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Cdhr5 cadherin-related family member 5 [ Mus musculus (house mouse) ]

Gene ID: 72040, updated on 12-May-2024

Summary

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Official Symbol
Cdhr5provided by MGI
Official Full Name
cadherin-related family member 5provided by MGI
Primary source
MGI:MGI:1919290
See related
Ensembl:ENSMUSG00000025497 AllianceGenome:MGI:1919290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mucdhl; Mupcdh; 1810074H01Rik
Summary
Predicted to enable beta-catenin binding activity; calcium ion binding activity; and cell adhesion molecule binding activity. Predicted to be involved in cell adhesion; intermicrovillar adhesion; and regulation of microvillus length. Predicted to act upstream of or within cell differentiation. Predicted to be located in apical plasma membrane; cell projection membrane; and clathrin-coated pit. Predicted to be spanning component of plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in liver; lung; metanephros; placenta; and yolk sac. Orthologous to human CDHR5 (cadherin related family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 477.0), small intestine adult (RPKM 353.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Cdhr5 in Genome Data Viewer
Location:
7 F5; 7 86.58 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140848993..140856708, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141269080..141276795, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1 Neighboring gene interferon regulatory factor 7 Neighboring gene secretin Neighboring gene STARR-seq mESC enhancer starr_20485 Neighboring gene dopamine receptor D4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Beck M, et al. Oncogene, 2021 Jan. PMID 33188295
  2. mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains. Goldberg M, et al. J Biol Chem, 2000 Aug 11. PMID 10801787
  3. Biallelic expression of HRAS and MUCDHL in human and mouse. Goldberg M, et al. Hum Genet, 2003 Apr. PMID 12589428
  4. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Lü J, et al. Dev Biol, 2004 Sep 15. PMID 15328023
  5. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Garrison WD, et al. Gastroenterology, 2006 Apr. PMID 16618389, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brush border assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in intermicrovillar adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microvillus length ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin-related family member 5
Names
mu-protocadherin
mucin and cadherin-like protein
mucin-like protocadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114322.1 → NP_001107794.1  cadherin-related family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001107794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK027913, BG063646
    Consensus CDS
    CCDS52442.1
    UniProtKB/Swiss-Prot
    Q8CEJ3, Q8VHF2, Q9D8I9
    UniProtKB/TrEMBL
    A0PJK7
    Related
    ENSMUSP00000127292.2, ENSMUST00000167263.9
    Conserved Domains (1) summary
    cd11304
    Location:133 → 229
    Cadherin_repeat; Cadherin tandem repeat domain

  2. NM_028069.3 → NP_082345.1  cadherin-related family member 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_082345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.
    Source sequence(s)
    AK007988, BB609487
    Consensus CDS
    CCDS22006.1
    UniProtKB/Swiss-Prot
    Q8CEJ3, Q8VHF2, Q9D8I9
    Related
    ENSMUSP00000079484.6, ENSMUST00000080654.7
    Conserved Domains (1) summary
    cd11304
    Location:133 → 229
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140848993..140856708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536260.4 → XP_006536323.1  cadherin-related family member 5 isoform X1

    See identical proteins and their annotated locations for XP_006536323.1

    UniProtKB/Swiss-Prot
    Q8CEJ3, Q8VHF2, Q9D8I9
    Conserved Domains (1) summary
    cd11304
    Location:133 → 229
    Cadherin_repeat; Cadherin tandem repeat domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHF2.1 GenPept UniProtKB/Swiss-Prot:Q8VHF2

Gene LinkOut

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