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Inhibition of HCV RNA IRES IIa by FRET assay
Assay data:3 Tested
SummaryPubMed Citation
Inhibition of Hepatitis C virus NS5B polymerase
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antiviral activity against Hepatitis C virus subtype 1b infected in Huh-7 cells transfected with HCV subgenomic replicon for NS5B polymerase assessed as inhibition of viral replication measured upto 96 hrs in presence of 40% of human serum by luciferase reporter gene assay
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Hepatitis C virus subtype 1b infected in Huh-7 cells transfected with HCV subgenomic replicon for NS5B polymerase assessed as inhibition of viral replication measured upto 96 hrs by luciferase reporter gene assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Binding affinity to HCV IRES
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to HCV RNA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:5 Tested
Antiviral activity against HCV subtype 1b in Huh-5-2 cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against HCV assessed as inhibition of HCV RNA replication at 5.0 uM relative to control
Assay data:1 Tested
Antiviral activity against HCV assessed as inhibition of RNA replication
Assay data:2 Active, 3 Tested
Antiviral activity against HCV GT1b-genotype assessed as viral growth inhibition measured after 24 hrs
Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested
Inhibition of Hepatitis C virus genotype 6a NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 5a NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 4a NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 3a NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 2b NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 2a NS3/NS4A protease
Inhibition of Hepatitis C virus genotype 1b NS3/NS4A protease
Antiviral activity against HCV GT-2a assessed as inhibition of viral replication measured after 24 hrs
Antiviral activity against HCV GT1b-genotype assessed as inhibition of viral replication measured after 24 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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