From HPO
Punctate palmoplantar hyperkeratosis- MedGen UID:
- 870406
- •Concept ID:
- C4024851
- •
- Disease or Syndrome
A palmoplantar keratosis characterized by keratoses with a "raindrop" pattern on the palmoplantar surface, skin lesions which may involve the whole of the palmoplantar surface, or may be more restricted in their distribution.
Acantholysis- MedGen UID:
- 1687
- •Concept ID:
- C0000887
- •
- Pathologic Function
The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.
Acrokeratosis- MedGen UID:
- 450988
- •Concept ID:
- C0001202
- •
- Disease or Syndrome
Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet.
Epidermal acanthosis- MedGen UID:
- 65136
- •Concept ID:
- C0221270
- •
- Finding
Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin).
Ridged nail- MedGen UID:
- 140853
- •Concept ID:
- C0423820
- •
- Finding
Longitudinal, linear prominences in the nail plate.
Hyperkeratosis- MedGen UID:
- 209030
- •Concept ID:
- C0870082
- •
- Disease or Syndrome
Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.
Verrucous papule- MedGen UID:
- 868483
- •Concept ID:
- C4022877
- •
- Anatomical Abnormality
A wartlike (with multiple small elevated projections) papule.
- Abnormality of limbs
- Abnormality of the integument