<Entrezgene>
  <Entrezgene_track-info>
    <Gene-track>
      <Gene-track_geneid>348</Gene-track_geneid>
      <Gene-track_status value="live">0</Gene-track_status>
      <Gene-track_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>1991</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-track_create-date>
      <Gene-track_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-track_update-date>
    </Gene-track>
  </Entrezgene_track-info>
  <Entrezgene_type value="protein-coding">6</Entrezgene_type>
  <Entrezgene_source>
    <BioSource>
      <BioSource_genome value="genomic">1</BioSource_genome>
      <BioSource_origin value="natural">1</BioSource_origin>
      <BioSource_org>
        <Org-ref>
          <Org-ref_taxname>Homo sapiens</Org-ref_taxname>
          <Org-ref_common>human</Org-ref_common>
          <Org-ref_db>
            <Dbtag>
              <Dbtag_db>taxon</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_id>9606</Object-id_id>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Org-ref_db>
          <Org-ref_orgname>
            <OrgName>
              <OrgName_name>
                <OrgName_name_binomial>
                  <BinomialOrgName>
                    <BinomialOrgName_genus>Homo</BinomialOrgName_genus>
                    <BinomialOrgName_species>sapiens</BinomialOrgName_species>
                  </BinomialOrgName>
                </OrgName_name_binomial>
              </OrgName_name>
              <OrgName_attrib>specified</OrgName_attrib>
              <OrgName_lineage>Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</OrgName_lineage>
              <OrgName_gcode>1</OrgName_gcode>
              <OrgName_mgcode>2</OrgName_mgcode>
              <OrgName_div>PRI</OrgName_div>
            </OrgName>
          </Org-ref_orgname>
        </Org-ref>
      </BioSource_org>
      <BioSource_subtype>
        <SubSource>
          <SubSource_subtype value="chromosome">1</SubSource_subtype>
          <SubSource_name>19</SubSource_name>
        </SubSource>
      </BioSource_subtype>
    </BioSource>
  </Entrezgene_source>
  <Entrezgene_gene>
    <Gene-ref>
      <Gene-ref_locus>APOE</Gene-ref_locus>
      <Gene-ref_desc>apolipoprotein E</Gene-ref_desc>
      <Gene-ref_maploc>19q13.32</Gene-ref_maploc>
      <Gene-ref_db>
        <Dbtag>
          <Dbtag_db>HGNC</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>HGNC:613</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>Ensembl</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>ENSG00000130203</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>MIM</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_id>107741</Object-id_id>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>AllianceGenome</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>HGNC:613</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
      </Gene-ref_db>
      <Gene-ref_syn>
        <Gene-ref_syn_E>AD2</Gene-ref_syn_E>
        <Gene-ref_syn_E>LPG</Gene-ref_syn_E>
        <Gene-ref_syn_E>APO-E</Gene-ref_syn_E>
        <Gene-ref_syn_E>ApoE4</Gene-ref_syn_E>
        <Gene-ref_syn_E>LDLCQ5</Gene-ref_syn_E>
      </Gene-ref_syn>
    </Gene-ref>
  </Entrezgene_gene>
  <Entrezgene_prot>
    <Prot-ref>
      <Prot-ref_name>
        <Prot-ref_name_E>apolipoprotein E3</Prot-ref_name_E>
      </Prot-ref_name>
      <Prot-ref_desc>apolipoprotein E</Prot-ref_desc>
    </Prot-ref>
  </Entrezgene_prot>
  <Entrezgene_summary>The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]</Entrezgene_summary>
  <Entrezgene_location>
    <Maps>
      <Maps_display-str>19q13.32</Maps_display-str>
      <Maps_method>
        <Maps_method_map-type value="cyto"/>
      </Maps_method>
    </Maps>
  </Entrezgene_location>
  <Entrezgene_gene-source>
    <Gene-source>
      <Gene-source_src>LocusLink</Gene-source_src>
      <Gene-source_src-int>348</Gene-source_src-int>
      <Gene-source_src-str2>348</Gene-source_src-str2>
    </Gene-source>
  </Entrezgene_gene-source>
  <Entrezgene_locus>
    <Gene-commentary>
      <Gene-commentary_type value="genomic">1</Gene-commentary_type>
      <Gene-commentary_heading>Reference GRCh38.p14 Primary Assembly</Gene-commentary_heading>
      <Gene-commentary_label>Chromosome 19 Reference GRCh38.p14 Primary Assembly</Gene-commentary_label>
      <Gene-commentary_accession>NC_000019</Gene-commentary_accession>
      <Gene-commentary_version>10</Gene-commentary_version>
      <Gene-commentary_seqs>
        <Seq-loc>
          <Seq-loc_int>
            <Seq-interval>
              <Seq-interval_from>44905795</Seq-interval_from>
              <Seq-interval_to>44909392</Seq-interval_to>
              <Seq-interval_strand>
                <Na-strand value="plus"/>
              </Seq-interval_strand>
              <Seq-interval_id>
                <Seq-id>
                  <Seq-id_gi>568815579</Seq-id_gi>
                </Seq-id>
              </Seq-interval_id>
            </Seq-interval>
          </Seq-loc_int>
        </Seq-loc>
      </Gene-commentary_seqs>
      <Gene-commentary_products>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>Reference</Gene-commentary_heading>
          <Gene-commentary_label>transcript variant 1</Gene-commentary_label>
          <Gene-commentary_accession>NM_001302688</Gene-commentary_accession>
          <Gene-commentary_version>2</Gene-commentary_version>
          <Gene-commentary_genomic-coords>
            <Seq-loc>
              <Seq-loc_mix>
                <Seq-loc-mix>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44905795</Seq-interval_from>
                        <Seq-interval_to>44905922</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44906601</Seq-interval_from>
                        <Seq-interval_to>44906666</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44907759</Seq-interval_from>
                        <Seq-interval_to>44907951</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44908532</Seq-interval_from>
                        <Seq-interval_to>44909392</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                </Seq-loc-mix>
              </Seq-loc_mix>
            </Seq-loc>
          </Gene-commentary_genomic-coords>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>1676318530</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_heading>Reference</Gene-commentary_heading>
              <Gene-commentary_label>isoform a precursor</Gene-commentary_label>
              <Gene-commentary_accession>NP_001289617</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_genomic-coords>
                <Seq-loc>
                  <Seq-loc_mix>
                    <Seq-loc-mix>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44905868</Seq-interval_from>
                            <Seq-interval_to>44905922</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44906601</Seq-interval_from>
                            <Seq-interval_to>44906666</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44907759</Seq-interval_from>
                            <Seq-interval_to>44907951</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44908532</Seq-interval_from>
                            <Seq-interval_to>44909249</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                    </Seq-loc-mix>
                  </Seq-loc_mix>
                </Seq-loc>
              </Gene-commentary_genomic-coords>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>705044002</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>Reference</Gene-commentary_heading>
          <Gene-commentary_label>transcript variant 5</Gene-commentary_label>
          <Gene-commentary_accession>NM_001302691</Gene-commentary_accession>
          <Gene-commentary_version>2</Gene-commentary_version>
          <Gene-commentary_genomic-coords>
            <Seq-loc>
              <Seq-loc_mix>
                <Seq-loc-mix>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44905795</Seq-interval_from>
                        <Seq-interval_to>44905840</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44906586</Seq-interval_from>
                        <Seq-interval_to>44906666</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44907759</Seq-interval_from>
                        <Seq-interval_to>44907951</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44908532</Seq-interval_from>
                        <Seq-interval_to>44909392</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                </Seq-loc-mix>
              </Seq-loc_mix>
            </Seq-loc>
          </Gene-commentary_genomic-coords>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>1676440320</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_heading>Reference</Gene-commentary_heading>
              <Gene-commentary_label>isoform b precursor</Gene-commentary_label>
              <Gene-commentary_accession>NP_001289620</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>CCDS</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>CCDS12647.1</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_genomic-coords>
                <Seq-loc>
                  <Seq-loc_mix>
                    <Seq-loc-mix>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44906624</Seq-interval_from>
                            <Seq-interval_to>44906666</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44907759</Seq-interval_from>
                            <Seq-interval_to>44907951</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>44908532</Seq-interval_from>
                            <Seq-interval_to>44909249</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>568815579</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                    </Seq-loc-mix>
                  </Seq-loc_mix>
                </Seq-loc>
              </Gene-commentary_genomic-coords>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>705044152</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>Reference</Gene-commentary_heading>
          <Gene-commentary_label>transcript variant 2</Gene-commentary_label>
          <Gene-commentary_accession>NM_000041</Gene-commentary_accession>
          <Gene-commentary_version>4</Gene-commentary_version>
          <Gene-commentary_genomic-coords>
            <Seq-loc>
              <Seq-loc_mix>
                <Seq-loc-mix>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44905795</Seq-interval_from>
                        <Seq-interval_to>44905840</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44906601</Seq-interval_from>
                        <Seq-interval_to>44906666</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44907759</Seq-interval_from>
                        <Seq-interval_to>44907951</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>44908532</Seq-interval_from>
                        <Seq-interval_to>44909392</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815579</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                </Seq-loc-mix>
              </Seq-loc_mix>
            </Seq-loc>
          </Gene-commentary_genomic-coords>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>1519315198</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_heading>Reference</Gene-commentary_heading>
              <Gene-commentary_label>isoform b precursor</Gene-commentary_label>
              <Gene-commentary_accession>NP_000032</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>CCDS</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>CCDS12647.1</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_genomic-coords>
                <Seq-loc>
                  <Seq-loc_mix>
                    <Seq-loc-mix>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
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                          <Seq-id>
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                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>47732455</Seq-interval_from>
                        <Seq-interval_to>47732647</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>2194972797</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>47733228</Seq-interval_from>
                        <Seq-interval_to>47734088</Seq-interval_to>
                        <Seq-interval_strand>
                          <Na-strand value="plus"/>
                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>2194972797</Seq-id_gi>
                          </Seq-id>
                        </Seq-interval_id>
                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                </Seq-loc-mix>
              </Seq-loc_mix>
            </Seq-loc>
          </Gene-commentary_genomic-coords>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>1889569396</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_heading>Reference</Gene-commentary_heading>
              <Gene-commentary_label>isoform b precursor</Gene-commentary_label>
              <Gene-commentary_accession>NP_001289619</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_genomic-coords>
                <Seq-loc>
                  <Seq-loc_mix>
                    <Seq-loc-mix>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>47731320</Seq-interval_from>
                            <Seq-interval_to>47731362</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194972797</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>47732455</Seq-interval_from>
                            <Seq-interval_to>47732647</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194972797</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>47733228</Seq-interval_from>
                            <Seq-interval_to>47733945</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="plus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194972797</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                    </Seq-loc-mix>
                  </Seq-loc_mix>
                </Seq-loc>
              </Gene-commentary_genomic-coords>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>705044104</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
      </Gene-commentary_products>
    </Gene-commentary>
  </Entrezgene_locus>
  <Entrezgene_properties>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_label>Nomenclature</Gene-commentary_label>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_anchor>HUGO Gene Nomenclature Committee</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_properties>
        <Gene-commentary>
          <Gene-commentary_type value="property">16</Gene-commentary_type>
          <Gene-commentary_label>Official Symbol</Gene-commentary_label>
          <Gene-commentary_text>APOE</Gene-commentary_text>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="property">16</Gene-commentary_type>
          <Gene-commentary_label>Official Full Name</Gene-commentary_label>
          <Gene-commentary_text>apolipoprotein E</Gene-commentary_text>
        </Gene-commentary>
      </Gene-commentary_properties>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="property">16</Gene-commentary_type>
      <Gene-commentary_label>Exon count</Gene-commentary_label>
      <Gene-commentary_text>6</Gene-commentary_text>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>GeneOntology</Gene-commentary_heading>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_pre-text>Provided by</Other-source_pre-text>
          <Other-source_anchor>GOA</Other-source_anchor>
          <Other-source_url>http://www.ebi.ac.uk/GOA</Other-source_url>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Function</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8089103</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>11305869</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25207746</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1540</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>amyloid-beta binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9003062</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1540</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>amyloid-beta binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9685360</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>16209</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>antioxidant activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>120020</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>cholesterol transfer activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15654758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19899</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>enzyme binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9488694</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23676495</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43395</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>heparan sulfate proteoglycan binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2745454</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7635945</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8201</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>heparin binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>4066713</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8340399</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42802</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>identical protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>4066713</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8289</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>lipid binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17305370</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5319</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>lipid transporter activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>71813</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>lipoprotein particle binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>210175</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1530612</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7635945</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>50750</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17326667</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>50750</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20005821</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>50750</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9685360</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>46911</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>metal chelating activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>60228</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>phosphatidylcholine-sterol O-acyltransferase activator activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15654758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>60228</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>phosphatidylcholine-sterol O-acyltransferase activator activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5543</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>phospholipid binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>4066713</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5543</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>phospholipid binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7972031</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8245722</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12950167</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14754908</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15182176</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15615705</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17116874</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19758344</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20030366</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21163940</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21593558</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22528093</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24447298</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25122793</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26387950</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26468283</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26921451</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28887769</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>29507344</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>30341064</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>30448281</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>31270237</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>32814053</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5515</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>46983</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protein dimerization activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8089103</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8245722</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42803</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protein homodimerization activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25207746</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>44877</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protein-containing complex binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>27477018</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5102</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>signaling receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5198</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>structural molecule activity</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7566652</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48156</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>tau protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1384047</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70326</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12950167</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70326</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Process</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24328732</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>97113</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>acts_upstream_of_or_within_positive_effect</Other-source_pre-text>
                  <Other-source_anchor>AMPA glutamate receptor clustering</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16443932</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7186</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>G protein-coupled receptor signaling pathway</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24328732</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>97114</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>acts_upstream_of_or_within_positive_effect</Other-source_pre-text>
                  <Other-source_anchor>NMDA glutamate receptor clustering</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>55090</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>acylglycerol homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21593558</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42982</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>amyloid precursor protein metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48844</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>artery morphogenesis</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>98869</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cellular oxidant detoxification</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6707</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol catabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>33344</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>11162594</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16443932</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23620513</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>33344</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9649566</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42632</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42632</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8203</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9649566</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8203</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>3771793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8203</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cholesterol metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1911868</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34382</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>chylomicron remnant clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7175379</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34382</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>chylomicron remnant clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7010</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>cytoskeleton organization</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24345162</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>55089</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>fatty acid homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10467</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>gene expression</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14754908</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17305370</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34380</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>high-density lipoprotein particle assembly</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>210175</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34384</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>high-density lipoprotein particle clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12401887</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34375</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>high-density lipoprotein particle remodeling</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1917954</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>71831</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>intermediate-density lipoprotein particle clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6874</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>intracellular calcium ion homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>46907</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>intracellular transport</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10877</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>lipid transport involved in lipid storage</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23620513</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42158</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>lipoprotein biosynthetic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42159</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>lipoprotein catabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>35641</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>locomotory exploration behavior</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24345162</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>15909</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>long-chain fatty acid transport</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7616</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>long-term memory</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34374</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle remodeling</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51651</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>maintenance of location in cell</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26387950</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>32438</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>melanosome organization</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9685360</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43407</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of MAP kinase activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905907</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of amyloid fibril formation</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24154541</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1902430</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of amyloid-beta formation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8995232</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>30195</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of blood coagulation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9685360</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43537</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of blood vessel endothelial cell migration</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16805831</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90090</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of canonical Wnt signaling pathway</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16805831</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90090</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of canonical Wnt signaling pathway</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22988876</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90090</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of canonical Wnt signaling pathway</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1917954</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>45541</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of cholesterol biosynthetic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23142051</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10596</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of endothelial cell migration</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9685360</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1937</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of endothelial cell proliferation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10629</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of gene expression</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8995232</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>50728</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of inflammatory response</Other-source_anchor>
                  <Other-source_post-text>evidence: IC</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16273551</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1900272</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of long-term synaptic potentiation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7592957</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10977</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of neuron projection development</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8995232</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10544</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of platelet activation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16805831</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51248</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of protein metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>27044754</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>50709</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of protein secretion</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48662</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>acts_upstream_of</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of smooth muscle cell proliferation</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90209</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of triglyceride metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8939961</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>31175</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>neuron projection development</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8995232</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>38060</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>nitric oxide-cGMP-mediated signaling</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>33700</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>phospholipid efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>11162594</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>33700</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>phospholipid efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25122793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>44794</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation by host of viral process</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15654758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905920</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of CoA-transferase activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28111074</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>45893</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of DNA-templated transcription</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28111074</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70374</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of ERK1 and ERK2 cascade</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9228033</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20005821</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905908</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of amyloid fibril formation</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1900223</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of amyloid-beta clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12042316</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14754908</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10875</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of cholesterol efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12401887</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10875</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of cholesterol efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15654758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90205</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of cholesterol metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24328732</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>60999</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>acts_upstream_of_or_within</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of dendritic spine development</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24328732</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1902952</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>acts_upstream_of_or_within</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of dendritic spine maintenance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8300609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>45807</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of endocytosis</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8300609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905860</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of heparan sulfate proteoglycan binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12042316</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>46889</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of lipid biosynthetic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24345162</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1903002</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of lipid transport across blood-brain barrier</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15950758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>32805</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of low-density lipoprotein particle receptor catabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15950758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51044</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of membrane protein ectodomain proteolysis</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25015123</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51044</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of membrane protein ectodomain proteolysis</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7592957</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23845000</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10976</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of neuron projection development</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10976</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of neuron projection development</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8995232</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>45429</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of nitric oxide biosynthetic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12042316</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1902995</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>positive regulation of phospholipid efflux</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24446231</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>17038</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>protein import</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1917954</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6898</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>receptor-mediated endocytosis</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6898</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>receptor-mediated endocytosis</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16443932</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>32489</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of Cdc42 protein signal transduction</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25207746</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905906</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of amyloid fibril formation</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28164773</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1902991</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of amyloid precursor protein catabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24446231</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1900221</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of amyloid-beta clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42981</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of apoptotic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>30516</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of axon extension</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2000822</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of behavioral fear response</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7592957</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1905890</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of cellular response to very-low-density lipoprotein particle stimulus</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90181</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of cholesterol metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>45088</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of innate immune response</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48168</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of neuronal synaptic plasticity</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28111074</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>61136</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of proteasomal protein catabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51246</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of protein metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25207746</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43254</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>regulation of protein-containing complex assembly</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24412220</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>61771</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to caloric restriction</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2021</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to dietary excess</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>11743999</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>302</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to reactive oxygen species</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8127890</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43691</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>reverse cholesterol transport</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7271</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>synaptic transmission, cholinergic</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70328</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>triglyceride homeostasis</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9649566</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6641</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>triglyceride metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>3771793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6641</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>triglyceride metabolic process</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23676495</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>71830</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>triglyceride-rich lipoprotein particle clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42311</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>vasodilation</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>1917954</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2762297</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34447</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9649566</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34447</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle clearance</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15654758</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34372</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle remodeling</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12401887</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34372</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle remodeling</Other-source_anchor>
                  <Other-source_post-text>evidence: IGI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25122793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19068</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>virion assembly</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Component</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25122793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5794</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>Golgi apparatus</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22516433</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>72562</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>blood microparticle</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42627</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>chylomicron</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8245722</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16935699</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42627</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>chylomicron</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34360</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>chylomicron remnant</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>30669</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>clathrin-coated endocytic vesicle membrane</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23658023</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>27559042</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>62023</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>collagen-containing extracellular matrix</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8083695</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5737</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>cytoplasm</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9622609</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5737</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>cytoplasm</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8083695</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>30425</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>dendrite</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22383525</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34365</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>discoidal high-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5769</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>early endosome</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>71682</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>endocytic vesicle lumen</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25122793</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5783</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>endoplasmic reticulum</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5788</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>endoplasmic reticulum lumen</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19056867</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20458337</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23533145</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70062</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular exosome</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26387950</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70062</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular exosome</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9488694</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>31012</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular matrix</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>27068509</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular region</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8089103</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16805831</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular region</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular region</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>16502470</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20551380</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5615</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular space</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8340399</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5615</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular space</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5615</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular space</Other-source_anchor>
                  <Other-source_post-text>evidence: ISS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24769233</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1903561</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular vesicle</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1903561</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>is_active_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular vesicle</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22637583</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>98978</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>is_active_in</Other-source_pre-text>
                  <Other-source_anchor>glutamatergic synapse</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34364</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>high-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>210174</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2280190</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8071364</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14754908</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34364</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>high-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2280190</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17336988</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34363</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>intermediate-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1990777</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34362</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2280190</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8245722</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34362</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>low-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26387950</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42470</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>melanosome</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19946888</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>16020</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>membrane</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>26387950</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>97487</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>multivesicular body, internal vesicle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8083695</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43025</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>neuronal cell body</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21630459</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5634</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>nucleus</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5886</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>plasma membrane</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22637583</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43083</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>is_active_in</Other-source_pre-text>
                  <Other-source_anchor>synaptic cleft</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34361</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>2280190</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7683668</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8071364</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>8245722</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9211985</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17154273</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22138302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34361</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>part_of</Other-source_pre-text>
                  <Other-source_anchor>very-low-density lipoprotein particle</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
  </Entrezgene_properties>
  <Entrezgene_comments>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>RefSeq Status</Gene-commentary_heading>
      <Gene-commentary_label>REVIEWED</Gene-commentary_label>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Clone Names</Gene-commentary_heading>
      <Gene-commentary_text>MGC1571</Gene-commentary_text>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38691476</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38661357</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38637538</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38635499</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38598053</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38594621</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38563295</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38547662</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38509472</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38491412</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38480892</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38472178</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38424036</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38396791</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38393898</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38378514</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38374759</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38363572</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38339074</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38336940</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38334983</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38303161</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38301647</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38280459</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38280312</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38279679</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38279143</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38253819</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38228523</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38216055</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38212861</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38159571</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38145596</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38115150</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38112569</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38102657</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38086389</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38054895</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38054821</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38035998</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38030292</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38010414</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38007652</PubMedId>
          </Pub_pmid>
        </Pub>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
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                          <Object-id_str>C1864205</Object-id_str>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
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                          <Object-id_id>603075</Object-id_id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
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          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GTRDisease</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1863051</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1863051</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Alzheimer disease 3</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>Gene Reviews</Gene-commentary_heading>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
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                  <Gene-commentary_refs>
                    <Pub>
                      <Pub_pmid>
                        <PubMedId>20301340</PubMedId>
                      </Pub_pmid>
                    </Pub>
                  </Gene-commentary_refs>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>GeneReviews</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>NBK1161</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>GeneReviews</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GTRDisease</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1843013</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>MedGen</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1843013</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>607822</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MIM: 607822</Other-source_anchor>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Alzheimer disease 4</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>Gene Reviews</Gene-commentary_heading>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>Alzheimer Disease Overview</Gene-commentary_label>
                  <Gene-commentary_refs>
                    <Pub>
                      <Pub_pmid>
                        <PubMedId>20301340</PubMedId>
                      </Pub_pmid>
                    </Pub>
                  </Gene-commentary_refs>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>GeneReviews</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>NBK1161</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>GeneReviews</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GTRDisease</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1847200</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>MedGen</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C1847200</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>606889</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MIM: 606889</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>An atlas of genetic influences on human blood metabolites.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24816252</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/24816252</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23419831</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23419831</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23844046</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23844046</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Biological, clinical and population relevance of 95 loci for blood lipids.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20686565</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20686565</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17998437</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/17998437</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18802019</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/18802019</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Common variants at 30 loci contribute to polygenic dyslipidemia.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19060906</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19060906</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20885792</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20885792</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Discovery and refinement of loci associated with lipid levels.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24097068</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/24097068</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Examination of the current top candidate genes for AD in a genome-wide association study.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19125160</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19125160</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Familial type 3 hyperlipoproteinemia</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GTRDisease</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C0020479</Object-id_str>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>MedGen</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C0020479</Object-id_str>
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                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
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                  <Other-source_anchor>MIM: 617347</Other-source_anchor>
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        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.</Gene-commentary_heading>
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            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24023260</PubMedId>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.</Gene-commentary_heading>
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            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22331829</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22331829</Other-source_url>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19567438</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19567438</Other-source_url>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25378659</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/25378659</Other-source_url>
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              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24468470</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/24468470</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genetic variants influencing circulating lipid levels and risk of coronary artery disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20864672</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20864672</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide analysis of genetic loci associated with Alzheimer disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20460622</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20460622</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association analysis of age-at-onset in Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22005931</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22005931</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24688116</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/24688116</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19197348</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19197348</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23118302</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23118302</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21418511</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/21418511</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study identifies multiple loci influencing human serum metabolite levels.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22286219</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22286219</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19734903</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19734903</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19734902</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19734902</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study of Alzheimer&apos;s disease with psychotic symptoms.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22005930</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22005930</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study of Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22832961</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22832961</Other-source_url>
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              </Gene-commentary_source>
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          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21123754</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/21123754</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23726366</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23726366</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide scan of copy number variation in late-onset Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20061627</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20061627</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22399527</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22399527</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23562540</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23562540</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23067351</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23067351</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
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            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23326517</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23326517</Other-source_url>
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              </Gene-commentary_source>
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        <Gene-commentary>
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          <Gene-commentary_heading>Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.</Gene-commentary_heading>
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            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21909109</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/21909109</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Lipoprotein glomerulopathy</Gene-commentary_heading>
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            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
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                          <Object-id_str>C2673196</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>MedGen</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C2673196</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>611771</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MIM: 611771</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>19060911</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/19060911</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women&apos;s Genome Health Study.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18439548</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/18439548</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20838585</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/20838585</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Newly identified loci that influence lipid concentrations and risk of coronary artery disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18193043</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/18193043</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22916037</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/22916037</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Overrepresentation of glutamate signaling in Alzheimer&apos;s disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>24755620</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/24755620</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25350695</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/25350695</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18439552</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/18439552</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Sea-blue histiocyte syndrome</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>GTR</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GTRDisease</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C0036489</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Genetic Testing Registry</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>MedGen</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MedGen</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>C0036489</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MedGen</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>OMIM</Gene-commentary_heading>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>MIM</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>269600</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MIM: 269600</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Seven new loci associated with age-related macular degeneration.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23455636</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23455636</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18193044</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/18193044</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>Sorl1 as an Alzheimer&apos;s disease predisposition gene?</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>17975299</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/17975299</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>SORL1 is genetically associated with late-onset Alzheimer&apos;s disease in Japanese, Koreans and Caucasians.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23565137</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/23565137</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>SUCLG2 identified as both a determinator of CSF A&amp;#x000df;1-42-levels and an attenuator of cognitive decline in Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25027320</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/25027320</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
          <Gene-commentary_heading>The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer&apos;s disease.</Gene-commentary_heading>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="phenotype">19</Gene-commentary_type>
              <Gene-commentary_heading>EBI GWAS Catalog</Gene-commentary_heading>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21627779</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_anchor>EBI GWAS Catalog</Other-source_anchor>
                  <Other-source_url>https://www.ebi.ac.uk/gwas/publications/21627779</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>NCBI Reference Sequences (RefSeq)</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_heading>RefSeqs maintained independently of Annotated Genomes</Gene-commentary_heading>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_000041</Gene-commentary_accession>
              <Gene-commentary_version>4</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1519315198</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_000041</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1519315198</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_000032</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>4557325</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_000032</Other-source_anchor>
                      <Other-source_post-text>apolipoprotein E isoform b precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>4557325</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(1)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396157</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01442: Apolipoprotein; Apolipoprotein A1/A4/E domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 86 - 266</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Related</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>Ensembl</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>ENSP00000252486.3</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/TrEMBL</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>A0A0S2Z3D5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>A0A0S2Z3D5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>B2RC15</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>B2RC15</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>C0JYY5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>C0JYY5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P02649</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P02649</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q9P2S4</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q9P2S4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS12647.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (2) contains an alternate 5&apos; terminal exon, and it thus differs in the 5&apos; UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>BC003557,HY056112</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>BC003557,HY056112</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Related</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Ensembl</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>ENST00000252486.9</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001302688</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1676318530</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001302688</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1676318530</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001289617</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>705044002</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001289617</Other-source_anchor>
                      <Other-source_post-text>apolipoprotein E isoform a precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>705044002</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(1)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>279749</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01442: Apolipoprotein; Apolipoprotein A1/A4/E domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 112 - 292</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P02649</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P02649</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>BC003557,BM042032,HY056112</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>BC003557,BM042032,HY056112</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001302689</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1676318097</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001302689</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1676318097</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001289618</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>705044063</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001289618</Other-source_anchor>
                      <Other-source_post-text>apolipoprotein E isoform b precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>705044063</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(1)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396157</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01442: Apolipoprotein; Apolipoprotein A1/A4/E domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 86 - 266</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/TrEMBL</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>A0A0S2Z3D5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>A0A0S2Z3D5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>B2RC15</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>B2RC15</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>C0JYY5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>C0JYY5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P02649</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P02649</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q9P2S4</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q9P2S4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS12647.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (3) contains an alternate 5&apos; terminal exon, and it thus differs in the 5&apos; UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>BC003557,DB486513,HY074384</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>BC003557,DB486513,HY074384</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001302690</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1889569396</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001302690</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1889569396</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001289619</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>705044104</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001289619</Other-source_anchor>
                      <Other-source_post-text>apolipoprotein E isoform b precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>705044104</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(1)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396157</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01442: Apolipoprotein; Apolipoprotein A1/A4/E domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 86 - 266</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/TrEMBL</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>A0A0S2Z3D5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>A0A0S2Z3D5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>B2RC15</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>B2RC15</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>C0JYY5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>C0JYY5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P02649</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P02649</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q9P2S4</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q9P2S4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS12647.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (4) contains an alternate 5&apos; terminal exon, and it thus differs in the 5&apos; UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>BC003557,CA771535,HY074888</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>BC003557,CA771535,HY074888</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001302691</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1676440320</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001302691</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1676440320</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001289620</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>705044152</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001289620</Other-source_anchor>
                      <Other-source_post-text>apolipoprotein E isoform b precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>705044152</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(1)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396157</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01442: Apolipoprotein; Apolipoprotein A1/A4/E domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 86 - 266</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/TrEMBL</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>A0A0S2Z3D5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>A0A0S2Z3D5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>B2RC15</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>B2RC15</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>C0JYY5</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>C0JYY5</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P02649</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P02649</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q9P2S4</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q9P2S4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS12647.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS12647.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (5) contains an alternate 5&apos; terminal exon and uses an alternate splice site in another 5&apos; exon, and it thus differs in the 5&apos; UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>BC003557,BI550631</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>BC003557,BI550631</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
          </Gene-commentary_products>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_label>RefSeqGene</Gene-commentary_label>
              <Gene-commentary_accession>NG_007084</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>163954918</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NG_007084</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>5014</Seq-interval_from>
                      <Seq-interval_to>8611</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="plus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>163954918</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_heading>RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10</Gene-commentary_heading>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_heading>Reference GRCh38.p14 Primary Assembly</Gene-commentary_heading>
              <Gene-commentary_accession>NC_000019</Gene-commentary_accession>
              <Gene-commentary_version>10</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>568815579</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>44905795</Seq-interval_from>
                      <Seq-interval_to>44909392</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="plus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>568815579</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products></Gene-commentary_products>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_heading>Alternate T2T-CHM13v2.0</Gene-commentary_heading>
              <Gene-commentary_accession>NC_060943</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>2194972797</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>47730491</Seq-interval_from>
                      <Seq-interval_to>47734088</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="plus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>2194972797</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products></Gene-commentary_products>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Related Sequences</Gene-commentary_heading>
      <Gene-commentary_products>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>AB035149</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>8051697</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>AB035149.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>8051697</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>BAA96080</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8051698</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>BAA96080.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>8051698</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>AC011481</Gene-commentary_accession>
