U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Amigo3 adhesion molecule with Ig like domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316003, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Amigo3provided by RGD
    Official Full Name
    adhesion molecule with Ig like domain 3provided by RGD
    Primary source
    RGD:631413
    See related
    Ensembl:ENSRNOG00000064183 AllianceGenome:RGD:631413
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of neuron projection development; and nervous system development. Predicted to be integral component of membrane. Biomarker of sciatic neuropathy. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Amigo3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117620499..117622025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108741899..108743425)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116830773..116832299)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480233 Neighboring gene cadherin-related family member 4 Neighboring gene inositol hexakisphosphate kinase 1 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene macrophage stimulating 1 Neighboring gene acylaminoacyl-peptide hydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury. Ahmed Z, et al. PLoS One, 2013. PMID 23613963, Free PMC Article
    2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula J, et al. J Cell Biol, 2003 Mar 17. PMID 12629050, Free PMC Article
    3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    amphoterin-induced protein 3
    Names
    AMIGO-3
    alivin-3
    amphoterin induced gene and ORF 3
    transmembrane protein AMIGO3
    NP_835280.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178144.1 → NP_835280.1  amphoterin-induced protein 3 precursor

      See identical proteins and their annotated locations for NP_835280.1

      Status: PROVISIONAL

      Source sequence(s)
      AY237731
      UniProtKB/Swiss-Prot
      Q80ZD5
      UniProtKB/TrEMBL
      A6I331
      Related
      ENSRNOP00000081738.1, ENSRNOT00000118165.1
      Conserved Domains (4) summary
      sd00033
      Location:65 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65 → 121
      LRR_8; Leucine rich repeat
      pfam13927
      Location:279 → 355
      Ig_3; Immunoglobulin domain
      cd00096
      Location:295 → 303
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117620499..117622025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZD5.1 GenPept UniProtKB/Swiss-Prot:Q80ZD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials