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Cenpq centromere protein Q [ Mus musculus (house mouse) ]

Gene ID: 83815, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpqprovided by MGI
Official Full Name
centromere protein Qprovided by MGI
Primary source
MGI:MGI:1933744
See related
Ensembl:ENSMUSG00000023919 AllianceGenome:MGI:1933744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610528M18Rik
Summary
Predicted to be involved in metaphase plate congression and positive regulation of protein localization to kinetochore. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of Mis6-Sim4 complex. Predicted to be active in nucleus. Is expressed in embryo and otocyst. Orthologous to human CENPQ (centromere protein Q). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 14.0), CNS E11.5 (RPKM 11.3) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Cenpq in Genome Data Viewer
Location:
17 B2; 17 19.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (41231700..41247637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (40920809..40934574, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130008F23 gene Neighboring gene glycine-N-acyltransferase-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:41071423-41071532 Neighboring gene methylmalonyl-Coenzyme A mutase Neighboring gene predicted gene, 54006 Neighboring gene STARR-seq mESC enhancer starr_42552 Neighboring gene lactate dehydrogenase A, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic structure of murine methylmalonyl-CoA mutase: evidence for genetic and epigenetic mechanisms determining enzyme activity. Wilkemeyer MF, et al. Biochem J, 1993 Dec 15. PMID 7904153, Free PMC Article
  2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein Q
Names
CENP-Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031863.4 → NP_114069.2  centromere protein Q

    Status: VALIDATED

    Source sequence(s)
    AC121932, AK076094, BY078791
    Consensus CDS
    CCDS28789.1
    UniProtKB/Swiss-Prot
    Q8C2G4, Q8VEF8, Q9CPQ5, Q9CX70
    UniProtKB/TrEMBL
    A0A1I7Q4A6
    Related
    ENSMUSP00000084353.5, ENSMUST00000087114.5
    Conserved Domains (1) summary
    pfam13094
    Location:116 → 266
    CENP-Q; a CENPA-CAD centromere complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    41231700..41247637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160859.1 → XP_036016752.1  centromere protein Q isoform X1

    Conserved Domains (1) summary
    pfam13094
    Location:119 → 161
    CENP-Q; a CENPA-CAD centromere complex subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPQ5.2 GenPept UniProtKB/Swiss-Prot:Q9CPQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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