          <Gene-commentary_version>4</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>13487947</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>AC011481.4</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
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                    <Dbtag>
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              <Other-source_src>
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        <Gene-commentary>
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                  <Other-source_src>
                    <Dbtag>
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        <Gene-commentary>
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          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
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                  </Dbtag_tag>
                </Dbtag>
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        <Gene-commentary>
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          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
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                </Dbtag>
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              <Seq-loc_whole>
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        </Gene-commentary>
        <Gene-commentary>
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              <Other-source_src>
                <Dbtag>
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        </Gene-commentary>
        <Gene-commentary>
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          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
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                <Dbtag>
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        <Gene-commentary>
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          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
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                </Dbtag>
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        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
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                </Dbtag>
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        <Gene-commentary>
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              <Other-source_src>
                <Dbtag>
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        <Gene-commentary>
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              <Other-source_src>
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                    <Dbtag>
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                    <Seq-id>
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                <Dbtag>
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            <Seq-loc>
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                <Seq-id>
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            </Seq-loc>
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          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                  <Other-source_anchor>AAB59518.1</Other-source_anchor>
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              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>178849</Seq-id_gi>
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                  </Seq-loc_whole>
                </Seq-loc>
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            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
          <Gene-commentary_accession>X00199</Gene-commentary_accession>
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          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>28808</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>X00199.1</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>28808</Seq-id_gi>
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              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>CAA25017</Gene-commentary_accession>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
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                  <Other-source_anchor>CAA25017.1</Other-source_anchor>
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              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>929610</Seq-id_gi>
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                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
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          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
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          <Gene-commentary_accession>Z70760</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
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            <Seq-loc>
              <Seq-loc_whole>
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          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
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                    <Dbtag>
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              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
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          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
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                </Other-source>
                <Other-source>
                  <Other-source_src>
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      <Gene-commentary_comment>
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          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_text>MIM</Gene-commentary_text>
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                <Dbtag>
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        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_text>ALSoD/APOE genetic mutations</Gene-commentary_text>
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              <Other-source_url>http://alsod.iop.kcl.ac.uk/Als/Overview/gene.aspx?gene_id=APOE</Other-source_url>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>APOE database</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_url>http://databases.lovd.nl/shared/genes/APOE</Other-source_url>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>PharmGKB</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>PA55</Object-id_str>
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                  </Dbtag_tag>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UCSC</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>UCSC</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>UCSC</Other-source_anchor>
              <Other-source_url>http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_001302688</Other-source_url>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>MGC</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>BC003557</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>MGC</Other-source_anchor>
              <Other-source_url>https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC003557</Other-source_url>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
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                <Dbtag>
                  <Dbtag_db>HuGE Navigator</Dbtag_db>
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                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HuGE Navigator</Other-source_anchor>
              <Other-source_url>https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=APOE&amp;geneID=348&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y</Other-source_url>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_text>UniGene</Gene-commentary_text>
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              <Xtra-Terms_tag>UNIGENE</Xtra-Terms_tag>
              <Xtra-Terms_value>Hs.654439</Xtra-Terms_value>
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              </Other-source_src>
              <Other-source_anchor>Hs.654439</Other-source_anchor>
              <Other-source_url>https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&amp;CID=654439</Other-source_url>
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          </Gene-commentary_source>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
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      <Gene-commentary_text>Serum Apo Lipoprotein E, Apo Lipoprotein E Gene Polymorphisms, and Parkinson&apos;s Disease.</Gene-commentary_text>
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        <Pub>
          <Pub_pmid>
            <PubMedId>38691476</PubMedId>
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              <Date-std_day>3</Date-std_day>
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    <Gene-commentary>
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      <Gene-commentary_text>Impact of APOE-epsilon alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.</Gene-commentary_text>
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        <Pub>
          <Pub_pmid>
            <PubMedId>38635499</PubMedId>
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          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
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              <Date-std_minute>40</Date-std_minute>
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        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Correlation between APOE4 gene and gut microbiota in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38661357</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38637538</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Rare genetic variation in fibronectin 1 (FN1) protects against APOEepsilon4 in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38598053</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Onset of Alzheimer disease in apolipoprotein varepsilon4 carriers is earlier in butyrylcholinesterase K variant carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38594621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37857825</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The influence of APOE status on rate of cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38253819</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The cell biology of APOE in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37805344</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Perivascular space burden interacts with APOE-epsilon4 status on cognition in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38280312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38547662</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer&apos;s disease pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38301647</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4/4 is linked to damaging lipid droplets in Alzheimer&apos;s disease microglia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38480892</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>1</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38563295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Abeta uptake in astrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38280459</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriage associates with improved myocardial performance from adolescence to older age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38509472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>7</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E E3/E4 genotype is associated with an increased risk of type 2 diabetes mellitus complicated with coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38491412</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Independent and combined effects of methamphetamine use disorders and APOEepsilon4 allele on cognitive performance and brain morphometry.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37563863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38472178</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Machine Learning Predicts Conversion from Normal Aging to Mild Cognitive Impairment Using Medical History, APOE Genotype, and Neuropsychological Assessment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38393898</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38396791</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
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              <Date-std_year>2024</Date-std_year>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The roles of apolipoprotein E epsilon4 on neuropathology and neuroinflammation in patients with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37697966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
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            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_hour>20</Date-std_hour>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The current state of apolipoprotein E in dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38054895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
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            <Date-std>
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              <Date-std_day>8</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuropsychiatric symptoms and ApoE genotype in older adults without dementia: a cross-sectional study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38303161</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_minute>32</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38424036</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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            <Date-std>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Comparison of genetic and health risk factors for mild cognitive impairment and Alzheimer&apos;s disease between Hispanic and non-Hispanic white participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37104247</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Letter to the Editor: Alzheimer&apos;s Disease-Associated APOE epsilon4 Frequencies in Indian Population Genomes May Suggest Implications in Lecanemab Treatment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38374759</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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            <Date-std>
              <Date-std_year>2024</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37728850</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
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            <Date-std>
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              <Date-std_hour>20</Date-std_hour>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Gene in alpha-Synucleinopathies: A Narrative Review.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38339074</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
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        </Date>
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    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype dictates lipidomic signatures in primary human hepatocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38216055</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
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            <Date-std>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38336940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>23</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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        </Date>
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            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>27</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Leading determinants of incident dementia among individuals with and without the apolipoprotein E epsilon4 genotype: a retrospective cohort study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38378514</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
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        <Date>
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            <Date-std>
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              <Date-std_hour>20</Date-std_hour>
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        </Date>
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    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38363572</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38279679</PubMedId>
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        </Pub>
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              <Date-std_year>2024</Date-std_year>
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              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE gene with longitudinal changes of CSF amyloid beta and tau levels in Alzheimer&apos;s disease: racial differences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37759100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38334983</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer&apos;s disease spectrum, moderation and mediation role of insula network connectivity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37577852</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>GSK-3beta activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37700547</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38212861</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Beneficial Effect of Societal Factors on APOE-epsilon2 and epsilon4 Carriers&apos; Brain Health: A Systematic Review.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37792627</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37653269</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The interaction effects of age, APOE and common environmental risk factors on human brain structure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38112569</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>6</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mild behavioral impairment in early Alzheimer&apos;s disease and its association with APOE and BDNF risk genetic polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38279143</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38228523</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE3ch alters microglial response and suppresses Abeta-induced tau seeding and spread.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38086389</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Role of APOE in glaucoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38145596</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>3</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the &quot;Mugello study&quot;.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37710144</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Capillary dysfunction in healthy elderly APOE epsilon4 carriers with raised brain Abeta deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37679610</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Obstructive sleep apnea and cognitive functioning in the older general population: The moderating effect of age, sex, ApoE4, and obesity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37309703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Genotype Modifies the Association between Midlife Adherence to the Planetary Healthy Diet and Cognitive Function in Later Life among Chinese Adults in Singapore.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38035998</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>6</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer&apos;s brains.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38159571</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37438877</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between APOE-epsilon4 allele and cognitive function is mediated by Alzheimer&apos;s disease pathology: a population-based autopsy study in an admixed sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38115150</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>5</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Prognostic significance and immune characteristics of APOE in gastric cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38054821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE-Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35606148</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>5</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The inverse association between the apolipoprotein E epsilon4 allele and C-reactive protein levels is stronger in persons with obesity and diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37801334</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>7</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-Genotype and Insulin Modulate Estimated Effect of Dietary Macronutrients on Cognitive Performance: Panel Analyses in Nondiabetic Older Adults at Risk of Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37778510</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>7</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PICALM Variation Moderates the Relationships of APOE varepsilon4 with Alzheimer&apos;s Disease Cerebrospinal Biomarkers and Memory Function Among Non-Demented Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38007652</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease phenotype based upon the carrier status of the apolipoprotein E varepsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37646624</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case-control study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38102657</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37957317</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>6</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Molecular modeling of apoE in complexes with Alzheimer&apos;s amyloid-beta fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38010414</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease cortical morphological phenotypes are associated with TOMM40&apos;523-APOE haplotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37804609</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37010884</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>6</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of ApoE Polymorphisms with Postoperative Atrial Fibrillation and Cardiac Injury in Patients with Coronary Artery Bypass Graft Surgery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38030292</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE and vascular disease: Sequencing and genotyping in general population cohorts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37586954</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
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      <Gene-commentary_update-date>
        <Date>
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            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36732588</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex and APOE epsilon4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37496307</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE-epsilon4 and GAP-43-related presynaptic loss with beta-amyloid, tau, neurodegeneration, and cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37852045</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential association of cerebral blood flow and anisocytosis in APOE epsilon4 carriers at midlife.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37132287</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37988105</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37958971</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>5</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Potential Modifying Effect of the APOEepsilon4 Allele on Age of Onset and Clinical Manifestations in Patients with Early-Onset Alzheimer&apos;s Disease with and without a Pathogenic Variant in PSEN1 in a Sample of the Mexican Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37958671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated ApoE, ApoJ and lipoprotein-bound alpha-synuclein levels in cerebrospinal fluid from Parkinson&apos;s disease patients - Validation in the BioFIND cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37479568</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>1</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Absence of the influence of the APOE gene on the incidence of type 2 diabetes mellitus in a cohort of workers: Effect of diet and shift work.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37211496</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37051669</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Body Mass Index Decrease Has a Distinct Association with Alzheimer&apos;s Disease Pathophysiology in APOE varepsilon4 Carriers and Non-Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37840490</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37777962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37350319</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>6</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TOMM40 &apos;523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEvarepsilon3 Homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37718796</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37310025</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37594184</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
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              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex differences in associations between APOE epsilon2 and longitudinal cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36994910</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 impairs the microglial response in Alzheimer&apos;s disease by inducing TGFbeta-mediated checkpoints.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37749326</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
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            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 potentiates amyloid beta effects on longitudinal tau pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37749258</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>18</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polygenic Propensity for Longevity, APOE-epsilon4 Status, Dementia Diagnosis, and Risk for Cause-Specific Mortality: A Large Population-Based Longitudinal Study of Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37434484</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The effect of apoprotein E gene polymorphism on neurocognitive functions of children with CHD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36047305</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        <Date>
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            <Date-std>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genotypic Effects of the TOMM40&apos;523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37874111</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
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              <Date-std_day>25</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37738239</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_month>10</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37572524</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37335131</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>1</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
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        <Date>
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              <Date-std_day>20</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37686334</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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        <Date>
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            <Date-std>
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              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37657448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        <Date>
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              <Date-std_day>18</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 and BIN1 increase risk of Alzheimer&apos;s disease pathology but not specifically of Lewy body pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37700353</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
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        </Date>
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        <Date>
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            <Date-std>
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              <Date-std_day>18</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lower mortality risk in APOE4 carriers with normal cognitive ageing.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37699966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
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            </Date-std>
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        <Date>
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            <Date-std>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alteration of Blood Immune Biomarkers in MCI Patients with Different APOE Genotypes after Cognitive Training: A 1 Year Follow-Up Cohort Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37686198</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
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    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37459083</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37037656</PubMedId>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 influences within and between network functional connectivity in posterior cortical atrophy and logopenic progressive aphasia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36999481</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hippocampal connectivity and memory decline in cognitively intact APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36906845</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between APOE, APOA1, and LPL Gene Polymorphisms and Variability in Changes in Lipid and Blood Pressure following Orange Juice Intake: A Pilot Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37128695</PubMedId>
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        <Date>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Common Variants of APOE, CETP, and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37446094</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37456207</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_year>2023</Date-std_year>
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              <Date-std_day>8</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon2 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37531722</PubMedId>
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      <Gene-commentary_create-date>
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              <Date-std_hour>13</Date-std_hour>
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              <Date-std_minute>42</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene polymorphisms and metals and their interactions with cognitive function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37644506</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Transcriptomic Downregulation of APOE, Polymorphic Variations of APOE, Diet, Social Isolation, and Co-morbidities as Contributing Factors to Alzheimer&apos;s Disease: a Case-Control Study of Kashmiri Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37357229</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A polygenic risk score for Alzheimer&apos;s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37649099</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reelin Plasma Levels Identify Cognitive Decline in Alcohol Use Disorder Patients During Early Abstinence: The Influence of APOE4 Expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37350760</PubMedId>
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              <Date-std_hour>13</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37605285</PubMedId>
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              <Date-std_day>28</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36997127</PubMedId>
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              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E4-related Microvascular Disease in the Alzheimer&apos;s Disease Hippocampal CA1 Stratum Radiatum.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37385335</PubMedId>
          </Pub_pmid>
        </Pub>
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              <Date-std_hour>18</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Blood-Brain Barrier Dysfunction and Abeta42/40 Ratio Dose-Dependent Modulation with the ApoE Genotype within the ATN Framework.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37569528</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37414536</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuropathology-based APOE genetic risk score better quantifies Alzheimer&apos;s risk.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>36795776</PubMedId>
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              <Date-std_day>11</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
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              <Date-std_hour>20</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (ApoE) epsilon4 Genotype (ApoE rs429358-ApoE rs7412 Polymorphisms) Is Not Associated with Long COVID Symptoms in Previously Hospitalized COVID-19 Survivors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37510324</PubMedId>
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              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Gene Associated with Dementia-Related Traits, Depression, and Anxiety in the Hispanic Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37510309</PubMedId>
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        <Date>
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              <Date-std_year>2023</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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              <Date-std_minute>35</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic association between the APOE epsilon4 allele, toxicant exposures and Gulf war illness diagnosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37415220</PubMedId>
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            <Date-std>
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              <Date-std_day>9</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
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              <Date-std_day>9</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCepsilon mislocalization in cholinergic neuronal cells.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of the APOEvarepsilon4 Allele on the Relationship Between Tau and Amyloid-beta in Early- and Late-Onset Alzheimer&apos;s Disease.</Gene-commentary_text>
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          <Pub_pmid>
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              <Date-std_minute>6</Date-std_minute>
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              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37509110</PubMedId>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
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              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Abeta Deposition in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37093447</PubMedId>
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        </Pub>
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              <Date-std_minute>59</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carboxyl truncation of alpha-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of alpha-synuclein pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37482615</PubMedId>
          </Pub_pmid>
        </Pub>
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              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Effect of Gender and APOE varepsilon4 Status on Brain Amyloid-beta Deposition in Different Age Groups of Mild Cognitively Impaired Individuals: A PET-CT Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37334590</PubMedId>
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              <Date-std_year>2023</Date-std_year>
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              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apoprotein E methylation is correlated with immune microenvironment in hepatocellular carcinoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37352133</PubMedId>
          </Pub_pmid>
        </Pub>
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              <Date-std_year>2023</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>7</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 synergizes with sleep disruption to accelerate Abeta deposition and Abeta-associated tau seeding and spreading.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37279069</PubMedId>
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        </Pub>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37462970</PubMedId>
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        </Pub>
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              <Date-std_hour>12</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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          <Pub_pmid>
            <PubMedId>37155564</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37270543</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Gender specific factors contributing to cognitive resilience in APOE varepsilon4 positive older adults in a population-based sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37198167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-Analysis of Variations in Association between APOE varepsilon4 and Alzheimer&apos;s Disease and Related Dementias Across Hispanic Regions of Origin.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37182874</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE expression and secretion are modulated by mitochondrial dysfunction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37171075</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Paradoxical Long-Term Impact Between Serum Apolipoprotein E and High-Density Lipoprotein Cholesterol in Patients Undergoing Percutaneous Coronary Intervention.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35934781</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4, but not polygenic Alzheimer&apos;s disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37225733</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37221560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Contribution of APOE Genetic Variants to Dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37051929</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37072097</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>2</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Detecting amyloid-beta positivity using regions of interest from structural magnetic resonance imaging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36912182</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer&apos;s disease pathogenesis in the brain during peripheral chronic inflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37060729</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36722399</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Respective influence of beta-amyloid and APOE epsilon4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37061167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>18</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between the LRP1B and APOE loci and the development of Parkinson&apos;s disease dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36348503</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>7</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of ApoE gene polymorphisms with serum lipid levels and the risk of type 2 diabetes mellitus in the Chinese Han population of central China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37123009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Female APOE varepsilon4 Carriers with Slow Rates of Biological Aging Have Better Memory Performances Compared to Female varepsilon4 Carriers with Accelerated Aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36872781</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>5</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
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      </Gene-commentary_update-date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36549843</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neurostructural and neurocognitive correlates of APOE epsilon4 in youth bipolar disorder.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36919310</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship of Muscle Apolipoprotein E Expression with Markers of Cellular Stress, Metabolism, and Blood Biomarkers in Cognitively Healthy and Impaired Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36847010</PubMedId>
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            <Date-std>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Race and Apolipoprotein E-e4 Allele Status Differences in the Association Between Loneliness and Cognitive Decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36626598</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>37016464</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2023</Date-std_year>
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              <Date-std_day>6</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36871219</PubMedId>
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        <Date>
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            <Date-std>
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              <Date-std_day>4</Date-std_day>
              <Date-std_hour>3</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction analysis of ancestry-enriched variants with APOE-varepsilon4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36991100</PubMedId>
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              <Date-std_year>2023</Date-std_year>
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              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE differentially moderates cerebrospinal fluid and plasma phosphorylated tau181 associations with multi-domain cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36780762</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE (rs429358 and rs7412) and PON1 (Q192R and L55M) Variants with Myocardial Infarction in the Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36980959</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mitochondria Profoundly Influence Apolipoprotein E Biology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36776072</PubMedId>
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      <Gene-commentary_text>In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36709412</PubMedId>
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      <Gene-commentary_create-date>
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              <Date-std_hour>2</Date-std_hour>
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      <Gene-commentary_text>Resting-state brain signal complexity discriminates young healthy APOE e4 carriers from non-e4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>36656069</PubMedId>
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        </Pub>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>36946043</PubMedId>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36878326</PubMedId>
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              <Date-std_year>2023</Date-std_year>
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        <Pub>
          <Pub_pmid>
            <PubMedId>36835187</PubMedId>
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          <Pub_pmid>
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      <Gene-commentary_text>Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer&apos;s Disease.</Gene-commentary_text>
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          <Pub_pmid>
            <PubMedId>36901420</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE Modifier Alleles for Alzheimer&apos;s Disease Discovered by Information Theory Dependency Measures: MIST Software Package.</Gene-commentary_text>
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          <Pub_pmid>
            <PubMedId>36322888</PubMedId>
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          <Pub_pmid>
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          <Pub_pmid>
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              <Date-std_hour>7</Date-std_hour>
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          <Pub_pmid>
            <PubMedId>36621546</PubMedId>
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          <Pub_pmid>
            <PubMedId>36787293</PubMedId>
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          <Pub_pmid>
            <PubMedId>35661582</PubMedId>
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              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35439339</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Correlations between the NMR Lipoprotein Profile, APOE Genotype, and Cholesterol Efflux Capacity of Fasting Plasma from Cognitively Healthy Elderly Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36768512</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>5</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36759834</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactive association of posttraumatic stress disorder, apolipoprotein epsilon4 genotype, and age on cognitive functioning.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36757293</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36766752</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>18</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age-Related Association Between APOE varepsilon4 and Cognitive Progression in de novo Parkinson&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36565124</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Morphological and Structural Network Analysis of Sporadic Alzheimer&apos;s Disease Brains Based on the APOE4 Gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36530087</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 effect: structural brain differences in Alzheimer&apos;s disease according to the age at symptom onset.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36463489</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of APOE epsilon4 genotype on amyloid-beta, glucose metabolism, and gray matter volume in cognitively normal individuals and amnestic mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36448771</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between APOE varepsilon4 and Age Is Associated with Emotional Distress One Year after Moderate-Severe Traumatic Brain Injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35996348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of apolipoprotein E epsilon 4 and cognitive impairment in adults living with human immunodeficiency virus: a meta-analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36719356</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Diagnosis of Familial Dysbetalipoproteinemia Based on the Lipid Abnormalities Driven by APOE2/E2 Genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36644927</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E gene variants shape the association between dietary fibre intake and cognitive decline risk in community-dwelling older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36729469</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A metabolomic signature of the APOE2 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35997888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
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              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36640294</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
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              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 status and plasma p-tau181 interact to influence cognitive performance among non-demented older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36608927</PubMedId>
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        </Pub>
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            <Date-std>
              <Date-std_year>2023</Date-std_year>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36528961</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOE epsilon2 allele on basal forebrain functional connectivity in mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36468416</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35243969</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apoe4 and Alzheimer&apos;s Disease Pathogenesis-Mitochondrial Deregulation and Targeted Therapeutic Strategies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36614219</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer&apos;s disease?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35900209</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The influence of hypertension, diabetes, lipid disorders and the presence of the APOE4 allele on the cognitive functions of patients over 65 years of age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36645688</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of CSF GAP-43 and APOE epsilon4 with Cognition in Mild Cognitive Impairment and Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36611808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36434832</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of the APOE epsilon2 and epsilon4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer&apos;s disease biomarkers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36399096</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36330582</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36116165</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between apolipoprotein E genotypes, excessive daytime sleepiness, and cognitive function in obstructive sleep apnea patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36577409</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (APOE) Genotypes in the Israeli population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36573773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOEvarepsilon4 genotype on age-associated change in cognitive functions among Japanese middle-aged and older adults: A 20-year follow-up study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36435340</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype, hippocampus, and cognitive markers of Alzheimer&apos;s disease in American Indians: Data from the Strong Heart Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35142437</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2023</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
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            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE mediated neuroinflammation and neurodegeneration in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35232622</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Amyloid-beta and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer&apos;s disease polygenic risk score.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36522743</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36520946</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer&apos;s disease and related dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36512526</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Inverse Association of APOE epsilon4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36479943</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36155836</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactions between the apolipoprotein E4 gene and modifiable risk factors for cognitive impairment: a nationally representative panel study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36474172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE locus is linked to decline in general cognitive function: 20-years follow-up in the Doetinchem Cohort Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36446774</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33455613</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36429044</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Alleles With Tau and Abeta Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36130843</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36385529</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Analysis of APOE and SLCO1B1 Gene Polymorphism and Correlation with Dyslipidemia in China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36377985</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 genotype, amyloid-beta, and sex interact to predict tau in regions of high APOE mRNA expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36383681</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>RNA Hypomethylation and Unchanged DNA Methylation Levels in the Cortex of ApoE4 Carriers and Alzheimer&apos;s Disease Subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36045519</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35229693</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36361733</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
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        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cardiorespiratory fitness decreases the odds for subclinical carotid plaques in apolipoprotein e4 homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36357490</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Common human genetic variants of APOE impact murine COVID-19 mortality.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36130725</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer&apos;s disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36324176</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 Allele, Sex, and Dementia Risk in Parkinson&apos;s Disease: Lessons From a Longitudinal Cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34958617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36318198</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36284363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of apolipoprotein E4 genotype on cerebro-cerebellar connectivity, brain atrophy, and cognition in patients with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36201963</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Alzheimer&apos;s Disease with Genetic Variants of Apolipoprotein E, Clusterin, TNF-alpha, and IL-6 Among Elderly Saudis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35135450</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Identifying differential regulatory control of APOE varepsilon4 on African versus European haplotypes as potential therapeutic targets.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34978147</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Missing apolipoprotein E epsilon4 allele associated with nonamnestic Alzheimer&apos;s disease in a Tunisian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36226340</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35858818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer&apos;s dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36217192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations between Apolipoprotein E Gene Polymorphism, Diet and Dyslipidemia in a Yao Minority Area, China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34339344</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>(1) H, (15) N and (13) C chemical shift assignments of the N-terminal domain of the two isoforms of the human apolipoprotein E.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35451799</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer&apos;s disease pathology and brain diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36153580</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer&apos;s disease pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35977442</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_text>Associations Between Sub-Threshold Amyloid-beta Deposition, Cortical Volume, and Cognitive Function Modulated by APOE varepsilon4 Carrier Status in Cognitively Normal Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35964194</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The correlation between APOE expression and the clinical characteristics and prognosis of patients with endometrial cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36123916</PubMedId>
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        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35977543</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Role of apolipoprotein E in suppressing oxidative stress in gestational diabetes mellitus patients and mouse model.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34929050</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOE gene epsilon4 allele on serum lipid profiles and risk of cardiovascular disease and tumorigenesis in southern Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36057714</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Osteoarthritis and APOE4 Interact to Influence Memory Decline in Non-Demented Older People.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35848022</PubMedId>
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      <Gene-commentary_create-date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Establishing the relationship between familial dysbetalipoproteinemia and genetic variants in the APOE gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35781703</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Rare APOE Missense Variants-Can We Overcome APOE epsilon4 and Alzheimer Disease Risk?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35639398</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36011277</PubMedId>
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        </Pub>
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      <Gene-commentary_text>Increased plasma and brain immunoglobulin A in Alzheimer&apos;s disease is lost in apolipoprotein E epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36008818</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>36002891</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35995824</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-kappaB activation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35977506</PubMedId>
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        </Pub>
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        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35948759</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
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        <Pub>
          <Pub_pmid>
            <PubMedId>35896049</PubMedId>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>35779013</PubMedId>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Does personalised nutrition advice based on apolipoprotein E and methylenetetrahydrofolate reductase genotype affect dietary behaviour?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34817242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of APOE genotype with COVID-19 disease severity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35931737</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Relationship Between APOE Gene Polymorphism and In-stent Restenosis After Stenting at the Beginning of the Vertebral Artery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34728399</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic polymorphisms of apolipoprotein E in nonarteritic anterior ischemic optic neuropathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35258716</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peripheral apoE4 enhances Alzheimer&apos;s pathology and impairs cognition by compromising cerebrovascular function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35915180</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35915083</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The envelope protein of Zika virus interacts with apolipoprotein E early in the infectious cycle and this interaction is conserved on the secreted viral particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35902969</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE Serum Levels and APOE epsilon2, epsilon3, and epsilon4 Alleles with Optic Neuritis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35885971</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphisms in adults over 60 years of age with mild cognitive impairment and Alzheimer&apos;s disease in different Venezuelan populations&quot;, trans &quot;Polimorfismos del gen de la apolipoproteina E en adultos mayores de 60 anos con disminucion de la memoria cognitiva y enfermedad de Alzheimer en diferentes poblaciones venezolanas</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35866735</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>GBA and APOE Impact Cognitive Decline in Parkinson&apos;s Disease: A 10-Year Population-Based Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35106798</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Role of ApoE Serum Levels and ApoE Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35892323</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35891722</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-wide association study identifies APOE locus influencing plasma p-tau181 levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35250029</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential Effects of APOE and Modifiable Risk Factors on Hippocampal Volume Loss and Memory Decline in Abeta- and Abeta+ Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35169009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34965472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The protective gene dose effect of the APOE epsilon2 allele on gray matter volume in cognitively unimpaired individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34877786</PubMedId>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of apolipoprotein E epsilon4 allele and amyotrophic lateral sclerosis in Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34279165</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_minute>22</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 and late-life cognition: mediation by structural brain imaging markers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35471691</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis of the association between Apolipoprotein E polymorphism and risks of myocardial infarction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35331149</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_minute>21</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Value of Brain Structural Magnetic Resonance Imaging Combined with APOE--epsilon4 Genotype in Early Diagnosis and Disease Progression of Senile Vascular Cognitive Impairment No Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35317127</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35850541</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35639372</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms of apolipoprotein E in the Afro-descendant population of Buenaventura, Colombia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35803688</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism status (E4) may help in predicting the risk of recurrent implantation failure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34767643</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
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        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ASSOCIATION BETWEEN APOLIPOPROTEIN E POLYMORPHISMS AND EPILEPSY IN CHILDREN.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35734486</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35705959</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer&apos;s disease outside of the APOE region.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35658006</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35525326</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_minute>3</Date-std_minute>
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              <Date-std_hour>13</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer&apos;s Disease Risks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35491776</PubMedId>
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        </Pub>
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              <Date-std_year>2022</Date-std_year>
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              <Date-std_minute>3</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Relationship Between Sleep Disturbance and Apolipoprotein E epsilon4 in Adults With Mild Cognitive Impairment and Alzheimer&apos;s Disease Dementia: An Integrative Review.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35439097</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E varepsilon4 Allele with Enlarged Perivascular Spaces.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35373386</PubMedId>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Early-life educational attainment, APOE epsilon4 alleles, and incident dementia risk in late life.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35306636</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Don&apos;t forget about tau: the effects of ApoE4 genotype on Alzheimer&apos;s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35061102</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Magnetic susceptibility in the deep gray matter may be modulated by apolipoprotein E4 and age with regional predilections: a quantitative susceptibility mapping study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34981175</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer&apos;s Disease in Humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35466940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 and Confluent White Matter Hyperintensities Have a Synergistic Effect on Episodic Memory Impairment in Prodromal Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35431245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Education and Cardiovascular Health as Effect Modifiers of APOE epsilon4 on Dementia: The Atherosclerosis Risk in Communities Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34614170</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E*E2 carriers exhibit high aspirin-treated platelet reactivity and low cardiovascular risk during long-term aspirin treatment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35647761</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Molecular Spectrum in a French Cohort with Primary Dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35628605</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene region methylation is associated with cognitive performance in middle-aged urban adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35561457</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33991295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mediation of the APOE associations with Alzheimer&apos;s and coronary heart diseases through body mass index and lipids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34554385</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 exacerbates alpha-synuclein seeding activity and contributes to neurotoxicity in Alzheimer&apos;s disease with Lewy body pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35471463</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An exploratory pilot study on the involvement of APOE, HFE, C9ORF72 variants and comorbidities in neurocognitive and physical performance in a group of HIV-infected people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35353274</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age, sex and APOE-epsilon4 modify the balance between soluble and fibrillar beta-amyloid in non-demented individuals: topographical patterns across two independent cohorts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35236958</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34942620</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE varepsilon4 and Plasma p-tau181 with Preclinical Alzheimer&apos;s Disease and Longitudinal Change in Hippocampus Function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34924376</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 allele impairs cortical activity in healthy aging and Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34871705</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Longitudinal association of apolipoprotein E and sleep with incident dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34477303</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Correlation Between ApoE Gene Polymorphism and LEAD in Patients with T2DM That are of Han Nationality in Northern China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35535404</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Brain myelin water fraction is associated with APOE4 allele status in patients with cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34964524</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35508522</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of APOE genotype on prion-type propagation of tauopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35440098</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35332187</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Midlife alcohol consumption and later life cognitive impairment: Light drinking is not protective and APOE genotype does not change this relationship.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35275952</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35205269</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Interactive Effect of Genetic and Epigenetic Variations in FKBP5 and ApoE Genes on Anxiety and Brain EEG Parameters.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35205209</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer&apos;s Disease Pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34987110</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34954207</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between Apolipoprotein E Polymorphism and Clinical Outcome after Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34915479</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lower cerebral oxygen utilization is associated with Alzheimer&apos;s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34743630</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34310026</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein epsilon4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35303671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>5</Date-std_month>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of ApoE Genotypes and Recovery From Intracerebral Hemorrhage in Very Low Birth Weight Infants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34619984</PubMedId>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35409035</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism alters cerebral oxygen saturation and quantitative EEG in early-stage traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35193096</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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            <Date-std>
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              <Date-std_hour>12</Date-std_hour>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism epsilon4-stratified longitudinal association between daytime naps, sleep apnea and mild cognitive impairment: A prospective cohort study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35104029</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_hour>12</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34171089</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>23</Date-std_day>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses&apos; Health Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34125204</PubMedId>
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        </Pub>
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              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>23</Date-std_day>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E homozygous epsilon4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33648793</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34406390</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[Correlation of serum lipids levels of Alzheimer&apos;s disease patients with sex, age and apolipoprotein E gene polymorphism].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Risk Factors for Severe COVID-19 and Hepatitis C Infections: The Dual Role of Apolipoprotein E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35359998</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Combined homocysteine and apoE rs429358 and rs7412 polymorphism in association with serum lipid levels and cognition in Chinese community-dwelling older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35351068</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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            <Date-std>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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          </Date_std>
        </Date>
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    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dementia Incidence, APOE Genotype, and Risk Factors for Cognitive Decline in Aboriginal Australians: A Longitudinal Cohort Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35140131</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEvarepsilon4 Allele Moderates the Association Between Basal Forebrain Nuclei Volumes and Allocentric Navigation in Older Adults Without Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35034896</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35023380</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4, Alzheimer&apos;s disease neuropathology and sleep disturbance, in individuals with and without dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35354468</PubMedId>
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        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ASSOCIATION BETWEEN APOE-epsilon4 CARRIER STATUS AND QUALITATIVE NEUROIMAGING CHARACTERISTICS IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Isoform-specific changes related to stress and trauma exposure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35347119</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dissecting the Association of Apolipoprotein E Gene Polymorphisms With Type 2 Diabetes Mellitus and Coronary Artery Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35211094</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The detrimental effects of APOE4 on risk for Alzheimer&apos;s disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35051676</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A gene-environment interplay between omega-3 supplementation and APOE epsilon4 provides insights for Alzheimer&apos;s disease precise prevention amongst high-genetic-risk population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34710256</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34612548</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE epsilon4 Allele in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34533445</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35154509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic mutations of APOEepsilon4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34757642</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Smaller hippocampal volume in APOE epsilon4 carriers independent of amyloid-beta (Abeta) burden.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34508954</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Role of Apolipoprotein E in the Clinical Profile of Atypical Parkinsonian Syndromes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35001031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35041557</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer&apos;s disease and myocardial infarction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33856023</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of circulating C-reactive proteins, APOE epsilon4, and brain markers for Alzheimer&apos;s disease in healthy samples across the lifespan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34920091</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35276898</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association Between Apolipoprotein E epsilon2 vs epsilon4, Age, and beta-Amyloid in Adults Without Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33044487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex-Dependent Effects of the APOE varepsilon4 Allele on Behavioral Traits and White Matter Structures in Young Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32954402</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 Polymorphism and Outcomes from Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>30848161</PubMedId>
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              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Examining the effects of the CLU and APOE polymorphisms&apos; combination on coronary artery disease complexed with type 2 diabetes mellitus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34686405</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE epsilon4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35122970</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E varepsilon4-related effects on cognition are limited to the Alzheimer&apos;s disease spectrum.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34591236</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34980257</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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            <Date-std>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E and Alzheimer&apos;s Disease: Findings, Hypotheses, and Potential Mechanisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34460318</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Abeta generation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34450034</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
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        </Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E varepsilon4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34228042</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_minute>22</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between apolipoprotein E gene polymorphism and nonalcoholic fatty liver disease in Southern China: A case-control study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34664321</PubMedId>
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        </Pub>
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        <Date>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
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        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increase of serum uric acid levels associated with APOE epsilon2 haplotype: a clinico-genetic investigation and in vivo approach.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34532841</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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        <Date>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
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        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Network dysfunction in cognitively normal APOE epsilon4 carriers is related to subclinical tau.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34002449</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between arteriosclerosis and the APOE4 gene in cognitive decline in older adults: a cross-sectional study in rural minority areas in western China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35048467</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship between Apolipoprotein E Genotype and Lipoprotein Profile in Patients with Coronary Heart Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35209166</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
