mmp2 matrix metallopeptidase 2 [Takifugu rubripes (torafugu)] - Gene

Summary

Gene symbol: mmp2
Gene description: matrix metallopeptidase 2
See related: Ensembl:ENSTRUG00000010165
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Takifugu rubripes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu
Also known as: mmp-2; fgmmp-2
Orthologs: human zebrafish all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
103	current	fTakRub1.2 (GCF_901000725.2)	13	NC_042297.1 (9064457..9074903)
101	previous assembly	FUGU5 (GCF_000180615.1)	13	NC_018902.1 (5952853..5963249)

Chromosome 13 - NC_042297.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that MMP-2 is primarily involved in regulation of the activity of stem/progenitor cells that give rise to new granule neurons.
Title: Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: Functional implications for adult neurogenesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 72 kDa type IV collagenase

Names: matrix metalloproteinase-2

NP_001032958.1

EC 3.4.24.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037869.1 → NP_001032958.1 72 kDa type IV collagenase precursor

See identical proteins and their annotated locations for NP_001032958.1

Status: PROVISIONAL

Source sequence(s)

AB193483

UniProtKB/TrEMBL

A0A674P1U4, H2TLN6, Q4JF84

Related

ENSTRUP00000076684.1, ENSTRUT00000082228.1

Conserved Domains (5) summary

smart00059
Location:342 → 390

FN2; Fibronectin type 2 domain

cd00094
Location:464 → 658

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:119 → 446

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:119 → 446

Peptidase_M10; Matrixin

pfam01471
Location:70 → 97

PG_binding_1; Putative peptidoglycan binding domain