640120.

Bim Binding Assays (Mcl-1 TR-FRET Assays (with 5% human serum) ) from US Patent US11274105: "Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:170 Active, 2 Activity ≤ 1 nM, 158 Activity ≤ 1 µM, 171 Tested

AID:: 1806401

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

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Target

Proteins (9)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Chemical Probes (2)
BioAssays with compounds reported as validated chemical probes

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (10)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (20)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (3)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (32)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (11)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (43)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (10)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (34)
BioAssays extracted from the literature
NIH MLP (9)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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