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              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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            <Date-std>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer&apos;s Disease: Data from the PUMCH Dementia Cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34958020</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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            <Date-std>
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              <Date-std_hour>11</Date-std_hour>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>35193676</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management.</Gene-commentary_text>
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        <Pub>
          <Pub_pmid>
            <PubMedId>34749748</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34587962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Protective Effects of APOE epsilon2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33748669</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33864613</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33835624</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 Allele Affects Cognitive Functions Differently in Carriers of APP Mutations Compared to Carriers of PSEN1 Mutations in Autosomal-Dominant Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34946903</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34867826</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34828374</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer&apos;s risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34625307</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 activates C/EBPbeta/delta-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33716161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Race-Related Association between APOE Genotype and Alzheimer&apos;s Disease: A Systematic Review and Meta-Analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34334408</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E e4 is associated with worse self-reported neurobehavioral symptoms following uncomplicated mild traumatic brain injury in U.S. military service members.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34333069</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34647905</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEpsilon4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34488832</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE epsilon2 protective effect in Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34480088</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer&apos;s disease spectrum via disturbing default mode network.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34387022</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33837271</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Role of Apolipoprotein E epsilon4 in Early and Late Mild Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34340229</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Protective association of the epsilon2/epsilon3 heterozygote with Alzheimer&apos;s disease is strengthened by TOMM40-APOE variants in men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34310032</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Redox index of Cys-thiol residues of serum apolipoprotein E and its diagnostic potential.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34286848</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34551374</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Predictability of polygenic risk score for progression to dementia and its interaction with APOE epsilon4 in mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34465370</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34328600</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene varepsilon4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34313350</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 and epsilon3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-beta in mild cognitive impairment but not in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34258926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E allele 4 effects on Single-Subject Gray Matter Networks in Mild Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34469849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer&apos;s disease and age-matched non-demented brains.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34238312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34944024</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Identification of epigenome-wide DNA methylation differences between carriers of APOE epsilon4 and APOE epsilon2 alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33397400</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34890142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34586066</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential Effects of the Interaction Between the Education and APOE epsilon4 Allele on Amyloid-beta Retention and Memory Performances in Cognitively Normal Older Adults and Alzheimer&apos;s Disease Patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33372875</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipoprotein glomerulopathy associated with the Osaka/Kurashiki APOE variant: two cases identified in Latin America.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34311745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[Influence of ApoE gene polymorphisms on therapeutic effects of lipid-lowering statins among patients with ischemic cerebral infarction].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34964977</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34949230</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 Moderates the Association Between Vascular Risk Factors and Brain Pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33734100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34116692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-kappaB-Mediated Production of CXCL1.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34049975</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Association Between Plasma alpha-Synuclein (alpha-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE epsilon4) Alleles and Cognitive Decline in 60 Patients with Alzheimer&apos;s Disease Compared with 28 Age-Matched Normal Individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34312362</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34311431</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4, amyloid, and cognition in Alzheimer&apos;s and Lewy body disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34242895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 as a Novel Treatment Target for Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34907696</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Isoform-Specific Effects of Apolipoprotein E on Hydrogen Peroxide-Induced Apoptosis in Human Induced Pluripotent Stem Cell (iPSC)-Derived Cortical Neurons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34769014</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of sex and APOE on Parkinson&apos;s Disease-related cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34642926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34615909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of Apolipoprotein E4 on the Driving Behavior of Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer&apos;s Disease Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34602476</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34041846</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Plasma amyloid beta levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34002480</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2022</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of the apolipoprotein E epsilon4 allele on early Parkinson&apos;s disease progression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33484977</PubMedId>
          </Pub_pmid>
        </Pub>
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              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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              <Date-std_minute>12</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34486652</PubMedId>
          </Pub_pmid>
        </Pub>
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            <Date-std>
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              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Longitudinal analysis of APOE-varepsilon4 genotype with the logical memory delayed recall score in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34470924</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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              <Date-std_month>12</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
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        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33957555</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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            <Date-std>
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              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E 4 allele and neuropsychiatric symptoms among older adults in Central Africa (EPIDEMCA study).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33715647</PubMedId>
          </Pub_pmid>
        </Pub>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34039480</PubMedId>
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              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>25</Date-std_day>
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              <Date-std_minute>2</Date-std_minute>
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            <Date-std>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex modifies APOE epsilon4 dose effect on brain tau deposition in cognitively impaired individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33876815</PubMedId>
          </Pub_pmid>
        </Pub>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
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        </Date>
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    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33565324</PubMedId>
          </Pub_pmid>
        </Pub>
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              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
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              <Date-std_minute>10</Date-std_minute>
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      <Gene-commentary_text>Evidence of cerebral hemodynamic dysregulation in middle-aged APOE epsilon4 carriers: The PREVENT-Dementia study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34078163</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Bioenergetic and inflammatory systemic phenotypes in Alzheimer&apos;s disease APOE epsilon4-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33939248</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-epsilon4 Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32662517</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer&apos;s disease in China: Data from the PUMCH dementia cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34555265</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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            <Date-std>
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              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
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        </Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Nonlinear interaction between APOE epsilon4 allele load and age in the hippocampal surface of cognitively intact individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33017488</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32163130</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study on the relationship between SLCO1B1 and ApoE gene polymorphisms and the risk of coronary heart disease in the Mongolian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34423691</PubMedId>
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        </Pub>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Depression associated with APOE status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34570541</PubMedId>
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              <Date-std_hour>10</Date-std_hour>
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              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34449808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Risk of COVID-19 in People Having a Particular Set of Gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34819448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic influence of Apolipoprotein E gene epsilon2/epsilon3/epsilon4 isoforms on odds of mesial temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34795746</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of amyloid pathology and the APOE epsilon4 allele on the association between cerebrospinal fluid Abeta38 and Abeta40 and brain morphology in cognitively normal 70-years-olds.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33548794</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dissecting the role of Amerindian genetic ancestry and the ApoE epsilon4 allele on Alzheimer disease in an admixed Peruvian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33541779</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34020725</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Association between Apolipoprotein E Polymorphism and Response to Statins in Group of Hyperlipidemic Patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32628603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Distribution of APOE gene polymorphism in the Chinese Uyghur children &amp; its association with urolithiasis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34782536</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 and IL-6-174G/C Polymorphism may Lead to Early Onset of Alzheimer&apos;s Disease with Atypical Presentation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34747789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Testing for Interactions Between APOE and Klotho Genotypes on Cognitive, Dementia, and Brain Imaging Metrics in UK Biobank.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34219715</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The associations of the BDNF and APOE polymorphisms, hippocampal subfield volumes, and episodic memory performance across the lifespan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32573858</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Different posterior hippocampus and default mode network modulation in young APOE epsilon4 carriers: a functional connectome-informed phenotype longitudinal study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33496907</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein e (APOE) epsilon4 genotype influences memory performance following remote traumatic brain injury in U.S. military service members and veterans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34487993</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33215813</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactive effects of the APOE and BDNF polymorphisms on functional brain connectivity: the Tasmanian Healthy Brain Project.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34267235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cross-sectional and longitudinal interaction effects of physical activity and APOE-epsilon4 on white matter integrity in older adults: The MAPT study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34674803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Association of Essential Metals with APOE Genotype in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34057084</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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            <Date-std>
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              <Date-std_day>22</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Superior short-term memory in APOE epsilon2 carriers across the age range.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32961217</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
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            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association Between the APOEvarepsilon2/varepsilon4 Genotype and Alzheimer&apos;s Disease and Mild Cognitive Impairment Among African Americans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33935088</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon2 , epsilon3 , and epsilon4 variants of ApoE; rs2228570 (VDR), rs4588 and rs7041 (VDBP) polymorphisms in patients with multiple sclerosis: A case-control study in Turkish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34486787</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 attenuates autophagy via FoxO3a repression in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34475505</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33437219</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E varepsilon4 (APOE varepsilon4) Allele is Associated with Long Sleep Duration Among Elderly with Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33361595</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Influence of APOE genotype in primary age-related tauopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33287896</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33213513</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE varepsilon4 Allele Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33749649</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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            <Date-std>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
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            </Date-std>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34285334</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34108509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34586832</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33488947</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Accelerated long-term forgetting over three months in asymptomatic APOE varepsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33369208</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34530340</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
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            <Date-std>
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              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 increases the risk of depression recurrence.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34509777</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
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            <Date-std>
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              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 genotype and risk of freezing of gait in Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33161290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between serum apolipoprotein E and cognitive functions in Egyptian patients with temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31197659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (APOE) epsilon4 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33138883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32924542</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein e polymorphism with SARS-CoV-2 infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34419671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
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          <Date_std>
            <Date-std>
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              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32662384</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evaluation of APOE polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33467888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Functional co-activation of the default mode network in APOE epsilon4-carriers: A replication study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34329959</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32580638</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33057949</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The TOMM40 &apos;523&apos; polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33737565</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE epsilon4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34061824</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34010987</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Changes in retinal microvasculature and retinal layer thickness in association with apolipoprotein E genotype in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33469106</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33216038</PubMedId>
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      <Gene-commentary_text>Genetic variation in APOE, GRN, and TP53 are phenotype modifiers in frontotemporal dementia.</Gene-commentary_text>
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          <Pub_pmid>
            <PubMedId>32972771</PubMedId>
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      <Gene-commentary_text>Apolipoprotein varepsilon4 Affects Multiple Domains of Neuropsychological Functioning in a Sample of Elderly Hispanics.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>31592904</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Are KIF6 and APOE polymorphisms associated with power and endurance athletes?</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex differences in brain aging among adults with family history of Alzheimer&apos;s disease and APOE4 genetic risk.</Gene-commentary_text>
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          <Pub_pmid>
            <PubMedId>33857772</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Synergistic Effects of APOE and CLU May Increase the Risk of Alzheimer&apos;s Disease: Acceleration of Atrophy in the Volumes and Shapes of the Hippocampus and Amygdala.</Gene-commentary_text>
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          <Pub_pmid>
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          <Pub_pmid>
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          <Pub_pmid>
            <PubMedId>33646158</PubMedId>
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      <Gene-commentary_text>Association Between Elevated Depressive Symptoms and Cognitive Function Moderated by APOE4 Status: Framingham Offspring Study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33646152</PubMedId>
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      <Gene-commentary_text>Asymmetric left-right hippocampal glutamatergic modulation of cognitive control in ApoE-isoform subjects is unrelated to neuroinflammation.</Gene-commentary_text>
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          <Pub_pmid>
            <PubMedId>34309092</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Education Moderates the Negative Effect of Apolipoprotein E varepsilon4 on Response Inhibition in Older Adults.</Gene-commentary_text>
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        <Pub>
          <Pub_pmid>
            <PubMedId>34151797</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Segmented Linear Mixed Model Analysis Reveals Association of the APOEvarepsilon4 Allele with Faster Rate of Alzheimer&apos;s Disease Dementia Progression.</Gene-commentary_text>
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        <Pub>
          <Pub_pmid>
            <PubMedId>34120907</PubMedId>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Is APOE epsilon4 associated with cognitive performance in early MS?</Gene-commentary_text>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mechanistic insight into the capacity of natural polar phenolic compounds to abolish Alzheimer&apos;s disease-associated pathogenic effects of apoE4 forms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34019932</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Race, APOE genotypes, and cognitive decline among middle-aged urban adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34193248</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Refined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer&apos;s disease in apolipoprotein E epsilon4 allele carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32506713</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased apolipoprotein E and decreased TNF-alpha in the cerebrospinal fluid of nondemented APOE-epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32426945</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of APOE epsilon4 genotype on initial cognitive symptoms differs for Alzheimer&apos;s and Lewy body neuropathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33485373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Diagnosis Test Meta-Analysis for Apolipoprotein E in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33101544</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32798512</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of APOE epsilon4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33397450</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33924242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32580938</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Transcript Variants of Genes Involved in Neurodegeneration Are Differentially Regulated by the APOE and MAPT Haplotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33804213</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>DNA methylation QTL analysis identifies new regulators of human longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32160291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33375167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Role of ApoE Expression and Variability of Its Glycosylation in Human Reproductive Health in the Light of Current Information.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34281251</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE polymorphisms with lipid-lowering efficacy of statins in atherosclerotic cardiovascular diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34195754</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype, lifestyle and coronary artery disease: Gene-environment interaction analyses in the UK Biobank population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34082327</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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            </Date-std>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
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      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene variants in primary dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34058468</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34209175</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34135129</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33776373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33658354</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32378476</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex differences in the association between the APOEepsilon4 allele and hearing impairment: A longitudinal memory clinic study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33989962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 exacerbates alpha-synuclein pathology and related toxicity independent of amyloid.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32024798</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship Between the ApoE Gene Polymorphism and Type 2 Diabetes Mellitus Complications.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33596139</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential associations of APOE-epsilon2 and APOE-epsilon4 alleles with PET-measured amyloid-beta and tau deposition in older individuals without dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33521872</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex-Specific Protective Effects of APOE epsilon2 on Cognitive Performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32992326</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32891149</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Selected LDLR and APOE Polymorphisms Affect Cognitive and Functional Response to Lipophilic Statins in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32474901</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32460813</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of apoE gene polymorphisms with lipid metabolism in renal diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33402986</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32818802</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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        <Date>
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              <Date-std_minute>14</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The relationship between physical activity, apolipoprotein E epsilon4 carriage, and brain health.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32331531</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30465491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TOMM40 and APOE variants synergistically increase the risk of Alzheimer&apos;s disease in a Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32725468</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism carriers exhibit objective cognitive deficits: a single center trial.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32634047</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differences in Recycling of Apolipoprotein E3 and E4-LDL Receptor Complexes-A Mechanistic Hypothesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>34068576</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon4 Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32304722</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33771840</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31915896</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of CD33 rs3865444:C&gt;A polymorphism with a reduced risk of late-onset Alzheimer&apos;s disease in Slovaks is limited to subjects carrying the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32333488</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E isoforms and susceptibility to genetic generalized epilepsies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31877079</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic analysis of familial hypercholesterolemia in Asian Indians: A single-center study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32044282</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age-at-Onset and APOE-Related Heterogeneity in Pathologically Confirmed Sporadic Alzheimer Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33722993</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive changes in patient living with HIV-AIDS and apolipoprotein-E polymorphism: is there an association?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33085049</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of sex and APOE epsilon4 with brain tau deposition and atrophy in older adults with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32929366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32651323</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The impact of social networks and APOE epsilon4 on dementia among older adults: tests of possible interactions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30587010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32840654</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE(-/-) mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31982616</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32822813</PubMedId>
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            <Date-std>
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              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Homozygosity in the APOE 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33178131</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32290718</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The redox status of cysteine thiol residues of apolipoprotein E impacts on its lipid interactions.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by APOE mutations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32441489</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Considering the APOE locus in Alzheimer&apos;s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33143703</PubMedId>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32250307</PubMedId>
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      <Gene-commentary_text>In Vivo Chimeric Alzheimer&apos;s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32726626</PubMedId>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32682842</PubMedId>
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              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Inflammation in Alzheimer&apos;s Disease: Do Sex and APOE Matter?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33016923</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEvarepsilon4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33016906</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 and cognitive reserve effects on the functional network in the Alzheimer&apos;s disease spectrum.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32314201</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30903549</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 and cognitive function after surgery in middle-aged and elderly Danish twins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32618758</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer&apos;s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32474466</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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          </Date_std>
        </Date>
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        <Date>
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              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32103509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The sex-specific effect of the apolipoprotein E allele and methylenetetrahydrofolate reductase gene polymorphism on the biochemical, anatomical, and cognitive profiles of patients clinically diagnosed with probable Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33166415</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32819031</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
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              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Exosome derived from CD137-modified endothelial cells regulates the Th17 responses in atherosclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32149463</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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            <Date-std>
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              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Impact of Apolipoprotein E Genetic Variability in Health and Life Span.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32789475</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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            <Date-std>
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              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Testing influences of APOE and BDNF genes and heart failure on cognitive function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32703621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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          </Date_std>
        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Hakka postmenopausal women in southern China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32546237</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon2 allele and epsilon2-involved genotypes (epsilon2/epsilon2, epsilon2/epsilon3, and epsilon2/epsilon4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32534589</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31771052</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Subjective Hearing Loss and Apolipoprotein E epsilon4 Allele on Alzheimer&apos;s Disease Neurodegeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33301284</PubMedId>
          </Pub_pmid>
        </Pub>
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          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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      <Gene-commentary_text>Sex-Specific Effects of Apolipoprotein epsilon4 Allele on Mortality in Very Old and Centenarian Japanese Men.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex difference in the association of APOE4 with cerebral glucose metabolism in older adults reporting significant memory concern.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein varepsilon4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32116259</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32110803</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32081835</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein varepsilon4 Allele and Subjective Cognitive Functioning in Parents of Adults With Disabilities.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32361736</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33824317</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>33189719</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E epsilon4 Allele Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33255701</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Components of the choline oxidation pathway modify the association between the apolipoprotein epsilon4 gene variant and cognitive decline in patients with dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction of neuropsychiatric symptoms with APOE epsilon4 and conversion to dementia in MCI patients in a Memory Clinic.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32709881</PubMedId>
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      <Gene-commentary_text>Relationship between the Presence of the ApoE epsilon4 Allele and EEG Complexity along the Alzheimer&apos;s Disease Continuum.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32664228</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32586852</PubMedId>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E expression pattern in human induced pluripotent stem cells during in vitro neural induction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32685135</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 allele is associated with vascular cognitive impairment no dementia in Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31865187</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31947546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations of Vascular Risk Factors and APOE Genotype With Perivascular Spaces Among Community-Dwelling Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32805190</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32572010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Multi-omic comparison of Alzheimer&apos;s variants in human ESC-derived microglia reveals convergence at APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32941599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32511104</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32012263</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32167787</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        <Date>
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            <Date-std>
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              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
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        </Date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33450186</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A Study on PHF-Tau Network Effected by Apolipoprotein E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33258666</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Cardiovascular Risk Factors and APOE Polymorphism with Mortality in the Oldest Old: A 21-Year Cohort Study.&quot;, trans &quot;Associacao de Fatores de Risco Cardiovascular e Polimorfismo de APOE com Mortalidade em Idosos Longevos: Uma Coorte de 21 Anos.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32876203</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Triggers Complement Activation in Joint Synovial Fluid of Rheumatoid Arthritis Patients by Binding C1q.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32253242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31654486</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32575521</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
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        </Date>
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    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32575457</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32211081</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33331535</PubMedId>
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              <Date-std_year>2021</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE and Alzheimer&apos;s disease: advances in genetics, pathophysiology, and therapeutic approaches.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33340485</PubMedId>
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              <Date-std_year>2021</Date-std_year>
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              <Date-std_hour>13</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E gene polymorphism with the risk of T2DM and obesity among Egyptian subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33059023</PubMedId>
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        </Pub>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of common genetic variants with brain microbleeds: A genome-wide association study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32913026</PubMedId>
          </Pub_pmid>
        </Pub>
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        <Date>
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            <Date-std>
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              <Date-std_minute>3</Date-std_minute>
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              <Date-std_minute>27</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31236578</PubMedId>
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        <Date>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33490286</PubMedId>
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        </Pub>
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      <Gene-commentary_create-date>
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              <Date-std_year>2021</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Establishment of SIAISi001-A, an induced pluripotent stem cell (iPSC) line from 66-year old mild cognitive impairment (MCI) with two copies of APOE4 gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32007762</PubMedId>
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        </Pub>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>23</Date-std_day>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E impairs amyloid-beta fibril elongation and maturation.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>31571352</PubMedId>
          </Pub_pmid>
        </Pub>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>23</Date-std_day>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson&apos;s Disease: A Study from Eastern India.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31134487</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
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              <Date-std_year>2021</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of the apolipoprotein E-epsilon4 allele is associated with an increased risk of sepsis progression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32978453</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
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              <Date-std_hour>15</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age-dependent effect of APOE and polygenic component on Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32464432</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Older, non-demented apolipoprotein epsilon4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32447009</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
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            <Date-std>
              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
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        </Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32614373</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
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          <Date_std>
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              <Date-std_year>2021</Date-std_year>
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              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
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              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31364446</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mid age APOE epsilon4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32080211</PubMedId>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced Influence of apoE on Abeta43 Aggregation and Reduced Vascular Abeta43 Toxicity as Compared with Abeta40 and Abeta42.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31953617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association study of Apolipoprotein E polymorphisms and chronic obstructive pulmonary disease in the Chinese population: A case-control study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33285739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-Wide Association Study of Cerebral Microbleeds on MRI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31209788</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Short-term memory advantage for brief durations in human APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32528115</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype and in vivo amyloid burden in middle-aged Hispanics.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32847955</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Investigating APOE, APP-Abeta metabolism genes and Alzheimer&apos;s disease GWAS hits in brain small vessel ischemic disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32345996</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Systematic Review on Apolipoprotein E: A Strong Genetic Cause of Hemorrhagic Stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33116113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between APOE epsilon2 and Abeta burden in patients with Alzheimer- and vascular-type cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32928967</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE epsilon4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32788242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Close-Range Blast Exposure Is Associated with Altered White Matter Integrity in Apolipoprotein varepsilon4 Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31232163</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32388179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E epsilon4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32076055</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer&apos;s disease patient iPSC-derived cerebral organoids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33139712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK Biobank.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31450492</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31854268</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype Are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31424390</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
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      <Gene-commentary_text>APOEvarepsilon4 Gene Dose and Sex Effects on Alzheimer&apos;s Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_text>Race, APOEvarepsilon4, and Long-Term Cognitive Trajectories in a Biracial Population Sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31561363</PubMedId>
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      <Gene-commentary_text>APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex, Education, Depression, and Vascular Risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32646381</PubMedId>
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      <Gene-commentary_text>Impaired memory-guided attention in asymptomatic APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells.</Gene-commentary_text>
      <Gene-commentary_refs>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic resilience to Alzheimer&apos;s disease in APOE epsilon4 homozygotes: A systematic review.</Gene-commentary_text>
      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>31506248</PubMedId>
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      <Gene-commentary_refs>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>31065058</PubMedId>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>31561966</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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      <Gene-commentary_refs>
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          <Pub_pmid>
            <PubMedId>32451497</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lowering circulating apolipoprotein E levels improves aged bone fracture healing.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31534056</PubMedId>
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        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30914707</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32817639</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_hour>13</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactive effect of age and APOE-epsilon4 allele load on white matter myelin content in cognitively normal middle-aged subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31520917</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
              <Date-std_year>2020</Date-std_year>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism in ATTR amyloidosis patients treated with lipid nanoparticle siRNA.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31648569</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Comparative profiling of the synaptic proteome from Alzheimer&apos;s disease patients with focus on the APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31862015</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Long-term exposure to ambient air pollution, APOE-epsilon4 status, and cognitive decline in a cohort of older adults in northern Manhattan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31926436</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Linking APOE-epsilon4, blood-brain barrier dysfunction, and inflammation to Alzheimer&apos;s pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31733942</PubMedId>
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        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30958375</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_hour>15</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30478798</PubMedId>
          </Pub_pmid>
        </Pub>
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      <Gene-commentary_create-date>
        <Date>
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              <Date-std_year>2020</Date-std_year>
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              <Date-std_hour>10</Date-std_hour>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is also required in TREM2 R47H variant carriers for Alzheimer&apos;s disease to develop.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29411406</PubMedId>
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      <Gene-commentary_create-date>
        <Date>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31493534</PubMedId>
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          <Pub_pmid>
            <PubMedId>31473137</PubMedId>
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      <Gene-commentary_type value="generif">18</Gene-commentary_type>
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        <Pub>
          <Pub_pmid>
            <PubMedId>31545048</PubMedId>
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          <Pub_pmid>
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          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of Worry Level on Recall Memory for Odors in ApoE-epsilon4 Carriers and Non-Carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30987686</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>19</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE and ApoEp, but not truncated apoE lacking the low-density lipoprotein receptor binding domain, physically interacted with N-terminal APP and thereby mediated Abeta production.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31208706</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype status moderated the age-related declines in episodic memory: APOE-epsilon4+ middle-aged adults exhibited impairments relative to both APOE-epsilon4- middle-aged participants, and APOE-epsilon4+ younger adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31473197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data found DNA methylation in ABCG1 and APOE to be related to ischemic stroke and atherosclerosis in a Chinese population. Epigenetic modification of ABCG1 and APOE may play a key role in the pathway from disturbed blood lipid levels to the development of cardiovascular diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31823830</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Female APOE epsilon4 carriers show a greater longitudinal reduction of hippocampal volume:intracranial volume ratio than their male counterparts in cognitively normal older adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31102429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Anxiety correlates with cortical surface area in subjective cognitive decline: APOE epsilon4 carriers versus APOE epsilon4 non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31159873</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31724059</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results indicate that the elevated risk of developing dementia conferred by APOEepsilon4 genotype involves mechanisms associated with both amyloid-beta and tau aggregation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31860000</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis and longitudinal analysis shows APOE-epsilon4 allele predicts worsening severity of hallucinations and delusions in late adulthood among people with schizophrenia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30584027</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism was associated with blood lipid and serum UA metabolism in patients with hypertension or coronary heart disease. Compared with APOE E3 homozygote, APOE E4 allele was related to elevated triglycerides, and APOE E2 allele was correlated with increased serum UA level.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31559922</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Disrupted sleep was more frequent in males (42.4%) compared to females (35.1%), and in carriers (42.3%) as opposed to non-carriers (36.5%) of epsilon4. Amongst female subjects with high Alzheimer&apos;s Disease load and Lewy body pathology, homozygous (epsilon4/epsilon4) carriers experienced disrupted sleep more often compared with heterozygous (epsilon4/x) or non-carriers of epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30605058</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>n patients with transient ischemic attack and stroke, APOE-epsilon4 homozygosity was associated with both pre- and post-event dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32070224</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Women with the APOE epsilon4 allele and midlife dyslipidemia increased the risk for amyloid Beta deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30689578</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there are sex differences in gene expression patterns associated with the APOE4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31448102</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The majority of non-reduced-apoE3 in HDL exists in a reversible oxidized form. The apoE3-AII protein complex, formed from the reversible oxidized apoE3, is beneficial for maintaining the redox equilibrium of apoE3 by preventing the modification of apoE3 to its irreversible oxidized form.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30948502</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study uncovered the central role for ApoE in injury-induced neurogenesis in the adult hippocampus, where it influences dendritogenesis and synaptogenesis in mice lacking ApoE or expressing the human ApoE4 allele, which may help inform how ApoE influences neurological diseases where neurogenesis is defective.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32119690</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our work confirmed the association of the APOE4 allele with a dose-dependent increased presentation of Alzheimer&apos;s disease and an association between the E4 allele alone and mild cognitive impairment, but not with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson&apos;s disease, or vascular cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31217043</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subjects carrying epsilon4 allele have increased risk of cardiovascular disease and type 2 diabetes, and exhibit higher level of lipid profiles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31521122</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that breakdown of the blood-brain barrier contributes to APOE4-associated cognitive decline independently of Alzheimer&apos;s disease pathology, and might be a therapeutic target in APOE4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32376954</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we reveal that the APOE4 genotype has a profound impact on several aspects of microglial functionality, whereas PSEN1DeltaE9 and APPswe mutations trigger minor alterations. The APOE4 genotype impairs phagocytosis, migration, and metabolic activity of iMGLs but exacerbates their cytokine secretion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31522977</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Review summarizes studies on APOE polymorphisms and their relation to early life neuroplasticity and later-life neurodegenerative disorders .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30677746</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>our study exposed the changes of hippocampal protein expression profiles at the early stage of APP/PS1 and ApoE4 knockin mice, and the change of insulin signaling and mitochondrial electron transport chain may be the key molecular processes involved in Alzheimer&apos;s disease (AD) progression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31055927</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype associated with greater impairment of mitochondrial energy production in females than males in the Alzheimer&apos;s disease serum metabolome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32123170</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The proportion of APOE epsilon4 carriers was elevated in amnestic but not aphasic manifestations of Alzheimer disease (AD). These results suggest that APOE epsilon4 is an anatomically selective risk factor that preferentially increases the vulnerability to AD pathology of memory-related medial temporal areas rather than language-related neocortices.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31704790</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE can function as an endogenous, concentration-dependent pulmonary danger signal that primes and activates the NLPR3 inflammasome in BALF macrophages from asthmatic subjects to secrete IL-1beta.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30872118</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE3 and apoE4 form stable protein-protein interactions in lipid-free state, and that they could be localized on the same lipoprotein particle.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30802357</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these findings indicate that APOE genotype is associated with specific gut microbiome profiles in both humans and APOE-TR mice. This suggests that the gut microbiome is worth further investigation as a potential target to mitigate the deleterious impact of the APOE4 allele on cognitive decline and the prevention of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30958695</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphisms are associated with the increased risk for the development of Type 2 Diabetes.[Meta analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31910940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE p.(Leu167del) mutation is found in a rare form of familial hypercholesterolemia and may have a role in lipid-lowering response to statins with or without ezetimibe</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30731287</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study employed APOE2 and APOE4 knock-in mice and adenovirus-mediated gene transfer to identify a tissue-specific role of the natural human APOE2 and APOE4 isoforms in white and brown adipose tissue metabolic activation respectively, that appears dependent on circulating APOA1 levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31678510</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The E2 allele was associated with a lower risk of mortality compared with the E3 allele, whereas the E4 genotype was not associated with mortality in Koreans</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31625294</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Low apoE and mir-650 plasma concentrations were risk factors for developing Alzheimer&apos;s disease (AD) and were particularly pronounced in severe dementia. APOE E4 allele in both AD patients and controls led to a reduction in apoE, while APOE E3/E3 genotype was associated with an increased apoE concentration and level of miR-107 in AD, which inversely correlated with the number of APOE E4 alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31556571</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study employed a model of human apoE targeted replacement mice and high-fat diet(HFD)-induced obesity to study the potential link between E4 and insulin resistance (IR), at rest and following a postprandial challenge.  HFD-induced IR was associated with impaired cognition, reduced cerebral blood volume and decreased glucose uptake. These effects were more profound in E4 than E3 mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29215310</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduction of vascular and cardiometabolic risk factors (VCMRFs), including low Physical activity, could be valuable for dementia prevention, especially among APOE*4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31455442</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We discovered the presence of APOE circular RNA (circRNA) and found that circRNA and full-length mRNA each constitute approximately one third of the total APOE RNA, with truncated mRNAs likely constituting some of the missing fraction. All APOE RNA species demonstrated significantly higher expression in Alzheimer disease frontal lobe than in control frontal lobe.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31978088</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer&apos;s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer&apos;s dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32015339</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed that the presence of apoE e3e4/LRP1 CC genotype combination in patients multiplies the chance (7.6 times) for the occurrence of the metabolic syndrome (MetS) in comparison to the presence of other genotype combinations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31538302</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis showed a higher incidence of Alzheimer disease among individuals carrying the APOE epsilon4 allele, more notably in those with the APOE epsilon4/e4 genotype, while carrying the APOE epsilon3 allele was demonstrated to have a protective effect.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31444704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study suggests that APOE mostly contributes to amyloid accumulation and the POLYGENIC RISK SCORE affects risk of further conversion to ALZHEIMER DISEASE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31199530</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations Between APOE Variants, Tau and alpha-Synuclein</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32096038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuroinflammation is one of the pathological pathways of Alzheimer&apos;s disease (AD), mediating the progression of neurodegeneration. Polymorphisms of proinflammatory cytokines have been linked to increased AD risk. Identification of certain combinations of polymorphisms could help predict disease in its preclinical stage. The aim of the study was to evaluate differences in the prevalence of TNFalpha -850T (rs1799724), IL...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31618972</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson&apos;s disease patients have been reported.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31270237</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TOMM40 and APOE variants are independently and additively associated with body mass index.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30462377</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 risk variant for Alzheimer&apos;s disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals. this study provides novel insights on the mechanisms through which APOE-epsilon4 posits an increased Alzheimer&apos;s disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30991302</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>MRI based imaging analyses indicated that in multiple white matter tracts, hAPOE4 males and females exhibited lower fractional anisotropy than their hAPOE3 counterparts, suggesting a lower level of white matter integrity in hAPOE4 mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31917799</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E and clusterin inhibit the early phase of amyloid-beta aggregation in an in vitro model of cerebral amyloid angiopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30691533</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 has a propensity to polymerize to form wavy filaments, which do not share the characteristics of cross-beta amyloid fibrils. Self-assembly of the ApoE4 isoform may play a role in pathogenesis of Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31051176</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Women with hypertension and at least one APOE e4 allele had worse average cognitive function compared with women without hypertension with the e3/3 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31697783</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Synaptic Abeta was increased by apoE4 in control and AD samples. These results are consistent with uptake of apoE/Abeta complex and associated lipids into synaptic terminals, with subsequent Abeta clearance in control synapses and accumulation in AD synapses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31108099</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Non-alcoholic fatty liver disease is characterized by increased plasma ApoE levels, even when taking account of the various ApoE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31386691</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31012816</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>DNA sequencing suggested that the patient has carried a heterozygous c.527G&gt;C (p.R176P) variant of the APOE gene</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32034747</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Oscillatory hyperactivity and hyperconnectivity in young APOE-E4 carriers and hypoconnectivity in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31038453</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cross-sectional analyses revealed an age-dependent association of HSV carriage with lower episodic memory function, particularly among APOEvarepsilon4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30636735</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In spontaneous clearance patients, the APOE epsilon4 allele and low-density lipoprotein cholesterol conferred a protective effect in the course of the HCV infection in the context of excess body weight.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31636475</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Compared with APOE-epsilon3, APOE-epsilon2 is associated with prolonged survival, whereas mortality risk is increased for APOE-epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31356640</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 and epsilon2 alleles appear to affect lobar ICH risk variably by race/ethnicity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30726504</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The long-term consumption of a Mediterranean diet modulates postprandial hypertriglyceridemia through apolipoprotein E genetic variants in coronary heart disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31166609</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate that that neither apolipoprotein E (ApoE) genotype status nor promoter status are associated with white matter hyperintensities (WMH).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31551090</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele carriers with PTSD have substantially greater cognitive difficulties than epsilon4 carriers without PTSD; these results underscore the importance of assessing, monitoring, and treating PTSD in trauma-affected individuals who are at genetic risk for cognitive decline and dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31385647</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis of 13 publications with 14 studies, including a total of 1632 GSD patients and 5001 controls, found insufficient evidence for the effect of APOE E4 allele on gallstone disease (GSD) risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31200656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there is an increase in CSF Abeta42 early in Alzheimer&apos;s disease before its decline while tau pathology progresses; this pattern is particularly observed in non-APOE4 subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31086391</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study provides evidence for a role of APOE, eNOS and FTO gene polymorphisms in longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31446792</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 may influence the association between white matter hyperintensities and cognitive performance in Alzheimer and Lewy body dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31575706</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Compared to epsilon2 and epsilon3 alleles, the presence of APOE-epsilon4 allele might increase the risk for AD in a dose-dependent manner in southern China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31199015</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is specifically repressed in Alzheimer&apos;s disease oligodendrocyte progenitor cells and astrocyte subpopulations and upregulated in an Alzheimer&apos;s disease-specific microglial subopulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31768052</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes have shown only a modest association with deep vein thrombosis and were not statistically significant. A lateral association of these genotypes with thrombophilic risk factors was observed which may be investigated further for the possible pathogenetic mechanisms and their therapeutic implications.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30282515</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is involved in Abeta-independent pathways as part of the cascade leading to Alzheimer pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31029938</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4-associated brain-region specific glucose metabolism pattern in patients with mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30991617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31686034</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results suggest that rapid brain aging and APOE epsilon4 are synergistic risk factors, and interventions that slow aging may substantially reduce risk of neurological disease and decline even in the presence of APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31133613</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>identification of brain eQTLs for APOE which can interact with APOE epsilon4 allele to confer Alzheimer&apos;s disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29795290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cerebral amyloid angiopathy-related vasculopathic changes and fragility associated with APOE epsilon2+ allele might have a biologically meaningful role in the pathophysiology and severity of cortical superficial siderosis.[Meta-Analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31243071</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Both candidate-gene studies and genome-wide analysis reveal APOE involvement in the attainment of an extreme lifespan by exerting a pleiotropic effect in a polygenic context. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30884759</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we confirm association of the APOE epsilon4 allele with increased risk for Lewy body dementia, and importantly demonstrate that APOE epsilon2 reduces risk of this disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30798004</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Older men with APOE4 allele may be more vulnerable to postoperative cognitive dysfunction than older women with APOE4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30922389</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A significant association between MMSE score and sex was observed in the lowest educational group, especially among carriers of APOE rs405509 TT genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31100889</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There were significant associations between APOE [epsilon]4 and worse cognitive abilities, independent of potential confounders, and between lifestyle risk factors and worse cognitive abilities; however, there were no interactions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31028125</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study concluded that the variation of the APOE gene may not influence familial longevity status at a certain age but the moderate-high HDL-C level contributes to the familial longevity in Bama.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30485248</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The genotypes of TT in MTHFR C667T and epsilon4+in APOE may increase the severity of Coronary Artery Disease in a Chinese Han population, and higher Hcy, LDL-C, and ApoE levels may be involved in this pathogenic process.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31163415</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate the age- and gender-specific reference intervals (RIs) of serum apolipoprotein E (Apo E) in healthy Chinese Han adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31232033</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) epsilon4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE epsilon2) shows the opposite. [Meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31413261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It was concluded that lower circulating retinol and higher alpha-tocopherol (TOH)/retinol ratio potentially predicts an increased risk for the development of cognitive decline in aging Chinese adults. ApoE2 or E4 carriers with higher circulating alpha-TOH/retinol ratio infer poor cognitive performance and an increased risk of developing MCI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30573705</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>both b APOE gene allele plays beneficial and detrimental roles in cognition of healthy older people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30342272</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 carriers which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early amyloid-beta deposition in later life and have risk for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30339963</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE locus may be linked with dementia risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30293724</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic variability in the APOE locus contribute to Alzheimer&apos;s disease pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31346172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these results indicate that EZH2 inhibition promotes lipoprotein-dependent lipid accumulation via inducing ApoE expression in adipocytes, suggesting a novel mechanism of lipid regulation by EZH2.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30971429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE and apoCIII on HDL interact to affect metabolism and coronary heart disease (CHD). ApoE promotes metabolic steps in reverse cholesterol transport and is associated with lower risk of CHD. ApoCIII, when coexisting with apoE on HDL, abolishes these benefits. Therefore, differences in metabolism of HDL subspecies pertaining to reverse cholesterol transport are reflected in differences in association with CHD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29467335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>astrocytes expressing E4 accumulate significantly more and smaller lipid droplets compared to E3 astrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30791549</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results showed that the APOE 3 allele was a protective factor for PD [ Parkinson disease ](OR = 0.90, 95% CI: 0.81-0.99; P = .04), whereas no significant differences in PD risk among all cases compared to controls were found for APOE 2 and 4. In Asian subgroups, the APOE 4 allele was shown to be a risk factor for PD [ Parkinson disease ]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30526202</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipoprotein glomerulopathy (LPG)-associated apoE3 mutations R25C, R114C, and A152D induce protein misfolding, which may contribute to protein aggregation in glomerular capillaries. The thermodynamic destabilization and enhanced aggregation of both proline and non-proline mutations may constitute a common underlying mechanism behind the pathogenesis of LPG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30309894</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dementia risk was significantly higher among participants at high or intermediate APOE risk compared with those at low APOE risk ..APOE genotype significantly modified the association between protective factors and dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31451782</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggest a meaningful relationship between APOE genotype and psychiatric distress post-military-related traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29463164</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data show that APOE4 may be associated with lower bone formation as well as increased risk of osteoporosis and bone fractures, whereas APOE3 seems to decrease lowering BMD in postmenopausal women, and its presence seemed to lower the incidence of bone breaking in patients with osteoporosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28784276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results provide independent validation that the APOE CGI holds lower DNA methylation levels in AD compared to control in frontal lobe but not cerebellar tissue. Data also indicate that the non-neuronal cells of the AD brain, which are mainly composed of glia, are the main contributors to the lower APOE DNA methylation observed in AD PMB.