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    Scamp5 secretory carrier membrane protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65171, updated on 2-May-2024

    Summary

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    Symbol
    Scamp5provided by RGD
    Full Name
    secretory carrier membrane protein 5provided by RGD
    Primary source
    RGD:68356
    See related
    Ensembl:ENSRNOG00000054008 AllianceGenome:RGD:68356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in regulation of synaptic vesicle endocytosis. Located in synaptic vesicle. Is integral component of synaptic vesicle membrane. Orthologous to human SCAMP5 (secretory carrier membrane protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 75.5), Kidney (RPKM 25.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scamp5 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66739794..66778538, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57845831..57884516, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62221820..62266269, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479975 Neighboring gene phosphopantothenoylcysteine decarboxylase Neighboring gene uncharacterized LOC134480187 Neighboring gene ribonuclease P and MRP subunit p25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity. Zhao H, et al. J Neurosci, 2014 Jul 23. PMID 25057210, Free PMC Article
    2. SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity. Lee U, et al. Mol Brain, 2021 Mar 4. PMID 33663553, Free PMC Article
    3. Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis. Liao H, et al. Am J Physiol Cell Physiol, 2008 Mar. PMID 18171723
    4. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. Noh JY, et al. J Biol Chem, 2009 Apr 24. PMID 19240033, Free PMC Article
    5. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. Han C, et al. J Immunol, 2009 Mar 1. PMID 19234194

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity.
      Title: SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity.
    2. Knockdown of SCAMP5 severely impairs synaptic vesicle endocytosis during stimulation.
      Title: SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity.
    3. exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway
      Title: SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.
    4. SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
      Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion-dependent exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretory carrier-associated membrane protein 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429251.1 → NP_001416180.1  secretory carrier-associated membrane protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    2. NM_001429252.1 → NP_001416181.1  secretory carrier-associated membrane protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_031726.3 → NP_113914.2  secretory carrier-associated membrane protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K464, A0A0G2K806, A6J4V3
      Related
      ENSRNOP00000072922.1, ENSRNOT00000080012.2
      Conserved Domains (1) summary
      pfam04144
      Location:6 → 179
      SCAMP; SCAMP family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66739794..66778538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595896.3 → XP_017451385.1  secretory carrier-associated membrane protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K464, A0A0G2K806, A6J4V3
      Conserved Domains (1) summary
      pfam04144
      Location:6 → 179
      SCAMP; SCAMP family

    2. XM_039082103.2 → XP_038938031.1  secretory carrier-associated membrane protein 5 isoform X3

      Conserved Domains (1) summary
      pfam04144
      Location:44 → 108
      SCAMP; SCAMP family

    3. XM_039082104.2 → XP_038938032.1  secretory carrier-associated membrane protein 5 isoform X3

      Conserved Domains (1) summary
      pfam04144
      Location:44 → 108
      SCAMP; SCAMP family

    4. XM_017595898.3 → XP_017451387.1  secretory carrier-associated membrane protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K464, A0A0G2K806, A6J4V3
      Conserved Domains (1) summary
      pfam04144
      Location:6 → 179
      SCAMP; SCAMP family

    5. XM_039082105.2 → XP_038938033.1  secretory carrier-associated membrane protein 5 isoform X3

      Conserved Domains (1) summary
      pfam04144
      Location:44 → 108
      SCAMP; SCAMP family

    6. XM_017595897.3 → XP_017451386.1  secretory carrier-associated membrane protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K464, A0A0G2K806, A6J4V3
      Conserved Domains (1) summary
      pfam04144
      Location:6 → 179
      SCAMP; SCAMP family

    7. XM_017595899.3 → XP_017451388.1  secretory carrier-associated membrane protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K464, A0A0G2K806, A6J4V3
      Conserved Domains (1) summary
      pfam04144
      Location:6 → 179
      SCAMP; SCAMP family

    8. XM_063266087.1 → XP_063122157.1  secretory carrier-associated membrane protein 5 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKE3.1 GenPept UniProtKB/Swiss-Prot:Q9JKE3

    Gene LinkOut

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