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Arpc5l actin related protein 2/3 complex, subunit 5-like [ Mus musculus (house mouse) ]

Gene ID: 74192, updated on 30-Apr-2024

Summary

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Official Symbol
Arpc5lprovided by MGI
Official Full Name
actin related protein 2/3 complex, subunit 5-likeprovided by MGI
Primary source
MGI:MGI:1921442
See related
Ensembl:ENSMUSG00000026755 AllianceGenome:MGI:1921442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARC16-2; 2010015J01Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in glutamatergic synapse. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and integumental system. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.9), testis adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arpc5l in Genome Data Viewer
Location:
2 B; 2 24.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38895283..38905889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39008066..39015878)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 29985 Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene golgin A1 Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene suppressor of cancer cell invasion Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
  2. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
  3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  4. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
actin-related protein 2/3 complex subunit 5-like protein
Names
arp2/3 complex 16 kDa subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418772.1 → NP_001405701.1  actin-related protein 2/3 complex subunit 5-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AL844588

  2. NM_001418773.1 → NP_001405702.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588

  3. NM_001418775.1 → NP_001405704.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588

  4. NM_001418776.1 → NP_001405705.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588

  5. NM_001418778.1 → NP_001405707.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588

  6. NM_028809.2 → NP_083085.1  actin-related protein 2/3 complex subunit 5-like protein isoform a

    See identical proteins and their annotated locations for NP_083085.1

    Status: VALIDATED

    Source sequence(s)
    AL844588
    Consensus CDS
    CCDS38120.1
    UniProtKB/Swiss-Prot
    Q9D898
    Related
    ENSMUSP00000108483.3, ENSMUST00000112862.7
    Conserved Domains (1) summary
    pfam04699
    Location:9 → 151
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38895283..38905889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D898.1 GenPept UniProtKB/Swiss-Prot:Q9D898

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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