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30081037</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Participants with ApoE4(e3/e4) allele had higher levels of LDL-C (p=0.010), independently of HbA1c. CONCLUSIONS: Females and subjects with suboptimal metabolic control had more adverse lipid profiles. ApoE4(e3/e4) alleles were associated with significantly higher LDL-C levels, independently of HbA1c</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29679801</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30546063</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Prior work has shown that beta-amyloid and Apolipoprotein E epsilon4 combine to influence memory decline in nondemented older adults. This study indicate that increasing age may further exacerbate these effects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29356823</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE rs7412 and rs429358 SNPs showed a statistically significant association for the risk of cervical spondylotic myelopathy in Indian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31126849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 is the largest risk factor for Alzheimer disease (AD), and is an independent risk factor for coronary heart disease (CHD); ApoE4 is likely to be the bridge between AD and CHD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29623835</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-e4 allele is associated with Alzheimer disease risk in Jordanian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29455218</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E region molecular signatures of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29797398</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 is a risk factor for TDP-43 deposition in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30422173</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>age, sex and APOE genotype robustly identify high-risk groups for Alzheimer disease and all dementia; these groups can potentially be targeted for preventive interventions</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30181149</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results highlight the importance of the LSR polymorphism and reveal the existence of complex molecular links between LSR and ApoE for the regulation of lipid levels, revealing potential new pathways of interest in type III hyperlipidemia and its involvement in cardiovascular disease pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29178324</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings evidenced a novel role of BDNF in the modulation of ApoE and cholesterol homeostasis in glial and neuronal cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29323721</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Studied the association between chronic low-grade inflammation (C reactive protein levels) and risk of Alzheimer Disease (AD) in ApoE4 carrier genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30646251</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data indicate that apoE and FH interact with monocytic cells in a concerted action and this interaction reduces complement activation and inflammation in the atherosclerotic lesions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30519244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein epsilon4 prevalence and Abeta burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Abeta exhibited faster decline than males. Post hoc contrasts suggested that females who were Abeta and apolipoprotein epsilon4 positive declined faster than their male counterparts. Findings suggest that sex may play a modifying role on risk of Alzheimer&apos;s disease-related cog...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29803541</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Tests for the detection of apoE4 for patients&apos; stratification.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29654261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Across the Alzheimer&apos;s disease/dementia with Lewy bodies spectrum: (1) hippocampal volumes were smaller with increasing APOE-epsilon4 dosage (no genotype x diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-epsilon4 carriers, and (3) APOE-epsilon4 carriers performed worse on long-delay free word recall.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29782824</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that carrying the apolipoprotein (ApoE)-epsilon4 allele may be a vulnerability factor in the adverse effects of Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation on cognition during aging, while ApoE-epsilon3 allele could be associated to a more adaptive HPA axis response.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30130588</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cholesterol content, synthesis rates (desmosterol) and export of 24-hydroxycholesterol are reduced in the brain of the severe hypercholesterolemic apoE-KO mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29675736</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LDLR and APOB gene mutations in Mexican patients with homozygous familial hypercholesterolemia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29576406</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows that both Abeta and tau lesions are present in the brains of young individuals decades before the age of clinical onset of Alzheimer disease. Abeta lesions closely correlate with the ApoE4 allele and appear as the earliest event in the development of senile plaques.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30099348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows a significant synergistic interaction effect was found between the APOE4 and family history of late-onset Alzheimer disease (AD) on amyloid-beta deposition in the AD signature brain regions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30134963</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results show that the APOE SNPs rs405509 and rs439401 were associated with leprosy, and the effect might be mediated by altered APOE mRNA expression and its potential role in lipid metabolic pathways during M. leprae infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28977675</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study suggests that APOE epsilon4 may impact both the diagnostics of Alzheimer disease in early stages and potentially also effects of disease-modifying treatments.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30107289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 versus APOE3 carriers were 6-13times more likely to exhibit olfactory bulb vascular amyloid, neuronal amyloid accumulation, alpha-synuclein aggregates, hTau neurofibrillary tangles, and neurites. Remarkably, APOE4 carriers were 4.57 times more likely than non-carriers to die by suicide.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29935448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>longitudinal thinning was significantly altered by hypertension and Apolipoprotein-E epsilon4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28444388</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE and CETP TaqIB polymorphisms might not be the genetic risk factors for type 2 diabetes mellitus in Southern Thai population, however, APOE and CETP TaqIB polymorphisms were associated with serum lipids in healthy controls and type 2 diabetes mellitus, respectively.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30853126</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that autophagy plays an important role in trafficking of ApoE in HCV-infected cells. While it led to autophagic degradation of ApoE, it also promoted the interaction between ApoE and HCV E2 to enhance the production of infectious progeny viral particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29695434</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results revealed that, contrary to APOE4-carrier patients, noncarriers are successful in recruiting secondary cortical networks to improve memory performance as long as the integrity and functionality of the temporal lobe is preserved, a fact primarily dependent on hippocampal degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29475078</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 genotype is related to reduced memory and processingspeed performance, as well as overall cognitive impairment, in those with a history of mTBI</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30124361</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Additional computational work concerning the apoE-Alphabeta complex also designates apoE amyloidogenic regions as important binding sites for oligomeric Alpha beta; taking an important step forward in the field of Alzheimer&apos;s anti-aggregation drug development</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31071995</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results indicate that APOE e4 is independently associated with a greater severity of Lewy Body disease pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30143564</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this case-control study provide evidence that the epsilon2 and epsilon3 alleles of APOE modify lipid profile, and constitute independent risk factors of diabetic nephropathy in type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31357022</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>levels of remnant-like particle cholesterol and of triglycerides in low-density lipoprotein associated with APOE variants</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29976289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study used native electrospray ionization and mass spectrometry (native MS) coupled with ion mobility (IM) to examine the monomer and tetramer of the three WT isoforms of APOE. Although collision-induced unfolding (CIU) cannot distinguish the WT isoforms, the monomeric mutant (MM) of apoE3 shows higher stability when submitted to CIU than the WT monomer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30887458</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these data suggest that exosome pathway dysfunction is a previously unappreciated component of the brain pathologies that occur as a result of apolipoprotein E4 expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30496349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a weak association between APOE e4 and subjective cognitive decline (meta-analysis).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29169179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 status and higher polygenic risk of Alzheimer dementia were associated with higher rates of decline in neuropsychological assessments of memory and executive function in Abeta+ individuals. The effect of polygenic risk on cognitive decline was above and beyond APOE epsilon4 and specific to the Abeta+ group, suggesting a synergistic effect between abnormal Abeta and genetic risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29592889</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In type 2 diabetic patients Apo epsilon4 has a protective effect against the development of nephropathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28937055</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study establishes a reference for human cell-type-specific changes associated with the APOE4 variant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29861287</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele modulated the associations of sleep latency (SL), mesor, and acrophase with Abeta positivity. Moreover, the interactions between APOE epsilon4 status and SL and between APOE epsilon4 status and acrophase remained significant after adjusting for multiple comparisons. In APOE epsilon4 noncarriers, advanced acrophase was associated with increased Abeta positivity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29490913</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This observational study indicates that midlife, but not late-life, insulin resistance associates with greater brain amyloid accumulation in elderly individuals without dementia, in both carriers and noncarriers of APOE epsilon4 genotype. Voxel-by-voxel comparisons showed that, in individuals with midlife insulin resistance, [11C]PiB uptake was evident in the regions also affected in early Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29476033</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found a significant association of HMGCR rs3846662 with mild cognitive impairment (MCI) in females independent of APOE [epsilon]4. In contrast, it revealed that the association of SIRT1 rs7895833 with MCI was dependent on with APOE [epsilon]4. Data also showed that hypermethylation of APOE in MCI was independent of APOE [epsilon]4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31305452</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE E2/E3 genotype is associated with the presence of pituitary adenoma (PA) while the ApoE genotype E2/E4 is associated with noninvasive PA development.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31054363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>confirmed that APOE4-positive females are at a higher risk (OR=18.7; p=9.7E-09) of developing Alzheimer&apos;s disease compared to APOE4-positive males</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29278785</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30477909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carrying the APOE-epsilon4 allele is the main genetic risk factor for Abeta deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30136422</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential APOE methylation and increased plasma ApoE levels were correlated with mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30897703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Unlike controls, mild cognitive impairment (MCI) showed significant reduction of cortical thickness in bilateral insula and right superior frontal gyrus in APOE-varepsilon4 carriers compared with APOE-varepsilon4 non-carriers. APOE-varepsilon4 and HMGB1 have reduction in cortical thickness independently and have a more widespread cortical thinning in MCI when they interact.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28659393</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>that the APOE4 allele may exert effects in midlife years before symptom onset, promoting amyloid deposition before altering cognitive performance or brain structure</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30530186</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relationship between baseline CSF Abeta1-42 and tau accumulation was strongest in APOEepsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30947113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In patients with chronic kidney disease the APOE level and its distribution between lipoprotein classes is associated not only with APOE gene polymorphism but also with kidney function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30851738</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Studies provide evidence that that APOE epsilon2 and epsilon4 are both risk factors for the occurrence of spontaneous intracerebral hemorrhage, and the influence differs with ethnicity. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30868499</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29042594</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Studies provide evidence that the presence of the APOE epsilon4 allele is associated with increased Alzheimer&apos;s disease (AD) risk and reduced age of AD onset. Accelerated cognitive decline and abnormal internal environment, structure, and function of the brain were also found in epsilon4 carriers. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30866553</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E knockout (ApoE-KO) mice were infused with angiotensin II (AngII) for 28 days to induce AAA formation. CAR-DCN or vehicle was administrated systemically until day 15. Mortality due to AAA rupture was significantly reduced in CAR-DCN-treated mice compared to controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29158532</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE 4 allele may be associated with the occurrence of Wilson disease in Indian patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29059476</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this genetic study showed that neither the APOE varepsilon4 nor varepsilon2 alleles were notably associated with risk of Multiple system atrophy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29442376</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the genetic-association study of the association with neurocognitive disorders by means of multivariate logistic models, the APOE-E4 allele increased the risk for cognitive impairment in the Mexican populations by approximately 6 % (OR: 5.83, p = 0.0025)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30464349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that APOE4 allele polymorphisms can be considered as a significant risk factor to late onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31102717</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study identified neural correlates of episodic memory (EM) function by correlating intrinsic hippocampal functional connectivity networks with neuropsychological EM performances in a voxelwise manner, with 129 cognitively normal elderly subjects (36 epsilon2 carriers, 44 epsilon3 homozygotes, and 49 epsilon4 carriers); demonstrated significantly different EM neural correlates among the three APOE allele groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29396739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased iron results in sequestration of ApoE within adipocyte primary cell cultures.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30105281</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele is strongly associated with Alzheimer&apos;s disease, whereas epsilon2 and epsilon3 are negatively associated with this disease. APOE significantly affects risk of Alzheimer&apos;s disease, but apparently not longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30658061</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>methylation levels at multiple CpGs in the APOE genomic region are inversely associated with delayed recall during normal cognitive aging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29739406</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Of the brains in the National Alzheimer&apos;s Coordinating Center database with pathologically confirmed dementia, seven were found to be homozygous for APOEvarepsilon2, which represents only 0.2% of the autopsy-confirmed sample. Furthermore, pathology-confirmed AD represents 29% (2/7) of the APOEvarepsilon2/varepsilon2 patients diagnosed with dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29562509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Adjusting for demographic and clinical covariates, results showed that both APOE varepsilon4 status and elevated pulse pressure (PP) predicted greater functional difficulty trajectories across four years of follow-up. Interestingly, however, elevated PP was associated with greater functional decline over time in varepsilon4 non-carriers versus carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29562507</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found a significant epistatic interaction between APOE and two lipolysis-stimulated lipoprotein receptor (LSR) variants, rs34259399 and rs916147. Interestingly, the interaction of LSR polymorphisms with APOE non-epsilon4 alleles increased Alzheimer Disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29858039</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic predisposition to late-onset Alzheimer&apos;s disease, through APOE genotype or Alzheimer&apos;s disease family history, is not associated with Cerebral small vessel disease in middle age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29156222</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows there is interaction between ApoE4 gene and aluminum on the Abeta content, especially the change of the Abeta42 content, which may be related to the down-regulation of the expression of ApoER2 and LRP1 proteins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30649678</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows that apolipoprotein E epsilon4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29909179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>revealed that the APOE polymorphism is not associated with cognitive status in Parkinson&apos;s disease patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29776682</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that The risk of developing dementia/CIND was increased more than threefold in APOE epsilon4 carriers or diabetics with low levels of physical activity compared with epsilon4 noncarriers or nondiabetics who engaged in high physical activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28692819</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found an association between ApoE polymorphism and the risk of Alzheimer&apos;s disease (AD) in type 2 diabetes mellitus (T2DM) patients, and the epsilon3/4 and epsilon4 genotype of ApoE were the risk factor for AD among patients with T2DM.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30890475</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results confirm the importance of Alzheimer&apos;s disease biomarkers as risk factors for cognitive decline in established Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29168904</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Acute coronary syndrome patients with the E4 allele were associated with higher low-density lipoprotein cholesterol and total cholesterol levels compared with the patients without the E4 allele. The patients with the E4 allele were associated with a higher rate of major adverse cardiovascular events compared with the patients without the E4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30130761</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate that ApoE is a classical complement cascade checkpoint inhibitor by binding to activated C1q and that the resulting C1q-ApoE complex emerges as a common player to impact brain inflammation and atherosclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30692699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is a glycoprotein responsible for lipid transport in the brain and circulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30622009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the presence of ApoEepsilon4 allele might also have a possible effect on the amyloid beta phagocytosis efficiency of the macrophages.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30694418</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The current study found that in young adults, carrying an epsilon4+ allele is associated with differences in executive function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30472114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that APOE epsilon4 is a strong genetic predictor of the presence and severity of TDP-43 proteinopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30093249</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>combination of ApoE gene polymorphism and hydrogen proton magnetic resonance spectroscopy may be more useful to differentiate and diagnose Alzheimer&apos;s disease and amnestic mild cognitive impairment early.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31006219</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study for the first time identifies that the APOE gene is associated with modified lung physiology in women. This suggests that a link may exist between the APOE epsilon4 allele, female sex, and a reduction in the FEV1/FVC ratio (the forced expiratory volume in one second divided by the forced vital capacity) in older individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30412599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 (Arg112, Arg158) carriers have a higher risk of panic disorder in a Turkish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29888635</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>E4 non-demented aged carriers perform worse versus noncarriers on forward digit span and delayed recall of the Rey-Osterrieth complex figure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28844148</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-varepsilon4 may alter aging by accelerating the change in segregation between high-level cognitive systems.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29520911</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactive effect of SPON1 and APOE4 on brain activation during working memory performance in Chinese non-demented elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29573041</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We showed that single nucleotide polymorphism frequency profiles within APOE locus are highly skewed to population-specific haplotypes, suggesting that the ancestral background within different sites at APOE gene may shape the disease phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29745836</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the major rs644234*T allele of ABO was associated with increased levels of soluble E-selectin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29373315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism has proteictive effect on age-related macular degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30102097</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE promoter methylation may be associated with atherosclerotic cerebral infarction in Han Chinese people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30658954</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 allele carriers had significantly higher behavior problem scores than noncarriers, and adverse associations with PAHs and NO2 were stronger or limited to epsilon4 carriers for behavior problem scores (P-interaction 0.03 and 0.04), caudate volume (P-interaction 0.04 and 0.03), and inattentiveness trajectories (P-interaction 0.15 and 0.08, respectively).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30073950</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study confirmed the association between APOE genotype and the rate of cognitive decline in a predominantly Han Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30339707</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data demonstrated that ApoE 4/2 genotype was less frequently observed in old patients (65 years and more) with exudative AMD compared to old healthy controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29851526</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>AIP and apo B/apo A-I associated with cIMT in NAFLD patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29359590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CSF-ApoER2 fragments as a read-out of reelin signaling: Distinct patterns in sporadic and autosomal-dominant Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30552869</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>hyperlipidemic transgenic human CETP and APOE*3-Leiden mice develop many features and molecular signatures characteristic of human nonalcoholic steatohepatitis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29907965</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Common variants with small individual effects jointly modify the risk and age at onset of Alzheimer&apos;s disease and dementia, particularly in APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29555425</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Alzheimer&apos;s disease patients, psychosis and the presence of APOE epsilon4 were both associated with lower Mini-Mental State Exam (MMSE) scores, while only psychosis was associated with higher Functional Activities Questionnaire (FAQ) scores. Patients with hallucinations had lower MMSE and higher FAQ scores than patients with only delusions. APOE epsilon4 was positively associated with the presence of Lewy body patho...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28847281</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-varepsilon4 homozygotes, but not heterozygotes, bear a significantly higher risk of displaying pathological white matter hyperintensities</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28492093</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Pilot study showed that a subset of patients with gliomas treated with conformal radiotherapy +/- chemotherapy had continued decline in attention and verbal learning abilities over an approximately nine-year period, and that the APOE epsilon-4 allele may have influenced cognitive decline. Progressive worsening in aspects of attention and executive functions may occur over several years despite adequate disease control.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29168082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>our results suggest that young epsilon4 carriers are more efficient than non-carriers at allocating cognitive control resources based on the actual task requirements</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30342978</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 status was more predictive of Alzheimer&apos;s disease (AD) than Genetic risk scores (GRSs), although the GRSs did add to AD prediction accuracy beyond APOE epsilon4. GRSs might contribute to identifying genetic risk of AD beyond APOE. [systematic review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30143603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 alleles on an African background conferred a lower risk than those with a European ancestral background, regardless of population (Puerto Rican: OR = 1.26 on African background, OR = 4.49 on European; African American: OR = 2.34 on African background, OR = 3.05 on European background). The lower risk effect in the ApoE gene epsilon4 allele is likely due to ancestry-specific genetic factors near ApoE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30517106</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data highlight a pathogenic role of apoE4 that could be linked to the capacity of the protein to form oligomeric species especially in the presence of Abeta42 and to induce cytotoxicity. Carboxyl-terminal residues L279, K282 or Q284 appear to be involved in the conformation of apoE4 that may underlie the protein&apos;s functional properties related to neurotoxicity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30367942</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>rs4420638 at the APOE locus was associated with an increased risk of type 2 Diabetes and a decreased risk of Coronary Artery Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29731020</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results show that in Thai individuals, the presence of ApoE4 allele is accompanied by a multifarious decline in neurocognitive functions and behavioral features and that ApoE3 may convey protection against neuropsychiatric symptoms and a decline in social skills.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29307083</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A -219T/G heterozygosity increased risk for Alzheimer&apos;s disease in APOE epsilon4 carriers, but not in APOE epsilon4 non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29990559</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Systematic review and meta-analysis found no evidence that APOE epsilon4 carriership or zygosity is associated with the presence of depression, anxiety, apathy, agitation, irritability or sleep disturbances in cognitively impaired subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30513312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Young healthy adults carrying APOE epsilon4 and APP/presenilin-1/2 displayed different hippocampus functional connectivity patterns</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28502043</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The methylation of APOE was important for the risk of Coronary Heart Disease in men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30576806</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The lower level of HDL-C and ApoA1 and higher ratios of total cholesterol:HDL-C, LDL-C:HDL-C, and ApoB:ApoA1 are risk factors for MI in young patients. No significant pattern of ApoE polymorphisms was observed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30595248</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>incidence of amnestic mild cognitive impairment (aMCI) in Tujia region of Enshi may be related to the rs744373 polymorphic site of BIN1 gene, ApoEepsilon2 is the protective factor and ApoEepsilon4 is the risk factor for aMCI in Tujia region of Enshi</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29764032</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 is not associated with the recovery of sleep disturbance after mild traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28752509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant association between ApoE genotype status and the presence of white matter hyperintensities after high altitude exposure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30359295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the potential relationship of APOE rs7412 and rs429358 with pregnancy loss (PL) in Bosnian women, was investigated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30338758</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitively normal, elderly E4/E4 show an atypical pattern of both brain hypometabolism and amyloid deposition compared with that known to occur in Late-Onset Alzheimer&apos;s Disease. Metabolism is dissociated in localization from amyloid deposition. The region of greatest amyloid deposition localizes to the putamen.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29497704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon-4 carriers with cognitive impairment increased latency evoked potentials P300 and N200.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28833437</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Young Alzheimer&apos;s (&lt;65y) APOE4 noncarriers had the most severe frontal and perisylvian atrophy, while in old (&gt;/=75y) APOE4 carriers had the most severe medial temporal atrophy. In &lt;75y APOE4 noncarriers and heterozygotes showed worse performance in language, visuospatial, and frontal function compared to homozygotes, while, in old &gt;/=75y APOE4 homozygotes showed worse performance in memory compared to noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29376853</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the effects of apoE and HLA DRB1*13 on brain function by examining changes in neural network properties with age in healthy adults, is reported.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30139626</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 allele carriers that predominantly use non-spatial strategies have decreased fMRI activity in the hippocampus and increased atrophy in the hippocampus, entorhinal cortex, and fimbria compared to APOE varepsilon4 allele carriers who use spatial strategies. In contrast, APOE varepsilon4 allele carriers who use spatial strategies have grey matter levels comparable to non-APOE varepsilon4 allele carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29278888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study shows by Atomic Force Microscopy that attachment of ApoE4/ABETA complexes to basement membrane laminin is significantly weaker than ApoE3/ABETA complexes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26327683</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>GMF and ApoE4 were strongly expressed and co-associated in amyloid plaques (APs) and in the reactive astrocytes surrounding APs in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29172001</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Both groups of older adults showed enhanced recognition memory for narrative information following self-referential processing relative to semantic elaboration, and the magnitude of this memory effect was not affected by epsilon4 status. However, older adult epsilon4 carriers did not show an emotional enhancement effect, whereas older adult epsilon4 noncarriers did.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28044474</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among the 160 Alzheimer&apos;s disease patients, 50% presented rapid disease progression. Extrapyramidal signs at disease onset were predictors of worse outcome, especially among Apolipoprotein E varepsilon4 allele carriers, while the presence of family history for dementia decreased the risk of rapid progression by about 50%. Higher educated varepsilon4-carriers showed a slower AD progression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29226870</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although BuChE-K alone does not seem to play a major role in progression to Alzheimer&apos;s disease, in mild cognitive impairment (MCI patients a synergistic effect with the ApoE varepsilon4 allele was found, highlighting the importance of assessing these combined genotypes for evaluating risk progression in MCI patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29254094</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CETP I405V polymorphism is likely a risk factor for Alzheimer&apos;s disease and vascular dementia in our cohort, independent of APOEE4 status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29332048</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>implicate the LXR/ApoE axis in the regulation of innate immune suppression and as a target for enhancing the efficacy of cancer immunotherapy in patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29336888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4, but no epsilon2, might be a risk factor for Parkinson disease in Asian population (meta-analysis).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30412083</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>myeloid-produced apoE is a key physiological modulator of dendritic cell antigen presentation function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30082772</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In conclusion, variations in APOE genotype led to differential effects on the lipid response to the replacement of saturated fatty acids with monounsaturated fat and low glycemic index carbohydrates.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30336580</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>mice with targeted replacement (TR) of the ApoE gene with human ApoE4 have reduced neocortical cerebral blood flow.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30232327</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the absence of behavioural differences, young adult epsilon4 carriers already show a different linkage between functional brain activity and behaviour, as well as aberrant hippocampal recruitment patterns. This may have relevance for genotype differences in cognitive ageing trajectories.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29856823</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No difference in the frequency of any APOE allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher epsilon4 frequency (15.71%) than the 24-50 and 51-75 age groups (10.2% and 11.32%, P &gt; 0.05).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28607446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study showed that E4 allele was found in 7% of the study population, and in contrast to hypercholesterolemia, it was correlated with the risk of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30457419</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Intratracheal instillation of particles (0.5 or 5 mg/kg) once a week for 5 weeks in ApoE-/- mice was associated with an accelerated progression of atherosclerosis in aorta and telomere shortening in the lung and spleen, whereas there was no effect on inflammation in the lungs</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30124895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients having Glutathione S-transferase M1 allele and Apolipoprotein E E2 allele are predisposed to oxidative stress-induced cardiac injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30095041</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOEepsilon4 alleles were significantly higher in patients with Alzheimer&apos;s disease (AD) and there was a potential synergistic interaction between the CYP46A1 C allele and APOEepsilon4 allele in AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29516283</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>familial hypercholesterolemia case-control study was associated with the E4 allele in the Saudi population. However, E4 allele was appeared as a reliable risk marker for lipid profiles, but not for ApoE alleles</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30235358</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant interactions between APOE epsilon4 and mild cognitive impairment were found in general cognitive function (p = 0.001) and white matter connectivity network (clustering coefficient, p = 0.004, and local efficiency.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27785756</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data presented here could increase the knowledge of ApoE3 activity and be a starting point for the study of the impact of variations on APOE gene</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28559539</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 is associated with a subtly faster rate of memory decline from midlife to early old age</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29317609</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PPARgamma knockdown resulted in increased levels of TOMM40, APOE and APOC1 -mRNAs, showing the strongest impact on APOE transcript levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28065845</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study aimed to assess the association between APOE genotype and saccade latency using a prosaccade and antisaccade task in young individuals (N=97, age: 17-35 years). Results showed that prosaccade latency was significantly delayed in a group of epsilon4 carriers in comparison to non-carriers, which was due to a lower rate of signal accumulation rather than a change in the criterion threshold.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30003976</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Higher plasma ApoE concentrations (&gt; 5.9 mg/dL) are the independent risk factor for hemorrhage during endobronchial biopsy in patients with lung cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30031394</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E Mutation is associated with Lipoprotein Glomerulopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29398675</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Collectively, these findings suggest that apoC1 and apoE have redundant functions in the hepatitis C virus (HCV) infection and morphogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30130702</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these results suggest a susceptibility of E4+ carriers to metabolic and cognitive impairments brought on by a HFD, and may help guide development of novel therapeutic targets for AD and related dementias.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28272510</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28276521</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29860106</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>U.S. military veterans who are APOE epsilon4 allele carriers and exposed to a high number of traumas may be at increased risk for developing PTSD symptoms than epsilon4 noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29172227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>found that the ApoE genotype was significantly associated with aneurysmal subarachnoid hemorrhage risk, whereas its effect on certain ethnic populations differs</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30010064</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism might be associated with the incidence of aneurysmal subarachnoid hemorrhage in Chinese Fujian Han population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29769126</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced expression of miR-98 may relate to LOX-1 expression and foam cell formation and lipid accumulation in aortas of ApoE(-/-) mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29549823</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4+ subjects exhibited lower inter- and intrahemispheric coherences than the epsilon4- individuals. CONCLUSION: epsilon4 carriers have lower corticocortical communication than noncarriers during an intelligence task, implying that carrying the epsilon4 allele may reduce brain networking in adolescence, several decades before the onset of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28848214</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 modified the association between central arterial stiffening and cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29656011</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The rs7755 and rs3211956 loci polymorphisms of CD36 gene and genotype E2/E3, E3/E4, E4/E4 of ApoE gene, and E2 and E4 alleles were statistically related with Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30235742</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results show great changes in men carrying ApoE2, mainly in TG and TC concentrations after treatment with hypocaloric diet and controlled exercise</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29756962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genetic polymorphisms conferred susceptibility to steroid-induced ONFH in Chinese Han population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29892926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>t results point out that APOE4 genotype influences healthy aged cognition, although factors such age or educational attainment seem to modulate its effects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29414814</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced content of ApoE in blood serum of men with arterial hypertension was associated with APOE4 gene polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29658078</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In summary, our findings from the two cohorts confirm that genetic variations at the APOE locus influence plasma total cholesterol concentrations, however, the gene-diet interactions on lipids require further investigation in larger cohorts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29712557</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is the association between ApoE polymorphism and hypertension. [meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30180966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The authors propose that APOE4-driven hyperactivity may be a causative factor driving increased risk of Alzheimer&apos;s disease among APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29133888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results showed that ApoE epsilon4 and PON1-55M alleles act synergistically to increase the risk of systemic lupus erythematosus by 1.47 times</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29273831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study presents evidence that odor identification ability starts to decline already in middle-aged, and that carriers of varepsilon4/4, who are at highest risk of developing dementia, decline twice as fast.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28455505</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE-APOC2 gene region correlate with AD-related biomarkers and TOMM40 or APOE gene expression in AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29371683</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggest that the apolipoprotein E4 genotype selectively modulates the functional integration of brain networks in patients with amnestic mild cognitive impairment, thus providing important insight into the gene-connectome interaction in this disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28341847</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings revealed that APOE epsilon4 allele has a detrimental effect on parietal and frontal white matter in cognitively normal elderly; and demonstrate that information processing speed deficits can be explained by parietal white matter hyperintensities volume, age and interaction between parietal white matter hyperintensities volume and age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27444731</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study demonstrated that the APOE epsilon3/epsilon3 and epsilon3/epsilon4 genotypes played a protective role against cerebral infarction in Chinese men, but not women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29479056</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>corroborating evidence that supports the fact that the presence of the APOE e4 polymorphism confers greater susceptibility to combat-related post-traumatic stress disorder (meta-analysis)&gt;</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28430712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes ( P &lt; .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA ( P &lt; .001). In multivariate analysis, LDL size was independently predicted by APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26941371</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In het mice, RIF had no effect on plasma lipids composition, CYP27A1 activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29191818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hypertension and the ApoEepsilon4/epsilon4 genotype may be associated with the occurrence of MCA stenosis in the ischemic stroke Chinese patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29494434</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study, detection of AD-related DNA oligonucleotide sequence associated with Apolipoprotein E4 gene sequence was achieved using localized-surface plasmon resonance (LSPR) on 2D-Photonic crystal (2D-PC) and Au-coated 2D-PC surfaces.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29291596</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism has an influence on the risk of aneurysmal subarachnoid hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29213291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evidence for an interaction between APOE SNP rs1064725 and dietary fat intake on fasting total plasma cholesterol concentrations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29169396</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 carriers had elevated carotid intima media thickness independent of demographics and vascular risk factors. Diabetes was an effect modifier of the relationship between APOE-epsilon4 and cIMT.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29103864</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is a risk gene for ischemic stroke (IS), but not independent, especially for large artery atherosclerosis IS.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29074556</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among APOE4 carriers, race was not associated with risk of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28863046</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28589856</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-epsilon4 allele may confer an increased risk of impairment of 6-month verbal memory for patients suffering mild traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28948085</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE e4 allele is a risk factor for late onset Alzheimer&apos;s disease as well as for other types of dementia.Living arrangements, perceived social support, and loneliness were found to moderate the relationship between the APOE e4 allele and cognitive function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28329797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon2 carriers perform better on cognitive tests as this group have a lower risk of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29032015</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Overnight hypoxemia and sleepiness were associated with cognition. The average effect estimates were small, similar to effect estimates for several other individual dementia risk factors. Associations were strongest in APOE-epsilon4 risk allele carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28731362</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Downregulation of apoE and apoJ in CSF strongly suggests a critical role of lipid metabolism in the development and progression of Moyamoya disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28843803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 alleles are associated with dementia risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28657841</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggest a possible relationship between the epsilon4 allele and post-concussion impairment, as well as between the epsilon4 allele and neurocognitive performance variability, suggesting that the epsilon4 genotype may be a risk factor for less efficient cognitive processing in concussed athletes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28541413</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carriers and the CETP genotype were associated with a decreased response to simvastatin therapy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28851085</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results of this study suggest that the process of preclinical Abeta pathology might start in early middle age in APOE epsilon4 carriers. Hypothesize that the APOE epsilon4 allele affects CSF Abeta42 concentrations by speeding up the process of preclinical Abeta accumulation and deposition in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29061195</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>FNDC5 gene interactions with candidate genes FOXOA3 and APOE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29143599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the role of APOE polymorphisms in retinal vein occlusion</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26851238</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study used eigenvector centrality mapping to analyze APOE epsilon4-related effects on whole-brain functional connectivity in healthy elderly populations, documented that presence of APOE epsilon4 allele is linked to decreased brain interconnectedness in brain regions susceptible to Alzheimer&apos;s disease-related pathology and observed a possible compensatory effect for epsilon4 allele in middle frontal gyrus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27714554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Blood samples were obtained from 30 patients with relapsing-remitting MS (RRMS) along with 30 age and sex-matched healthy individuals, then peripheral blood mononuclear cells (PBMCs) were isolated. The quantitative Real-Time PCR was carried out for Klotho mRNA derived from PBMCs. The results showed that klotho gene expression in the PBMCs of patients with RRMS is nearly 2.5-fold less than healthy individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28991703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE genotyping revealed that epsilon4 allele frequency was significantly high in Alzheimer Disease in a North Indian Population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28633142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon2, epsilon3 and epsilon4 variants of ApoE causes a statistically significant increase in trigliseride levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29096742</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data did not support a possible association between apolipoprotein E genotypes and allelic frequencies, and recurrent miscarriages</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29778421</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>that APOE and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27620974</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study demonstrated the different aging trajectories of hippocampal resting-state functional connectivity networks between ApoEepsilon4 carriers and non-carriers. The compensatory increases were accelerated in epsilon4 carriers with normal cognitive function, but were subsequently exhausted in the amnestic-type mild cognitive impairment stage (aMCI); the compensation in non-carriers was gradually displayed during the aM...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27734307</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this meta-analysis of 5,709 subjects suggested that ApoE epsilon4 allele was associated with an increased risk of mild cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29180857</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype is related to beta-amyloid (Abeta) burden in brain regions preferentially affected by Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29111487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The authors show that lipoproteins including brain (apoE) and circulating (high-density lipoprotein, HDL) synergize to facilitate beta-amyloid transport across bioengineered human cerebral vessels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28994390</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoAI modulates the cellular fate of Treg cells and thus influences the immune response during atherosclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29545616</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results strongly suggests a role for human ApoE4 in cerebral ceramide and fatty acid (FA) homeostasis. The absence of mouse apoE resulted in low cerebral ceramide levels, which was not restored by human ApoE4. The APOE genotype affected brain FA profile when mice were fed a high fat/high cholesterol diet.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28035926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that the retinal arteriolar central reflex is strongly linked to APOE epsilon4 status and exhibits a weaker, independent trend with Alzheimer&apos;s disease diagnosis. The retina may be useful as a novel model for non-invasive monitoring of the effects of APOE epsilon4 on the central nervous system, particularly in cerebrovascular disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28290247</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This cross-sectional study suggests that both AD diagnosis and APOE4 genotype affect fasting insulin levels and insulin resistance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28550261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Multicenter study investigating a large spectrum of Diffusion Tensor Imaging indexes of white matter (WM) microstructure. Findings support previous evidence in monocentric studies indicating a modulatory role of APOE varepsilon4 allele on WM microstructure in elderly individuals at risk for Alzheimer&apos;s disease suggesting early vulnerability and/or reduced resilience of WM tracts involved in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28596117</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 role on inflammation and oxidation through the Notch signaling pathway could be crucial in elucidating the risk factors of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27585646</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that APOE acts in a co-dominant fashion on Abeta levels, episodic memory, and hippocampal volume in cognitively normal older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28550258</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study demonstrated that the female APOE-epsilon4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28673336</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine in apoE3. It remains unclear why apoE3 and apoE4 are functionally different. Described here is a proposal for understanding the functional differences between these two isoforms with respect to lipid binding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28559318</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 genotype did not predict post-operative delirium in an older elective arthroplasty population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28383643</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE rs405509-epsilon2/epsilon3/epsilon4 haplotypes modulate the risk of concussion susceptibility</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28645497</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>19</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study of this results showed that the significantly higher fractions of subjects with pAbeta, APOE varepsilon4 allele carriers and MCI subjects in the group referred from memory clinic compared to self-referred subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28826181</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of the analysis of covariance stratified by sex and serum insulin level showed that the serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were significantly associated with changes in the serum C-peptide levels, independent of the serum insulin level.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28869884</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results show that in cognitively normal young adults carrying APOE epsilon4 mutations had different spontaneous brain activity patterns without cerebral structural differences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28987665</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The positions, dynamics, and stabilities of the helical segments in ApoE3 and ApoE4, in their normal tetrameric state and in mutation-induced monomeric mutants were determined .Helix stabilities are relatively low. Secondary structure in the tetrameric apoE3 and E4 isoforms is similar except that some helical segments in apoE4 spanning residues 12-20 and 204-10 are unfolded, causing its higher lipid binding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28096372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study provides evidence for neuronal-specific responses to ApoE4 that could affect neurogenesis and neuronal survival</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28321820</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE(-/-) mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27491335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested significant alterations in hippocampal dendritic structure and synaptic function in Apoe4 mice, even at an early age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28786172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Overall, these findings suggest that the ability of apoE fragments to promote Abeta42 intraneuronal accumulation is specific for both the apoE4 isoform and the particular structural and thermodynamic properties of the fragment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27476701</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27379525</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE transcriptionally represses PPP2R5E and triggers demethylation of the catalytic subunit PP2AC.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28720530</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results support the hypothesis that ApoE 4 predisposes to an early development of mesial temporal lobe epilepsy with hippocampal sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27875923</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that theCalmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer&apos;s disease patients with apolipoprotein E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28592211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study found that APOE3 and APOE4 targeted replacement mice demonstrate similar cognitive impairment following moderate TBI with differences reflecting the preexisting deficits in APOE4 mice at baseline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28502803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>People with an APOEvarepsilon32 genotype have a reduced risk of Alzheimer&apos;s disease. It may be relevant that they have a higher level of post-synaptic proteins in the hippocampus even in earlier adulthood.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28731446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele has a female-specific effect in inducing psychosis in AD through the formation of Lewy bodies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28219318</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrates an apoE isoform-dependent effect on ADAM10 function and AbetaPP processing which may describe the elevated amyloid levels in the brains of AD subjects carrying the APOE4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28164773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that the APOE epsilon4 carriers had lower platelet mitochondria COX and citrate synthase activities than the APOE epsilon4 non-carriers suggesting that mitochondria at least partly mediate the well-recognized association between APOE alleles and Alzheimer&apos;s disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28448944</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regression analysis revealed significant risk for memory loss that are dependent on age and genetic variants APOE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28777751</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the rs405509 T/T allele of APOE causes an age-related cognitive decline in non-demented elderly people, possibly by modulating brain network communication efficiency</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27636845</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele was associated with increased Abeta deposition, which may lead to the formation and progression of WMH, especially in frontal lobe. Besides, interaction between the increased frontal WMH burden and epsilon4 allele can exert long-term detrimental effects on individual&apos;s trajectory of cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28574812</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Taken together, these results suggest that ApoE4 enhances Abeta inhibition of insulin-stimulated AMPA receptor function, which accelerates memory impairment in ApoE4xAPP mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27189808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this meta-analysis demonstrated that APOE epsilon4 was a genetic risk factor for FTLD patients in Caucasian and Asian populations, thereby corroborating the role of APOE genetic variants in FTLD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28487499</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that APOE genotype and obesity interact to promote Alzheimer disease pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28612048</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an ApoE2 or ApoE3 mediated positive regulation of BDNF may be protective while ApoE4 related defects in BDNF processing could lead to Alzheimer&apos;s disease pathophysiology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28569173</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings in this study suggest that there is a poor concordance between apo E genotyping and lipoprotein electrophoresis in diagnosing dysbetalipoproteinemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28689531</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In US veterans assessed for their lifetime trauma exposure and severity of PTSD symptoms, there is significantly higher resilience in participants with apoE genotype containing the E2 allele (E2/2, E2/3) as compared to participants with the E4 allele (E4/4, E4/3).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28299413</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among those with APOE epsilon4, those with positive age beliefs were 49.8% less likely to develop dementia than those with negative age beliefs</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29414991</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study investigated the association between APOE epsilon7 expression and cognitive impairment; as verified by the results of structural prediction, APOE epsilon7 could serve as another risk factor for cognitive impairment and is particularly associated with vascular disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28744113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human APOE4 gene in mice was associated with elevated calcineurin activity and fewer dendritic spine numbers compared with APOE3 mice. Importantly, calcineurin in APOE4 remained sensitive to pharmacological inhibition and spine density can be rescued by treatment with FK506.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28542068</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriers and non-carriers differ in hippocampal organization and there are differences as a function of sex and hippocampal segment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28284953</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*E4 status had no impact on gray matter density in areas affected early by neurofibrillary tangle formation such as the hippocampus and mesial temporal lobe</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28495939</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>With Abeta status unknown and risk from demographic characteristics controlled, varepsilon4 carriage increased risk for clinical disease progression in cognitively normal older adults over 72 months by 2.66 times compared to risk of non-varepsilon4 carriage. Re-analysis with Abeta status included showed that abnormally high Abeta increased risk for clinical disease progression over 72 months by 2.11 times compared to r...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28234254</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-beta pathology; ApoE4 exerts a &apos;toxic&apos; gain of function whereas the absence of ApoE is protective</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28959956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 and slow wave sleep in older adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29370207</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28480219</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Severe traumatic head injury patients with the APOE epsilon4 allele seems to be more prone to undergo decompressive hemicraniectomy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28372905</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 allele affects the functional connectivity within posterior Default mode network, particularly the atrophy-corrected interhemispheric functional connectivity strength before the clinical expression of neurodegenerative disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28351449</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>support the hypothesis that mtDNA-nuclear retrograde signaling may mediate expression levels of APOE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27109188</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In 227 unrelated individuals from Barranquilla, Colombia, the most frequent APOE allele was the epsilon3, with 85%, followed by the epsilon4 allele (13%) and epsilon2 (1.8%). The genotypes found were: epsilon3/epsilon3: 71.8%, epsilon3/epsilon4: 24.2%, epsilon2/epsilon3: 2.2%, epsilon2/epsilon4: 1.3% and epsilon4/epsilon4: 0.4%. The epsilon2/epsilon2 genotype was not found in this study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27622438</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In vitro and in vivo models show that ApoE4 promotes AD neuroinflammation while ApoE2 has a protective effect against Alzheimer&apos;s Disease neuroinflammation, acting via the vitamin D receptor signaling pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28372324</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study reinforced the association between APOE and AD(Alzheimer&apos;s disease). The hazard of developing AD (Alzheimer&apos;s disease) was eight times higher for those with recent depression and the E4 homozygote</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27020605</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Advancing age was associated with decreased GMV of DMN subregions. Compared to HC, APOE epsilon 4 carriers presented cortical atrophy in right cingulate gyrus. Our results highlight the difference between different cortical measures and suggest that the cortical reduction of CG and insular maybe a potential neuroimaging marker for APOE 4 epsilon senior carriers, even in the context of relatively intact cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27097839</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Large population-based study found that current smoking is associated with decline in global cognition and decline on specific cognitive tests but no evidence for effect modification by APOE varepsilon4 genotype on this relation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28304310</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Across all participants, total brain Grey Matter Volume (GMV) was positively associated with extraversion and negatively related to age. In APOE varepsilon4-carriers-but not in APOE varepsilon4-non-carriers-conscientiousness was negatively associated with total GMV. In this subset of young APOE varepsilon4-carriers, the reduction in conscientiousness could then along adverse health behavior, potentiating the risk for l...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28106551</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study found that elderly individuals with a lower number of teeth had an increased risk of developing memory decline and that this risk remained after adjustment for demographics, vascular risk factors, and APOE varepsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27716671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27716659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings in large APOE neuroimaging dataset show that hippocampal volume loss is present in patients with and in with an increased risk of developing Alzheimer&apos;s disease (AD), particularly subjects with memory impairment. However, healthy older individuals did not show APOE varepsilon4 dependent changes in the hippocampus, suggesting that the relationship between APOE varepsilon4 and Abeta may be mediated by the presen...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28157104</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed the APOE4 affects the Abeta deposition in the brain of Idiopathic Normal Pressure Hydrocephalus and Alzheimer&apos;s Disease patients in a similar manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27802227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of ApoE4 results in reduced Trx1 levels and activation of apoptosis. These effects are likely mediated by impaired lysosomal integrity, resulting in Cathepsin D translocation to the cytosol and increased Trx1 degradation. Furthermore, the Trx1 levels were decreased in a primary endothelial cell model of stress-induced senescence. This was accompanied by increased Cathepsin D activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28035917</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>IL-6R CC genotype was associated with a three times greater concussion risk and APOE4 with a 40% lower risk in college athletes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28918391</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study reveals the degeneration pattern of the varepsilon4 allele, which could be used as a potential biomarker for early detection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27593520</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Authors sought to extend previous studies by examining whether cognitively normal older adults without self-reported sleep apnea who carry the APOE epsilon4 allele have altered sleep characteristics compared to noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28747136</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the apolipoprotein EE4 and apolipoprotein EE2 genotypes, although related to cholesterol and triglyceride levels, do not affect recovery during rehabilitation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29390290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study elucidated that the APOE4 epsilon4 allele can enhance AD susceptibility and promotes the expressions of inflammatory factors in Alzheimer&apos;s disease (AD). Additionally, the epsilon3/4 genotype and TNF-alpha, IL-6, and IL-1beta levels were associated with AD susceptibility in the Han population, while the epsilon3/4 and epsilon4/4 genotypes and TNF-alpha, IL-6, and IL-1beta levels were associated with AD susceptibi...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28461186</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data of this study question the relevance of the APOE-epsilon4 allele as a predictor of cognitive impairment in PD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27321987</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study shows protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27542235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report altered hippocampal functional connectivity in carriers with risk APOE epsilon4 or SORL1 G-allele, which may predispose these risk-allele carriers to be susceptible for Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28229235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that Young adult APOE4 carriers displayed upregulation of specific glucose (GLUT1 &amp; GLUT3) and monocarboxylate (MCT2) transporters, the glucose metabolism enzyme hexokinase, the SCOT &amp; AACS enzymes involved in ketone metabolism, and complexes I, II, and IV of the mitochondrial electron transport chain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27128370</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>RNA interference of transcriptional factor activator protein 2alpha (AP-2alpha) reversed the inhibitory effects of aspirin on atherosclerosis in Apoe-/- mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27391154</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease was associated with decreased selenium concentration in both soluble (i.e., cytosolic) and insoluble (i.e., plaques and tangles) fractions of brain homogenates. The presence of the APOE epsilon4 allele correlated with lower total selenium levels in the temporal cortex and a higher concentration of soluble selenium.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28453930</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest an increase in the DHA incorporation coefficient in several brain regions in APOE4 carriers. These findings may contribute to understanding how APOE4 genotypes affect AD risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28335828</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that apoE4-driven brain pathology and cognitive impairments in young apoE4 TR mice are associated with down regulation of the VEGF system and can be reversed by upregulation of the expression of VEGF in the hippocampus. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in Alzheimers disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27372644</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer disease susceptibility of APOE4 may originate in part from defective phagocytic capacity of astrocytes which accelerates the rate of accumulation of C1q coated senescent synapses, enhancing synaptic vulnerability to classical-complement-cascade mediated neurodegeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27559087</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Logistic regression and Bonferroni correction in a subgroup of the cohort adjusted for gender, age, and population maintained the association of APOE rs429358 and varepsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27314523</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon 4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV-infected individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27021072</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study examined APOE genotype effects on cognition and brain structure in younger adults and whether genotype effects differed by age and with presence of depression. There were no significant interactions between APOE genotype and depression diagnosis. The epsilon4 allele benefits younger adults by allowing them to maintain executive function performance and volumes of cingulate and temporal cortex regions through age ...