PF3D7_1133400 apical membrane antigen 1 [Plasmodium falciparum 3D7] - Gene

Summary

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Gene symbol: PF3D7_1133400
Gene description: apical membrane antigen 1
Primary source: PlasmoDB:PF3D7_1133400
Locus tag: PF3D7_1133400
See related: VEuPathDB:PF3D7_1133400
Gene type: protein coding
RNA name: apical membrane antigen 1
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_1133400 in Genome Data Viewer

Location:: chromosome: 11

Exon count:: 1

Sequence:: Chromosome: 11; NC_037282.1 (1293856..1295724)

Chromosome 11 - NC_037282.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037282.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Polymorphism and Natural Selection of Apical Membrane Antigen-1 in Plasmodium falciparum Isolates from Vietnam.
Title: Genetic Polymorphism and Natural Selection of Apical Membrane Antigen-1 in Plasmodium falciparum Isolates from Vietnam.
Genetic diversity of Plasmodium falciparum AMA-1 antigen from the Northeast Indian state of Tripura and comparison with global sequences: implications for vaccine development.
Title: Genetic diversity of Plasmodium falciparum AMA-1 antigen from the Northeast Indian state of Tripura and comparison with global sequences: implications for vaccine development.
Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity.
Title: Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity.
This study shows that AMA1 and MAEBL are important for P. falciparum sporozoites to perform typical functions necessary for infection of human hepatocytes. These two proteins therefore have important roles during infection at distinct points in the life cycle, including the blood, mosquito, and liver stages.
Title: AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver.
Results indicate that both apical membrane antigen 1 (PfAMA1) constructs bound to the rhoptry neck protein 2 (PfRON2) peptide with the formation of one intermediate in a sequential reversible reaction: A<-->B<-->C.
Title: Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII) Loop.
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax.
Title: Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax.
Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene.
Title: Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene.
Being heterozygous or homozygous for alpha-thalassaemia was associated with an increased prevalence of antibodies to AMA-1 [odds ratio (OR): 1.83, 95% confidence interval (CI): 1.07-3.12, p = 0.027] and MSP-1 (OR: 2.04, 95% CI: 1.16-3.60, p = 0.013)
Title: α-Thalassaemia trait is associated with antibody prevalence against malaria antigens AMA-1 and MSP-1.
We also confirm that R1 in solution binds to AMA1 with 1:1 stoichiometry and adopts a secondary structure consistent with the major form of R1 observed in the crystal structure of the complex.
Title: Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide.
Presented is the X-ray crystal structure of AMA1 domains I and II from Plasmodium falciparum strain FVO. The structure is compared to those of AMA1 from P. falciparum 3D7 and Plasmodium vivax.
Title: Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by GeneDB

Function	Evidence Code	Pubs
enables host cell surface binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within symbiont entry into host	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in microneme	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed