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interferons, peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy

MedGen UID:
1003146
•Concept ID:
CN322717
•
Sign or Symptom

Professional guidelines

PubMed

Simeprevir for the treatment of chronic hepatitis C genotype 1 infection.
Takehara T
Expert Rev Anti Infect Ther 2014 Aug;12(8):909-17. Epub 2014 Jun 2 doi: 10.1586/14787210.2014.925800. PMID: 24882512
Pharmacokinetics and pharmacodynamics of peginterferon and ribavirin: implications for clinical efficacy in the treatment of chronic hepatitis C.
Noureddin M, Ghany MG
Gastroenterol Clin North Am 2010 Sep;39(3):649-58. doi: 10.1016/j.gtc.2010.08.008. PMID: 20951922Free PMC Article
Peginterferon-alpha-2a (40kD) plus ribavirin: a review of its use in the management of chronic hepatitis C.
Keating GM, Curran MP
Drugs 2003;63(7):701-30. doi: 10.2165/00003495-200363070-00008. PMID: 12656650

Recent clinical studies

Etiology

Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Current management and perspectives for HCV recurrence after liver transplantation.
Coilly A, Roche B, Samuel D
Liver Int 2013 Feb;33 Suppl 1:56-62. doi: 10.1111/liv.12062. PMID: 23286847
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article
A review of the treatment of chronic hepatitis C virus infection in cirrhosis.
Vezali E, Aghemo A, Colombo M
Clin Ther 2010 Dec;32(13):2117-38. doi: 10.1016/S0149-2918(11)00022-1. PMID: 21316532
A comparison of peginterferon α-2a and α-2b for treatment-naive patients with chronic hepatitis C virus: A meta-analysis of randomized trials.
Zhao S, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P
Clin Ther 2010 Aug;32(9):1565-77. doi: 10.1016/j.clinthera.2010.08.009. PMID: 20974315

Diagnosis

Current management and perspectives for HCV recurrence after liver transplantation.
Coilly A, Roche B, Samuel D
Liver Int 2013 Feb;33 Suppl 1:56-62. doi: 10.1111/liv.12062. PMID: 23286847
Optimal treatment with boceprevir for chronic HCV infection.
Maasoumy B, Manns MP
Liver Int 2013 Feb;33 Suppl 1:14-22. doi: 10.1111/liv.12070. PMID: 23286841
Hepatitis C: epidemiology, diagnosis, natural history and therapy.
Pol S, Vallet-Pichard A, Corouge M, Mallet VO
Contrib Nephrol 2012;176:1-9. Epub 2012 Jan 30 doi: 10.1159/000332374. PMID: 22310776
Improving anti-hepatitis C virus therapy.
Pol S, Mallet VO
Expert Opin Biol Ther 2006 Sep;6(9):923-33. doi: 10.1517/14712598.6.9.923. PMID: 16918259
Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation.
Shepherd J, Brodin H, Cave C, Waugh N, Price A, Gabbay J
Health Technol Assess 2004 Oct;8(39):iii-iv, 1-125. doi: 10.3310/hta8390. PMID: 15461877

Therapy

Antiviral therapy in chronic hepatitis E: a systematic review.
Peters van Ton AM, Gevers TJ, Drenth JP
J Viral Hepat 2015 Dec;22(12):965-73. Epub 2015 Mar 11 doi: 10.1111/jvh.12403. PMID: 25760481
Pegylated interferon-α2a and ribavirin versus pegylated interferon-α2b and ribavirin in chronic hepatitis C : a meta-analysis.
Flori N, Funakoshi N, Duny Y, Valats JC, Bismuth M, Christophorou D, Daurès JP, Blanc P
Drugs 2013 Mar;73(3):263-77. doi: 10.1007/s40265-013-0027-1. PMID: 23436591
Peginterferon alfa-2a is superior to peginterferon alfa-2b in the treatment of naïve patients with hepatitis C virus infection: meta-analysis of randomized controlled trials.
Singal AK, Jampana SC, Anand BS
Dig Dis Sci 2011 Aug;56(8):2221-6. Epub 2011 Jun 4 doi: 10.1007/s10620-011-1765-0. PMID: 21643737
A comparison of peginterferon α-2a and α-2b for treatment-naive patients with chronic hepatitis C virus: A meta-analysis of randomized trials.
Zhao S, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P
Clin Ther 2010 Aug;32(9):1565-77. doi: 10.1016/j.clinthera.2010.08.009. PMID: 20974315
Pharmacokinetics and pharmacodynamics of peginterferon and ribavirin: implications for clinical efficacy in the treatment of chronic hepatitis C.
Noureddin M, Ghany MG
Gastroenterol Clin North Am 2010 Sep;39(3):649-58. doi: 10.1016/j.gtc.2010.08.008. PMID: 20951922Free PMC Article