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26843007</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4- carriers resisted any functional or cognitive effects of Blood Pressure variations in patients with late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27398980</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study is a reappraisal of the strong association of APOE variability with Alzheimer&apos;s dementia in southern India when compared to other dementia groups, while the transcriptional differences between MAPT haplotypes have a limited role in Indian dementia patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27705964</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings of this study indicated that human ApoE isoforms differentially modulate regulatory mechanisms of bioenergetic and synaptic function in female brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27340853</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study shown a risk score incorporating common genetic variation outside the APOEvarepsilon4 locus improved Alzheimer&apos;s Disease risk prediction and may facilitate risk stratification for prevention trials.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27340842</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 (and BCHE-K*) carriers display a significant earlier age of onset in Alzheimer&apos;s Disease and an accelerated cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27567841</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>More history of Attempted Suicide among Depressed elderly who were carriers of the APOE 4 allele gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26743828</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lower results of cognitive functions were associated with the presence of the epsilon4 APOE allele in postmenopausal women. The epsilon4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27649316</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>some individuals with an FH-causing mutation may not present with LDL-C levels over the specified cut-off because they have also inherited one or more common LDL-C-lowering variants</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28349888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction of APOE e4 status and parenting style in predicting long-term outcomes following early TBI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27480909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>among participants without the epsilon4 allele, cognitive decline increased significantly after stroke compared to before stroke; the association of stroke with cognitive decline appears to differ by the presence of the APOE epsilon4 allele, but no such interaction was observed for mortality</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27849638</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genotype and severity of depressive and anxiety symptoms in cognitively normal older persons</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27742526</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data suggest that APOE4 mice may resist weight gain via an APOE4-directed global metabolic shift toward lipid oxidation and enhanced thermogenesis, and may represent a critical first step in the development of APOE-directed therapies for a large percentage of the population affected by disorders with established links to APOE and metabolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27163745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of cerebral microbleeds was not associated with APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27638784</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE genotype may be a risk factor for delivering a Small for Gestational Age infant. More specifically, women who are carriers of the epsilon2 allele were more likely to have had a Small for Gestational Age birth.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26890557</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Levels of protein carbonyls were moderately higher in liver tissue of APOE4 vs. APOE3 mice. Other biomarkers of oxidative stress were similar between the two genotypes. Under basal conditions, the stress-response pathways investigated appeared largely unaffected by the APOE genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27130033</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mid-life socioeconomic status was positively associated with cognitive status among both Baby Boomers and pre-Boomers, even after adjusting for APOE polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28545399</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 Polymorphism is a genetic risk factor for left ventricular failure in Beta-Thalassemia major.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28670684</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Influence of APOE varepsilon4 genotype on phospholipid profiles associated with mTBI and/or PTSD diagnostic categories.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26714394</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Rather, we hypothesize that PA may protect APOE-epsilon4 allele carriers from selective neurodegeneration of individual fiber populations at locations of crossing fibers within projection and association WM fiber tracts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26265157</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon2 as a risk factor in FTD-3 and epsilon4 plays a protective role in the disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28888721</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data indicate that the APOE rs405509 T homozygote modulates the effect of APOE epsilon4 on both cognitive performance and brain gray matter structure</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27259692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE2 and apoE4 increase the risk for heart disease; ApoE4 also increases the risk for neurodegenerative diseases. (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27277824</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It influences regional white-matter axonal density loss in Alzheimer&apos;s disease.(</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28578156</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in a population with low levels of cerebrovascular disease and a lower prevalence of SNAP than the general population, APOE and known genetic drivers of AD do not appear to contribute to the neurodegeneration observed in SNAP</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29190651</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data conclude that the ER-stress mediated reduction in apoA-I transcription could be partly mediated via the inhibition of PPARalpha mRNA expression and activity. In addition, BET inhibition increased apoA-I transcription, even if PPARalpha production and activity were decreased. Both BET inhibition and PPARalpha activation ameliorate the apoA-I lowering effect of ER-stress and are therefore interesting targets to elev...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28012209</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated cholesterol and APOE 4 genotype are independent risk factors for cognitive decline in ART-adherent HIV(+) men aged &gt;50 years. Treatment of dyslipidemia may be an effective strategy to reduce cognitive decline in older HIV(+) individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27448678</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P &lt; 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC SNP.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28183528</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that both the APOE epsilon4 allele and education appear to be associated with cognitive function even in centenarians, but the interaction between the epsilon4 allele and education might depend on gender in this cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27558117</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggested positive association of a specific ApoE genotype and onset of non-lesional temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29120117</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>protective role of epsilon4 on each subtypes of age-related macular degeneration (AMD), but no supportive evidence of the association of epsilon2 with AMD. [meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28889998</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that in healthy mid-age individuals, carrying the e4 variant of APOE is not associated with disadvantaged performance on dynamic scaling and perceptual load measures of visuospatial attention, despite the established detrimental effects of this gene in older adults. Association of e2 genotype with slower visual search performance complicates premised protective effects of this allele in cognitive ageing.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28750833</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The cholesterol metabolism pathway gene-based imaging genetics approach may provide new opportunities to understand the mechanisms underlying Alzheimer&apos;s disease and suggested that APOE rs429358 is a core genetic variation that is associated with disease-related differences in brain function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26985771</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype proportions in patients with persistent HCV infection significantly differed from healthy controls. The distribution of APOE4 allele positive genotypes (epsilon2epsilon4, epsilon3epsilon4, epsilon4epsilon4) also significantly differed between chronically HCV-infected patients and healthy controls. The findings suggest that the APOE4 allele may confer a protective effect in the course of HCV infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26880346</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study showed that peripheral inflammation interacts with APOE4 and Abeta to induce and accelerate cerebrovascular and cognitive deficits. Thus, cerebrovascular dysfunction is a key mechanistic process linking Alzheimer&apos;s disease hits to pathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28707482</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results provide no evidence of an association of the APOE E4 and gray matter degenerative changes in patients with Parkinson disease, either with or without dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27479921</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study investigated the potential role of APOE epsilon4 in the modulation of grey matter activity, white matter integrity, and brain morphology in healthy APOE epsilon4 carriers when compared to non-carriers. Results suggested that APOE epsilon4 gene can modulate gray matter activity and white matter integrity in cognitive and memory related regions, even before any clinical or neuropsychic symtoms or signs of imminent ...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28108320</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No APOE e4 effect on cognitive abilities or risk of developing Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27103599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>1</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28733268</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data (including data from studies using transgenic mice) suggest that plasma and liver cholesterol homeostasis and hepatic expression of LDL receptor and lipolysis-stimulated lipoprotein receptor are modulated differently and independently by APOE allele (E4 versus E3) and docosahexaenoic acid intake. (APOE = apolipoprotein E)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27239755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Utilizing knock-in mice humanized to ApoE4 versus the more common ApoE3, study examined a simple olfactory perceptual memory and recorded in vivo resting and odor-evoked local field potentials in brain across aging. Findings indicate that early ApoE4-driven olfactory memory impairments and olfactory bulb network abnormalities may be a precursor to later network dysfunction in the piriform cortex.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28003161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study, we found no significant association between allele and genotype frequencies of APOE; the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27028259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele is neither a risk factor for rapid eye movement sleep behavior disorder(RBD) nor it is associated with conversion from RBD to dementia with Lewy bodies or other synucleinopathies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27814994</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype presents a systematic array of potential associations with cognitive performance</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28131014</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 genotype is the major driver of accumulation of white matter hyperintensities volume.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28235680</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon2 and APOEepsilon4 alleles produce both convergent and divergent topological effects on brain function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28319835</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele increases the risk for sporadic Alzheimer&apos;s disease and modifies brain activation patterns of numerous cognitive domains.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28528773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carriers were more susceptible to the association of particular air pollutant exposure and cognitive decline and dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28140404</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>indicates that measurable apolipoprotein E-related brain atrophy does not occur in early adulthood and midlife</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27173368</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype; studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28482100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study provides support for the argument that Apolipoprotein E (APOE varepsilon4+) and catechol-O-methyl transferase Met/Met genotypes can be used as predictors of faster cognitive decline in Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27061069</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>both apolipoprotein E and Abeta1-42 abundance can differ depending upon the type of CJD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27597180</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28387812</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Abnormal hippocampal recruitment in young adult e4 carriers, manifesting as both up and downregulation of neural activity, in the absence of behavioral performance differences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28239522</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We conclude that ApoA-I physically interacts with LL-37 and antagonizes LL-37-induced down-regulation of endothelial cell viability suggesting that this mechanism counteracts endothelial cell dysfunction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28919413</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with white matter hyperintensity load so that APOE4 carriers may be more vulnerable to the insults of poor glycemic control.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27208321</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Compared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27703028</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results show that epsilon2 allele may favorably influence LDL-C, HD, and survival through three mechanisms. Two of them (HD- and survival-related) are pronounced in the long-living parents and their offspring; the survival-related mechanism is also sensitive to gender.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27447179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In elderly African Americans in an exercise program, non-APOEepsilon4 carriers showed a significant increase in brain-derived neurotrophic factor levels at the 6month time point while epsilon4 carriers did not.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27864047</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study used 3 and 7 month old EFAD mice, which express human APOE and over-express specifically human Abeta42 via 5 familial-Alzheimer&apos;s disease mutations, to investigate APOE genotype-specific effects on site-specific tau phosphorylation. Results suggest that the APOE4 genotype contributes to increased site-specific tau phosphorylation via activation of the calpain-CDK5 signaling pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27087442</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Taken together, lipoprotein-bound ApoE was required in both postprandial TRL-induced adipogenesis and TRL endocytosis by the differentiating adipocytes, the latter could be partially through low density lipoprotein receptor family dependent-pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28893538</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study provides evidence linking plasma levels of the individual apoE3 and apoE4 isoforms to structural and metabolic changes in the brains of cognitively intact APOE epsilon3/epsilon4 carriers: relative ratio between plasma levels of apoE4 and apoE3 appears to be of importance, females exhibiting higher levels of the apoE4 isoform than males and increasing plasma apoE3 concentrations as a function of age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28137305</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our work identifies the TREM2-APOE pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28930663</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 allele and lower CSF Abeta42 levels were associated with less transport of docosahexaenoic acid to CSF in Alzheimer&apos;s Disease patients taking docosahexaenoic acid supplements.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27358067</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that early mild cognitive impairment (EMCI) disrupts functional connectivity strength in many important functionally-linked areas; APOE e4 disrupts functional connectivity strength in similar areas to EMCI; and the differences in functional connectivity between groups shows a multifactor contribution to functional network dysfunction along the trajectory leading to dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26409470</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27661410</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between an Alzheimer&apos;s Disease-Related Index and APOE epsilon4 Gene Dose</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23840615</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE levels positively associate with incident CVD risk with apoE-associated risk likely residing in apoB-containing lipoproteins</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27578115</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>male epsilon4 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28086184</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE protein plays a significant role in Oral squamous cell carcinoma tumor invasion</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28751006</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed that the APOE varepsilon4 genotype impaired neither explicit memory nor memory-based orienting of spatial attention. Interestingly, however, we found that the possession of the varepsilon4 allele broke the relationship between declarative long-term memory and memory-guided orienting of visuo-spatial attention, suggesting an earlier modulation exerted by pure genetic characteristics on cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27395443</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings of this study suggested that inheritance of APOE-epsilon4 causes life long changes to the brain that may be related to the late risk of Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27033053</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report presents the largest population-based study on APOE allele distribution and its association with Alzheimer&apos;s disease carried out in China. The results showed the general distribution of ApoE alleles and genotypes similar to those observed in the non-Chinese populations in Western countries. The results suggest that ApoEepsilon4 allele is a risk factor of Alzheimer&apos;s disease for Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27033052</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age &lt;/=65 years, and LDL-C levels &gt;/=160 mg/dl.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28958330</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE and MS4A6A. Results suggest that in addition to APOE, MS4A6A polymorphisms should be considered in hormone trials targeting gonadotropins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27337227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1], and rs429358 [APOE]) were significantly associated with survival to 90 years after correction for multiple testing (p &lt; .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27707806</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 &apos;523-L</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28672022</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27494721</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>To evaluate comprehensively the APOE (apolipoprotein E) haplotype variants (E1/E2/E3/E4), the markers rs7412 and rs429358 were genotyped in 93 AD affected carriers of the E280A mutation. We found that the APOE*E2 allele, and not APOE*E4, modifies Alzheimer&apos;s Disease Age Of Onset in carriers of the E280A mutation (beta=8.24, 95% CI: 4.45-12.01, P=3.84 x 10-5).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26619808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that APOE gene polymorphism is associated with the lipid profile but not with coronary artery disease in Afro-Caribbean people. This lack of association with coronary artery disease may be explained by the low atherogenic profile observed in epsilon4 carriers, which may warrant further investigation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28727855</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Objective of this study was to understand their structural and functional role by generating domain swapped chimeras: apoE3-N-terminal/apoAI-C-terminal and apoAI-N-terminal/apoE-C-terminal. Results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that N-terminal-C-terminal domain interactions significantly modulate their structure and function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28644829</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Risk-reducing Apolipoprotein E genotypes protects against the consequences of poor vascular health on executive function performance and change in older adults without dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27143425</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data provide a direct connection between APOE varepsilon3/4 and another Alzheimer&apos;s disease susceptibility gene and demonstrate in proof of principle the utility of induced neuron-based modelling of Alzheimer&apos;s disease for therapeutic discovery</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28899010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings suggest that APOE4 may be considered as evolutionarily adaptive in an adverse pathogen-rich environment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28683096</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the identification of the e4 allele of Apolipoprotein E as a strong genetic risk factor for both early-onset and late-onset Alzheimer disease (AD) , and evolved to the more recent detection of at least 21 additional genetic risk loci for the genetically complex form of AD emerging from genome-wide association studies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26312828</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon2 allele was more frequent in ALS patients than in controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28239025</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE3 genotype predisposes to obesity and its metabolic complications in humanized targeted replacement mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27895108</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study analyzed 595 older adults without dementia classified cross-sectionally as Abeta- and Abeta+ using longitudinal florbetapir positron emission tomography. APOE epsilon4 carriage and older age were predictors of longitudinal Abeta accumulation within the Abeta- group but not the Abeta+ group. APOE epsilon2 carriage was protective against longitudinal Abeta accumulation within the Abeta- group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28794245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Amazonian forager-horticulturalist population, APOE4 carriers with high parasite burdens showed slight improvements in cognitive performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28031319</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis suggested that there is no association between APOE polymorphism and subarachnoid hemorrhage risk for overall population.  Increased risk of SAH was found in Asian subjects when epsilon4 allele compared with epsilon3 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27241684</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carrying one or more APOE4 alleles was associated with higher overall Cerebral amyloid angiopath scores</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27179972</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Here, we have shown that genetic restoration of plasma ApoE to wild-type levels normalizes plasma lipids in ApoE KO mice. While this does not rescue synaptic loss, it does completely restore learning and memory in the mice, suggesting that both CNS and plasma ApoE are independent parameters that affect brain health.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27683909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings from the current study show that ApolipoproteinE epsilon4-positive (APOEepsilon4+) individuals exhibit an altered lifespan trajectory in the ability of the brain to dynamically modulate function to cognitive challenge compared with APOEepsilon4- individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28652414</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the results of current study found a significant gene- gene interaction between rs405509 of APOE gene polymorphism and rs1805192 of PPARG polymorphism associated with increased Late-Onset Alzheimer&apos;s Disease risk</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28346566</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28249002</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that the redox status of serum apoE might be related to the synthesis of HDL; the cysteine-thiol residue of reduced-apoE is in a naive state, while that of non-reduced-apoE is in a reversibly or irreversibly oxidized state. Data suggest that apoE homodimer and apoE-AII complex are typical reversibly oxidized forms of apoE. (apoE-AII complex = a complex of apolipoprotein E and apolipoprotein A-II)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28366823</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carriers of the ApoE varepsilon4 polymorphism genotype show demonstrable improvement in VA after treatment with ranibizumab in exudative AMD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26398858</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings do not provide significant support for presenilin 1 (PSEN1) E318G as a risk factor for Alzheimer&apos;s disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27357204</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that the APOE-related risk of Alzheimer&apos;s disease in patients with idiopathic normal-pressure hydrocephalus is not higher than in the general population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27441602</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study examined the effect of human cerebrospinal fluid (CSF) on amyloid beta (Abeta) aggregation kinetics in relation to Alzheimer&apos;s disease (AD) diagnosis and carrier status of the apolipoprotein E (APOE) epsilon4 allele, the main genetic risk factor for sporadic AD. Aggregation of Abeta was inhibited in the presence of CSF and the effect was more pronounced in APOE epsilon4 carriers, but it was not the ApoE protein t...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27653981</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid levels of very low density lipoprotein and triglycerides were found to be associated with APOE (E2/E4 and E3/E4) genotypes in ischemic stroke</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27329241</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings highlight the specific impact of early loss of entorhinal input on hippocampal hyperactivity and cognitive deficits characterizing early stages of AD, especially in APOE4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27707979</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The authors found that secreted ApoE (sApoE) can also bind to viral particles via its C-terminal domain after hepatitis C virus is released from the cell.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28539442</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE e4 associations with different domains of cognitive ability were relatively small and, in many cases, nominally significant despite the very large sample size.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26395552</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We applied the Brain Age Gap Estimation (BrainAGE) method to examine the impact of the Apolipoprotein E (APOE) genotype on structural brain aging, utilizing longitudinal magnetic resonance image (MRI) data of 405 subjects from the Alzheimer&apos;s Disease Neuroimaging Initiative (ADNI) database.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27410431</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO)C1 GG and AG carriers, APOE varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27806189</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Aged APOE epsilon4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27801933</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High APOE3 expression is associated with Amyloidosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27793990</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with beta-amyloid peptide-negative suspected non-AD pathophysiology display significantly less temporoparietal hypometabolism and temporal lobe atrophy, which is associated with their disproportionately low APOE epsilon4 and disproportionately high APOE epsilon2 carrier prevalence.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28319241</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE mRNA levels were not affected by complement challenge. ApoE was frequently colocalized with MAC in complement-treated cells and drusen from human eyes. ApoE was released into complement-treated conditioned media after a single complement challenge and accumulated on ECM after repetitive complement challenge.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28632844</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A higher epsilon4 allele frequency was observed in Laotian minorities than in the Laotian majority.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27168072</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE single nucleotide polymorphism and it&apos;s association with LDL cholesterol level and risk of coronary heart disease in Pakistani population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27112212</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4/TOMM40 risk locus (rs769449) is strongly significantly associated with cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26873889</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Adults with childhood-onset epilepsy, particularly APOE epsilon4 carriers, have an increased brain amyloid load at late middle age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28346588</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CRP protein-dependent association between APOE polymorphisms and triglyceride levels in a Taiwanese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27177774</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 may intensify the vascular health risk for MCI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26362601</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found no connection between apolipoprotein E genotype and the clinical course of Down syndrome .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27067497</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Four SNPs within the APOE cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1/PSRC1 (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27943270</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hypoxanthine induces cholesterol accumulation in hepatic cells through alterations in enzymes that control lipid transport and induces atherosclerosis in APOE-deficient cells and mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27396856</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes strongly influence Lp(a) and apoB-related lipoprotein levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28062489</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This article discusses the complex interplay between the three greatest risk factors for Alzheimer&apos;s disease, age, APOE-epsilon4 genotype and chromosomal sex. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26969397</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings in transgenic mice suggest that a long-term diet rich in docosahexaenoic acid suppresses the APOE4-specific disturbances in hepatic transport and concentration of AA and DHA and also reduces hepatic total fatty acid concentrations, regardless of genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27306896</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Ala-9Val polymorphism does not appear to be related to AD. However, the presence of the Ala/Ala genotype increases the risk provided by the varepsilon4 allele of the APOE gene: AlaAla/varepsilon3varepsilon4 (OR=3.47, P=.03), AlaAla/varepsilon4varepsilon4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25542503</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of our study confirmed the role of Na(+)/K(+)-ATPase signalosome in cytotoxicity of cardiac steroids and suggested that APOE regulated the sensitivity of cells to cardiac steroids by affecting formation and function of Na(+)/K(+)-ATPase signalosome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27507851</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we report the characterization of a new AMP corresponding to residues 133-150 of human apolipoprotein E. Our results show that this peptide, produced either by chemical synthesis or by recombinant techniques in Escherichia coli, possesses a broad-spectrum antibacterial activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27028511</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest ApoE epsilon2 allele may be a risk factor; however ApoE epsilon4 allele may play a protective role of diabetic nephropathies in Chinese type 2 diabetic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28326331</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>p.Leu167del mutation in APOE gene is the cause of hypercholesterolemia in the 3.1% of our autosomal dominant hypercholesterolemia subjects without LDLR, APOB, and PCSK9 mutations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27014949</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study identified the E4 allele of the APOE gene as being significantly associated with obesity in the Saudi population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28085496</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this sample of older HIV-infected individuals, having at least 1 ApoE epsilon4 allele was associated with decreased cognitive performance in the executive functioning domain, reduced brain white matter integrity, and brain atrophy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27228100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results reveal an association of APOE epsilon3/3-TOMM40&apos;523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28108637</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data describe a novel signal transduction pathway in neurons whereby ApoE activates a non-canonical MAP kinase cascade that enhances APP transcription and amyloid-beta synthesis; using embryonic stem cell-derived human neurons, show that ApoE secreted by glia stimulates neuronal Abeta production with an ApoE4 &gt; ApoE3 &gt; ApoE2 potency rank order.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28111074</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Multimodal imaging study of APOE2 effects in a large sample of older individuals without dementia expanded on previous unimodal imaging studies and provided evidence that the APOE2 allele has a relatively selective effect on reduced accumulation of amyloid pathology compared to conventional imaging markers of Alzheimer&apos;s Disease-relevant changes in brain structure and function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28062720</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings validated and extended prior smaller studies that showed altered brain development in APOE epsilon4-carrier children. The epsilon4epsilon4 and epsilon2epsilon4 genotypes may negatively influence brain development and brain aging at the extremes of age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27412137</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitively normal elderly individuals who engage in specific mentally stimulating activities even in late life have a decreased risk of incident MCI. The associations may vary by APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28135351</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings indicate the rs9331888 SNP of CLU is associated with LOAD independent of APOE [apolipoprotein E].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27076484</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these studies revealed that GP73 promotes hepatitis C virus (HCV) secretion by directly mediating the interaction of ApoE with HCV replication complex through binding with HCV NS5A.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27697522</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study showed that Caribbean Hispanic families, the GRS also significantly predicted LOAD (OR 1.73; 1.57-1.93).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28213371</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>selective degeneration of dopaminergic terminals throughout the striatum in individuals with Lewy body disease, and serotonergic degeneration in human ventromedial caudate nucleus from individuals with an APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28212814</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE alleles have highly significant differences between dementia and non-dementia patients in Toxoplasma infected patients compared to non-infected ones.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28209315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Several genetic variants of apoE play roles in the genesis of Type III Hyperlipoproteinemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27481046</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although APOE variants were not confirmed as the risk factor for development of MetS, the APOE alleles were associated with some of the metabolic parameters in young Croatian subjects. The relation of APOE alleles with a concentration of adiponectin and leptin depends on the diet intake.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27388789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data of this study suggest that individuals who are APOE [epsilon]4+ may be experiencing worse sleep quality than APOE [epsilon]4- older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27777343</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26337529</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26372964</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of mild cognitive impairment with ApoE4 and depressive symptoms suggested that mild cognitive impairment is a confounder for the association between ApoE4 and DSC.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22700491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain n-3 fatty acid intake from food. These associations were not present in APOE epsilon4 noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27164694</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that individuals carrying both APOE epsilon4 alleles are more susceptible to lead impact on global cognitive decline during aging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27474937</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Gender, BMI and APOE influence children&apos;s cognitive responses to air pollution and glucose is likely a key player, and APOE 4 heterozygous females with &gt;75% to &lt;94% BMI percentiles are at the highest risk of severe cognitive deficits (1.5-2SD from average IQ).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27376929</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we explored the frequency specific effects of ApoE e4 allele on the default mode network (DMN) and the salience network (SN) functional connectivity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28396874</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study results suggest that the varepsilon4 determines the functional association between ongoing episodic memory decline and olfaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26956928</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In cognitively normal older adults, Abeta+ is associated with memory decline in epsilon4 noncarriers; however, the rate of this decline is much slower than that observed in epsilon4 carriers. These data indicate that the processes by which epsilon4 carriage increases the rate of Abeta-related cognitive decline occur in the preclinical stage of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27029632</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that APOE genotype affects APOE distribution in human brain samples.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27085394</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Using hydrogen-deuterium exchange, we determined that EZ-482 binds to the C-terminal domains of both apoE3 and apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27065061</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found that myoinositol levels are elevated already at asymptomatic stages of Alzheimer disease; myoinositol/creatine concentrations were increased in healthy APOE epsilon4 carriers with normal CSF Abeta42 levels, suggesting that myoinositol levels may reveal regional brain consequences of APOE epsilon4 before detectable amyloid pathology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27164711</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Thus, the present protocol may facilitate simple, fast and costeffective screening for important SNPs, as demonstrated by the evaluation of the prevalence of ApoE variants in a Han Chinese cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27665864</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study suggested that the APOE genotype and haplotype significantly associated with plasma TC and LDL-C level in Vietnamese children. The association of APOE genotype with hypoalphalipoproteinemia was independent of obesity-related traits.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27724906</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>According to multivariate regression logistic analyses of this study, higher cortisol levels, lower high-density lipoprotein (HDL-c) and very low-density lipoprotein (VLDL-c), presence of epsilon4 allele of APOE, and aging were associated with cognitive impairment no dementia and dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26302887</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings indicated that variants in TOMM40/APOE/APOC1 region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26657933</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 expression was shown to be associated with age-related diseases, including cardiovascular and Alzheimer&apos;s disease, and therefore an increased mortality risk with advanced age. (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27457486</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Metaanalysis: the epsilon2 allele in APOE may appear as a risk factor for premature coronary artery disease in Asians while a protective factor in Caucasians and that the epsilon4 allele acted as a genetic risk factor for premature coronary artery disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27394044</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE rs429358 variant C allele and 4 allele are associated with the anti-epileptic drugs resistance in Han Chinese patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26726928</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>low-normal thyroid function, as indicated by higher TSH levels within the euthyroid range, may influence the metabolism of triglyceride-rich lipoproteins by affecting apoE regulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26916531</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study suggested that conventional criteria for Mild Cognitive Impairment may be susceptible to false positive diagnostic errors, and that onset of Abeta accumulation may occur earlier in APOE varepsilon4 carriers compared to non-carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27031472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The analysis suggested that ApoEepsilon4 mutation was associated with the increased risk of CHD, while ApoEepsilon2 allele had a decreased risk of CHD just in Caucasians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27868062</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data revealed that ApoE e4 allele is associated with increased risk of coronary artery disease (CAD) in Kashmiri population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26409839</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Review/Meta-analysis: APOE E2/E2 might be one of the factors affecting warfarin dose requirements. The effect of APOE may vary between ethnicities.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27062534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of the APOE gene was significantly associated with both early and late onset Alzheimer&apos;s distributions but with opposite effect.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26714935</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Haplotype analysis reveals a strong association of the interaction of DNMT3B gene with APOEepsilon4 in a sample of Alzheimer disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27188425</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27236033</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found a significant interaction of age and ApoE genotype on task-related activation bilaterally in anterior cingulate gyrus and superior frontal gyrus, as well as left and right insula. Old age was associated with increased activity in varepsilon4 carriers. Recruitment of neuronal resources resulted in enhanced memory performance in young varepsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27003211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is involved with late onset Alzheimer&apos;s disease. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27773727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We evaluated whether APOE is a &apos;variability gene&apos; for body mass index, depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries, and whether it partly represents the &apos;G&apos; in GxE effects. Results suggested that APOE may represent a &apos;variability gene&apos; for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26538244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lack of association between ApoE gene polymorphism and Type 2 diabetic foot ulcers might be due to ethnic differences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26476487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26226973</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE plays an important role in HCV genotype 2a infection and in HCV genotype 1b RNA replication, but not in the replication of HCV genotype 2a.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27225463</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR-C677T) and apolipoprotein-E (apo-E) as risk factors for ischemic stroke patients in south Indian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27378745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25601895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Large intracranial volume increased the risk of conversion to Alzheimer&apos;s disease in males and APOE4 non-carriers with mild cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26674540</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there is no significant association between APOE polymorphism (APOE2, APOE3) and the susceptibility of atherosclerosis, while APOE4 gene may be a risk factor for clinical atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26005211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The clinical implication of the results is that ApoE varepsilon4 in Down Syndrome may play a role in pain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27193365</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>SAR1B polymorphisms were associated with Alzheimer&apos;s disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25703997</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>allele distribution differed between bvFTD and controls, but genotype and allele frequencies of APOE did not affect the risk of bvFTD, SD, and DLB</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26981880</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline during aging, is the greatest genetic risk factor for Alzheimer&apos;s disease and has links to other neurodegenerative conditions</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26884068</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study indicates that the APOE-rs405509 interaction impairs elderly&apos;s cognitive performance through brain functional network</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26825091</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>our findings suggest that the increased risk for gastric cancer by APOE epsilon2 allele might be mediated through lowered serum total cholesterol levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26817942</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>cross-domain interactions showed that personality trait effects on declarative memory were moderated by APOE and CLU allelic risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26343804</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data of this study demonstrated that 4+ athletes report greater symptomatology post-concussion than 4- athletes, suggesting that the 4 genotype may confer risk for poorer post-concussion outcome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26483005</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 is significantly associated with dementia and Cognitive Impairment due to Alzheimer&apos;s Disease pathology, but not with Vascular Cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26923016</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review specifically addresses the susceptibility of apolipoprotein E gene allele 4 as the plausible commonality for the etiology of co-morbidities that eventually result from periodontal diseases and ultimately progress to dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26923007</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The genotype frequency of APOE (rs429358, rs7412) in a cohort of patients with CAA-associated intracerebral hemorrhage was compared with hypertension-associated ICH, Alzheimer disease, and controls.  APOE4 frequency was higher in Alzheimer disease and CAA.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26661731</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ging, activation of peripheral circulating GSK-3beta, expression of ApoE epsilon4 and increase of olfactory score are diagnostic for the mild cognitive impairment in type 2 diabetes mellitus patients, and combination of these biomarkers can improve the diagnostic accuracy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27077117</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the pathological effects of ApoE4 in astrocytes may be mediated by impaired autophagy and by the concomitant impaired ability of the cells to remove Abeta plaques</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26923027</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest the role of the apolipoprotein-E (APOE) E4 allele as an independent risk factor for ischemic stroke and ischemic coronary heart disease among Greek patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27629735</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE status influences CSF Alzheimer&apos;s disease (AD) variables. However, the presence of APOE 4 does not appear to be a deterministic factor for the development of AD, because CSF variables have a greater influence on progression to the disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27092308</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study demonstrates one of the significant drawbacks of post hoc analyses based on APOE4 carrier status, particularly for Alzheimer&apos;s disease clinical trials: a sizeable number of such analyses are likely to yield incorrect conclusions, with no clear method for determining if any one particular trial is erroneous</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26836180</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings support the hypothesis that variants in both coding and regulatory regions of APOE may contribute to longevity in humans</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26930295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype influences cognitive function in the initial recovery period following TBI, regardless of injury severity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26898659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is required for injury-induced proliferation of neural stem cells after experimental traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25905575</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Its polymorphism does not predict late onset depression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26785975</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study confirms the maternal/newborn APOE genotype interaction influences the risk for pre-eclampsia, as well as prognosis and lipid profile.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25806651</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that two dimers of CT domain are juxtaposed around helix C3 leading to apoE3 tetramerization, and that dissociation to monomeric units is a required step in lipid binding, with helix C3 likely seeking stability via lipid interaction prior to helices C1 or C2.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26902251</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report increased intestinal cholesterol absorption and elevated serum cholesterol in families with primary hypercholesterolemia without mutations in APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26802983</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E 2 and 4 carriers have opposite aging trajectories of default mode network functional connectivity changes, primarily in the bilateral anterior cingulate cortex regions, although they both showed similar decreased functional connectivity compared with 3 homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25336599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased levels of neutrophil defensin 1, apolipoprotein E, clusterin, and zinc-alpha-2-glycoprotein are present in carotid atherosclerotic plaque secretomes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26795031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No evidence of association was found in a Tunisian population upon comparison between patients and healthy controls or upon stratification by APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26563666</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 polymorphism has no major influence on risk of aneurysmal subarachnoid haemorrhage .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26374096</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Independently or combined with APOE, LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25329009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Suggest high homocysteine, or MTHFR C677T TT in combination with the APOE-epsilon4 allele, might be associated primarily with executive dysfunctions in the elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26774227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In light of research providing controversial reports about the effect of APOE epsilon4 on memory compromise in AD, this effect remains open to debate.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26876367</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Of the six APOE genotypes, the epsilon2epsilon2 variant is associated with an increased risk for peripheral arterial disease in patients at high risk for cardiovascular disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26800308</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE variants were found to be significantly associated with autosomal dominant hypercholesterolemia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26802169</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein epsilon4 (ApoE4) is a strong genetic risk factor for sporadic Alzheimer&apos;s disease and memory decline in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27033407</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results did not show a difference in APOE gene polymorphisms between patients with moyamoya disease and healthy persons; however, they imply that APOE gene polymorphisms may play certain roles in the presence of microbleeds but not microinfarcts in patients with moyamoya disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26566210</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed that the presence of the APOE varepsilon4 allele was linked with decreased inter-hemispheric resting-state functional connectivity, which was attributed to memory performance in carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26836191</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increasing age was associated with poorer olfactory memory performance, and observed age-related deficits were further exacerbated for carriers of the APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26827650</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It is a risk factor for the development of sporadic Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26827639</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Physical activity is significantly protective for Alzheimer&apos;s disease and vascular dementia among ApoE e4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25457293</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Suggest that high plasma levels of apoE are associated with ischemic heart disease in men but not in women. Triglyceride-rich lipoproteins may partly explain these associations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26761769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evidence of a significant association was found between the ApoE epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26751679</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no association between APOE varepsilon2/varepsilon3/varepsilon4 and obstructive sleep apnoea susceptibility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26740500</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism in various neurological disorders is discussed (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26646927</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>BCHE-K is associated with a reduced risk for Alzheimer disease and Lewy body dementia whereas APOEvarepsilon4 is associated with more rapid cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26757188</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Nevertheless, the expression levels of ApoA-1, ApoC-III, and ApoE were not correlated with SCLC staging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26996551</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subjective memory complaints was associated with high Abeta burden, especially in APOEepsilon4 carriers and younger subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26639956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carrying APOE*4 alleles increases MetS in a dose-dependent manner, characterizing individual&apos;s APOE genotype might help identify at-risk subjects for preventive intervention.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26691908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>suggested that ApoE may have a role in the pathogenesis and progression of HBV-related liver disease and indicated the possible underlying mechanisms</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26823800</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE mutations may have a role in increasing the development of diabetic nephropathy among the Egyptian individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26662731</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study identified differences in task-dependent functional connectivity between APOEvarepsilon4 carriers and noncarriers during memory encoding and retrieval.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26503161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data suggest that the APOE-epsilon4 allele is protective against attention deficit and especially against poor working memory in Hepatitis C virus-infected subjects with mild liver disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26306786</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We demonstrated the benefits of a questionnaire-based approach for assessment of lifestyle risk factors to facilitate clinical interpretation of APOE genotyping genetic subgroup of dyslipidemic patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26481640</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The possession of the APOE epsilon4 allele has a small, nonsignificant effect on the presence of delirium. It seems that there is no association between APOE and the occurrence of delirium.[review; meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26901792</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study shows that the frequency of epsilon4 allele of ApoE is significantly lower among hypertensive patients on hemodialysis with the highest levels of Asymmetric dimethylarginine .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26790728</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study demonstrated ApoE4-containing astrocyte-conditioned media increases mitochondria-associated endoplasmic reticulum membranes (MAM) function relative to ApoE3; data are consistent with a role of upregulated MAM function in the pathogenesis of Alzheimer disease and may help explain the contribution of ApoE4 as a risk factor in the disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26564908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In older surgery patients free of dementia, the findings do not support the hypothesis that the ApoE genotype does not confer either risk or protection in postoperative delirium incidence, severity, or duration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26238230</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene polymorphisms associate with CVD and affect the lipid profile. The epsilon4 allele is an independent risk factor for both T2DM and CVD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26800892</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study did not find any differences in the frequencies of ApoE alleles or genotypes between febrile seizures and typically developing individuals</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26233231</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that APOE4 is associated with hypertriglyceridaemia, with a slightly increased risk for MetS, but APOE2 is associated with protection against MetS in Uyghur males in China</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26739741</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This present study revealed significant effects of the APOE promoter (rs405509) variation on cognitive performance in nondemented elderly people and explored the related topological alterations in the brain structural connectome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26314833</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26310205</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*4 is not associated with the diagnosis of bipolar disorder and does not impact the occurrence of dementia in bipolar disorder. APOE*2 was more frequent in cognitively impaired bipolar disorder patients compared to Alzheimer&apos;s disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26877211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>combined hippocampal and entorhinal cortex amyloid loads with perceptual speed in the low Braak group after adjusting for age, gender and apolipoprotein E epsilon4 status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26686670</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein APOE4 allele confers greater risk of Alzheimer&apos;s disease (AD) for women than men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26686669</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>presence of APOE epsilon4 and epsilon2 alleles was not associated with PHF-tau tangles in the absence of b-amyloid and an additional evidence that PHF-tau tangles in the absence of b-amyloid may reflect a pathologic process distinct from Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26481403</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review showed that No association between ApoE and Schizophrenia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26372448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Tissue or cellular hypoxic/ischemic injury within the globus pallidus may underlie the pathogenesis of pantothenate kinase-associated neurodegeneration due to PANK2 mutations and apoE aggregates.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26547561</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of one or more APOE E4 alleles had positive effects on spatial function and memory and object location memory.This study is the first to show that APOE E4 has a positive effect on spatial ability in young adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26581118</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study suggested that APOE polymorphism might be associated with intracranial aneurysms in Chinese population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26830841</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The interaction effect between APOE e4 genotype and hypercholesterolemia was statistically significant both in the KAROLA and ESTHER study (p = 0.021 and p = 0.017, respectively).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26495840</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with early-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26444786</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>C2238/alphaANP downregulates ApoE in vascular smooth muscle cells through type C natriuretic peptide receptor-dependent activation of Egr-1 and the consequent upregulation of miR199a.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26720342</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sporadic Abeta accumulation may be partly associated with increased amyloidogenic APP production, especially in APOE varepsilon4-negative subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26948379</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele increases the risk of Frontotemporal Dementia in ALS patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26903389</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic association studies in population in India: Data suggest there are no significant differences in distribution of APOE3 genetic polymorphisms between case/controls with/without type 2 diabetes and coronary artery disease in population studied.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26318958</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single-nucleotide polymorphisms in APOE gene is associated with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26543236</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Strong association between ApoE e4 allele and AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23038715</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of epsilon4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26958821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Higher peak velocity-reactivity in APOE epsilon4 carriers suggests vascular compensation for deleterious effects of this known risk allele for Alzheimer&apos;s disease and stroke</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27117804</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 carriers showed an inability to effectively modulate posteromedial cortex during scene, but not face and object, working memory and perception.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26552581</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results demonstrate that the impact of cerebrovascular risk on cortical thickness integrity may vary by the presence or absence of the APOE-4 allele, a well-known risk factor for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26006791</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24906966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that the apolipoprotein E (APOE) genotyping method with a flexible throughput is suitable for DNA template from different preparations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27078154</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE variants were not associated with the risk of prostate cancer or aggressive disease;; findings suggest that the mechanism of circulating cholesterol level affecting prostate cancer incidence may not rely on ApoE isoforms</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26189769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>elevated brain iron adversely impacts Alzheimer&apos;s Disease (AD) progression, brain iron elevation is a possible mechanism for APOE-epsilon4 being the major genetic risk factor for AD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25988319</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E allele e2 and genotype e2/e3 were risk factors for type 2 diabetic nephropathy (T2DN) and allele e3 and genotype e3/e3 played a protective role in T2DN</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25669588</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E genotype is a powerful risk factor for late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27065111</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 impact on brain metabolism and structure is modified by sex in a study on healthy volunteers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26397226</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4, but not epsilon2, is associated with capillary amyloid angiopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26341746</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is located in the nucleus and on the ApoD promoter in human hepatic and glioblastoma cells lines.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23715769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>1</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 allele possible risk factor for nonlesional mesial temporal lobe epilepsy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26945380</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Serum apoE is associated with long-term risk of Alzheimer&apos;s disease in the general population, independent of APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26876448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>elderly community dwelling residents of Han ethnicity carrying the APOE epsilon3/epsilon3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26998902</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neither total ApoE and ApoE4 levels nor the ApoE/ApoE4 ratio correlated with the diagnosis of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22918225</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed that women who possessed any APOE epsilon4 allele experienced a steeper decline in BMI in late life, after age 70 years, irrespective of dementia status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26402098</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that APOE and BDNF polymorphisms moderate amyloid beta-related cognitive decline in preclinical Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25288138</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we did not observe a significant association between multiple sclerosis severity score and APOE rs429358 or rs7412.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26669675</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings indicate that ApoE may be related to stress and trauma and the temporal severity of suicidal behaviour.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26519632</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This meta-analysis provides cumulative evidence that the APOE-epsilon4 allele is important to the prognosis of paediatric traumatic brain injury--{REVIEW}</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25904811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the apolipoprotein E (APOE*E4) allele predicted future depression in this Swedish population study. Suggests that the APOE*E4 allele could potentially identify people at high risk for clinically significant depression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25708227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that apolipoprotein E-genotype exerts its impact on cerebral blood flow at least partly independently from amyloid beta-deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26661143</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms was associated with antioxidant parameters in plasma or erythrocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26404360</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study suggests that the APOE epsilon 4 allele leads to a widescale impairment of brain white matter integrity, which is closely correlated with cognitive impairments</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26402101</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>present findings suggest that the effects of vitamin B12 and homocysteine on GM volume might be influenced by APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25919635</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>E3/E3 genotype may be a potential risk factor for prostate cancer and high Gleason scoring. The E4 allele maybe a risk-reducing factor for prostate cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26851028</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E regulates amyloid formation within endosomes of melanocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26387950</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no evidence of benefit of APOE epsilon4 allele on working memory</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26287823</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggested that chronic stress affects anxiety-like behavior and spatial and non-spatial memory in GFAP-ApoE transgenic mice in an ApoE isoform-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25938810</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study analyzed how age modulates the APOE genotype&apos;s influence on the volume and shape morphometrics of the hippocampus and the amygdala in both hemispheres based on a large sample of 540 subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26401700</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE gene is not.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26405973</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the APOE CpG island is differentially methylated in Alzheimer&apos;s Disease brain in a tissue- and APOE-genotype-specific manner</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26402071</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE E3 allele and the CYP2D6 rs1065852 polymorphism may provide clinically relevant information for predicting therapeutic responses to donepezil therapy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26768225</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrated that ApoE2 brain is associated with a more metabolically robust profile than both ApoE3 and ApoE4 brain, which provides a mechanistic rationale for its protective role against Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26402005</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>NO APOE genotype is associated with intelligence measures among young Chinese college students.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26574747</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study investigated olfactory functioning in homozygous varepsilon4/4 older adults diagnosed with probable Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25869786</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study identified that APOE varepsilon2/varepsilon3/varepsilon4 associated with Vascular Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25835425</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study showed that APOE genotype had no statistically significant effect on cognitive response to donepezil treatment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26402762</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic association study in population in United States: Data suggest that there is no association between genetic polymorphisms in ApoE and metabolic syndrome; data are from multicenter population-based study of predominantly White US men/women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25656378</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Studied and id&apos;d proteins differentially abundant in current smokers vs. ex-smokers &amp; never smokers; results demonstrated an increase of APOE in current smokers as compared to both never and ex-smokers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26058877</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results suggest that Abeta and APOE epsilon4 interact to increase the rate of cognitive decline in CN older adults and provide further support for the use of Abeta and APOE epsilon4 as biomarkers of early Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26430784</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>rs4420638 polymorphism of APOE significantly increases the risk of coronary heart disease(OR = 1.18, 95%CI = 1.14-1.22, P &lt; 0.0001, fixed-effect method)(Meta-Analysis)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26535656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>significant differences were observed according to APOE gene polymorphism in correlations between LDL/HDL and CHOL/HDL ratios, and results in the processing speed and reaction time, as well as between the BMI and results in processing speed in the postmenopausal women examined</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26094530</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carriers showed steeper hippocampal volume reductions with Alzheimer&apos;s disease progression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26239178</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association between the frequency of ApoE-varepsilon4 and the occurrence of depression was found in patients undergoing hemodialysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25707516</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Considering biological markers such as degree of White Matter Hyperintensity and APOE epsilon4 status may be clinically relevant to predicting progression of geriatric depressive symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26340080</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The interaction of BDNF and APOE has significant effect on Alzheimer&apos;s disease (AD). Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25853819</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The clustered methylation and dihydroxylation of plasma ApoE proteins may play a role in breast cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26079612</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variants near APOE is associated with dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26375028</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE polymorphism did not modify the onset of strokes or migraine in our CADASIL sample</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25819272</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Taken together, our study suggests that aging facilitates lesion development in apoE(-/-) mice with greater effect on male mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26592663</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The polymorphisms rs662799 near APOA5 and rs769450 in APOE had significant association with metabolic syndrome X and its components in Korean males.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26365620</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest a modifying influence of APOE varepsilon2 on white matter hyperintensity volume caused by CADASIL .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25920955</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE status did not affect change in depressive symptoms in response to physical activity intervention in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26980363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The blood-brain barrier is damaged in Alzheimer&apos;s disease, particularly in individuals carrying apolipoprotein E4 (APOE4) gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25757756</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that several PTSD-like behavioral, cognitive, and neuroendocrine alterations are more pronounced in mice expressing human E2</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25857685</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism is associated with obstructive Sleep Apnea.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26284518</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lower white matter integrity may represent one of several mechanisms through which APOE affects perceptual speed performance in elderly persons free of dementia and preclinical dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26252210</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriers present both increased and decreased functional connectivity in default mode network, which is correlated with clinical cognitive performances.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26177270</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report increased risk of dementia in APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26586657</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE and amyloid beta peptide complex formation and domain interaction interface</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25546376</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A meta-analysis supported a genetic association between APOE gene and coronary heart disease (CHD). epsilon4 increased the risk of CHD, whereas epsilon2 decreased the risk of CHD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25963363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Healthy APOE epsilon4 carriers until the age of 65 years do not experience significantly different rates of cell division, cytotoxicity, and chromosomal DNA damage when compared with non-APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25820038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>possible effects of the APOE epsilon4 allele on memory and executive functioning (EF); a lower executive functioning performance in cognitively intact older APOE epsilon4 allele carriers might be related to an early Alzheimer&apos;s dementia prodrome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25365563</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26717353</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26130946</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Studies indicate that apolipoprotein E E2, E3 and E4 exhibit differences in lipid binding, integrating into lipoprotein particles and affinity for lipoprotein receptors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26427386</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE, VHL and MTHFR gene polymorphisms were related to the risk of renal cell carcinoma</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26191297</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested APOE polymorphisms may affect neuron apoptosis after mechanical injury through different influences on intracellular calcium levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26073697</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E (APOE) epsilon4 allele has been implicated in a range of neuropsychiatric conditions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25709077</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25968937</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that ApoE4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25585996</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the organization of metabolic network in APOE epsilon4 carriers indicated a less optimal pattern and APOE epsilon4 might be a risk factor for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26161964</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 allele is not associated with migraine susceptibility, but is positively related to headache [meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26264634</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 genotype was not directly associated with HIV-associated neurocognitive disorder, but moderated CSF levels of Abeta1-42 in a minority of participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25880550</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among those with one or more APOE epsilon4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26102276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphisms associated with risk of primary hyperuricemia in Uygur men</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25890021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Children with cerebral palsy were more likely than expected to carry the APOEepsilon3 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25596901</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The absence of a depression by APOE interaction on cognitive abilities suggests that these synergistic effects only operate at the level of cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26035038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results of this exploratory investigation suggest that an APP SNP and an APH1B SNP are marginally associated with PD CSF Abeta42 levels in APOE varepsilon4 noncarriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25808939</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Epilepsy, impaired fine motor function and gastrostomy tube feeding were less common in cerebral palsy children with single nucleotide polymorphisms in the APOE or TOMM40 genes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25703783</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The joint presence of APOE epsilon4 and elevated systolic blood pressure, even at prehypertensive levels, is associated with lower cognitive performance in healthy, middle-aged adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25730733</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human schistosomiasis causes dyslipidemia and the associated changes in plasma lipid and lipoprotein levels depend on APOE gene polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25051269</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>MRI measures of medial temporal atrophy, ApoE-varepsilon4 genotype, and the protective effects of higher CR all predict the time to onset of symptoms associated with MCI in a largely independent, additive manner during the preclinical phase of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25879865</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate apolipoprotein E (ApoE) and two isoforms of vitamin D binding protein (DBP) as biomarkers to subdivide the multiple sclerosis (MS) patients into subgroups correlated with clinical classification.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26046356</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>relationships between ApoE gene polymorphism and coronary heart disease in Asian populations[review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26142535</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis showed no association between Alzheimer&apos;s disease and the PPARgamma G allele in any of the study subjects with or without the APOE epsilon4 allele. (Meta-analysis)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26125935</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CREB enhances KLF4 up-regulatory effect on apoE promoter.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26546821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between APOE and depression to be dependent on timing of depression onset.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25670333</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In carriers of the apolipoprotein E (APOE) genotype epsilon3/epsilon3 or epsilon3/epsilon4, the presence of a very long (VL) polyT repeat allele in (TOMM40) was less frequent in patients with sporadic inclusion body myositis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25670332</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data show how FH interacts with apoE molecules via domains 5-7 and regulates alternative pathway activation on plasma HDL particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26468283</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 allele has a role in modulating the immediate impact of acute exercise on prefrontal function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25218559</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the possible involvement of ApoE epsilon4 in BDNF metabolism might be another molecular mechanism underlying the contribution of ApoE epsilon4 to the development of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24986007</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The rest-stimulus interaction improved the detectability of network integrity changes in apolipoprotein E-epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26053677</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis indicates APOE epsilon4 is associated with the poor long-term functional outcome of patients with traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26579811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study measured small-vessel cerebrovascular reactivity to carbon dioxide (CO2-CVR) to characterize the effect of APOE on cerebral vasculature, and assessed the contribution of CO2-CVR to the pattern of APOE-related differences in the BOLD signal</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25160043</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-4 is associated with decreased problems in snoring and sleep apnea, in non-demented older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26314507</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The result also shows that Apolipoprotein E4 induces the aggregation of ABETA 42 more specifically and rapidly than that of ABETA 40.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25982728</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms were not linked to the influence of cognitive reserve on cognitive function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26125153</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that the Apo E4 allele could confer genetic susceptibility for the development of gallstone disease among the Mexican population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26019038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In conclusion, ApoE polymorphisms were not associated with lipodystrophy in patients undergoing antiretroviral therapy but influenced lipid alteration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25420659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The -491 T allele of APOE polymorphism may be associated with a risk of POAG occurrence in the Polish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24073598</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We report an association between APOE4 and neurocognitive function five years following cardiac surgery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25744138</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The aim of this study was to explore the main and interaction effects of the APOE polymorphisms on treatment efficacy and cognitive side effects of electroconvulsive therapy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25148110</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The main finding is a strong negative association between the presence of APOE epsilon4 allele and memory dimension in the mini-mental state examination.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25132317</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 risk for prevalent amnestic mild cognitive impairment varies depending on the definition of objective neuropsychological impairment for MCI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25497326</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Higher metabolism in higher (compared to lower) educated APOE epsilon4 carriers was found in brain regions that sustain episodic memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26408498</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The combination of PCSK9 E670G and APOE polymorphisms may represent an independent factor for the determination of lipid levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25899039</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No statistically significant difference was detected either in APOE or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26738354</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Frequency of APOE E4 allele was higher in Alzheimer disease than controls, supporting its use as a biomarker.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26738348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>BDNF, APOE, and HSP70-1 genes, but not GRIN2B, might be associated with a risk of POAG occurrence in the Polish population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25893192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>more than one-third of APOE4 noncarriers with the primary clinical diagnosis of mild to moderate Alzheimer dementia had minimal Abeta plaque accumulation in the cerebral cortex</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26302353</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon2/epsilon3 genotype likely provided a protective effect against depression in the overall population and the epsilon2 allele acted as a protective factor for depression in the Caucasian population--{REVIEW}</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25979253</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated levels of TOMM40 and APOE transcripts found in the brains of late-onset Alzheimer&apos;s disease-affected individuals compared with unaffected control brains</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24439168</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E alleles might influence improvement in lipid profiles after diet and exercise interventions</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25870958</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Omega 3 PUFAs content in HDL and LDL were not APOE isoform-dependent in young participants. However, young E4+ participants already had a tendency toward lower baseline-DHA levels in LDL particles as well as a more atherogenic omega-6/omega-3 PUFA ratio in LDL...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25933487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25751510</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene polymorphism was associated with a risk for cerebral infarction in a Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25730003</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed APOE genotypic effects on the cognitive profile and hippocampal structural and functional characteristics in patients at early stages of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25624419</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of the APOE-epsilon4 allele has become firmly established as a risk factor for the incidence of late-onset Alzheimer&apos;s Disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25826114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results highlight the complex role of the e4 allele in genetic susceptibility to health span.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25482294</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>mild cognitive impairment APOE-epsilon-4 carriers showed a significant increase in relative power within a 4.5-6.5 Hz frequency range in the superior frontal gyrus resting state</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25079806</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism and risk of coronary stenosis in Pakistani population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25883965</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings of a strongly increased dementia mortality risk for ApoE epsilon4 carriers and the protective effect for epsilon2 carriers are in line with other reports using clinical dementia diagnoses as end point.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26088392</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A study of APOE gene polymorphisms in participants of the ERJ showed that the presence of the epsilon4 allele was more prevalent in young individuals with repeatedly abnormal lipid variables during longitudinal follow-up (tracking effect).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26131702</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CYP7A1 and APOE isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26333513</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study showed that APOE4 carrier participants with mild cognitive impairment had decreased walking speed compared with non-carrier participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24730603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed how APOE2 provokes and APOE4 inhibits the cardinal Age-Related Macular Degeneration features, inflammation, degeneration, and exaggerated neovascularization.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26446211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that cognitively normal elderly APOEepsilon4 carriers already exhibit topological alterations in both white matter and functional brain networks</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25403724</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 affects brain function and suggest that inhibition of PKR is a way to restore memory impairment in early stages of sporadic Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26400930</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CETP TaqIB and ApoE polymorphisms may not be considered as genetic risk factors for MetS in a Southern Thai population. epsilon4 allele, associated with one metabolic component, low HDL-C levels, might predispose the subjects to develop metabolic disturbances.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26014924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study demonstrated the profound effects of APOE4 on both cognitive performance and intrinsic functional brain networks in patients with Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25619771</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results off this study showed that apoE4 mice performed worse than apoE2 and apoE3 carriers in the acquisition period of the spatial task, and that apoE2 mice had poorer retention than the other two genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25747767</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE status appears to be associated with functional alterations in regions related to Alzheimer disease before behavioral differences can be detected</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25666727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PVRL2, TOMM40 and APOE might be associated with human longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24924924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This report significant differences in the genotype distribution for APOE epsilon-4 and epsilon-2 between South African individuals with and without a family history of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25731628</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that novel loci are associated with AD(Alzheimer disease) in APOE epsilon4 non-carriers. This study indicates the distinct genetic risk genes for AD non-carrying APOE epsilon4 and provides new insight into the molecular mechanisms of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25731621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Specific APOE genotypes are associated with OSAS in a high-risk population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25613112</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We observed that cell-to-cell HCV viral spread was compromised after ApoE interference in donor but not in acceptor hepatocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26202245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epistasis study indicated significant association between ApoE and MTHFR polymorphisms and hypertension</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25055800</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant association between APOE genotype and overall risk of colorectal neoplasms(CRN), however, persons with APOE epsilon4 genotype have significant decreased risk of suffering from proximal, but not distal CRNs.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25029444</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we found no difference in total APOE, APOE-005 or the common isoform, APOE-001, between AD cases and controls. Our findings are consistent with ApoE acting largely at the protein level to increase the risk for sporadic AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24996286</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study supports the possibility of a beneficial effect of rs429358 and APOE epsilon4 allele on cognition in subsets of the general population, specifically in the oldest men and suggests rs429358, and not the combination of other polymorphisms, may underlie the effect of the APOE epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25085564</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Children with a GH deficiency carrying apoE4 had higher baseline LDL-C concentrations and experienced a greater reduction in LDL-C after GH replacement therapy than those without apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26120788</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that ApoE effects on white-matter microstructure are less abundant than has been suggested in some previous studies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24506254</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation, which is associated with an inability to initiate differentiation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26201081</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Alzheimer&apos;s patients, higher DNA methylation levels were associated with the presence of APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25452147</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of the APOE epsilon4 allele with brain volume loss was demonstrable only in Chinese participants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25738563</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone than women with genotypes without ApoE4, which indicates higher potential fertility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25673673</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate few effects of BDE-209 during development, while the vulnerability conferred by the apoE genotype may vary depending on age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25193018</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the Czech population studied, ApoE genetic variations were not associated with susceptibility to CP or the presence of periodontopathic bacteria.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25545672</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results provide tentative evidence that APOE genotype moderates the association between high blood pressure and cognitive decline in later life.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25672766</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>beta-amyloid positivity coupled with APOE varepsilon4 was associated with moderately increased decline in memory</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25559335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this Scandinavian autopsy study shows that the apoE polymorphism is associated with the probability of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25898889</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is associated with recurrent Inrtacerebral hemorrhage in nonlobar brain regions. No associations were identified between APOE e2 and recurrent nonlobar ICH.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26115730</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Two genetic risk factors for late onset Alzheimer&apos;s disease are in the apolipoprotein-e and translocase of outer mitochondrial membrane 40 (TOMM40) gene poly-T repeat loci.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25247594</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE genotype modifies the relation between adiposity and plasma lipid levels in patients with vascular disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24946908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is a strong genetic risk factor for dementia with Lewy bodies, confirming previous findings.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24973356</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 genotype, parental family history of Alzheimer&apos;s disease, age, and sex are all associated with microstructural white matter differences in late middle-aged adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24936424</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It was confirmed that apoE gene polymorphism e4 allele is one of genetic determinants responsible for the development of insulin resistance and metabolic syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24879316</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE expression attenuated intracellular trafficking of APP and Alcbeta</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26213366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE2 was significantly overrepresented in stillbirths but APOE genotype did not correlate with neuropathological findings.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25617864</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-HhaI polymorphism is not associated with age-related macular degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25945528</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 is a risk allele, and apoE epsilon3 is protective against the development of Alzheimer&apos;s disease in the Chinese population. (Meta-analysis)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24632849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 reduces brain insulin signaling and glucose level leading to higher insulin content.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24435134</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that APOE genotype (homozygote vs. heterozygote for APOE4) and overweight (indicated by body mass index) are important variables that determine the plasma long-chain PUFA response to dietary fat manipulation (fish oil supplementation).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26085515</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings add to the growing evidence that effects of APOE epsilon4 on hippocampal size begin early in life, underscoring the importance of early interventions to increase reserve</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24929969</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE c.109G&gt;A genetic polymorphism might influence the development of hemodialysis and could be a risk factor for assessing hemodialysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25565166</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Obesity favors apolipoprotein E- and C-III-containing high density lipoprotein subfractions associated with risk of heart disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24966274</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The frequency of the APOE E 2 allele (158Cys) was higher in patients with endometrial hyperplasia + endometrial carcinoma than in controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25741405</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association has been found between Apo E4 alleles, HIV infection, age, neuropsychological outcome, or death.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25388225</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that methylation may be a potential mechanistic explanation for APOE functions related to aging and call for further molecular mechanistic studies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25476875</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genetic variation impacts HDL-cholesterol and triglycerides in addition to affecting LDL-cholesterol</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25502880</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism is associated with risk of developing inflammatory bowel disease and early age of onset in Saudi patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25624723</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we have found a novel relationship between ApoE 4 homozygosity and swallowing dysfunction in an otherwise healthy older popula- tion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24261350</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 genotype specifically modulates astrocyte secretion of potent microglial chemotactic agents, including CCL3</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25092803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our meta-analysis supports that the apolipoprotein E epsilon2 allele and acetyl-CoA carboxylase beta rs2268388 C&gt;T might act as promotion factors of nephropathy in type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25262148</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>20</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is significant association of APOE4 allele observed with the development of coronary artery disease in Indian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24407534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It plays predictive and modifying roles in normal cognitive aging, mild cognitive impairment, and Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25107496</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>increasing apoE2 in APOE4 carriers is a beneficial strategy to treat Alzheimer&apos;s disease, whereas increasing apoE4 in APOE4 carriers is likely harmful</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25871773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is a strong risk factor of Alzheimer&apos;s Disease risk in Chinese Han population, and APOE epsilon4epsilon4 genotype might be related to the AAO of late-onset AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25673977</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The different conformational organizations of the N- and C-terminal domains have a minor effect on the steady-state lipid-binding behavior of apoE3 and apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25281910</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that epigenetic control of APOA1 expression and DNA methylation levels are associated with episodic memory performance in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25261444</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 may facilitate HHV-6B reactivation, DNA replication, virus protein expression and increase seizure frequency in mesial temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25576704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carrying the rs8702 C KLC1 allele was associated with a decreased cortical cataract risk among individuals devoid of the APOE4 allele, whereas it has no significant effect among APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25883527</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Seven highly conserved regions, representing approximately 47 amino acids (of 299) have been found. These regions are distributed throughout the protein and reflect ligand binding sites.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25377861</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>remarkable association especially between the -1131C Apo A5 variant and increased tPA levels in asymptomatic dyslipidemic patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24815086</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data suggest a role of the APOE genotype as a disease-modifying factor in patients with late-onset Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24646656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results suggest that elastase-like proteases in the microglial cells surrounding Abeta plaques are responsible for ApoE degradation in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25956321</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subretinal mononuclear phagocytes in age-related macular degeneration patients accumulate on the retinal pigment epithelium and express high levels of APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25604058</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE inhibits cerebrovascular pericyte mobility through a RhoA-mediated pathway</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25903128</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 was associate with decreased cognitive functioning in breast cancer patients treated with adjuvant chemotherapy. This was moderated by smoking history, that is, patients without a smoking history had significantly lower performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24789331</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE SNP is significantly associated with late onset Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25022885</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a possible effect of APOEepsilon4 on early apoptosis via inhibiting Ik(DR) following injury which may adversely affect the outcome of traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25773779</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that APOE, DBP and AGT identified were associated with survival outcomes in metastatic colorectal cancer patients treated with chemotherapy and bevacizumab.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25428203</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carrying the APOEepsilon2 allele may imply developing a clinically and pathologically milder form of Alzheimer&apos;s.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25623662</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 increases the risk of beta-amyloid deposition in primary progressive aphasia and progressive speech apraxia but does not influence regional beta-amyloid distribution or severity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24985533</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25440562</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25256133</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Authors summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2. [Review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25358504</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is associated with increased parietal lobe white matter.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25304991</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E4 carrier status is associated with a steeper cognitive decline in a Korean population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25530658</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggests that the APOE gene does not have a significant effect in ALS aetiopathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24918518</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PON1 and ApoE4 genes showed synergistic epistasis, increasing the odds of having both Alzheimer disease and vascular dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24965284</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E2/E2 genotype is a potential genetic risk factor for vertebral fractures in humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24880936</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s patients with the epsilon4 allele have a worse response to cholinesterase inhibitors treatment than those without the epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24951635</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>When Abeta was co-treated with each apoE isoform, Abeta-induced shedding was reduced with apoE2 and apoE3. Lipoprotein receptor shedding in the presence of apoE4 increased. ApoE4 appears less efficient than other isoforms in regulating LDLR shedding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25015123</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest that the APOE epsilon4 and epsilon2 alleles have the opposing effects on brain morphology across the spectrum of cognitive aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25114090</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>End-stage renal disease patients who are e4 and e2 allele carriers are more likely to present an atherogenic lipoprotein profile.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25155022</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that ApoE2 protein abundance, coupled with its inability to bind to low-density lipoprotein receptors, may act to increase amyloid-beta (Ab) clearance</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24492349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE 2 allele is an independent risk factor for ulcerated carotid plaque</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24846706</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>cognitive function in postmenopausal women with breast cancer is modified by APOE genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25355028</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between ApoE gene and cardiovascular disease may be modulated by the presence of metabolic syndrome (MetS), with an increased cardiovascular burden observed among E4 allele carriers with the syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25413697</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest Alzheimer&apos;s disease and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE epsilon4 carrier</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24613704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effectiveness of treatment with donepezil hydrochloride for elderly dpatients with dementia is more pronounce in epsilon4 allele carriers compared with epsilon3/epsilon3 group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25796815</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>All genotypes of ApoE epsilon4 allele, that is, epsilon2/4, epsilon3/4, and epsilon4/4, are associated with an increased risk of AD, whereas ApoE epsilon2/2, epsilon2/3, and epsilon3/3 are protective for AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25551132</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Amphipathic alpha-helices in ApoB and ApoE are crucial to the formation of infectious hepatitis C virus particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25502789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms were associated with a requirement for lower warfarin dose for thrombosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25312789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid profiles were not increased after Paliperidone treatment under the control of ApoE gene polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25085446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study casts doubt on the role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25369462</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Kyoto mutation was found in a new Chinese patient with Lipoprotein glomerulopathy, accompanied by Cys112Arg</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25300642</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-epsilon2epsilon3 genotype and the APOE-epsilon2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon2 allele have a higher risk of hyperuricemia than non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25356596</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is a potential indicator of metastatic lung adenocarcinoma; secretomes may offer a valuable resource for biomarkers of lung adenocarcinoma with lymph node metastases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25098600</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Thus, ClfA recruitment of serum ApoE to the Staphylococcus aureus surface may sequester ApoE and blunt its host defence function against Staphylococcus aureus-invasive infections to humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25878259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>trait-specific genetic risk scores are robustly associated with 10-yr changes in lipid levels and three individual SNPs in APOE, TRIB1, and APOA1 were strongly associated with 10-yr changes in lipid levels</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24922540</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The - 491A genotype of APOE promoter was a risk factor predisposing spontaneous subarachnoid hemorrhage patients to rebleeding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25752291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 gene may be responsible for up to 45% of the genetic component of the Alzheimer&apos;s disease, and may act as a discriminator between Alzheimer&apos;s disease and vascular dementia as well.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24678786</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Compound heterozygotes for a novel mutation, apo E1 Nagoya (Arg142Ser) and Apo E2 (Arg158Cys) is associated with severe type III hyperlipoproteinemia and familial hypercholesterolemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24953047</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was a synergistic interaction between depression or apathy and APOE epsilon4 in elevated risk for incident dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25653291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25268647</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic polymorphism is associated with acenocoumarol treatment safety in patients with atrial fibrillation or venous thromboembolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24919870</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The detrimental effects of vascular risk factors on white matter microstructure were exacerbated among APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25672924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic analysis revealed that the Alzheimer disease groups (AD, limbis system-AD, and Hippocampual Sclerosis-AD) were more likely to be APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24899141</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings indicate that decreased glucose metabolism in the temporoparietal junction associated with APOE epsilon4 is mediated by Amyloid beta deposition, and the effect of APOE epsilon4 on hypermetabolism in the frontal and temporal regions is independent of Ab.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24495404</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study reveals complex ApoE- and gender-dependent effects on synaptic function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24810422</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association of epsilon4 allele with longevity varies among birth cohorts</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24809632</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results support the reduction in association of APOE-e4 with dementia in extreme old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24731780</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Together, these data indicate that hepatitis C virus hijacks apolipoprotein E to initiate its interaction with specific heparan sulfate structures.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25609801</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that genetic variations in one of the sequences regulating the expression of APOE, may be associated with worse clinical outcome in children with cerebral palsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24786335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Spatial navigation deficits worsened in a dose-dependent manner as a function of APOE epsilon4 status. This was at least partially due to differences in right hippocampal volume.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24749727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Development of diabetic nephropathy is associated with APO E polymorphisms in Asian populations, especially in East Asians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25196797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>low content of apoE in blood can be considered as a predictor of increasing of ratio apoB/apoA-1 in healthy persons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25872266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We did not identify new genome-wide significant associations with longevity and did not replicate earlier findings except for APOE and FOXO3. Meta-analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25199915</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25197062</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In patients with neovascular age-related macular degeneration, the presence of the epsilon2 allele of the APOE gene was associated with having intraretinal fluid at baseline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25077528</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphisms are not associated with the development of complications from dopaminergic replacement therapy in Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24625478</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E (APOE) epsilon4 allele may be associated with microvascular brain injury in hypertensive older adults even in the absence of clinical Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25688603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon4 allele of ApoE is a risk factor for the development of MI and the epsilon2 allele of ApoE is a protective factor in the development of MI</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25111308</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>demonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24709297</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study showed higher conversion to Alzheimer&apos;s disease (AD) in MCI epsilon4 carriers than in non epsilon4 carriers. These</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21411037</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings of this study suggest APOE may be a &quot;plasticity&quot; gene that makes individuals more or less amenable to the influence of protective factors such as cognitively-stimulating lifestyle activities.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24867440</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study did not confirm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25304313</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings suggest TBI is associated with long-term cognitive impairment and decline across the adult lifespan. A role for APOE genotype was apparent in the younger but no evidence that it is associated with impairment in early old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24670469</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested an important role for the APOE promoter polymorphism in the human brain and also provide valuable insights into how the rs405509 genotype shapes the neural system to modulate the risk of developing AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25632120</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>While there were no differences in cognitive performance between participants with and those without metabolic syndrome, ApoE and CYP46 genotypes did correlate with mental manipulation scores.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24924840</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE has little influence on physical capability. In addition, other LDL-C-related genotypes have little impact on these traits.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25073452</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carriers may be more vulnerable to the insults of poor glycemic control.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24875283</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Alzheimer&apos;s disease APOE genotype was the risk factor for apraxia.The presence of apraxia in AD is related to APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24603451</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype does not alter postprandial serum levels of lipoproteins after intake of omega-3 fatty acids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25227179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24595593</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Influence of APOE genotype on whole-brain functional networks in cognitively normal elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24349461</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>REVIEW: APOE contributes to Aalzheimer Disease pathogenesis through both amyloid-beta (Abeta)-dependent and Abeta-independent pathways.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24821312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data suggest that apoE and apoA5 variants have an effect on hemostatic parameters, but they neither influence nor predict cognitive performance in non-demented individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25073959</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Found no correlation between BMI and apo E polymorphisms in male coronary heart disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24402318</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24838911</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE haplotypes, marital status and history of depression were the most important factors to influence the age of Alzheimer disease onset in this sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25591674</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>hypertension moderated the effects of APOE epsilon4 on the rate of change for cognitive flexibility, such that the presence of the APOE epsilon4 allele and hypertension was associated with steeper cognitive decline over a 21-year period</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24956008</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Profound divergences were observed between APOE genotypes at the cerebrovascular interface, suggesting that APOE4-induced blood-brain barrier anomalies may contribute to Alzheimer&apos;s disease development.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25335802</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Female APOE epsilon4 carriers showed overall significantly reduced functional connectivity between the hippocampus and precuneus/posterior cingulate cortex in healthy adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24814213</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Low plasma levels of apoE are associated with increased risk of future dementia in the general population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25469919</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>human-apoE-isoform-dependent differences modulate the cellular uptake of Abeta mediated by LR11/SorLA</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25482438</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variants of MAPT and SNCA were not associated with, but APOE epsilon4 allele was only associated with, lower performance on word list learning and semantic verbal fluency</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25178429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report systemic changes in metabolite levels in plasma from APOE knockout mice with disturbed blood flow due to carotid ligation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25377480</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that the E (APOE) E4 allele may serve as a genetic marker for susceptibility to higher lipid profiles in the Guangxi Zhuang children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22016612</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows that the levels of hippocampal ApoE receptors Lrp1 and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24251389</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found significant morphological deformation in APOE e4 carriers relative to noncarriers in the entire cohort as well as in the nondemented (pooled MCI and control) subjects, and this effect was more pronounced in e4 homozygotes than heterozygotes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24453132</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant associations (P value, &gt; 0.05) were observed between the N-acetyltransferase 2 or apolipoprotein E gene polymorphisms and any hearing factor.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25155015</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no systematic differences in QAlb between ApoE genotypes within the present study. Increased QAlb levels were shown for those without E3 allele in the subgroup of CJD patients when assuming a dominant genetic model</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24386372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Depressive symptoms predict time to conversion to Mild Cognitive Impairment in cognitively normal people who do not carry the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23611364</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that BDE-209 impaired cued fear conditioning in apoE2 and apoE3 mice, but not in mice carrying apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24857698</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Authors demonstrate that ApoE interacts with the hepatitis C virus envelope glycoproteins, most notably E2.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25122793</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Its genotype has a unique impact on cortical glucose metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24702820</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data confirm an increased susceptibility of mild cognitive impairment patients with APOE epsilon4 to develop dementia, show an association between functional and anatomic impairment of the cerebral vessels and APOE epsilon4+ genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24625799</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE alleles might be genetic modifiers for spinocerebellar ataxia or Machado-Joseph disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24746364</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apoe gene polymorphism is risk of Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24504617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Computational design of apolipoprotein E4 inhibitors for Alzheimer&apos;s disease therapy from traditional Chinese medicine.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24967370</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele conferred an increased risk of Alzheimer disease (odds ratio 2.91). There was also a synergistic interaction with the CTSD T allele leading to a 6.25-fold increased risk of the disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24281128</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate that swainsonine alters leukocyte profiles in apolipoprotein E (ApoE) knockout mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24674240</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A detrimental effect of endogenously produced apoE4 on GABAergic interneurons leads to learning and memory deficits.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25319703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A relationship was found between APOE and brain connectivity and as a synaptic modulator in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25319693</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Age and APOE 4 genotype were associated with higher cerebral uptake of the amyloid tracer 11C-PIB; in this sample of cognitively healthy elderly individuals, men exhibited higher 11C-PIB uptake than women</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24603945</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest APOE genotype-dependent differences in L-carnitine synthesis or metabolism along Alzheimer&apos;s disease, and insinuate that L-carnitine treatments would be more beneficial for Alzheimer&apos;s disease patients not carrying the APOE4 isoform</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24595197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E (APOE) genotype and sleep apnea severity affect atherogenic dyslipidemia in patients with obstructive sleep apnea</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24232699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that nondemented APOE epsilon4 allele carriers with memory complaints may have a greater genetic risk for Alzheimer&apos;s disease and should be monitored more closely.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24914687</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon2 allele is associated with worse early ND outcomes after cardiac surgery in neonates and infants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25282659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study is the first to show that the ApoE-epsilon4 allele is directly associated with altered 3D profiles of longitudinal ventricular expansion rates and lateral ventricle surface morphology, both in dementia and in normal aging.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24411483</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this large population-based study in children, we did not find any significant association between single locus of the four common ApoE polymorphisms (-491A/T, -427T/C, -219T/G, and epsilon2/3/4) and MR or borderline MR.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24790992</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Certain APOE alleles and genotypes are associated with risk of psoriasis while others are protective for psoriasis in Saudis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24782577</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOEepsilon4 allele was associated with a significantly increased POCD risk about 1-week postsurgery, but the association depended on one large study. No association was found 1-3 months and 1-year postsurgery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24168388</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study support the compensatory recruitment hypothesis in older APOE varepsilon4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24193893</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE epsilon4 allele may be a risk factor for CHD in the Chinese population, however, epsilon2 allele has no significant association.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24755673</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that ovarian hormones differentially modulate synaptic integrity in an apoE-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24732142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele drives atrophy to the medial-temporal lobe region in AD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24878738</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24746514</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24751902</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 allele may be used as a biomarker in predicting the prognosis of traumatic brain injury patients.[meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24475734</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24887584</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoEepsilon4 carrier status enhances sporadic Alzheimer disease risk in a Chinese population with a ABCA7 genetic polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24113560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>review to understand the type of APOE mutations associated with lipoprotein glomerulopathy by comparing the differences in disease caused by a variety of APOE mutations with those of type III hyperlipoproteinemia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24570178</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of APOE epsilon4 with cognitive decline was lower in obese participants compared with normal BMI participants. Cognitive decline in obese participants with APOE epsilon4 was not significantly different from normal BMI participants without APOE epsilon4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24145695</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE [epsilon]4 carriers and noncarriers were affected differentially by ChEI treatment with respect to rs-fcMRI measures of resting state network integrity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24830360</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Based on the results of large-scale cohorts, family-based study, and meta-analyses, the e2 allele of the APOE polymorphism is considered to be associated with genetic susceptibility to the development and progression of diabetic nephropathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24026386</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data suggest that ApoE might be a candidate to influence exceptional longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24534555</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4 delays total dendritic spine formation and may induce early synaptic dysfunction</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24328732</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data indicate that APOE genotype had a modest impact on the postprandial response to meals of varying fat composition in normolipidemic men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25332476</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the polymorphism at the +2836 G&gt;A site in the apoE gene is strongly correlated with the susceptibility to essential hypertension in the Chinese Hui ethnic population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24634178</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E, gender, and Alzheimer&apos;s disease; review of previous literature on the APOE4 by gender interaction with a particular focus on imaging-related studies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24293121</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genetic variants correlate with specific aspects of cognitive impairment in Alzheimer&apos;s disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24530172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that APOE epsilon4 has a moderate effect on white matter (WM) integrity in healthy controls, but no effect on WM integrity in manifest Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23706516</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased levels of OxLDL are not associated with the risk of dementia, AD, and vascular dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24680324</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrate an interaction between APOE genotype and age in cross-sectional and longitudinal cognitive and morphometric manifestations of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23896613</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these data support a role for the proteolytic cleavage of apoE in the Vascular dementia and support previous reports that APOE polymorphism is significantly associated with susceptibility in this disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24696712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present findings revealed a subgroup at increased risk for cognitive decline (APOE epsilon4 carriers with midlife exposure to vascular risk factors)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23601373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study found that CSF Apo-E protein levels are decreased in association with neuronal damage, as measured by t-tau, in cognitively impaired subjects compared to cognitively normal subjects and that baseline CSF Apo-E levels are associated with cognitive decline and brain atrophy which is independent of CSF t-tau/Abeta1-42 ratio</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24385135</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings showed that association of depressive symptoms on cognitive decline was increased among participants with one or more copies of the APOE epsilon4 allele compared with those without the allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24434953</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the established association of APOE 4 with dementia was confirmed the first time in a Pakistani sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24746929</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 is associated with enhanced in vivo innate immune responses in human subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24655576</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23831342</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings show is no difference in total ApoE levels in plasma or CSF between Alzheimer&apos;s disease (AD) patients and non-AD individuals; CSF ApoE levels correlate positively to both tau and Abeta of which the latter findingwas evident in APOE epsilon4 carriers only</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24633805</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study found the -419T allele frequency was significantly higher in the Alzheimer&apos;s disease (AD)patients group than in the controls group and may possibly constitute a significant risk factor for AD. The APOE epsilon4 allele did not influence the distribution of the -491 polymorphism after stratification</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24326531</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE does not appear to be related in a direct way to the developmental sequelae of white or gray matter injury in extremely preterm infants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24503939</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon variants constitute strong risk factors for lobar warfarin-related intracerebral hemorrhage</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25150286</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE-epsilon4 non-carriers are protected from the detrimental affects of Alzheimer&apos;s disease on cortical thickness and neuropsychiatric symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24479631</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE locus association in frontotemporal dementia were eventually diagnosed as &quot;frontal variants&quot; of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24359501</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It is an Alzheimer-disease susceptibility gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24508314</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 alelle of the apolipoprotein E gene is known to be a key genetic risk factor for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24118648</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study is the first to establish a relationship between APOE epsilon4 and concomitant Alzheimer disease and stroke in the Tunisian</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23871727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrate that the apoE-LDLR interaction affects regional brain apoE levels, brain cholesterol, and cognitive function in an apoE isoform-dependent manner</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24412220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated combined influence of APOE and CLU genotype on brain activity long before frank AD symptoms arise, and indicate executive attention as a neural marker of AD genetic risk in young people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24388797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Its allele is strongly associated with increased risk of cognitive impairments in older adulthood. There is also a possible link to enhanced cognitive performance and the APOE e4 allele may constitute an example of antagonistic pleiotropy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24582638</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Its allele may interact with testosterone and moderate the hormone&apos;s association with cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24444806</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest functional alterations in the episodic memory network are modulated by the apolipoprotein E epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24296331</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results confirm the association of APOE with Abeta deposition and represent the largest known effect of BCHE on an AD-related phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23419831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TAM treatment induced similar plasma triglyceride increases in patients with positive or negative APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23828408</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrate that brain activation in the medial temporal lobe during memory processing is additively decreased by the presence of the APOE epsilon4 and the BDNF Met alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24321557</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggests that the epsilon2 allele suppresses the initiation of alzheimer disease development by lowering the cholesterol levels in synaptic membranes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24446209</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE variants constitute risk markers of type 2 diabetes mellitus in a Saudi population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24979464</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neurodevelopmental disability was not associated with the APOE genotype in this cohort of hypoxic-ischemic encephalopathy survivors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24322171</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Remitted geriatric depression and APOE epsilon 4 allele and their interaction are associated with the imbalanced hippocampal functional networks, which may contribute to cognitive deterioration for subjects with a high risk of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24856546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE (E2,E3,E4) polymorphism and the TNF-alpha-308 G &gt; A polymorphism are not associated with renal injury after CPB.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24059882</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A probabilistic generative model predicts with high confidence that the ceerebrospinal fluid (CSF) biomarkers become abnormal in a distinct sequence: amyloid-beta1-42, phosphorylated tau, total tau.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25012224</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon4 carriers had significantly poorer initial memory performance and greater decline in processing speed and word recognition than epsilon2 and epsilon3 carriers. After excluding participants with low global cognition scores, all genotype effects were nonsignificant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23567378</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In centenarians APOE 4 is directly related to positive affect and is related to negative affect in interaction with life events.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23998924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association of CSF apoE levels and cognitive function in newly diagnosed Alzheimer disease patients could be demonstrated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24277910</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data support association of the Apo epsilon4 allele with recurrent pregnancy loss; however, in silico analysis predicted that the amino acid substitution at residue 112 (Apo epsilon4 allele) is a benign mutation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25062970</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that A large ApoE epsilon4/epsilon4 homozygous cohort reveals no association with Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23794363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our meta-analysis supports a lowered level of blood ApoE in Alzheimer&apos;s disease patients, and indicates its potential value as an important risk factor for AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24558469</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated levels of CRP were linked to a decreased risk of longitudinal cognitive decline in the very old subjects not carrying an APOE e4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24305621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no association between the presence of an APOEepsilon4 allele and the occurrence of delirium in the acute phase after stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23969090</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is a close association between recurrent pregnancy loss and Apo E gene polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24221911</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the complex formed by HCV E1E2, ApoB, and ApoE may initiate lipoviral particle morphogenesis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24838241</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrate that TMEM106B and APOE interact to increase late-onset Alzheimer&apos;s disease in Han Chinese.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24166182</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these results demonstrate that apoE4 tips the balance of the glial and neuronal Abeta toward the intraneuronal accumulation of Abeta.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24154541</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results in this study identify the KIAA1462 locus as a candidate locus for late onset Alzheimer disease in APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24349219</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of ApoE4 may attenuate amylin&apos;s capacity to remove Abeta, especially Abeta1-40, from the Alzheimer&apos;s disease brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24520345</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon2/epsilon3/epsilon4 polymorphism is not associated with Primary open-angle glaucoma susceptibility in any populations(Meta-Analysis)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24312416</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Two of the key risk factors for Alzheimer&apos;s disease are increasing age and carriage of the APOE 4 allele. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24423223</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sufficient evidence is lacking to prove that the T allele of SNP 19 rs2070045 is associated with varepsilon4 allele of ApoE gene in late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24309291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon2 allele of apoE gene might increase the risk of ESRD. E2 carriers expressed higher level of plasma apoE in patients with ESRD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24349494</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with epsilon4 correlated with shorter life, and epsilon2 with longer life, than epsilon3.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24126160</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It is related to cognitive impairment primarily through Ab deposition and tangles formation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24199961</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present meta-analysis indicated that the epsilon4/epsilon4 genotype is associated with increased risk of primary open-angle glaucoma in Asians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25053873</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Fenofibrate can induce lipoprotein glomerulopathy (APOE Kyoto mutation) remission and the fibrate effects depend on the degree of lipid control and baseline proteinuria.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24025644</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Spatial distribution of microbleeds is affected by its genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24119543</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that the hepatitis C virus (HCV) entry inhibitor ficolin-2 is an antiviral innate immune molecule, whereas apolipoprotein E3 (ApoE3) blocks the effect of ficolin-2 and mediates an immune escape mechanism during chronic HCV infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24928988</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study demonstrates that the apoE-epsilon4 polymorphism is a strong independent risk factor for cognitive dysfunction at 1 month and as early as 1 day post-carotid endarterectomy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24139138</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results support an association between APOE polymorphisms and Creutzfeldt-Jakob disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24332811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study, in confirming the occurrence of oxidative stress in AD and MCI patients, shows how it can be related, at least for superoxide dismutase activity in MCI, to APO E4 allele risk factor.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23668794</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results show that the overall stability of the entire apoE molecule exerts a major influence on its lipid- and lipoprotein-binding properties</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24871385</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism is associated with carotid atherosclerosis in a South Korean population, and this association was partly mediated through blood lipids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24401234</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Extent to which environmental factors, specifically stress, influence the relationship between the APOE and cognitive functioning in African Americans vs Caucasians. Stressful late-lfe events impact the cognition of persons with an 4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24521139</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24386260</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the epsilon4 allele on LDL-cholesterol levels in an Algerian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24160669</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE mutations in Dysbetalipoproteinaemia And Atherosclerosis (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24405372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Microbleeds are present with cerebrospinal fluid (CSF) beta-amyloid 42 (Abeta42), total tau, and tau phosphorylated at threonine 181 (P-tau181) as well as a subset of APOE epsilon4 carriers and noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24818585</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Being Hispanic and having had a transient ischemic attack-like episode are predictors of cerebral amyloid angiopathy in persons with Alzheimer&apos;s disease who are carriers and noncarriers of the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24797962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Voxel-based DTI analysis can be performed on low signal to noise ratio images to detect subtle regional differences in cohorts using the proposed preprocessing techniques.