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Antiviral activity against mCMV infected in mouse NIH3T3 cells assessed as reduction in virus induced cytopathogenicity
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Murine cytomegalovirus Smith infected in mouse MEF cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 5.6 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 5.1 +/- 0.9 days)
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in kidney at 10 mg/kg, po relative to control
Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in spleen at 10 mg/kg, po relative to control
Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in lung at 10 mg/kg, po relative to control
Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in liver at 10 mg/kg, po relative to control
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 16.7 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 5.1 +/- 0.9 days)
Assay data:2 Tested
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 50 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 5.1 +/- 0.9 days)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 5.6 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 4.9 +/- 0.7 days)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 16.7 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 4.9 +/- 0.7 days)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mean day of death at 50 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 4.9 +/- 0.7 days)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 5.6 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 100%)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 16.7 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 100%)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 50 mg/kg, po qd for 5 days administered 48 hrs after viral infection (Rvb = 100%)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 5.6 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 67%)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 16.7 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 67%)
Antiviral activity against MCMV infected in BALB/c mouse assessed as decrease in virus-induced mortality at 50 mg/kg, po qd for 5 days administered 24 hrs after viral infection (Rvb = 67%)
Antiviral activity against Murine cytomegalovirus infected in severe combined immunodeficient mouse assessed as reduction in viral load
Antiviral activity against Murine cytomegalovirus in MEF by plaque reduction assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
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