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Toxicity in Drosophila infected with huntington disease assessed as survival rate at 1 to 30 uM relative to control
Assay data:1 Tested
Summary
Binding affinity to Laodelphax striatella (small brown planthopper) nicotinic acetylcholine receptor
Assay data:34 Active, 34 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from Article 10.1002/cbic.200900750: "Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II."
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition Assay from Article 10.1002/cbic.200800538: "The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A."
Assay data:4 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of tau protein accumulation in Drosophila larvae eye assessed as reduction in tau protein level at 0.75 mg/ml dripped every other day by immunohistochemistry
SummaryPubMed Citation
Effect on Drosophila melanogaster Nav1 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Inhibition of Drosophila topoisomerase II assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide staining based agarose gel electrophoresis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of locomotor deficit in OK371-GAL4-(G4C2)29 Drosophila expressing (G4C2)29 in motor neuron C9orf72 ALS/FTD model assessed as reduction in flies staying at the bottom of flask at 100 uM, po during larval stage by climbing assay relative to control (Rvb= 18.25%)
Assay data:2 Tested
Inhibition of eye degeneration in GMR-GAL4-(G4C2)29 Drosophila expressing (G4C2)29 in eyes C9orf72 ALS/FTD model assessed as reduction in rough-eye phenotype at 100 uM, po incubated 7 day by stereomicroscopy
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of eye degeneration in GMR-GAL4-(G4C2)29 Drosophila expressing (G4C2)29 in eyes C9orf72 ALS/FTD model assessed as reflective eyes at 100 uM, po incubated 7 day by stereomicroscopy
Inhibition of eye degeneration in GMR-GAL4-(G4C2)29 Drosophila expressing (G4C2)29 in eyes C9orf72 ALS/FTD model assessed as smoothening of eyes at 100 uM, po incubated 7 day by stereomicroscopy
Inhibition of Drosophila melanogaster Spastin N527C mutant (209 to 758 residues) in presence of ATP by NADH-coupled fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of wild-type Drosophila melanogaster Spastin (209 to 758 residues) in presence of ATP by NADH-coupled fluorescence assay
Assay data:1 Active, 1 Tested
Agonist activity at Drosophila melanogaster sNPFR1 expressed in wild type CHO-K1 cells assessed as increase in calcium level at 0.1 mM after 20 secs by luminescence assay
Assay data:4 Tested
Agonist activity at Drosophila melanogaster NPFR1 expressed in wild type CHO-K1 cells assessed as increase in calcium level at 0.1 mM after 20 secs by luminescence assay
Insecticidal activity against wild type Drosophila melanogaster L. assessed as mortality compound topically applied dorsally to the thorax at 23 to 25 25 degC, 60 to 70%RH measured per adult after 3 hr
Assay data:5 Tested
Adulticidal activity against Drosophila melanogaster larvae assessed as mortality measured per adult
Assay data:3 Tested
Insecticidal activity against first-instar larval stage of Drosophila melanogaster fed with artificial diet containing compound assessed as mortality measured after 24 hr
Insecticidal activity against first-instar larval stage of Drosophila melanogaster fed with artificial diet containing compound assessed as mortality measured after 72 hr
Assay data:6 Tested
Adulticidal activity against adult Drosophila melanogaster (males/females 1:1 ratio) assessed as mortality measured after 3 hr
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