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23589355</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>report expands the clinical description of inherited lipemic splenomegaly associated with the rare APOE p.Leu167del mutation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24314356</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that patients with brain tumors who are carriers of the APOE epsilon4 allele may have increased vulnerability to developing memory and executive dysfunction, and that additional SNPs in the APOE gene may be associated with cognitive outcome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24944262</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE p.V236E substitution was significantly associated with a marked reduction in risk of late-onset Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24607147</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24388885</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E3/E4 genotype is associated with a higher lower extremity deep venous thrombosis risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24456740</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 allele is associated with a higher risk of intracerebral hemorrhage. [Meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24621278</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphisms are associated with maximum oxygen uptake levels after exercise training in Chinese young adult.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24571688</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In sum, the present study yielded no evidence for a direct link between common genetic variants of the APOE gene and personality in young adulthood.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24884737</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Light to moderate alcohol consumption during late life protects against decline in memory and learning for non-APOE e4 allele carriers, but not for older adults who carry one or more alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24049153</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE region is significantly associated with nonpathological cognitive ageing.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23207651</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in a large community-dwelling sample of older adults, we found no effects of APOE epsilon or TOMM40 523 genotypes on hippocampal volumes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24260406</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the deletion of apolipoprotein E increased the number of ovarian follicles and the ratio of ovarian follicle atresia and apoptosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24196014</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed dysregulated expression of Pin1, Sirt1, and PS1 genes in different cerebral areas of apoE4 mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24161275</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of truncated apoE within Pick bodies suggests a broader role of apoE beyond AD and raises the question as to whether this protein contributes to pathogenesis associated with Pick&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24312462</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study ApoE4 homozygosity is strongly associated with dementia in males and females combined, but is not represented among those remaining cognitively normal.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24081379</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 significantly accelerated rates of Alzheimer disease decline, and women in all cohorts had higher rates of decline than men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23828104</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Thus, NR4A1 plays a role in hepatitis C virus replication through regulating the expression of hepatitis C virus receptors and ApoE, and facilitates hepatitis C virus entry and spread.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24744301</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study highlights the role of ApoE in neurogenesis, and shows for the first time an early inequality between the ApoE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24140109</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found support for joint effects of BDNFVal(66)MetxAPOExHbA1c and BDNFVal(66)MetxAPOExage on rates of episodic memory change over ten years, after controlling for age, sex, education and cardiovascular diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24055685</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lifetime cognitive activity moderates the APOE genotype effect in cerebral cortex deposition of beta-amyloid burden.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24948815</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that plasma Abeta is a potential Alzheimer&apos;s disease biomarker and highlight the importance of apoe4 genetic variation in interpretation of plasma Abeta levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23541187</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E gene epsilon4epsilon4 is associated with elevated risk of primary open angle glaucoma in Asians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24885013</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The combined effects of HIV infection and APOE epsilon4 may lead to greater cognitive deficits, especially in those with greater neuroinflammation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24850492</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24204574</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the APOE epsilon2 allele operates as a susceptibility gene for combat-related PTSD, with the relationship between alcohol use and PTSD differing according to the epsilon2-allele status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23761065</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the present meta-analysis did not show any association between APOE alleles and genotypes with incidence of cancer in general.[meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24706182</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an APOE p.Leu167del mutation has a role in familial hypercholesterolemia [case report]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24267230</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review highlights the importance of studying the APOE varepsilon2 allele to understand individual differences in cognitive ageing</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24183852</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest an epistatic interaction between apolipoprotein E and hemoglobin S genes such that sickle cell trait only had an effect on parasite density in APOE E4 children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24116184</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that structural and functional changes underlie the observed added risk for late-onset Alzheimer disease development in carriers of apoE4[L28P].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24644280</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An ApoB/TC ratio &lt;0.15 do not have an increased likelihood of mutation in the APOE gene, and rare variants in the APOE gene are not important in the development of hypertriglyceridemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24314366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings implicate a novel functional role for a 3&apos;-exon CGI and support a modified mechanism of action for APOE in disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23892237</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among patients with mild cognitive impairment, APOe4 was more frequent in those with subsyndromal symptoms of depression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23567388</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In cognitively intact older adults, the apoe4 allele was not associated with subjective memory complaints.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23567387</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene polymorphisms are a potential risk factor for CP in the Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24522486</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The meta-analysis suggests an association between ApoE E4 mutation and increased risk of recurrent pregnancy loss</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24141900</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that FBL in the UF is influenced by the presence of an ApoE e4 allele (ApoE4) in healthy older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23475756</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a Mexican population CYP2C19 is more involved in acenocoumarol metabolism than CYP2C9 and APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24222221</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphisms in moroccan population and their impact on lipid metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24396563</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results support the hypothesis that ApoE alleles modify the inflammatory responses in the brain and the periphery, thus contributing to altered functional outcome following stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23957944</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study study provides evidence for an association between the APOE epsilon4 allele and frontotemporal lobar degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23688578</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CLU and ApoE Alzheimer risk variants had combined effects on both volumetric expansion and lateral ventricle surface morphology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24806679</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 confers greater Alzheimer disease risk in women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24623176</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The relationship between beta-amyloid plaques and dementia in the oldest-old may vary by APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23474043</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The analyses suggest the existence of age- and gender-sensitive systemic mechanisms linking the e4 allele to lifespan which can non-additively interfere with cancer-related mechanisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24497847</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subjects with apo4 allele have a much higher triglyceride level than those with apo2 allele, playing a major role in lipid transport and metabolism by acting as a ligand.  [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24001346</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24175296</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In type 2 diabetes, islet amyloidosis and arteriosclerosis share common pathophysiological features with ApoE polymorphism as a probable linking factor.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24005233</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results demonstrate that RXR/RA receptor agonists, including several RA isomers, are effective modulators of apoE secretion and lipidation and may be explored as potential drugs for AD therapy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24599963</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Using human APOE2, 3, and 4 isoform-specific transgenic mice, we found a lower brain uptake of docosahexaenoic acid (DHA) in APOE4 than in APOE2 mice that may limit the biodistribution of DHA in cerebral tissues</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24345162</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant differences are found in the frequencies of APOE genotypes and alleles between polycystic ovary syndrome and control groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23746632</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE genotype moderates effects of psychological trauma on posttraumatic stress disorder pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24132908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cell-type and cycle-dependent expression of ApoD and ApoE within human endometrium suggests their role in endometrial modulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23895740</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 genotype plays a major role in the prediction of breast cancer and the PPARalpha mutation enhances this in a Taiwanese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23076161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Alzheimer&apos;s disease, the APOE epsilon4 allele is associated with accelerated rates of atrophy in 13 distinct brain regions in limbic and neocortical areas.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24475827</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>it was not possible to conclude that the presence of APOE polymorphism is related to the effect of prolactin on cognitive functions of the examined menopausal women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24745159</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results of this meta-analysis suggest that the ApoE epsilon2 and epsilon4 alleles may be associated with increased risks of T2DM and DN in Chinese Han population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24439487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LDLR calcium-binding repeats (LRs), apoB and apoE3 bind at the hydrophilic convex face of LR5, forming complexes that are weakened at low [Ca(2+) ] and low pH.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24447298</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>hormonal modulators of glial ABCA1 and apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23999864</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results suggest protective effect of apolipoprotein E epsilon2 allele on susceptibility for carotid plaque presence as well as low density lipoprotein cholesterol lowering effect in Serbian patients with carotid atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24783416</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated serum DDT levels are associated with an increased risk for AD and carriers of an APOE4 epsilon4 allele may be more susceptible to the effects of DDT.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24473795</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>activation of beta-adrenoceptor reduce the plaque area in the thoracic aorta and play an important anti-atherosclerotic role by regulating lipid metabolism disorders and the SR-B1 signal transduction pathway</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23911886</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings suggest that in the absence of clinically salient dementia pathology, APOE epsilon2 and epsilon4 alleles do not exhibit antagonistic pleiotropy in relation to cognition between the ages of 20 and 72 years.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23902936</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study suggests that the ApoE epsilon4 allele is a risk factor for frontotemporal dementia and Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23887281</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>evaluation of urinary Gla excretion in relation with apo E genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23817635</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele segregated dose-dependently and selectively with CA1 apical neuropil, or stratum radiatum/stratum lacunosum-moleculare thinning and worse episodic memory performance in a pool of older subjects across a cognitive spectrum</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24453080</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association between dietary fat and plasma concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in elderly persons, taking the APOE4 genotype into account</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23801662</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>our study suggests that APOE epsilon4 allele is associated with an increased risk of developing cerebral infarction in Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23571734</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the absence of ApoE, release of core protein from infected cells is reduced, and production of extracellular and intracellular infectivity is ablated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24173232</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study found that in the absence of ApoE4, subjects who had been taking central ACE inhibitor use or peripheral ACE inhibitor use had lower incidence of AD compared with those who had not been taking an ACE inhibitor.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23948883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The current findings suggest that in APOE E4 non-carriers with AD, executive dysfunction is closely linked to frontal gray matter atrophy and predictive of progression to dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23948881</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Positive diabetes mellitus type 2 status appears to exacerbate alzheimer disease neuropathology in the presence of ApoE epsilon4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23627755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was not relationship between APOE genotype and longitudinal change in depression symptoms, suggesting that depression symptoms may not be intrinsic to the early preclinical phase of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24434095</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuroepithelial progenitor cell cultures recognize HIV and respond to it by mounting an innate immune response with a vigor that is influenced by the ApoE genotype of the cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23744346</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It seems that the potential modest risk effect of the ABCG2 C/C genotype on Alzheimer disease risk is more pronounced in combination with the APOE varepsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23827224</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our exploratory results suggest a relationship between prostate aggressiveness, ApoE isoforms and cholesterol imbalance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23934233</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This meta-analysis suggests that Apo E epsilon2/epsilon3/epsilon4 polymorphisms may not be associated with the risk of POAG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24023758</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that left-handedness in adults is not related to APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23113606</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4+ Alzheimer&apos;s disease patients show lower global amyloid burden and greater medial temporal hypometabolism compared with matched ApoE4- patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23965289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effects of the APOE epsilon4 allele were, however, reduced to a nonsignificant level in all tests except 1 after accounting for incident dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23855979</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism assessment may be a factor in predicting the effect of hormone replacement on cognitive functioning in postmenopausal period.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24464001</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that the presence of at least one apolipoprotein E epsilon4 allele might act as a genetic factor predisposing individuals to develop fragile X-associated tremor/ataxia syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23492875</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TOMM40 intron 6 poly-T length may explain some of the variation in age at onset in PSEN2 familial Alzheimer&apos;s disease (AD) and may be associated with AD neuropathology in persons with APOE epsilon3/epsilon3</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23183136</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In APOE epsilon 4 carriers, there is a moderate negative relationship between cerebral beta-amyloid and episodic memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23159043</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactions between the APOE epsilon4 allele and ABGA7 SNPs are associated with all three cognitive factor scores in Alzheimer&apos;s disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23669301</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Infants who are carriers of APOE epsilon4 have early brain changes associated with the genetic predisposition to Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24276092</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Case Report:  extreme gestational hyperlipidemia with a partial LPL deficiency in the absence of an LPL gene mutation and the apolipoprotein E 3/2 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24009459</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23385359</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein e 3/4 genotype and baseline depression had a 7.97 fold greater risk of incident dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23255503</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Plasma PCSK9 levels were strongly associated with plasma triacylglycerols and cholesterol levels in homozygous carriers of ApoE2.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24308640</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study found likely millions of people worldwide derived from Sub-Saharan Africans are apolipoprotein E R145C; available evidence suggests it is a common cause of a mild triglyceride dyslipidemia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24239320</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>beta-amyloid imaging has prognostic value alone and in combination with memory performance, hippocampal atrophy, and apolipoprotein E epsilon4 status in nondemented, older individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24448836</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant associations between APOE epsilon2 allele with lower total cholesterol and LDL-cholesterol were found.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24291031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23769398</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The interaction between age and APOE genotype on rate of decline suggests that preclinical disease may be overrepresented in older epsilon4+ individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23876113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Quantitative EEG (qEEG) separates between patients with amnestic MCI and patients in early stages of probable AD. Adding information about Apo epsilon4 allele frequency slightly enhances diagnostic accuracy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23786792</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE mediates the effects of leptin on vascular lesion formation by stabilizing cav-1-enriched cell membrane microdomains in smooth muscle cells, thus allowing NADPH oxidase assembly and ROS-mediated mitogenic signalling.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23723060</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism may contribute to the recurrence of hypertensive intracerebral hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22410653</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study cannot comment on the effect of sleep consolidation and APOE genotype on the temporal trajectory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24145819</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the epsilon3/3 ApoE genotype, and late in epsiuln4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23773371</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A significant association of the epsilon4 allele, especially the E3/E4 genotype, with myocardial infarction was observed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23371373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carrier state with moderate to severe sleep disordered breathing associated with poorer performance on cognitive tests of memory and executive function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23729930</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate the physiological importance of apolipoprotein E (apoE) and heparan sulfate proteoglycan (HSPGs) in the hepatitis C virus attachment to hepatocytes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23844141</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present meta-analysis suggests an association between ApoE epsilon4 allele and increased risk of coronary artery disease in Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23826174</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE modifies the adverse effects of cord blood mercury on neurodevelopment at the age of two years.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23603214</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>SNP modulating serum LDL cholesterol via APOB, LDL receptor and APOE influence the risk, activity, and severity of rheumatoid arthritis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23588940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms Ser447Ter of lipoprotein-lipase gene, Cys112Arg and Arg158Cys of apolipoprotein E gene in patients with obesity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24340925</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele is related to faster decline in semantic memory and working memory for whites but not for blacks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23364031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carrier of its allele in patients with Alzheimer disease show severe slowing of ascillatory brain activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23587637</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Six apolipoproteins (APOA1, APOA2, APOB, APOC2, APOC3, and APOE) were able to differentiate bladder cancer from hernia. SAA4 was significantly increased in bladder cancer subgroups, whereas ProEGF was significantly decreased in bladder cancer subgroups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23631828</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found that APOE epsilon4 carrier status and neuropsychiatric symptoms (both presence/absence and total score on the NPI) were independently associated with greater odds of dementia and cognitive impairment, no dementia versus normal cognitive status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22927174</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuritic amyloid plaque load across progressive clinical stages of Alzheimer&apos;s disease varies strongly by ApoE4 genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23624169</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study found no significant association between the tested variants and migraine for any of the APOE variants investigated</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23660682</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results show evidence that the ApoE genotype may be associated with accelerated brain atrophy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23587689</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The carriers of ApoE epsilon4 have an earlier onset of alzheimer&apos;s disease (76.9 years) (p = 0.001) than ApoE epsilon3.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22899317</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data suggest a gender difference in the associations between APOE, SCARB1, PPARa genotypes and lipid levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23919842</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 reduces the ratio of soluble amyloid precursor protein alpha to Abeta, reduces Sirtuin T1 expression (reducing the ratio of neuroprotective SirT1 to neurotoxic SirT2), triggers Tau and APP phosphorylation, and induces programmed cell death.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24145446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results indicate that DHA metabolism is disturbed in E4+, and may help explain why there is no association between DHA levels in plasma and cognition in E4+ (epsilon4 allele carriers).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23631810</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>among patients with amnestic mild cognitive impairment apolipoprotein E epsilon4 allele carriers had elevated current Frontal Systems Behavior Scale Executive Dysfunction scores in comparison with noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22874659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results are consistent with the well-established role of the APOE*4 allele as a risk factor for sporadic Alzheimer disease.  GAB2 and GSK3B polymorphisms and the well-established genetic factor APOE may modify the overall risk of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23525328</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 genotype is associated with protection from type 2 DN, and subjects with e2 allele have increased risk of developing type 2 overt DN.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24163986</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LOXL1 is more abundant in the deposits in the iris region and, alternatively APOE is concentrated in the PEX material accumulated in the pupillary area of the anterior lens capsule.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23411028</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4 allele is associated with increased risk of gait speed decline and disability in older men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23902934</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show this allele in current smokers increases cardiovascular and all cause mortality</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23382465</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4-allele conferred increased risk for progression to dementia in mild cognitive impairment subjects based on meta-analysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23242623</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Coronary endothelin (ET)-1 overexpression induces development of compensatory mechanisms in the arteries of ApoE-knockout mice that have severe endothelial dysfunction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23902937</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study highlights the protective role of LXR-activated macrophages against breast cancer growth, and the implication of APOE protein in the anti-proliferative and pro-apoptotic effects observed</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24023310</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23408335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest that the counterpart APOE allele is not likely associated with the onset of LPG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23407349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype does not predict the efficacy of ezetimibe treatment on serum lipid parameters</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23815818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TOMM40 and APOE common genetic variants are not Parkinson&apos;s disease risk factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23522842</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genetic polymorphisms may affect brain functioning in subjects without dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23275593</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data suggest that brain BACEl levels may be influenced by the apolipoprotein E genotype before the onset of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23036023</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results indicate a significant contribution of the APOE genotype to the EPA-lipid profile relationship; however, the results do not explain the differences in previous findings regarding LDL-C, triglycerides or total cholesterol.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23466070</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women&apos;s healthy brains.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23503772</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes are associated with lipid levels in patients with rheumatoid arthritis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23613766</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipidation states of APOE and amyloid-beta peptides in the brain differ depending on apolipoprotein (APO)E genotype and cognitive diagnosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23779114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study demonstrated that AD pathology may manifest itself differently based on ApoE genotype and suggest that ApoE carriers and non-carriers may have different patterns of AD neuropathology location and density.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23663404</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Subjects with the apoE3/E2 genotype and PCSK9 R46L have increased plasma insulin, homeostasis model assessment of insulin resistance, and leptin, an intriguing finding that warrants further investigation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23743349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive enhancement by nicotine selectively benefits APOEepsilon4 carriers and genotype-specific differences are found in prospective memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23232444</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that differences in OERP activity as a function of age, ApoE epsilon4 status, response type, and electrode site.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23731072</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data from a population-based prospective study were used to examine longitudinal changes in blood pressure (BP) and seek interactions between apolipoprotein E (ApoE) genotypes, smoking and alcohol in a cohort of 557 elderly Brazilian men</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23324992</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data do not support the recently published evidence of the association between APOE e4 genotype and smoking outcomes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23808899</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Postprandial cholesterolemia was higher in APOE varepsilon4 than in varepsilon2 carriers, whereas under intense intermittent exercise, total and LDL cholesterolemia were higher in varepsilon4 than in varepsilon2 and varepsilon3 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23642733</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant difference was observed in CSF ApoE concentrations between the patients with Alzheimer&apos;s disease and the controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23612909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data further support a role for fibrinogen in Alzheimer&apos;s disease pathophysiology and link the APOE genotype with increased thrombosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23652625</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphisms in APOE-epsilon4, CLU and MS4A4A influence both Alzheimer disease risk and cerebrospinal fluid Amyloid-beta1-42 levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23573206</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study findings suggested that an interaction between apoE and HDL is facilitated by APOE4, and is possibly linked with an enhancement of neuroplasticity and with resultant protective effects on cognitive function in later life.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23576895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer&apos;s frontal cortex.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23593485</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 predicted the onset of Alzheimer&apos;s disease-type dementia in middle and high but not in low educated subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23380990</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon4 allele as a confounding covariate.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22544617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Alzheimer&apos;s disease, the E4 allele of APOE is differentially associated with delusions and hallucinations in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23270420</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 carrier status appears to be associated with severe peripheral neuropathy in type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22826377</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mild cognitive impairment patients with MAPT and APOE epsilon4 effects have gray matter loss in frontal and parietal cortex that could be due to changes in APOE epsilon4 expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23064258</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that the epsilon4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22825739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lipid parameters were not statistically different among various ApoE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23537987</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of LOXL1 with exfoliation syndrome and exfoliation glaucoma was investigated and apolipoprotein E and MTHFR polymorphisms as genetic risk factors for both conditions, were evaluated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23687437</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in patients with hyperlipidemias, G allele of NPC1L1 and APO E4 could account for some of the inter-individual variability in cholesterol absorption</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23415434</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High density lipoprotein(HDL)-ApoE3, acting as an amyloid-beta chaperone molecule, significantly reduces the death of cerebrovascular smooth muscle cells that results from low density lipoprotein receptor-related protein (LRP)-1-mediated uptake of amyloid-beta.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22914594</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Young, non-demented persons carrying the ApoE 4/4 genotype show molecular changes that are involved in specific processes associated with the pathophysiology of Alzheimeer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22914590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peripheral expression of ApoE mRNA was lower in the PSD group than the control stroke group (p&lt;0.701) while serum ApoE was higher than in the control stroke group (p&lt;0.05), possibly reflecting a feedback reduction in expression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23171142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Here, the signal transduction pathways of apoE and its role of gene expression in the pathogenesis of glomerulus diseases were reviewed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23384034</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>that hyperlipidemia in nephrotic children is not associated with apolipoprotein B (apoB) gene 3&apos; variable number of tandem repeat (VNTR) polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23546960</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings show that apoE4 stimulates the accumulation of Abeta42 and hyperphosphorylated tau and reduces the levels of VGlut in hippocampal neurons of young apoE4-targeted replacement mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23684315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a case-control study of 1,089 oldest-old (ages 92-93) and 736 middle-aged Danes, the minor allele frequency (MAF) of rs769449 (APOE) was significantly decreased in the oldest-old.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22234866</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that associations of increased risk for vascular cognitive impairment was found for APOE epsilon4 (1.818 (95% CI = 1.611-2.053), p &lt; 0.001; n = 3,554 cases, n = 12,277 controls).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23186985</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We propose a model of a pathogenic cascade underlying preclinical Alzheimer&apos;s disease in which APOE epsilon4 primarily influences the pathology of Alzheimer disease via Abeta-related mechanisms, and Abeta-associated neurodegeneration occurs only in presence of p-tau.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22976236</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study was unable to replicate a previous report finding left-handed adolescents were more than three times likely to have an apolipoprotein e2 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22721421</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that an interaction between age and APOE genotype in the left anterior cingulate cortex (ACC) was characterized by reduced CBF in older epsilon4 carriers and increased CBF in young epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23302659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results suggest that MAPT, PGRN and APOE play limited roles in frontotemporal lobar degeneration pathogenesis among Indians</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23317568</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-Analysis: apoE gene polymorphisms increase risk of essential hypertension.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22971752</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E4 polymorphism seems to be contributing to the thrombophilic risk factors as a background to recurrent pregnancy loss</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23292450</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphism rs7412 in APOE was strongly associated with LDL-C in African Americans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23067351</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that APOE genotype correlations with Abeta deposition in cerebral amyloid angiopathy only incompletely correspond to other alzheimer disease-linked brain pathologies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23771217</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE e4 allele and APOB CC genotype can play detrimental, neutral, and protective sex-specific roles in the etiology of cardiovascular disease at different ages and in different environments.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23320904</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of the apolipoprotein E gene is a genetic risk factor for Alzheimer&apos;s disease and is associated with decrements in memory and in olfactory function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22102296</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 genotypes affected the serum concentration of vitamin A and vitamin E in subjects with mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23321337</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In Conclusion, the APOE epsilon4 and E2 alleles are associated with higher risk of coronary artery disease in type2 diabetes mellitus than epsilon3 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23888546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphism genotypes were studied, and the difference in distribution of genotypes between preeclampsia patient subjects and normal pregnancy controls was found to be not significant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23865355</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In young adult mice, ApoE-4 transgenic subjects outperform ApoE-3 transgenic subjects on learning and memory hippocampus-dependent tasks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23291160</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene may not be a risk factor for functional decline among older Taiwanese adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23701536</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE locus is a longevity gene in humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23286790</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Chinese diabetics carrying the APOE epsilon4 allele had an increased likelihood of having dementia compared with non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22890095</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele is an independent risk factor for both Alzheimer&apos;s disease and mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22890094</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among healthy middle-aged ApoE4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23011382</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study supported the prodromal/preclinical Alzheimer&apos;s disease hypothesis and do not support the concept of a distinctive epsilon4-related cognitive phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23737466</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E4 allele is higher in patients with left ventricular dilatation and failure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23590983</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3/epsilon3 carriers had significantly decreased gray matter density in the left parahippocampal area compared with the APOE epsilon4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22784692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effect of apolipoprotein E epsilon 4 on the intrinsic cognitive networks</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23424640</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings support the hypothesis that both reduction in the frequency of the epsilon4 allele and increase in the frequency of the epsilon2 allele contribute to longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23040522</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A role of the genotype of apolipoprotein E (epsilon4 allele) in the pathogenesis of stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23396426</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E epsilon 4 allele was a susceptible allele for coronary heart disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22013795</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest complex mechanisms underlying the interaction of CR1, APOE, and brain amyloid pathways in Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23022416</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study showed APOE alleles had a very different distribution in Chinese aircrews compared with the general population; results demonstrated an association between the APOE polymorphisms and dyslipidemia with these subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23159296</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Peroxisome proliferator activated receptor-alpha/hypoxia inducible factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23372804</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study reports for the first time a protective effect of the epsilon2 allele against gastric cancer</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23098561</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hypertension, a prevalent vascular risk factor in aging populations, interacts with APOE 4 genotype to increase amyloid deposition in cognitively healthy middle-aged and older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23553344</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that the associations between APOE epsilon4, dementia, and mortality are age dependent, and that APOE epsilon4 no longer plays a role in dementia and mortality at very old ages.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23123227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE E4 allele was observed to have a dramatic effect on cognitive impairment, especially in homozygotes, which comprised approximately 2% of the population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23429815</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE influences sAbeta metabolism not through direct binding to sAbeta in solution but through its actions with other interacting receptors/transporters and cell surfaces</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23620513</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE single nucleotide polymorphisms are observed in primary progressive aphasia (PPA), but not in patients with a behavioral variant of frontotemporal dementia, nor in controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22710912</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neither APOE nor APOA5 polymorphisms showed a significant effect on the lipid responses to rosuvastatin in Chinese patients with hyperlipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23312054</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4-PPARA V162 allele combination was found to have higher frequencies in coronary heart disease patients with diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23583468</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we consider how to design effective strategies for Alzheimer disease therapy by targeting Apo-E--{REVIEW}</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23296339</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study proposes the possible involvement of the APOE epsilon4 allele in cognitive impairment in patients with epilepsy which is further worsened by phenytoin monotherapy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23273617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the epsilon4-allele of the apolipoprotein-E (APOE) gene has been implicated in short-term cognitive dysfunction after cardiac surgery.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23384292</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 status significantly modified a number of associations. Specifically, we observed a significant negative relationship between Q4-waist hip ratio and a measure of executive function in the apoE4(+) group but not in the apoE4(-) group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21835633</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Moderately severe Alzheimer Disease patients with the APOE 4 allele may respond more favorably to memantine plus rivastigmine patch than allele 4 noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23051684</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate the involvement of the APOE p.Leu167del in autosomal dominant hypercholesterolemia (ADH).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22949395</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sequence variants of TLR4 are associated with an increased risk of late-onset Alzheimer&apos;s disease, especially in ApoE e4 non-carriers and in hypertensive patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23272070</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study suggests that the risk of developing and dying from cardiovascular disease, including coronary heart disease and cerebrovascular disease, is influenced by the apolipoprotein E polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22440829</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Binding of apolipoprotein E inhibits the oligomer growth of amyloid-beta peptide in solution as determined by fluorescence cross-correlation spectroscopy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23430745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that APOE E4 allele frequency was significantly higher in cognitive impairment no dementia patients versus healthy controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23042215</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data provide clear support for an antagonistic pleiotropy hypothesis--that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23063453</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The current data strongly underline the general importance of apoE as a regulator of bone metabolism and identifies the APOE epsilon2 allele as a potential genetic risk factor for low trabecular bone mass and vertebral fractures in humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22991192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 carrier status was found to increase all-cause and cardiovascular mortality risks and interacted with sex and time-dependent AD status to affect all-cause mortality.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23581910</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E polymorphism may confer genetic susceptibility for perinatal arterial ischemic stroke. Larger population-based studies are required to confirm this finding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23290018</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results indicated that the epsilon2 allele was associated with increased risk of psoriasis, whereas the epsilon3 allele and epsilon3/epsilon3 genotype may decrease risk of psoriasis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23142524</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genome-wide association study to identify genetic variants associated with CSF APOE levels</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22821396</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Circulating apo-E predicted in both genders age-adjusted prevalent and incident coronary heart disease (CHD), independent of apo-E genotype and C-reactive protein (OR 1.32 [95 % CI 1.11; 1.58]).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23096223</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 genotype is associated with the severity of axonal injury in acute traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23584199</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A novel cleavage event of ApoE4 generates an amino-terminal fragment that localizes within neurofibrillary tangles of the Alzheimer&apos;s disease brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22902767</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of vitamin B12 status with cognitive test performance is stronger in the presence of the ApoE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23213264</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>rs769446 is a functional polymorphism involved in the regulation of the plasma APOE concentration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23430611</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is increased in Parkinson&apos;s patients&apos; cerebrospinal fluid relative to normal controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22889670</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3/epsilon4 group may have a different off-line memory consolidation process compared to epsilon2/epsilon3 group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23251595</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>diabetes-induced proinflammatory changes in the vasculature and the hLDLR-mediated cholesterol accumulation in macrophages synergistically trigger atherosclerosis in mice with human apoE4, although neither alone is sufficient.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23204275</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Transgenic mice bred on a human APOE2 background show reduced levels of cerebral amyloid angiopathy and emergence of parenchymal plaque amyloid.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22635103</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The number of epsilon4 alleles was related to hippocampal volumes in mild cognitive impairment, and this may explain the relationship between ApoE genotype and some aspects of memory performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23103838</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 homozygote substantially accelerates progression from mild cognitive disorder to dementia, and anticipate dementia occurrence by more than 3 years in people with mild cognitive disorder.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23247007</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE3 N-terminal domain unfolding due to mutation may constitute a common mechanism underlying the protein&apos;s association with the pathogenesis of lipoprotein glomerulopathy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23110818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No statistically significant association was found between the polymorphisms of the APOE gene and Down syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23242296</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mice overexpressing human ApoE4 already, at an early age, exhibited increased eIF2alpha phosphorylation together with mild impairment in cognitive tasks, compared with ApoE3 mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22883908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele may be protective on cognitive decline among the oldest old.  A 22% increased mortality risk for APOE epsilon4 carriers was found. No protective effect of the APOE epsilon2 allele on mortality compared with the APOE epsilon3 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23051975</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study APOE4 genotype was associated with personality traits of neuroticism/anxiety and extraversion as well as with poor cognitive function in individuals &gt;72 years of age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23079898</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It is unlikely that the two APOE missense Single nucleotide polymorphisms (SNPs) rs429358 (epsilon4) and rs7412 (epsilon2) exert any relevant effects on multiple sclerosis susceptibility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22972946</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E gene epsilon4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23049877</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lactobacillus reuteri modulates the metabolic syndrome in Apoe-/- mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23056479</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The low prevalence of extracranial carotid stenosis in this population might result from low frequencies of the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21296594</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE epsilon3/3 genotype frequency was higher in patients with hepatitis B virus-associated liver cirrhosis than in the controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23091810</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 possesses enhanced lipid and VLDL-binding ability relative to apoE3, which gives rise to impaired lipolytic processing of VLDL in apoE4-expressing mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23413428</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23152815</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PKC regulates the secretion of apoE from primary human macrophages</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23288845</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data confirm the association between the ApoE4 allele and Alzheimer&apos;s disease, and point out the E2 allele of ApoE gene as the possible risk factor for type 2 diabetes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22580620</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Both TOMM40 and APOE significantly influence age-related memory performance, but they appear to do so independently of each other</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23102119</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association exists between IVS2 + 335T &lt; A and the development of late onset Alzheimer&apos;s disease in ApoEepsilon 4 carriers within the northern Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23134962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE isoform-specific formation of soluble apoE/Abeta modulates oAbeta levels, suggesting a basis for APOE4-induced AD risk and a mechanistic approach to AD biomarkers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23293020</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review discusses the association of behavioral symptoms with the APOE epsilon4 allele Cys112Arg and Arg158Cys, one of 7 genes that implicates increased risk of missense substitutions in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22414959</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 allele and aging are independently associated with amyloid accumulation in the brain, although there are clear interactions between these important risk factors for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22633529</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>AD patients with mutant allele (*10) in CYP2D6 gene may respond better to donepezil than those with wild allele (*1). We did not find the relationship between APOE [Latin Small Letter Open E]4 status and the efficacy of donepezil in our study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22986607</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 allele is a strong risk factor across the Lewy Body Dementia spectrum and occurs at increased frequency in pure Lewy Body Dementia relative to Parkinson disease dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23407718</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We show that education and occupation act as proxies for reserve in Apolipoprotein Eepsilon4 carriers with early probable Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22173784</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with AD exhibited reduced parieto-occipital alpha oscillations compared with controls, and those carrying the APOE-4 allele had reduced alpha activity in the left inferior parietal and temporo-occipital cortex relative to noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23050006</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A molecular understanding of the interactions of apoE4 with Abeta, nitric oxide and IL-1beta on the regulation of the COX-2/prostaglandin pathway may open new avenues in understanding the mechanism of development of neurodegenerative disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22101739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive function may be affected by ApoE and neuroticism acting in tandem.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23042108</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in this largest GWAS of late-onset AD in African Americans ever assembled, aside from SNPs associated with APOE, the top-ranked SNP observed in this study was located in ABCA7 and had an effect size comparable with that of APOE 4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23571587</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data showed that impaired plasma clearance of apolipoprotein E2-containing, triglyceride-rich lipoproteins promotes lipid redistribution to neutrophils and adipocytes to accentuate inflammation and adiposity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22961083</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study found gene-environment interaction between APOE e4 allele status, serum lipids and serum organochlorine pesticides.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22904031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>possession of the APOE epsilon4 allele is associated with disruption of perivascular drainage of Abeta from the brain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22848551</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE3 more efficiently facilitates Abeta trafficking and degradation than apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23132858</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22285757</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that APOE genotype has a differential effect on the distribution of amyloid plaques and glucose metabolism in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23255822</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE alleles epsilon2, epsilon3, and epsilon4 account for essentially all the inherited risk of Alzheimer disease associated with this region.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22869155</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE2 isoform is associated with deficit in extinction of conditioned fear in a human targeted replacement in a mouse model.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22883220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22984509</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although the e3 allele has been considered neutral in several studies, our results suggest that it acts as a protective factor against Alzheimer disease in the population studied</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22068907</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A review of genetic association studies suggests that APOE appears to be associated with global outcomes after traumatic brain injury in children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23023254</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results show that ApoE genotype, and not aggregated fibrillar forms of Abeta, contributes to reduced glucose metabolism in aging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23238736</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4 appeared to be a risk variant for late onset Alzheimer&apos;s disease, while the APOE epsilon3 showed a protective effect</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22785395</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>protective role for APOE epsilon2 allele against severe preeclampsia in Kurdish population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22676395</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Examined ApoE in the oldest old and explore its association with quality of life and no association was found between ApoE epsilon4 and QOL.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22863665</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Severe WMHs appear to be predominantly associated with frontal/executive dysfunction, irrespective of APOE epsilon4 allele presence. WMH severity and APOE epsilon4 had an interactive effect on memory function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23146133</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This community-based study shows that varepsilon2 allele is helpful on lipid changes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22206590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E ~4 allele was more frequent in episodic memory decliners</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23110764</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE differentially regulates multiple aspects of Abeta accumulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23060451</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon2 or epsilon4 genotype was associated specifically with lobar intracerebral hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23175721</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that a nondemented elderly population, persons with the APOE4 allele have a smaller hippocampal volume</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22244650</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This tonic EEG analyses complement those of previous reports in that the ApoE epsilon4 allele has a negative impact on regional neural synchronization and inter-regional neural interaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22562716</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Distribution of APOE genotypes and alleles differed between fertile and infertile Iranian men and may be a risk factor for male infertility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22568769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Urinary concentration of Apoliporotein E is increased in patients diagnosed with bladder cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23088986</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study found that levels of glutamine synthetase and glutamate uptake transporters were unchanged among the APOE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22862561</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Thus, increased susceptibility of the WM structures underpinning the entorhinal-hippocampal network, offers a plausible explanation for the earlier onset of cognitive decline previously reported in APOE epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22796460</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism is not associated with semen quality, as it is present to a similar extent in both normal and impaired or absent spermatogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22490376</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE epsilon2 carriers harbor more robust white matter integrity that may be associated with decreased vulnerability to developing alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22383234</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carriage of L33P polymorphism for the ITGB3 gene, does not influence on predisposition to the longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23289212</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results show predominantly focal form of coronary artery disease in patients with ApoE epsilon2/epsilon3 genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22837136</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is no association between APOEepsilon2 alleles and Parkinson&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22349451</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In summary, the reviewed data indicate that APOE-4 carrier status modulates brain structure and function. [Review Article]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22359096</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic polymorphisms of apoE are a risk factor for nephrotic syndrome susceptibility. [Meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22760259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study identifies miR-1908, miR-199a-5p, and miR-199a-3p as endogenous promoters of metastatic invasion, angiogenesis, and colonization in melanoma. These miRNAs convergently target ApoE and the heat shock factor DNAJA4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23142051</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic association studies in population of adults in United Kingdom: Data indicate greater sensitivity of fasting triglyceride and C-reactive protein level in serum to dietary fat manipulation with APOE3/E4 genotype (compared to APOE3/E3 genotype).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23134888</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>individuals carrying APOE-epsilon4 allele and/or APOE-epsilon3epsilon4 genotype develop MS two times more than non-carriers. Also APOE-epsilon2epsilon3 genotype or APOE-epsilon2 allele may have a protective role against MS development in Iranian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22698480</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated altered white matter microstructure in APOE [epsilon]3/[epsilon]4 carriers compared with [epsilon]3/[epsilon]3 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23100402</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>SA exposure earlier in life may increase risk for declines in EF 50-60 years later in old age, particularly in the context of the APOE epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22357643</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In chronic hepatitis C, genetic heterogeneity in the APOE/TOMM40 genomic region is significantly associated with variation in serum ApoE and ApoB levels, and also with fibrosis suggesting a pleiotropic attribute of this genomic region.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22898894</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 is not a risk factor for iNPH and does not predict the response to shunt.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22955176</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of epsilon2/epsilon3 polymorphism of APOE gene impacted positively the obtained results of cognitive functions among postmenopausal women, whereas the presence of epsilon3/epsilon4, or epsilon4/epsilon4 polymorphisms worsened the obtained results.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22936261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present meta-analysis provides evidence that ApoE epsilon2 mutation is associated with MS risk. In addition, ApoE epsilon3/epsilon4 genotype appears to be a protective factor for MS.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22982410</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated taht Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23100439</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 genotype was associated with a decline in visual memory</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23071163</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype is significantly linked to the age at natural menopause.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21792545</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOEepsilon4allele is a strong genetic susceptibilityfactor for AD and other neurodegenerative and vascu-lar diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22596266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE may influence the severity of cerebral amyloid angiopathy through altered expression of LRP1.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22967844</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduction of rapid eye movement sleep in mild cognitive impairment patients with ApoE varepsilon4 is more noticeable than in varepsilon4 non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22211488</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 carriers had a higher percentage of Alzheimer Disease diagnoses at follow-up than non-APOE epsilon4 carriers. APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22815080</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study observed a synergistic negative effect of APOE epsilon4 allele and elevated pulse pressure on episodic memory in a life span sample of healthy, normotensive, adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22612575</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes, SFA intake, and obesity were found to be associated with blood lipid levels in Lithuanian adult population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22844488</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with the APOE epsilon4 allele may be more predisposed to brain cellular damage measured as S-100B and neuron-specific enolase (NSE).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22322856</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that the APOE-epsilon4 allele contributes to age-related hearing loss.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22542837</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study concluded that the combination of APOE-epsilon4 allele and high educational attainment may be a risk factor for accelerated cognitive decline in older age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22642392</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The statistical analysis indicated no significant association between APOE genotype and rebleeding in a Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22462403</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism is associated with obesity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22921891</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 shows an independent effect on hippocampal atrophy in mild cognition disorder and Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20833446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elevated levels of ApoE3 may play a role in controlling the formation of neurofibrillary tangles in subacute sclerosing panencephalitis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21788110</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that cognitively normal sedentary APOE epsilon4-positive individuals may be at augmented risk for cerebral amyloid deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22232206</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study reports a protective effect of the epsilon4 allele towards nonalcoholic fatty liver disease that might be attributable to its role in the regulation of hepatic triglycerides rich very low-density lipoproteins secretion</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22350157</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggests that genetic (APOE epsilon4) and environmental (education) factors are not only independently but also interactively related to dementia risk and that high education may buffer the negative effect of APOE epsilon4 on dementia occurrence.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22056199</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the presence of APOE epsilon2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21864519</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a pathway by which isoform specific conformational differences increase the level of cleavage at the hinge region of ApoE4, leading to a loss of ApoE function to mediate clearance of Abeta and increase the risk of AD for carriers of the APOEepsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21297948</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[review] APOE epsilon4 allele has been found to be potentially linked to Abeta accumulation and accrual, in turn contributing to Alzheimer disease pathology, despite its significant role in processing of amyloid precursor protein (APP) and lipid metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21545304</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>healthy young APOE epsilon4 carriers have smaller hippocampal volumes than APOE epsilon2 carriers. The difference in morphology is clinically silent in young adulthood, but could render APOE epsilon4 carriers more prone to the later development of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21606569</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphic ApoE alleles differentially modulate house dust mite-induced airway disease, which can be stratified, in order of increasing severity, epsilon3 &lt; epsilon4 &lt; epsilon2; results raise possibility that polymorphic apoE alleles may modify asthma severity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22058162</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype and haplotype distributions differ significantly along the age classes (Genotype: p=0.014; Haplotype: p=0.005) with APOE*epsilon4 genotype status and haplotype displaying negative association (Genotype: O.R.=0.377, p=0.002, Haplotype: O.R.=0.447, p=0.005</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21703254</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that plasma apoE have a positive influence on cognitive function in both E4 (-) and E4 (+) groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21407046</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that the APOE-epsilon2 allele provides a buffer against significant hanges in daily functioning over time and is associated with better neuropsychological performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21685781</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 and apoE2 transgenic mice show a worse performance during acquisition of a spatial task compared to apoE3 mice, and apoE2 mice show a worse performance compared to the other two genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22735491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The reduction of ER stress in macrophages may be a viable option to reduce inflammation and inflammation-related metabolic disorders associated with the apoE4 polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22730380</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In hepatitis C virus-G1, interferon sensitivity is characterised by low lipoviral particle ratios and low apoE levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22414761</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Non-APOE4 carriers showed improved cognitive performance in the memory domains at follow-up, while performance of APOE4 carriers did not change.