PF3D7_0831800 histidine-rich protein II [Plasmodium falciparum 3D7] - Gene

Summary

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Gene symbol: PF3D7_0831800
Gene description: histidine-rich protein II
Primary source: PlasmoDB:PF3D7_0831800
Locus tag: PF3D7_0831800
See related: VEuPathDB:PF3D7_0831800
Gene type: protein coding
RNA name: histidine-rich protein II
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_0831800 in Genome Data Viewer

Location:: chromosome: 8

Exon count:: 2

Sequence:: Chromosome: 8; NC_004329.3 (1374236..1375299, complement)

Chromosome 8 - NC_004329.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_004329.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.
Title: Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.
Pfhrp2/3 gene deletion and genetic variation in PfHRP2-based RDTs with P. falciparum positive samples from India and its implication on malaria control.
Title: Pfhrp2/3 gene deletion and genetic variation in PfHRP2-based RDTs with P. falciparum positive samples from India and its implication on malaria control.
Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo.
Title: Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo.
Epidemiology of mutant Plasmodium falciparum parasites lacking histidine-rich protein 2/3 genes in Eritrea 2 years after switching from HRP2-based RDTs.
Title: Epidemiology of mutant Plasmodium falciparum parasites lacking histidine-rich protein 2/3 genes in Eritrea 2 years after switching from HRP2-based RDTs.
HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions.
Title: HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions.
Data indicate that despite extreme sequence variation, diversity of histidine-rich protein 2 (PfHRP-2) does not appear to affect rapid diagnostic tests (RDTs) performance.
Title: Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests.
propose that HRPII is a virulence factor that may contribute to cerebral malaria by compromising endothelial barrier integrity within the central nervous system
Title: Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.
The study highlight the identification of unique epitopes of PfHRP2 and PfLDH, and the generated antibodies against these
Title: Detection of histidine rich protein & lactate dehydrogenase of Plasmodium falciparum in malaria patients by sandwich ELISA using in-house reagents.
The diversity survey of the pfhrp2 gene identified 29 SNPs as well as insertion and deletion polymorphisms within a 918 bp region. The Senegal pfhrp2 exhibited a substantial level of diversity.
Title: Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.
study provides evidence that the expansion of pfhrp2-negative P. falciparum parasites in Peru originated from multiple genetic backgrounds, rather than being caused by selection for a single, rare deletion event
Title: Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by GeneDB

Process	Evidence Code	Pubs
acts_upstream_of_or_within heme catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Maurer's cleft	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in food vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in host cell cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in host cell membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histidine-rich protein II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004329.3 Reference assembly

Range

1374236..1375299 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002808697.2 → XP_002808743.1 histidine-rich protein II [Plasmodium falciparum 3D7]

See identical proteins and their annotated locations for XP_002808743.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A143ZVM5, A0A2I0BUU4

Conserved Domains (1) summary

pfam05403
Location:1 → 72

Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)