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    MGAM2 maltase-glucoamylase 2 (putative) [ Homo sapiens (human) ]

    Gene ID: 93432, updated on 5-Mar-2024

    Summary

    Official Symbol
    MGAM2provided by HGNC
    Official Full Name
    maltase-glucoamylase 2 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:28101
    See related
    Ensembl:ENSG00000257743 AllianceGenome:HGNC:28101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum (RPKM 13.7), small intestine (RPKM 11.0) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MGAM2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (142111718..142222324)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (143426769..143537371)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141811518..141922124)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 38 Neighboring gene NANOG hESC enhancer GRCh37_chr7:141695377-141695878 Neighboring gene maltase-glucoamylase Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:141895891-141897090 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:141945363-141946562 Neighboring gene monooxygenase DBH like 2, pseudogene Neighboring gene serine protease 58

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16351, MGC138178, MGC138180

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucan 1,4-alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable maltase-glucoamylase 2; putative maltase-glucoamylase-like protein FLJ16351
    Names
    Putative maltase-glucoamylase-like protein FLJ16351
    maltase-glucoamylase (alpha-glucosidase)
    maltase-glucoamylase (alpha-glucosidase) pseudogene
    NP_001280555.1
    XP_011514994.1
    XP_011514995.1
    XP_011514996.1
    XP_024302765.1
    XP_054184683.1
    XP_054184684.1
    XP_054184685.1
    XP_054184686.1
    XP_054215304.1
    XP_054215305.1
    XP_054215306.1
    XP_054215307.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293626.2NP_001280555.1  probable maltase-glucoamylase 2

      See identical proteins and their annotated locations for NP_001280555.1

      Status: VALIDATED

      Source sequence(s)
      AC091742
      Consensus CDS
      CCDS78281.1
      UniProtKB/Swiss-Prot
      A4D2I3, C9JNC2, Q2M2H8
      Related
      ENSP00000420449.3, ENST00000477922.4
      Conserved Domains (7) summary
      PHA03255
      Location:18191965
      PHA03255; BDLF3; Provisional
      smart00018
      Location:908948
      PD; P or trefoil or TFF domain
      cd14752
      Location:207323
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam05109
      Location:18952410
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00088
      Location:4387
      Trefoil; Trefoil (P-type) domain
      pfam01055
      Location:304769
      Glyco_hydro_31; Glycosyl hydrolases family 31
      pfam16863
      Location:104215
      NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      142111718..142222324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446997.2XP_024302765.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X4

      Conserved Domains (6) summary
      smart00018
      Location:908948
      PD; P or trefoil or TFF domain
      cd14752
      Location:207323
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam00088
      Location:4386
      Trefoil; Trefoil (P-type) domain
      pfam01055
      Location:304769
      Glyco_hydro_31; Glycosyl hydrolases family 31
      pfam16863
      Location:104214
      NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
      cl25582
      Location:11711229
      Glyco_hydro_31; Glycosyl hydrolases family 31
    2. XM_011516692.3XP_011514994.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X1

      See identical proteins and their annotated locations for XP_011514994.1

      Conserved Domains (6) summary
      PHA03255
      Location:15491695
      PHA03255; BDLF3; Provisional
      cd06602
      Location:53410
      GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
      cd14752
      Location:806920
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam00088
      Location:637678
      Trefoil; Trefoil (P-type) domain
      pfam01055
      Location:34499
      Glyco_hydro_31; Glycosyl hydrolases family 31
      pfam16863
      Location:721813
      NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
    3. XM_011516693.3XP_011514995.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X2

      See identical proteins and their annotated locations for XP_011514995.1

      Conserved Domains (5) summary
      smart00018
      Location:5393
      PD; P or trefoil or TFF domain
      PRK10856
      Location:10371110
      PRK10856; cytoskeleton protein RodZ
      cd06602
      Location:335726
      GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
      cd14752
      Location:221335
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam05109
      Location:12041613
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. XM_011516694.3XP_011514996.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X3

      See identical proteins and their annotated locations for XP_011514996.1

      Conserved Domains (2) summary
      cd06602
      Location:1343
      GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
      pfam01055
      Location:1433
      Glyco_hydro_31; Glycosyl hydrolases family 31

    RNA

    1. XR_927547.3 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187562.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      73598..184204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328711.1XP_054184686.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X4

    2. XM_054328708.1XP_054184683.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X1

    3. XM_054328709.1XP_054184684.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X2

    4. XM_054328710.1XP_054184685.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X3

    RNA

    1. XR_008485611.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      143426769..143537371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359332.1XP_054215307.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X4

    2. XM_054359329.1XP_054215304.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X1

    3. XM_054359330.1XP_054215305.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X2

    4. XM_054359331.1XP_054215306.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X3

    RNA

    1. XR_008487774.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_026640.1: Suppressed sequence

      Description
      NG_026640.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
    2. NM_001008748.2: Suppressed sequence

      Description
      NM_001008748.2: This RefSeq was suppressed temporarily because the source transcript appears to be partial (the encoded protein is not consistent with other maltases) and an alternate source was not identified.
    3. NR_003715.1: Suppressed sequence

      Description
      NR_003715.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    4. NR_003717.1: Suppressed sequence

      Description
      NR_003717.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.