Prognosis

Peginterferon alfa-2a and peginterferon alfa-2b combined with ribavirin in patients with genotype 1 chronic hepatitis C: results of a prospective single-centre study.
Berak H, Laskus T, Kołakowska-Rządzka A, Wasilewski M, Stańczak JJ, Bardadin K, Walewska-Zielecka B, Horban A
Adv Med Sci 2014 Sep;59(2):261-5. Epub 2014 Jun 9 doi: 10.1016/j.advms.2014.01.005. PMID: 25117425
Hepatitis C: epidemiology, diagnosis, natural history and therapy.
Pol S, Vallet-Pichard A, Corouge M, Mallet VO
Contrib Nephrol 2012;176:1-9. Epub 2012 Jan 30 doi: 10.1159/000332374. PMID: 22310776
Phase III results of Boceprevir in treatment naïve patients with chronic hepatitis C genotype 1.
Manns MP, Markova AA, Calle Serrano B, Cornberg M
Liver Int 2012 Feb;32 Suppl 1:27-31. doi: 10.1111/j.1478-3231.2011.02725.x. PMID: 22212568
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article
Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation.
Shepherd J, Brodin H, Cave C, Waugh N, Price A, Gabbay J
Health Technol Assess 2004 Oct;8(39):iii-iv, 1-125. doi: 10.3310/hta8390. PMID: 15461877

Clinical prediction guides

Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Phase III results of Boceprevir in treatment naïve patients with chronic hepatitis C genotype 1.
Manns MP, Markova AA, Calle Serrano B, Cornberg M
Liver Int 2012 Feb;32 Suppl 1:27-31. doi: 10.1111/j.1478-3231.2011.02725.x. PMID: 22212568
A review of the treatment of chronic hepatitis C virus infection in cirrhosis.
Vezali E, Aghemo A, Colombo M
Clin Ther 2010 Dec;32(13):2117-38. doi: 10.1016/S0149-2918(11)00022-1. PMID: 21316532
Pegylated interferons for the treatment of chronic hepatitis C: pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b.
Foster GR
Drugs 2010;70(2):147-65. doi: 10.2165/11531990-000000000-00000. PMID: 20108989
Improving anti-hepatitis C virus therapy.
Pol S, Mallet VO
Expert Opin Biol Ther 2006 Sep;6(9):923-33. doi: 10.1517/14712598.6.9.923. PMID: 16918259

Recent systematic reviews

Antiviral therapy in chronic hepatitis E: a systematic review.
Peters van Ton AM, Gevers TJ, Drenth JP
J Viral Hepat 2015 Dec;22(12):965-73. Epub 2015 Mar 11 doi: 10.1111/jvh.12403. PMID: 25760481
Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Peginterferon alfa-2a is superior to peginterferon alfa-2b in the treatment of naïve patients with hepatitis C virus infection: meta-analysis of randomized controlled trials.
Singal AK, Jampana SC, Anand BS
Dig Dis Sci 2011 Aug;56(8):2221-6. Epub 2011 Jun 4 doi: 10.1007/s10620-011-1765-0. PMID: 21643737
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article
Treatment of chronic hepatitis C: a systematic review.
Chander G, Sulkowski MS, Jenckes MW, Torbenson MS, Herlong HF, Bass EB, Gebo KA
Hepatology 2002 Nov;36(5 Suppl 1):S135-44. doi: 10.1053/jhep.2002.37146. PMID: 12407587

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