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SPCS2 signal peptidase complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 9789, updated on 5-Mar-2024

Summary

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Official Symbol
SPCS2provided by HGNC
Official Full Name
signal peptidase complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:28962
See related
Ensembl:ENSG00000118363 MIM:619411; AllianceGenome:HGNC:28962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 48.0), prostate (RPKM 34.0) and 25 other tissues See more
Orthologs
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Genomic context

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See SPCS2 in Genome Data Viewer
Location:
11q13.4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74949266..74979033)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74878800..74908597)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74660311..74690078)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene uncharacterized LOC107984352 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74644275-74644750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74659504-74660358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74660359-74661213 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5261 Neighboring gene neuraminidase 3 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. Argente J, et al. EMBO Mol Med, 2014 Mar. PMID 24480542, Free PMC Article
  2. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Liaci AM, et al. Mol Cell, 2021 Oct 7. PMID 34388369
  3. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies KU, et al. J Biol Chem, 1996 Feb 16. PMID 8632014
  4. Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis. Chen Z, et al. EMBO J, 2021 Sep 1. PMID 34232536, Free PMC Article
  5. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Lobingier BT, et al. Cell, 2017 Apr 6. PMID 28388416, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of signal peptidase complex subunit 2 homolog (S. cerevisiae; SPCS2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 2 homolog (SPCS2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ56339, KIAA0102, MGC117366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
signal peptidase complex subunit 2
Names
SPase 25 kDa subunit
microsomal signal peptidase 25 kDa subunit
signal peptidase 25kDa subunit
signal peptidase complex subunit 2 homolog
NP_055567.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014752.3 → NP_055567.2  signal peptidase complex subunit 2

    See identical proteins and their annotated locations for NP_055567.2

    Status: VALIDATED

    Source sequence(s)
    AA921960, AP001992, BP338843, D14658
    Consensus CDS
    CCDS44681.1
    UniProtKB/Swiss-Prot
    Q15005, Q15507, Q3KQT0, Q641R4, Q6FG65, Q6IRX0, Q6P1P4, Q96HU9
    UniProtKB/TrEMBL
    B4DDB9
    Related
    ENSP00000263672.6, ENST00000263672.11
    Conserved Domains (1) summary
    pfam06703
    Location:61 → 217
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    74949266..74979033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    74878800..74908597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15005.3 GenPept UniProtKB/Swiss-Prot:Q15005

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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