From HPO
Lymphoproliferative disorder- MedGen UID:
- 6162
- •Concept ID:
- C0024314
- •
- Neoplastic Process
A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis).
Respiratory tract infection- MedGen UID:
- 11199
- •Concept ID:
- C0035243
- •
- Disease or Syndrome
An infection of the upper or lower respiratory tract.
Immunodeficiency- MedGen UID:
- 7034
- •Concept ID:
- C0021051
- •
- Disease or Syndrome
Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.
Lymphopenia- MedGen UID:
- 7418
- •Concept ID:
- C0024312
- •
- Disease or Syndrome
A reduced number of lymphocytes in the blood.
Decreased CD4:CD8 ratio- MedGen UID:
- 163125
- •Concept ID:
- C0853905
- •
- Finding
An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells.
Recurrent viral infections- MedGen UID:
- 332357
- •Concept ID:
- C1837066
- •
- Finding
Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection.
Severe viral infection- MedGen UID:
- 479058
- •Concept ID:
- C3277428
- •
- Finding
An unusually severe viral infection.
Decreased circulating IgG2 level- MedGen UID:
- 867187
- •Concept ID:
- C4021545
- •
- Finding
A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation.
Defective T cell proliferation- MedGen UID:
- 868165
- •Concept ID:
- C4022557
- •
- Cell or Molecular Dysfunction
A reduced ability of a T cell population to expand by cell division following T cell activation.
Decreased specific pneumococcal antibody level- MedGen UID:
- 868496
- •Concept ID:
- C4022890
- •
- Finding
The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.
Decreased proportion of memory B cells- MedGen UID:
- 893145
- •Concept ID:
- C4072913
- •
- Finding
A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).
Reduced antigen-specific T cell proliferation- MedGen UID:
- 1621145
- •Concept ID:
- C4531148
- •
- Finding
Impaired proliferation and expansion of a T cell population following activation by an antigenic stimulus.
Severe varicella zoster infection- MedGen UID:
- 1688785
- •Concept ID:
- C5139168
- •
- Disease or Syndrome
An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterized by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestions including VZV pneumonia, hepatitis, meningitis, and disseminated varicella.
Persistent viremia- MedGen UID:
- 1692312
- •Concept ID:
- C5139222
- •
- Finding
Persistence of virus in the blood circulation longer than would be normal in an immunocompetent host.
Partial absence of specific antibody response to tetanus vaccine- MedGen UID:
- 1699537
- •Concept ID:
- C5139460
- •
- Finding
A reduced ability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.
Decreased circulating IgG level- MedGen UID:
- 1720114
- •Concept ID:
- C5234937
- •
- Finding
An abnormally decreased level of immunoglobulin G (IgG) in blood.
Reduced proportion of mucosal-associated invariant T cells- MedGen UID:
- 1782351
- •Concept ID:
- C5539885
- •
- Finding
A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count.
- Abnormality of the immune system
- Abnormality of the respiratory system
- Neoplasm