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PF3D7_0217500 calcium-dependent protein kinase 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 812762, updated on 17-May-2024

Summary

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Gene symbol
PF3D7_0217500
Gene description
calcium-dependent protein kinase 1
Primary source
PlasmoDB:PF3D7_0217500
Locus tag
PF3D7_0217500
See related
VEuPathDB:PF3D7_0217500
Gene type
protein coding
RNA name
calcium-dependent protein kinase 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_0217500 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Sequence:
Chromosome: 2; NC_037280.1 (720437..722661)

Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene AP-2 complex subunit sigma, putative Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene E2F-associated phosphoprotein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037280.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites. Siddiqui MA, et al. ACS Infect Dis, 2020 Mar 13. PMID 32003970
  2. Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress. Iyer GR, et al. J Biol Chem, 2018 Jun 22. PMID 29716996, Free PMC Article
  3. PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection. Bansal A, et al. Proc Natl Acad Sci U S A, 2018 Jan 23. PMID 29311293, Free PMC Article
  4. Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1. Ansell KH, et al. Antimicrob Agents Chemother, 2014 Oct. PMID 25070106, Free PMC Article
  5. Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development. Azevedo MF, et al. Biochem J, 2013 Jun 15. PMID 23548171

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. critical role in mosquito infection
    Title: PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection.
  2. Expression of the J-domain of Plasmodium falciparum CDPK1 results in the arrest of parasite development late in the cell cycle during early schizogony.
    Title: Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development.
  3. PfCDPK1 regulates microneme discharge, a key process in erythrocyte invasion by malaria parasites.
    Title: Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcium-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within exit from host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-dependent protein kinase 1
XP_001349680.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037280.1 Reference assembly

    Range
    720437..722661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349644.1 → XP_001349680.1  calcium-dependent protein kinase 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349680.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A143ZWW4, A0A2I0BVG8, P62343, P62344, Q27731
    UniProtKB/TrEMBL
    A0A0L1I603, A0A8S9VSN6
    Conserved Domains (2) summary
    PTZ00184
    Location:369 → 515
    PTZ00184; calmodulin; Provisional
    cd05117
    Location:56 → 324
    STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62344.2

Gene LinkOut

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