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GTR Home > Conditions/Phenotypes > Hepatocellular carcinoma

Hepatocellular carcinoma

Synonyms
Hepatocellular cancer; Hepatoma; LIVER CELL CARCINOMA; Primary carcinoma of liver
Modes of inheritance
Not genetically inherited (Orphanet)

Summary

Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1 to 2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002). [from OMIM]

Available tests

179 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (179 available)

Biochemical Genetics Tests

Cytogenetics Tests

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46, APC
    Summary: APC regulator of WNT signaling pathway

  • Also known as: AXIN, CMDOH, PPP1R49, AXIN1
    Summary: axin 1

  • Also known as: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, CASP8
    Summary: caspase 8

  • Also known as: CTNNB, EVR7, MRD19, NEDSDV, armadillo, CTNNB1
    Summary: catenin beta 1

  • Also known as: CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI, IGF2R
    Summary: insulin like growth factor 2 receptor

  • Also known as: AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met, MET
    Summary: MET proto-oncogene, receptor tyrosine kinase

  • Also known as: PDGRL, PRLTS, PDGFRL
    Summary: platelet derived growth factor receptor like

  • Also known as: CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha, PIK3CA
    Summary: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

  • Also known as: BCC7, BMFS5, LFS1, P53, TRP53, TP53
    Summary: tumor protein p53

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

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