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Death in childhood

MedGen UID:
334390
•Concept ID:
C1843392
•
Finding
HPO: HP:0003819

Definition

Death in during childhood, defined here as between the ages of 2 and 10 years. [from HPO]

Professional guidelines

PubMed

Indications and management of implantable cardioverter-defibrillator therapy in childhood hypertrophic cardiomyopathy.
Kaski JP, Kammeraad JAE, Blom NA, Happonen JM, Janousek J, Klaassen S, Limongelli G, Östman-Smith I, Sarquella Brugada G, Ziolkowska L
Cardiol Young 2023 May;33(5):681-698. Epub 2023 Apr 27 doi: 10.1017/S1047951123000872. PMID: 37102324
Newborn screening for Tyrosinemia type 1 using succinylacetone - a systematic review of test accuracy.
Stinton C, Geppert J, Freeman K, Clarke A, Johnson S, Fraser H, Sutcliffe P, Taylor-Phillips S
Orphanet J Rare Dis 2017 Mar 9;12(1):48. doi: 10.1186/s13023-017-0599-z. PMID: 28274233Free PMC Article
Neuroimaging differential diagnoses to abusive head trauma.
Girard N, Brunel H, Dory-Lautrec P, Chabrol B
Pediatr Radiol 2016 May;46(5):603-14. Epub 2015 Dec 30 doi: 10.1007/s00247-015-3509-3. PMID: 26718196

Recent clinical studies

Etiology

Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.
Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O
Neuropathol Appl Neurobiol 2022 Feb;48(1):e12746. Epub 2021 Jul 16 doi: 10.1111/nan.12746. PMID: 34164845Free PMC Article
Determining the prevalence of sudden and unexplained death in childhood (SUDC): a national Australian perspective.
Duncan JR, Byard RW
Int J Legal Med 2021 May;135(3):793-800. Epub 2020 Oct 23 doi: 10.1007/s00414-020-02445-3. PMID: 33097983
Hippocampal abnormalities and seizures: a 16-year single center review of sudden unexpected death in childhood, sudden unexpected death in epilepsy and SIDS.
Kon FC, Vázquez RZ, Lang A, Cohen MC
Forensic Sci Med Pathol 2020 Sep;16(3):423-434. Epub 2020 Jul 25 doi: 10.1007/s12024-020-00268-7. PMID: 32712908
Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.
Myers KA, Shevell MI, Sébire G
Epilepsy Res 2019 Feb;150:66-69. Epub 2019 Jan 14 doi: 10.1016/j.eplepsyres.2019.01.009. PMID: 30660056
Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project.
Hefti MM, Kinney HC, Cryan JB, Haas EA, Chadwick AE, Crandall LA, Trachtenberg FL, Armstrong DD, Grafe M, Krous HF
Forensic Sci Med Pathol 2016 Mar;12(1):4-13. Epub 2016 Jan 19 doi: 10.1007/s12024-015-9724-2. PMID: 26782961Free PMC Article

Diagnosis

Cardiac Genetic Investigation of Sudden Infant and Early Childhood Death: A Study From Victims to Families.
Kotta MC, Torchio M, Bayliss P, Cohen MC, Quarrell O, Wheeldon N, Marton T, Gentilini D, Crotti L, Coombs RC, Schwartz PJ
J Am Heart Assoc 2023 Sep 5;12(17):e029100. Epub 2023 Aug 17 doi: 10.1161/JAHA.122.029100. PMID: 37589201Free PMC Article
Tonsillar hypertrophy and prolapse in a child - is epiglottitis a predisposing factor for sudden unexpected death?
Nieuwoudt I, Goussard P, Verster J, Dempers J
BMC Pediatr 2020 Jan 20;20(1):22. doi: 10.1186/s12887-020-1927-3. PMID: 31959132Free PMC Article
Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: recommendations from The 3rd International Congress on Sudden Infant and Child Death.
Goldstein RD, Blair PS, Sens MA, Shapiro-Mendoza CK, Krous HF, Rognum TO, Moon RY; 3rd International Congress on Sudden Infant and Child Death
Forensic Sci Med Pathol 2019 Dec;15(4):622-628. Epub 2019 Sep 9 doi: 10.1007/s12024-019-00156-9. PMID: 31502215Free PMC Article

Prognosis

Determining the prevalence of sudden and unexplained death in childhood (SUDC): a national Australian perspective.
Duncan JR, Byard RW
Int J Legal Med 2021 May;135(3):793-800. Epub 2020 Oct 23 doi: 10.1007/s00414-020-02445-3. PMID: 33097983
Tonsillar hypertrophy and prolapse in a child - is epiglottitis a predisposing factor for sudden unexpected death?
Nieuwoudt I, Goussard P, Verster J, Dempers J
BMC Pediatr 2020 Jan 20;20(1):22. doi: 10.1186/s12887-020-1927-3. PMID: 31959132Free PMC Article
Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report.
Gavotto A, Ousselin A, Pidoux O, Cathala P, Costes-Martineau V, Rivière B, Pasquié JL, Amedro P, Rambaud C, Cambonie G
BMC Pediatr 2019 Nov 27;19(1):462. doi: 10.1186/s12887-019-1847-2. PMID: 31771554Free PMC Article
To hold or not to hold: medicolegal death investigation practices during unexpected child death investigations and the experiences of next of kin.
Rudd RA, Marain LC, Crandall L
Am J Forensic Med Pathol 2014 Jun;35(2):132-9. doi: 10.1097/PAF.0000000000000089. PMID: 24781400

Clinical prediction guides

Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.
Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O
Neuropathol Appl Neurobiol 2022 Feb;48(1):e12746. Epub 2021 Jul 16 doi: 10.1111/nan.12746. PMID: 34164845Free PMC Article
Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project.
Hefti MM, Kinney HC, Cryan JB, Haas EA, Chadwick AE, Crandall LA, Trachtenberg FL, Armstrong DD, Grafe M, Krous HF
Forensic Sci Med Pathol 2016 Mar;12(1):4-13. Epub 2016 Jan 19 doi: 10.1007/s12024-015-9724-2. PMID: 26782961Free PMC Article

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      Clinical tests in GTR
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