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PF3D7_0930300 merozoite surface protein 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 813575, updated on 17-May-2024

Summary

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Gene symbol
PF3D7_0930300
Gene description
merozoite surface protein 1
Primary source
PlasmoDB:PF3D7_0930300
Locus tag
PF3D7_0930300
See related
VEuPathDB:PF3D7_0930300
Gene type
protein coding
RNA name
merozoite surface protein 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_0930300 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
1
Sequence:
Chromosome: 9; NC_004330.2 (1201812..1206974)

Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene heptatricopeptide repeat-containing protein, putative Neighboring gene leucine-rich repeat protein Neighboring gene zinc finger protein, putative Neighboring gene diacylglycerol kinase, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004330.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
    Title: Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
  2. Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
    Title: Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
  3. Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia.
    Title: Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia.
  4. Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates.
    Title: Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates.
  5. Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
    Title: Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
  6. The block 2 of msp-1 gene was found to be highly polymorphic, and overall allelic distribution showed that RO33 was the dominant allele (63%), followed by MAD20 (29%) and K1 (8%) alleles. However, an extensive diversity (9 alleles and 4 genotypes) and 6-10 repeat regions exclusively of R2 type were observed in glurp
    Title: Molecular characterization of Plasmodium falciparum in Arunachal Pradesh from Northeast India based on merozoite surface protein 1 & glutamate-rich protein.
  7. In northern India, extensive diversity was found in msp1 alleles with predominantly RO33 alleles.
    Title: Genetic diversity of Plasmodium falciparum merozoite surface protein-1 (block 2), glutamate-rich protein and sexual stage antigen Pfs25 from Chandigarh, North India.
  8. It is a vaccine candidate genes.
    Title: Isolation and Characterization of Vaccine Candidate Genes Including CSP and MSP1 in Plasmodium yoelii.
  9. peripheral merozoite surface proteins MSP3, MSP6, MSPDBL1, MSPDBL2, and MSP7 bind directly to MSP1, but independently of each other, to form multiple forms of the MSP1 complex on the parasite surface.
    Title: Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes.
  10. The authors show that SUB1-mediated processing of MSP1 is important for parasite viability, the processing modifies the secondary structure of MSP1 and activates its capacity to bind spectrin.
    Title: Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables host cell surface binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within exit from host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular vesicle HDA PubMed 
located_in food vacuole HDA PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
merozoite surface protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004330.2 Reference assembly

    Range
    1201812..1206974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001352134.1 → XP_001352170.1  merozoite surface protein 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001352170.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8I0U8
    UniProtKB/TrEMBL
    Q25922, W7KFP9
    Conserved Domains (4) summary
    TIGR01612
    Location:221 → 527
    235kDa-fam; reticulocyte binding/rhoptry protein
    pfam07462
    Location:981 → 1536
    MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
    pfam12946
    Location:1612 → 1648
    EGF_MSP1_1; MSP1 EGF domain 1
    pfam12947
    Location:1655 → 1698
    EGF_3; EGF domain
Nucleotide Protein
Heading Accession and Version

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