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Nkain1 Na+/K+ transporting ATPase interacting 1 [ Mus musculus (house mouse) ]

Gene ID: 67149, updated on 5-Mar-2024

Summary

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Official Symbol
Nkain1provided by MGI
Official Full Name
Na+/K+ transporting ATPase interacting 1provided by MGI
Primary source
MGI:MGI:1914399
See related
Ensembl:ENSMUSG00000078532 AllianceGenome:MGI:1914399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610200G18Rik; 2810426C15Rik
Summary
Enables ATPase binding activity. Predicted to be involved in regulation of sodium ion transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; lung; metanephros; and retina layer. Orthologous to human NKAIN1 (sodium/potassium transporting ATPase interacting 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 62.7), CNS E18 (RPKM 54.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Nkain1 in Genome Data Viewer
Location:
4 D2.2; 4 63.43 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130297176..130341115)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130530131..130574216, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074 Neighboring gene STARR-positive B cell enhancer ABC_E425 Neighboring gene small nuclear ribonucleoprotein 40 (U5) Neighboring gene STARR-seq mESC enhancer starr_11526 Neighboring gene STARR-seq mESC enhancer starr_11530 Neighboring gene predicted gene, 53228 Neighboring gene STARR-seq mESC enhancer starr_11531 Neighboring gene STARR-seq mESC enhancer starr_11533 Neighboring gene pumilio RNA-binding family member 1 Neighboring gene small nucleolar RNA, C/D box 85

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  3. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC144417

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427131.1 → NP_001414060.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    FO907130, FQ976844, MH423692

  2. NM_001427132.1 → NP_001414061.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    FO907130, FQ976844, MH423692

  3. NM_001427133.1 → NP_001414062.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    FO907130, FQ976844, MH423692

  4. NM_001427134.1 → NP_001414063.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    FO907130, FQ976844, MH423692

  5. NM_025998.5 → NP_080274.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080274.2

    Status: VALIDATED

    Source sequence(s)
    FO907130, FQ976844, MH423692
    Consensus CDS
    CCDS57302.1
    UniProtKB/Swiss-Prot
    A6MHP4, Q9D035, Q9D0Q6
    Related
    ENSMUSP00000101614.3, ENSMUST00000105993.4
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 206
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130297176..130341115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164361.1 → XP_036020254.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 110
    NKAIN; Na,K-Atpase Interacting protein

  2. XM_006539117.5 → XP_006539180.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam05640
    Location:26 → 210
    NKAIN; Na,K-Atpase Interacting protein

  3. XM_006539116.5 → XP_006539179.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    pfam05640
    Location:26 → 213
    NKAIN; Na,K-Atpase Interacting protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D035.2 GenPept UniProtKB/Swiss-Prot:Q9D035

Gene LinkOut

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