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Mtmr3 myotubularin related protein 3 [ Mus musculus (house mouse) ]

Gene ID: 74302, updated on 21-May-2024

Summary

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Official Symbol
Mtmr3provided by MGI
Official Full Name
myotubularin related protein 3provided by MGI
Primary source
MGI:MGI:1921552
See related
Ensembl:ENSMUSG00000034354 AllianceGenome:MGI:1921552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE10; FYVE-DSP1; mKIAA0371; 1700092A20Rik
Summary
Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to act upstream of or within lipid metabolic process. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtmr3 in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4430867..4544863, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4480867..4594863, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24803 Neighboring gene HORMA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28383 Neighboring gene STARR-seq mESC enhancer starr_28385 Neighboring gene STARR-positive B cell enhancer ABC_E5204 Neighboring gene STARR-seq mESC enhancer starr_28386 Neighboring gene STARR-seq mESC enhancer starr_28391 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene predicted gene 11961 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_28397

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking. Dewi Pamungkas Putri D, et al. J Biol Chem, 2019 May 24. PMID 30944173, Free PMC Article
  2. SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Wei N, et al. Cell Rep, 2015 Nov 24. PMID 26586428
  3. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
    Title: MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
  2. these results suggest that MTMR3 and MTMR4 regulate the production of PtdIns3P, which plays a critical role in suppressing DNA-mediated innate immune responses via modulating STING trafficking.
    Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC78036

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 5-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotubularin-related protein 3
Names
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_001360826.1
NP_083136.2
XP_006514908.1
XP_006514909.1
XP_006514911.1
XP_036012929.1
XP_036012930.1
XP_036012931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373897.1 → NP_001360826.1  myotubularin-related protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606521, AL645910
    UniProtKB/Swiss-Prot
    Q5NCA4, Q8K296
    UniProtKB/TrEMBL
    R4GML8
    Related
    ENSMUSP00000122422.3, ENSMUST00000123506.9
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1113 → 1173
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  2. NM_028860.2 → NP_083136.2  myotubularin-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_083136.2

    Status: VALIDATED

    Source sequence(s)
    AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279
    Consensus CDS
    CCDS48744.1
    UniProtKB/TrEMBL
    B1ATD5, Q66I45
    Related
    ENSMUSP00000105569.4, ENSMUST00000109943.10
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1076 → 1136
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4430867..4544863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157038.1 → XP_036012931.1  myotubularin-related protein 3 isoform X4

    UniProtKB/TrEMBL
    M0QW74
    Related
    ENSMUSP00000137687.2, ENSMUST00000130716.8
    Conserved Domains (2) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  2. XM_006514848.4 → XP_006514911.1  myotubularin-related protein 3 isoform X2

    UniProtKB/TrEMBL
    B1ATD4
    Related
    ENSMUSP00000116315.3, ENSMUST00000128256.3
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1076 → 1145
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  3. XM_006514845.4 → XP_006514908.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514908.1

    UniProtKB/TrEMBL
    R4GML8
    Related
    ENSMUSP00000159982.1, ENSMUST00000249885.1
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1113 → 1182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  4. XM_006514846.4 → XP_006514909.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514909.1

    UniProtKB/TrEMBL
    R4GML8
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1113 → 1182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  5. XM_036157036.1 → XP_036012929.1  myotubularin-related protein 3 isoform X1

    UniProtKB/TrEMBL
    R4GML8
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1113 → 1182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

  6. XM_036157037.1 → XP_036012930.1  myotubularin-related protein 3 isoform X3

    UniProtKB/TrEMBL
    B1ATD5, Q66I45
    Conserved Domains (3) summary
    cd13341
    Location:23 → 116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:1076 → 1136
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169 → 485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

RNA

  1. XR_003949519.1 RNA Sequence

    Related
    ENSMUST00000249884.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K296.2 GenPept UniProtKB/Swiss-Prot:Q8K296

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