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    Lin28b lin-28 homolog B [ Mus musculus (house mouse) ]

    Gene ID: 380669, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Lin28bprovided by MGI
    Official Full Name
    lin-28 homolog Bprovided by MGI
    Primary source
    MGI:MGI:3584032
    See related
    Ensembl:ENSMUSG00000063804 AllianceGenome:MGI:3584032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lin-28.2; 2810403D23Rik; D030047M17Rik
    Summary
    Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in RNA metabolic process and regulation of RNA metabolic process. Predicted to act upstream of or within gene silencing by RNA. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and lumbar dorsal root ganglion. Used to study neuroblastoma. Orthologous to human LIN28B (lin-28 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 3.2), liver E14 (RPKM 3.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lin28b in Genome Data Viewer
    Location:
    10 B2; 10 23.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (45252713..45362410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45376617..45486314, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15934 Neighboring gene popeye domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_26577 Neighboring gene blood vessel epicardial substance Neighboring gene STARR-seq mESC enhancer starr_26578 Neighboring gene STARR-seq mESC enhancer starr_26579 Neighboring gene predicted gene, 51827 Neighboring gene STARR-seq mESC enhancer starr_26582 Neighboring gene STARR-seq mESC enhancer starr_26583 Neighboring gene STARR-seq mESC enhancer starr_26584 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_26585 Neighboring gene HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 Neighboring gene STARR-seq mESC enhancer starr_26586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation. Jaiswal A, et al. Inflammation, 2020 Oct. PMID 32458348
    2. Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2. Wu K, et al. J Cell Physiol, 2019 Dec. PMID 31066045
    3. Lin28b regulates age-dependent differences in murine platelet function. Stolla MC, et al. Blood Adv, 2019 Jan 8. PMID 30622145, Free PMC Article
    4. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Madison BB, et al. Genes Dev, 2013 Oct 15. PMID 24142874, Free PMC Article
    5. Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Beachy SH, et al. Blood, 2012 Aug 2. PMID 22723554, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
      Title: The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
    2. Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
      Title: Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
    3. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
      Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
    4. LIN28B induces a differentiation program through CDX2 in colon cancer.
      Title: LIN28B induces a differentiation program through CDX2 in colon cancer.
    5. Lin28 paralogs regulate lung branching morphogenesis.
      Title: Lin28 paralogs regulate lung branching morphogenesis.
    6. Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
      Title: Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
    7. LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
      Title: LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
    8. A B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to let-7 gene expression.
      Title: An ontogenetic switch drives the positive and negative selection of B cells.
    9. lin28B is a crucial modulator determining the fate of transplanted mesenchymal stem cells by regulating IGF-2-associated pathways and thereby enhancing their protective effects against AD
      Title: Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.
    10. The Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19(-/-) adult mice.
      Title: Lin28b controls a neonatal to adult switch in B cell positive selection.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-28 homolog B
    Names
    lin-28B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031772.2 → NP_001026942.1  protein lin-28 homolog B

      See identical proteins and their annotated locations for NP_001026942.1

      Status: VALIDATED

      Source sequence(s)
      BC089037, DQ127225
      Consensus CDS
      CCDS35895.1
      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Related
      ENSMUSP00000078361.7, ENSMUST00000079390.7
      Conserved Domains (2) summary
      PTZ00368
      Location:151 → 187
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:29 → 99
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      45252713..45362410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243182.4 → XP_011241484.1  protein lin-28 homolog B isoform X2

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:176 → 212
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:54 → 124
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. XM_011243180.4 → XP_011241482.1  protein lin-28 homolog B isoform X1

      See identical proteins and their annotated locations for XP_011241482.1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:183 → 219
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:61 → 131
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    3. XM_036155874.1 → XP_036011767.1  protein lin-28 homolog B isoform X3

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:161 → 197
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:39 → 109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    4. XM_011243183.4 → XP_011241485.1  protein lin-28 homolog B isoform X3

      See identical proteins and their annotated locations for XP_011241485.1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:161 → 197
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:39 → 109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    5. XM_011243185.4 → XP_011241487.1  protein lin-28 homolog B isoform X3

      See identical proteins and their annotated locations for XP_011241487.1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:161 → 197
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:39 → 109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    6. XM_011243186.3 → XP_011241488.1  protein lin-28 homolog B isoform X3

      See identical proteins and their annotated locations for XP_011241488.1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:161 → 197
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:39 → 109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    7. XM_036155873.1 → XP_036011766.1  protein lin-28 homolog B isoform X1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:183 → 219
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:61 → 131
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    8. XM_011243187.3 → XP_011241489.1  protein lin-28 homolog B isoform X4

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:160 → 196
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:38 → 108
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    9. XM_011243188.1 → XP_011241490.1  protein lin-28 homolog B isoform X5

      See identical proteins and their annotated locations for XP_011241490.1

      UniProtKB/Swiss-Prot
      Q3UZC6, Q3V444, Q45KJ6
      Conserved Domains (2) summary
      PTZ00368
      Location:151 → 187
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd04458
      Location:29 → 99
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033152.1: Suppressed sequence

      Description
      NM_001033152.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q45KJ6.2 GenPept UniProtKB/Swiss-Prot:Q45KJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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