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21849821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the apo E4 isoform was associated with a higher level of Lp-PLA(2) index, a marker of vascular inflammation, synergistically increasing cardiovascular risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22632920</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This stuidy demonistrated that fitness differentially affects cerebral metabolism in apoe4 carriers only.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22226798</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[review] The ApoE (epsilon4) genotype is associated with a higher risk of Alzheimer&apos;s disease and an earlier onset of dementia in people with Down&apos;s syndrome, in the same way as in the general population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22935789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>More than 1/2 of Alzheimer patients are known to possess APOE epsilon 4allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22787761</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The distribution of APO E genotype and allele frequency does not differ between the Uighur and Han ethnicities. The APO E epsilon4 allele is a risk factor of AD for both populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22712640</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that there may be an association between APOE allelic frequency and spontaneous pregnancy loss in patients with endometriosis, which appears to be independent of mechanisms associated with infertility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22266326</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>examined the APOE epsilon4 allele, a known risk factor for Alzheimer&apos;s disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22771913</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive status and APOE genotype have interactive effects on cerebral blood flow.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22549621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype affects medial temporal lobe activation during an fMRI episodic memory task but does so in a predictable, age-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22868934</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22755192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Elderly in India with an ApoE4 allele have 4.7 times more risk of developing depression in old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22226379</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that apoE genetic polymorphisms influence on lipid profiles and are associated with the development of both type 2 diabetes mellitus with and without coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22520940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>To identify possible prognostic biomarkers, use of APOE3 and APOE4 transgenic mice demonstrates relatively favorable and unfavorable outcomes respectively, following traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21895520</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The fractional turnover rates of ApoE isoforms in 18 cognitively-normal adults were measured.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22675504</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR regulated trans-activation of apoE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22728266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Given the established relationship between apolipoprotein E and vasculopathic changes in cerebral amyloid angiopathy, our findings suggest that both hemostatic factors and vessel pathology influence spot sign presence</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22621984</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Anticholinergic medication use was associated with poorer performance on measures of cognition, sleep, and mood only in older persons who carried 1 or more epsilon4 alleles of the APOE gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22534472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results demonstrate that gender influences the effect of APOE genotype on both DMN connectivity and CSF tau levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22699906</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased expression of ApoE may not only disrupt cholesterol homeostasis but may also contribute to some of the neurobiological features of Alzheimer Disease, including plaque deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21676498</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The often-assumed link between APOE, the blood oxygenation level dependent response, and Alzheimer disease risk show an effect of APOE genotype on brain function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21232817</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In ApoE e4 carriers, the negative association between the ratio of campesterol to cholesterol and memory reached borderline significance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21482441</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report APOE mutations in Spanish subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22481068</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a specific apoE4 fragment with molecular mass similar that of apoE4 fragments detected in Alzheimer&apos;s disease patients&apos; brain, can influence the level of inflammatory molecules in brain cell lines.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22445724</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is overrepresented in primary progressive aphasia, thus likely acting as genetic risk factor on disease development.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22129783</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In women, APOE epsilon4-positive genotype is associated with earlier onset of WD symptoms, particularly among ATP7B p.H1069Q homozygous patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22221592</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association was found between the ApoE epsilon2 allele and deep venous thrombotic events in women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22006422</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data suggest that apolipoprotein E4 is a co-factor that enhances the toxicity of oligomeric amyloid-b both by increasing its levels and directing it to synapses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22637583</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that apolipoprotein E2 genotype contributes to increased risk of cardiovascular complications in acromegaly since it is concurrently present with other risk factors; apolipoprotein E4 genotype more common in subjects with acromegaly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22200909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>higher association of anxiety with the ApoE epsilon4 allele; a significantly higher frequency in the ApoE epsilon4 homozygotes when compared to the heterozygotes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22246233</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22343410</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome in patients with Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21617520</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no APOE epsilon4-related cognitive benefits in young adults, adolescents and children, and findings were not moderated by the level of executive demands in a cognitive task.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22329498</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3,3 genotype better protects neurons subjected to the hyperexcitability of epilepsy and thus confers less risk of AD (Alzheimer&apos;s disease).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22502727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphism may be not a major genetic factor that influences the individual dose for warfarin maintenance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21464541</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that plasma cyto-chemokine levels along with ICAM-1, Abeta and ApoE genotyp in Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22272623</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study revealed that engagement in leisure time physical activity, but not ognitively stimulating activity is associted with a reduced probability of cognition decline over 18 month in health older APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22272622</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22419519</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[review] Current cumulative evidence based on a few existing longitudinal studies shows no association of APOE genotypes with neuropsychiatric symptoms as a whole in late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21763789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there are subtle white matter differences between healthy young ApoE4 carriers and non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22558310</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that a modest association between ApoE epsilon4 carrier status and reduction in white matter tract integrity at medial temporal and limbic regions in both healthy and AD subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22269984</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated altered inflammatory responses in young and middle adulthood in epsilon4 carriers that may relate to Alzheimer disease risk later in life</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22689192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22615372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study concludes that, in middle-aged women, APOE -491 T allele contributes keeping lower levels of LDL cholesterol in the population studied, and would have a putative protective effect for the development of coronary artery disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22101914</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E levels predict incident cardiovascular disease risk in women with high levels of HDL cholesterol and C-reactive protein but not in men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22225956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the present meta-analysis suggests an association between ApoE E4 mutation and increased risk of vascular dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22381401</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer&apos;s disease in a Northern Han Chinese population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22353753</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOepsilon4 allele enhances electroencephalographic abnormalities at the early stage of traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22015765</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A longitudinal study of Chicago older adults concluded there is a simultaneous influence of social and genetic risk factors for cognitive decline linking APOE-E4 genotype with with neighborhood social disorder.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22465377</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of APOE epsilon2 predisposes individuals with lobar ICH to hematoma expansion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22535266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Collectively, these findings demonstrate that apoE mediates HCV attachment through specific interactions with cell surface heparan sulfate.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22532692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that Genetic factors, particularly the ApoE epsilon4 polymorphism, might contribute to variability in outcomes after stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22221491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Abnormally high levels of ApoE may play a causative role in the pathological events of Alzheimer&apos;s disease (AD), particularly those involving the early cholinergic deficit in the AD brain, through modulation of cholinesterase activities.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20538374</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In ApoE-epsilon4 carriers, long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may slow cognitive decline in visual working memory of subjects with depressed symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20570406</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE overexpression increases i) SR-BI-mediated selective uptake into the liver and ii) ABCA1-mediated efflux of RCT-relevant cholesterol from hepatocytes back to the plasma compartment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22383685</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study eemonistrated that Carrying at least one APOE epsilon4 allele is associated with more rapid cognitive decline in Parknison disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22344634</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings of a recent meta-analysis have not supported a role for APOE in MS susceptibility or severity. We have not found, in our data, any influence of this gene in the RRMS response to INFbeta</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21163235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 allele was associated with high total cholesterol and LDL cholesterol, and development of hypertension in an Asian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22113353</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>hypothesis-testing analysis results showed strong correlations between FDG PET-MRI gray matter scores and APOE-epsilon4 gene dose</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22348880</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The P3 latencies were significantly longer in epsilon4 young and middle age participants in olfactory event-related potential.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22100309</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association between the APOE genotype and cardiovascular disease risk is unlikely to be homogenous. Highlights risk of inaccurate estimations of genotype-phenotype associations in populations without appropriate stratification for sex and adiposity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22365656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In patients with hypertension, ApoE gene polymorphism could influence the lipid regulatory effect of xuezhikang, mainly by raising HDL-C and reducing TG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19848197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21984189</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis of ApoE-modified nanoparticle uptake on brain capillary endothelial cells</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22396775</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that in healthy older carriers of the APOE4 allele clinically unremarkable increase in vascular risk may be associated with reduced frontal volumes and impaired cognitive functions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22245009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An apoE gene mutation was identified in the patient&apos;s family.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22487820</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The SNP genotype pattern at the APOE gene is associated with episodic memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22539578</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High APOE epsilon 4 allele frequencies were associated with Alzheimer disease in a Tunisian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21710128</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex hormones and APOE epsilon4 status synergistically influence some neuropsychiatric symptoms among female but not male Alzheimer&apos;s disease patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22398564</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the APOE epsilon4 allele, and not the alleles of ER SNPs, is a risk factor for MCIa. Furthermore, APOE genotype seems to predict the conversion from MCIa to AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22311091</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22101883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the polymorphism associated with atherosclerosis in type1 diabetes mellitus (DM) is Apo E4/E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22394699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E4 was associated with a higher relative rate of cognitive decline in the 9th decade for verbal memory &amp; abstract reasoning, but not verbal fluency.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21263443</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>With the factors of sex, age, major depressive disorder, and Apoepsilon4 controlled, PGC-1alpha still increased the risk for insomnia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22392034</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21892657</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that the APOE epsilon4 allele has a differential effect on change in verbal memory performance depending on age, consistent with the hypothesis of antagonistic pleiotropy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21908077</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that The older ApoE-epsilon4 carriers had smaller HV-induced changes in EEG relative powers than the older ApoE-epsilon4 noncarriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22206848</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that the association between ApoE epsilon4 allele and cognitive decline in specific domains including verbal memory and learning is not sex neutral because women are at higher risk compared with men when possessing the epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20619505</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These cross-sectional data suggest leisure activity is associated with tissue volumes in the brain irrespective of the APOE epsilon4 risk allele status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21856047</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that APOE genotype affects several aspects of the inflammatory response in mouse brains, leading to increased neuronal damages in APOE4 mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22228589</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>increase in CSF cortisol associated with the presence of the APOE e4 allele was only detected when a short TOMM40 poly-T variant, shown to associate with later age of onset of AD in e4 carriers, was not present.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21803501</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The frequency of ApoE polymorphisms did not differ between patients with RA and controls. ApoE genotypes are strongly linked to inflammation and lipid levels in RA, raising interest in the prognostic implications of ApoE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22174202</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this first study of a Thai population, a higher frequency of APOE-epsilon2 allele is identified among patients with Parkinson disease than is found among controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21782446</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 carrier status amplifies the degree of neurodegeneration in mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21889115</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22334766</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE has a gene dose-dependent effect on amyloidbeta transgene accumulation in aged mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22492035</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism might play an important role in Parkinson disease susceptibility in our Japanese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21360299</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to apoE genetic polymorphisms and comorbid factors such as diabetes and, especially, alcohol consumption.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22251476</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype was not associated with insulin resistance or altered insulin secretion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21290252</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This meta-analysis of 20 case-control studies suggests that APOE epsilon4 (2 alleles) is not associated with multiple sclerosis susceptibility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21679970</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE genotype is associated with the risk of intracerebral hemorrhage in Chinese Han patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21819245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22071360</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE detection provided a novel diagnostic marker for invasive bacterial infections in pediatric patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22178110</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The correlation between osteoporosis and carotid atherosclerosis (CA)was analyzed by exploring the effects of ApoE gene polymorphisms on bone mineral density (BMD) of the lumbar spine and CA.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22178106</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hepatocyte-specific IKKbeta expression activates NFkappaB and aggravates atherosclerosis development in APOE*3-Leiden mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21798539</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that Apolipoprotein epsilon4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer&apos;s</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22012848</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LRP1 enables apoE to accumulate in an early endosomal recycling compartment that serves as a pool for the intracellular formation and subsequent re-secretion of apoE-enriched HDL particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22238606</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of total cholesterol in children with family history of coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22264578</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Abeta42 is a stronger predictor of progression to Alzheimer&apos;s disease in APOE epsilon4 non-carriers than in carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19748159</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that shortened telomere length may be associated with the ApoE4 homozygote in AD patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22016362</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22089642</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Men are normally protected by androgens against bulbar amyotrophic lateral sclerosis; the APOepsilon4 allele inhibits this protection, perhaps by interfering with the androgen pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21251163</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE e4 genotype prevalence varies among alzheimer&apos;s disease patients by region and within each country</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22179327</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this older non-demented population APOE-epsilon4 carriers may be more vulnerable to the potential detrimental effect of hypothalamic-pituitary-adrenal axis dysfunction on verbal memory performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19879666</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Serum ApoE level was independently associated with urinary albumin excretion in type 2 diabetic patients from Shanghai, China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22185986</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that olfactory processing speed may be a useful measure for detecting and following the effects of adiposity on brain integrity and cognitive function in those at genetic risk for AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22055839</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 may impart its pathological role through high protein expression and interaction with butyrylcholinesterase, which in turn may modulate central cholinergic activity and amyloidbeta load in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19713000</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findinfgs show apolipoprotein E4 allele may be related to the development of ischemic heart disease in patients with or without type 2 diabetes in Kuwait</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22039842</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A brief background introduction into the structure, established physiological and pathophysiological functions of apoE, and the emerging role of apoE in bone, are discussed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21798384</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study confirms the APOE epsillon 2 allele as a &apos;&apos;risk allele&apos;&apos; for early age-related macular degeneration (AMD); however, the relation of the APOE genotypes with AMD varied by smoking status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22328704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study suggests that APOE may not be associated with spontaneous abortions in Caucasians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21973221</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was a strong association between the APOE epsilon4 allele and Alzheimer&apos;s type pathology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22291217</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These observations suggest that the epsilon4 allele is associated with abnormal cell turnover of functional and possibly clinical significance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20395015</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that APOE epsilon4 modulates the structural integrity of critical nodes in brain attentional networks</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20382449</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The review discusses the interpretation of BOLD differences between epsilon4 carriers and noncarriers, provides suggestions for future studies, and highlights important limitations of this type of research</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20409610</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 does not increase coronary heart disease risk in carriers of LDLR mutations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22010136</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE-containing astrocyte lipoproteins exhibit the most robust interactions with Abeta.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22138302</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results are consistent with an influence of APOE status on Propositional density in young adulthood that is independent of the Alzheimer&apos;s disease risk</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22134129</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a significant reduction in tau phosphorylation at the Ser202/Thr205 epitope in APOEepsilon3 animals only</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21347323</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>SIGMAR1 and APOE interact to influence Alzheimer&apos;s disease severity across ethnic populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21605063</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there was a strong association between the apolipoprotein E epsilon4 and postoperative cognitive dysfunction in elderly patients undergoing inhalation anesthetics</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22108393</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 allele is associated with a twofold increased risk of developing hypertension in Chinese.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21228824</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>homozygous APOE epsilon4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22110642</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>pooled analysis demonstrating associations between late age-related macular degeneration and APOepsilon4 and APOepsilon2 following adjustment for age group and sex within each study and smoking status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21882290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In our population, APOE epsilon2 allele confers protection against hypercholesterolemia and a less atherogenic lipid profile</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22074026</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The iNOS-231 T allele and the apoE epsilon4 allele were more common in patients than in controls, but not significantly associated with Cerebal Palsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21857382</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study shows that despite a low incidence of dementia in North Indian population, APOE epsilon4 heterozygous/homozygous state is associated with risk of all types of dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21714688</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mutations in apolipoprotein E3 is not associated with its structural variation and type III hyperlipoproteinemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22069485</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphisms in APOE is associated with obesity and adiposity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22069463</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>among all single nucleotide polymorphisms of ApoE, the mutation in rs11542041 (R132S) has the most significant effect on functional variation in Alzheimer disease. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21769591</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The unique composition of fetal HDL (apoE-HDL)affects key functions of the growing fetal tissues.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21954452</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis of brain network local interconnectivity loss in aging APOE-4 allele carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22106308</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE-induced intracellular Abeta degradation is mediated by the cholesterol efflux function of apoE, which lowers cellular cholesterol levels and subsequently facilitates the intracellular trafficking of Abeta to lysosomes for degradation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22130662</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E (ApoE) gene plays a role in odor identification errors</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21517181</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21714002</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE isoforms modulate the harmful effects of amyloid beta on cognitive function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22189452</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data suggest that ApoE4 plays an important role in learning and memory impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21743131</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele frequencies in subjects with subjective cognitive impairment and amnestic mild cognitive impairment have a north-south gradient. The relation between the APOE epsilon4 allele and cognition is region dependent.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21952537</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that two synergistic interactions between subhaplogroup H5 and APOE4 status (p = 0.009) and between TFAM rs1937 and APOE4 status (p &lt; 0.001) were detected, influencing LOAD risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21799244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE varepsilon4 allele may be associated with poorer long-term outcome, but not acute injury severity in traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21651315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study supported that the apoe genotype a biomarker for mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21728427</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon2 carriers were less likely to have at-risk levels of high-density lipoprotein and total cholesterol (total-C) than non-carriers. ApoE epsilon4 carriers were less likely to have elevated levels of Creactive protein than non-carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21840004</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic association studies in populations in the United States: Findings suggest that APOE4 carrier status does not modify the association between increasing BMI and decreasing HDL levels</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21939561</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single polymorphisms within the saitohin gene were associated with increased cognitive impairment and functional dependence persons with moderate-to-advanced Alzheimer disease. APOE-epsilon4 was associated with increased baseline physical agitation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21934306</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>among individuals with a history of stroke or myocardial infarction at baseline, progression of Alzheimer&apos;s disease is influenced by APOE epsilon4 carrier status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21593560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms in the ApoE,ACE, MTHFR and LDLR genes, implicated in the pathogenesis of many diseases, including Alzheimers and myocardial infarction, were found to be prevalent in Angami and Lotha Naga populations in India. Lifestyle increase risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21461956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphism -491A/T and ATF4 elicit independent control of APOE gene expression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22028770</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The current knowledge regarding the APOE polymorphism, is reported.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21958003</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that abnormalities in adipose tissue that accompany expression of the apoE2 cannot be ascribed to adipocyte-specific effects on lipid metabolism. of this isoform on adipocyte lipid metabolismDU</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21743035</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>EOAD is a purely dominant, mitochondrial, X-linked, or polygenic disorder. The most likely explanation of the data is that approximately 4% of EOAD cases are due to apoe.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21911656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE appears to have an intrinsic effect on the differentiation of functional networks in the brain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21851856</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It has been elucidated that APOE gene is a risk gene of neuro-psychiatric diseases including Alzheimer&apos;s disease of the aged.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22204031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonistrated that ApoE epsilon4 allele associated with thinner frontal cortex in middle age in men of Vietnam.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21971450</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results describe the association of ACE and APOC1 gene polymorphisms with susceptibility to Alzheimer&apos;s disease and dementia in general, both alone and combined with the APOE gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21533863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene might not contribute to the risk of diabetic nephropathy in Taiwanese patients with T2D.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21689001</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22159114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The polymorphism at the APOE gene plays a role as a genetic modifier of Machado-Joseph disease phenotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22159055</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4 allele is associated with outcomes after spinal cord injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21132529</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21284913</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The polymorphisms of MIP-1alpha -906 (TA)(6)/(TA)(6) and ApoE are independent genetic risk factors for ulcerative colitis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21756796</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings did not suggest significant association between APOE polymorphism and presence of neuropsychiatric symptoms in Alzheimer&apos;s disease patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21905100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE E4 carriers with MS have worsening progression of cognitive deficits than noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21945984</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>stratification of our data by age groups clearly demonstrates that APOE4 is a risk factor not only for late-onset but for early-onset AD as well.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21556001</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest that cortical and cerebrovascular Abeta depositions are useful quantitative traits for genetic studies, as highlighted by the strong associations with the APOE epsilon4 variant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21654062</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>these data suggest a new mechanism by which apoA-I stimulates CETP secretion, in addition to apoE, from lipid loaded macrophages, a process involving NF-kappaB inhibition and/or PKA pathway activation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22056562</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE varepsilon4 allele modulates brain WM structure before any clinical or neurophysiological expression of impending disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20820167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene polymorphism can, to some degree, reflect the Traditional Chinese Medicine syndrome types of T2DM patients with macroangiopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21822540</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant differences were found in the response to induced ketosis among non-carriers of the APOE4 gene, with notable improvement among the E3/E3 genotype group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21992747</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study established male patients with multiple sclerosis had a higher APOE epsilon4 frequency and disease severity, but were likely to have lower serum ApoE levels</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22165672</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon-3 a favourable factor for the longevity: an association study in Chinese population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21869487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOEepsilon4 allele(s) may lead to premature aging with neurodegeneration in younger HIV patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21803164</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The aim of this study was to determine the allelic and genotypic distributions of the APOA5-1131T&gt;C (rs 662799) and the APOE HhaI polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21132386</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association between cognitive impairment and ApoE-4 or clinical markers was detected in the study sample of multiple sclerosis patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21208197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study refutes a role for the epsilon4 allele of APOE in MRI abnormalities in multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21723395</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found that in three loci (PCSK9, APOE, and LDLR) there were additional variants independently associated with LDL-C.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21829380</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20196787</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-epsilon4 allele is associated with a moderately increased risk for progression from mild cognitive impairment to Alzheimer&apos;s disease [Meta-analysis]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21493755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant interactions of APOA5 were detected with the APOE gene and with gender and menopause.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20304614</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of the epsilon4 allele for ApoE is associated with greater temporal and hippocampal atrophy well before the onset of cognitive deficits.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21098974</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype seems to influence cortical activation in patients with aMCI and to a lesser degree in healthy controls as well</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21192235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest a relatively specific impact of apolipoprotein E (APOE) epsilon4 burden in mild cognitive impairment and underline the value of linguistic assessment in preclinical diagnosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21192234</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21418511</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction between carrying APOE4 allele and chronic life stressors has significant impacts on self-reported health while controlling for various sociodemographic and health behavior factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21768502</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21943158</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>total cholesterol and low density cholesterol-plaque correlations were also stronger for the subgroup of 87 subjects with an APOE epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21244352</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE varepsilon4 carriers showed less activation in the hippocampus proper during encoding. Specifically, when spatial encoding was contrasted against the dot-control task, encoding-related activation was significantly lower in carriers than non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21549723</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic interaction between APOE and PRNP</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21799773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21740922</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 homozygote (epsilon4/4) might be an important influencing factor for the progression of cognitive impairment in patients with primary hypertension.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19813626</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>found an interaction between the polymorphisms APOE and IL-1RA (86 bp)n (higher lethality in the presence of IL-1RA heterozygosity and APOE epsilon2epsilon3 or epsilon3epsilon4 genotypes).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21575667</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association between metabolic syndrome (MS) and ApoE polymorphism; the morbidly obese patients had a higher incidence of MS and a different allelic distribution compared with others; the epsilon4 allele was associated with absence of MS and hypertension</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21570960</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Common polymorphism of ApoE gene is associated with the presence of MetS in an elderly Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21550086</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CETP Ile405Val and APOE Cys112Arg are associated with both the prevalence of low HDL-cholesterol level and with the prevalence of abdominal obesity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21767357</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic polymorphisms modifies the association between central obesity and lung function in taiwan asthmatics</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21790705</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E mutation is associated with dyslipidemia and lipoprotein glomerulopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21325775</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E2 mutation is associated with lipoprotein glomerulopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21670560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study presents experimental and epidemiological evidence that the APOE epsilon4 allele is associated with higher serum vitamin D in mice and humans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21659554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>overall structures are similar, with the exception of M108 in ApoE4 which is more solvent-accessible in this isoform than in ApoE2 and ApoE3</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21848287</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphisms are found in APOepsilon4 associated with dementia of Alzheimer&apos;s disease in subjects with Down syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20946940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21873229</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Prescence of of APOEepsilon4 allele and MAPT H2 haplotype in frontotemporal lobar degeneration had a significant influence on the expression of synaptophysin and SNAP-25</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21073671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Decreased in-phase connectivity in regions of the posterior default mode network are found in APOE epsilon4 carriers relative to APOE epsilon4 noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21555604</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the e4 allele polymorphisms carriers:effect on lifespan and ages at onset of cardiovascular diseases and cancer</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21332925</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study providence that APOE epsilon4 offered information on the risk of cognitive decline in this longitudinal study in chinease elders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21701228</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21595502</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the apolipoprotein epsilon gene did not influence the age of symptom onset or aid in the prediction of Alzheimer disease pathology in primary progressive aphasia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21346518</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>at least in East Asian origin populations, the APOE e4 allele is a stronger predictor of incident dementia in the presence of depressive syndrome, and particular depressive symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21845591</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results of a meta-analysis support a genetic association between ApoE polymorphism and diabetic nephropathy; epsilon2 increases the risk of DN in diabetes patients, while epsilon4 trends to be protective.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20177792</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found more profound deficits in spatial navigation in APOE epsilon4 allele+ relative to APOE epsilon4 allele-epsilon4- amnestic mild cognitive impairmentpatients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21124005</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21420681</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Approximately half of the adults in each group were ApoE e4 carriers and half were noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21443344</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The polyT polymorphism is associated with risk of late-onset Alzheimer disease in APOE 3 homozygotes in a large case-control series of APO3-TOMM40 haplotypes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21825236</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes -219T/T and +113C/C could be genetic markers for cortical bone strength</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21266206</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>determined the distribution of the polymorphic variants of CETP TaqIB and ApoE genes and their association with lipid and anthropometric parameters in hyperlipidemic and normolipidemic Asian Indians</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21380728</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings extend understanding of ApoE/Abeta interaction and may guide the discovery of inhibitors that treat AD by antagonizing ApoE/Abeta interaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21409287</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The frequency of ApoE epsilon4 allele differs significantly in Alzheimer&apos;s disease (AD) patients compared to controls, leading to an increased risk of AD in Tunisian subjects with this allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20198498</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we show further evidence for the role of APOE epsilon 4 in promoting cognitive impairment in HIV-infected patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21184197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele was more prevalent in those with alzheimer disease than in those with Subcortical Ischemic Vascular Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21297273</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the role of EDNRA -231 G&gt;A and APOE HhaI polymorphism for a possible association with migraine</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21453125</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evidence for different allele frequencies between Tsimane and other populations; correlations of CRP and apoE alleles suggest these variants are under selection in response to a high infection environment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21845926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Vasculopathic changes associated with the APOE epsilon2 allele might have a role in the severity and clinical course of lobar intracerebral hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21741316</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with APOE -219T promoter polymorphism are susceptible to cerebral vasospasm after spontaneous subarachnoid hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20868652</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found no evidence of higher cognitive performance in young apoe4 carriers, or cognitive deficits in older apoe4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21396385</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APO E epsilon 2/3 genotype may be linked to a risk for diabetic nephropathy in Turkish type 2 diabetes patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21500980</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE plays isoform-specific roles in determining the protein composition of peripheral nerves as well as regulating nerve regeneration pathways in vivo.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21478199</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20221865</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is no evidence to support an association of APOE polymorphisms with early or exudative age-related macular degeneration (AMD), suggesting that APOE is less likely to be a major AMD susceptibility gene in the Chinese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21541275</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphism within the ApoE gene is associated with serum LDL cholesterol in postmenopausal women with obesity and metabolic syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21488185</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations were found between the APOE-epsilon4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21474934</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The dichotomy of effects of APOE polymorphisms represents one of the best examples of genetic pleiotropy for complex traits known and illustrates the importance of allelic heterogeneity in APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20847432</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Young adult carriers of APOE epsilon4 allele have lower mitochondrial cytochrome oxidase activity than noncarriers in posterior cingulate cortex.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20847408</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE4 allele may modulate age of onset of Alzheimer&apos;s disease by interacting with the effect of calcium homeostasis modulator 1 (CALHM1).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20847397</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is not associated with significant hippocampal, hemispheric, or whole brain atrophy in patients with medically intractable temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21317045</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 genotypes were similar in Alzheimer&apos;s disease and dementia with Lewy bodies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21552550</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We have found a strong association between the APOE polymorphism and LDL-C concentrations as well as a dietary modulation in determining coronary heart disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20688498</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A significant association is detected between prior trauma and the ApoE epsilon4 allele in Chinese Han with temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20810250</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrate a necessary but quantitatively different role of PPARalpha in the modulation of liver metabolism, inflammation, and atherogenesis in ApoE2 knock-in mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21474829</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In patients with neovascular age-related macular degeneration, the presence of the APOE epsilon4 allele conferred significantly better visual outcomes after anti-VEGF treatment than did the epsilon2 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21245410</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the alleles epsilon4 and epsilon2 were associated with decreased and increased concentrations of CRP, respectively, compared to the wild-type allele epsilon3.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21310412</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>variants of APOA5 (rs662799) and APOE (rs429358) were associated with HDL-C and LDL-C responses in metabolic syndrome subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21324458</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there is a positive correlation between the expression of APOE and each of VEGF and eNOS in the capillaries of alzheimer disease brains</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21143177</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The objective of this study was to elucidate an association between Apo- Eepsilon4 allele and CSF biomarkers Abeta42 and tau for the diagnosis of Alzheimer&apos;s Disease (AD) patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21222606</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis did not reveal an impact of gene-gene interaction between BDNF and ApoE genes on hippocampal volumes or memory performance</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21190051</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Middle-aged and elderly APOE epsilon4 carriers have increased hippocampal default mode synchronization during rest.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21613490</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE rs439401 TT-genotype is associated with an adverse metabolic profile in a population of psychologically stressed Danish men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21283811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alternative splicing and promoter usage of the APOE gene in AD brain tissue might reflect the progression of neurodegeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21283692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was evidence of association for recently-reported late-onset Alzheimer&apos;s disease risk loci, including BIN1 and CLU and CUGBP2 with APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21379329</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between APOE4(-219T) and Alzheimer&apos;s disease, highlight the importance of the phase of the alleles for the observed effects on Alzheimer&apos;s disease risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21263195</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>NLRP3 inflammasome is not critically in atherosclerosis progression in the ApoE mouse model.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21451572</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21450082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A high WML load may interact with the ApoE-varepsilon4 genotype and increase the risk for reduced CSF Abeta42 in patients attending a memory clinic.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19888930</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>TJ integrity in BBB is regulated by apoE in an isoform-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21471207</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>preliminary findings suggest no clear APOE genotype influence on neuropsychological outcome in mild and moderate traumatic brain injury patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21534737</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>one copy of this variant, called APOE4, increases Alzheimer&apos;s Disease risk fourfold; two copies raise the risk about tenfold</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21760580</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>REVIEW: even if the presence of ApoE4 is not a deterministic factor for Alzheimer&apos;s disease, it seems to shift the progression of the disease towards a younger age and faster progression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21388338</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>interaction between stress and presence of E*2 allele; fibromyalgia was more frequent in patients with high stress levels that were E*2 non-carriers compared to patients with same stress level, but E*2 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21243303</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study suggests the apo E4 carrier might serve as a predictor of diabetic nephropathy progression in Taiwan.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21346330</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Investigate if apolipoprotein epsilon4 allele moderates the influence of earthquake exposure on survivor health. Findings suggest a genetic variation in the apolipoprotein E gene may modify the health effects of the stress from natural disaster exposure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21401257</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Retrospective review of clinical data (age at onset, family history, clinical presentation, diagnostic delay, diagnosis) and APOE genotype of patients with neuropathologically confirmed early-onset Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21576687</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in Choctaw Indians modifiable risk factors may play more of a role in disease pathogenesis than in whites and that nonmodifiable risk factors such as apoE4 may play less of a role.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20808139</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E promoter polymorphisms and their diplotypes were independently related with insulin resistance and serum fasting insulin levels among Turks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20723945</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21454574</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It may be implied that possibly APOE SNPs are in strong linkage disequilibrium with rs440446, and the collaborative effects of these SNPs influence plasma lipids, indirectly mediating the underlying pathophysiological determinants of osteoporosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20340021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest an involvement of the APOE gene locus in the genetics of FTD (Fronto-Temporal Dementia) and PPA (Primary Progressive Aphasia).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21555637</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>long range genomic interactions have a role in macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21372127</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest that apoC-III attenuates the binding of apoE to the lipoprotein surface and apoE-mediated cellular uptake of lipoprotein remnants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21080234</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observations suggest that apoE4 strongly stabilizes Abeta oligomers, the pathological species responsible for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21266538</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Decline of gray matter volume(GMV) and brain parenchymal volume were significantly faster in Apolipoprotein E eta4-positive than -negative patients in a 15-year-from-disease-onset model. Only GMV had the same trend in a 4-year model.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21324265</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>S-nitrosylation of ApoE proteins may play an important role in regulating lipid metabolism and in the pathogenesis of late-onset Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21443265</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19825914</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by Alzheimer pathology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21224004</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE plays an important role in obesity development in the Roma population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21244662</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the apoE4[R142C] mutant dramatically increased plasma cholesterol, triglyceride, and apoE levels; decreased esterification of cholesterol in all lipoprotein fractions; promoted formation of discoidal HDL; and caused accumulation of apoE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20861163</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE signaling via VLDL-R or apoER2 promotes macrophage conversion from the proinflammatory M1 to the antiinflammatory M2 phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21350196</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype is associated with each of the key features of Alzheimer disease pathology but not with cerebrovascular disease other than cerebral amyloid angiopathy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20880354</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Review discusses the pivotal role that APOE plays in maintaining neuronal membrane homeostasis, and that elevating the levels of APOE in the brain may be a viable therapeutic strategy for the prevention and/or treatment of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20079752</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The CFH, LOC387715 and HTRA1 polymorphisms are strongly associated with the development of age-related macular degeneration in the Hungarian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19845562</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CV risk factors influence age-related memory decline in APOE epsilon 4 homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21325652</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the effects of ethnic identity and genetic admixture on APOE genotype, its association with dementia, and dementia prevalence</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21435264</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increases in cortisol levels and mineralocorticoid receptor expression in Alzheimer&apos;s disease patients are associated with an apoE4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20858975</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer&apos;s disease, triggers the accumulation of intraneuronal oligomerized amyloid-beta following activation of the amyloid cascade.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20858958</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Oligomers of apoE first need to dissociate to monomers before binding to phospholipid liposomes, a step that is then followed by a large conformational reorganization of the monomer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21322570</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer APOE4 carriers with cognitive decline undergo faster GM atrophy than do noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21163916</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this review, apoE is a major Alzheimer&apos;s disease susceptibility gene implicated directly in the life cycle of the herpes simplex virus by the binding activity of the virus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20674675</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein epsilon4 allele, factor V Leiden, and plasma lipid and lipoprotein levels have a role in sickle cell disease in Southern Iran</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20373031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data suggest that specific interactions between genetically susceptible individuals (those with at least one copy of the Apo E4 allele) and the environment may contribute to the risk of being diagnosed with fibromyalgia syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21402364</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results suggest that both MAPT H1/H1 genotype and APOE epsilon4 allele lead to a more rapid progression to dementia among MCI subjects, probably mediating an increased rate of amyloid-beta and tau brain deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20930301</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>mechanism for colocalization of apoE with caveolin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21169230</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 genotype frequency varies among Alzheimer&apos;s disease patients in regional patterns similar to that of the general population--{REVIEW}</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21124030</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic association studies: APOE-epsilon4 and -epsilon2 allele frequencies are higher in patients with coronary stenosis than in controls in study using Iranian subjects; APOE alleles have no association with severity of disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21254242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Statistically significant associations between genotypes of APOE gene coding part polymorphism and some key lipid risk factors (blood total and LDL cholesterol, atherogenic index, etc.) for coronary atherosclerosis were found in males in West Siberia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21240353</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Living in a psychosocially hazardous neighborhood was associated with worse cognitive function in persons with the APOE epsilon4 allele, evidence of a novel gene x environment interaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21383266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>over-expression of ApoE was independently associated with poor survival in lung adenocarcinoma patients who had malignant pleural effusions at the time of diagnosis (P&lt;0.001).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20430468</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms were found not to be associated with either the occurrence or the time to development of levodopa-induced dyskinesia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21108621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Associations between PM(2.5) and HRV were modified by gene polymorphisms of APOE, LPL and VEGF.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19602472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between Apo epsilon4 and younger age at onset was significant in Caucasians and African Americans, where the epsilon4 allele was also most frequent</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21252542</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of both ApoE epsilon4 and IL-6 C genes increases the risk of having Alzheimer&apos;s and vascular dementia markedly</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21252539</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study confirmed the positive association of the ApoE4 polymorphism in dementia, both in the Alzheimer&apos;s and vascular etiology subgroups</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21252538</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4-(72-166) peptides displayed a higher lipid-binding and comparable receptor-binding ability as to full-length apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21219628</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE and apoE-mimetic peptides antagonize SET nuclear oncogene/inhibitor of protein phosphatase 2A (PP2A), increase cellular PP2A phosphatase activity, and decrease activation of inflammatory signal transduction pathways.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21289314</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggest a possible correlation between the use of dietary supplements and APOE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21276236</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE genotype may play a role in the regulation of both cholesterol and apoE levels in grey matter.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20964956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Some of the variability in the natural history of patients with persistently normal transaminases with initially mild hepatitis C can be related to their Apo E genetic background.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21261723</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Current findings related to the association between different isoforms of apoE and haemorrhagic stroke due to CAA do not allow us to formulate any clinical recommendations yet.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21225522</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon 4 allele and reduced left hippocampal volume were associated with CD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21218563</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results provide further evidence that APOE epsilon4 has a significant impact on the trajectory of age-related cognitive functioning in older adults</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20804847</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A modest but significant effect of APOE epsilon4 genotype is observed on annualized atrophy rates in the hippocampus and entorhinal cortex in early Alzheimer&apos;s disease and mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20620664</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We observed an ethnicity-specific variability in ApoB levels across the ApoE - 491 A/T polymorphism and a modulatory impact on this pattern by ApoE2/E3/E4 isoforms in coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20715976</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the role of APO E polymorphisms in cerebrovascular and coronary heart diseases (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20966513</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study supports the association between the possibly protective GAB2 haplotype and the risk of late-onset Alzheimer&apos;s disease in APOEepsilon4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20888920</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hippocampal loss of Alzheimer&apos;s disease biomarkers is steeper and occurs earlier in time in APOE epsilon4 carriers than in non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20538373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The significance of the temporal order of MAPT biomarker abnormalities in Alzheimer disease correlates with hippocampal volume and radial distance compared with apolipoprotein E4 carriers and noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20538372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20849521</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is a south-to-north, but not an east-to-west gradient for the apoE4 allele in China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20354905</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE gene polymorphism was associated with HBV infection, and the varepsilon2 allele showed positive correlation with HBV infection in northern China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20961200</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ are recognized major genetic risk factors for common Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20817608</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of all 3 APOE rare (or minor) alleles were nearly 10 times more likely to report a previous concussion. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21079443</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE epsilon4-allele constitutes an independent risk factor for cognitive impairment at 13 months post-stroke, and is associated with progression of cognitive decline in tasks related to verbal learning and memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19960482</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20700730</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein could be a nanovehicle to transport curcumin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20851099</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that expression of human apoE4 contributes to functional deficits in the amygdala very early in development and may be responsible for altering neuronal circuitry.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20951774</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>51</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study suggested that the decrease of Abeta1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEepsilon4 genotype in middle-aged and older adults with normal cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21084733</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an exaggerated postprandial lipaemia contributes to the increased coronary heart disease risk associated with carriers of the APOE E4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20643407</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human APOE epsilon2, epsilon3 &amp; epsilon4 knock-in mice showed increased 27-hydroxycholesterol and decreased lathosterol. APOE epsilon2 had the lowest oxidized cholesterol metabolites.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20416362</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype may have a role in development of cardiovascular disease in dialysis patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20546752</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that allele*4 was associated with worse performance in a few executive tasks. APOE*3*3 was associated with overall severe dysfunction on cognitive performance. In young individuals with nontreated BD-type I.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20406267</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association was observed between any APOE alleles and susceptibility to PD or age at onset in Parkinson disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20456244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon4 increased the risk of developing Alzheimer&apos;s disease both in amnestic mild cognitive impairment and in normal ageing in a clinic-recruited ethnic Chinese population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20660919</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study provided no evidence of an association between age at onset or cognitive dysfunction of PD and ApoE 4 in Korean population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20674461</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Renal transplant recipients are liable to develop hyperlipidemia, particularly hypertriglyceridemia among recipients with ApoE genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20832534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study provides novel evidence of a possible protective effect of the apolipoprotein E gene, epsilon2 allele against head and neck cancer</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20861397</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that the patients with APOEepsilon4 allele predispose to cerebral vasospasm after spontaneous subarachnoid hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21116929</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that APOEepsilon4 allele is a risk factor to brain function aggravation in the early stage of aneurysmal subarachnoid hemorrhage and it may contribute to early brain injury after aneurysmal subarachnoid hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21116912</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results did not definitively support a role for the APOE genotype in post-traumatic seizure susceptibility and indicates that larger populations are needed to fully evaluate the potential impact of APOE on post-traumatic seizure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20961174</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Clinical and prognostic significance of genetic markers of ApoE gene in traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21254576</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 allele carriers (E4+) differed significantly from E4-in functional connectivity of the precuneus to several brain regions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21159973</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that the APOE epsilon4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20825268</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study exposed a susceptibility haplotype CGTC, within APOE gene, which was found to be associated with BMD and risk of osteopenia and osteoporosis in postmenopausal females of India.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20663622</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data suggest taht APOE polymorphisms are important determinants of triglyceride concentrations, especially in the fasting state.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20729559</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of the APOE gene is associated with a worse lipid profile in the Brazilian urban population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21059196</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that the presence of the epsilon2 and epsilon4 alleles may play a role in the development of the disease. However, if any type of the disease has already developed the alleles show no association with the clinical parameters</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21110240</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated that an additive model for these APOE variants is superior to other forms of genetic risk modeling previously applied.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21061402</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene interact genetically with HRAS1 and LASS1 genes to reduce agerelated increase in lipotoxic events, and that a combination of variants or haplotypes in these three genes is associated withexceptional survival.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20569235</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A possible association between particular subtypes of schizophrenia and APOE epsilon3/epsilon3 genotype compared to epsilon4 allele shows a tendency toward positive association with response to typical neuroleptics in Serbian patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20583903</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study demonstrated an association between APOE +113C/G (rs440446) polymorphism with measures of bone mineral density in Singaporean Chinese females.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20546958</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 exhibits better lipid binding ability than apolipoprotein E3 as a consequence of a rearrangement involving the segment spanning residues 261-272 in the C-terminal domain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21114327</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of an APOE epsilon4 allele, a history of heavy drinking, or a history of heavy smoking were each associated with an earlier onset of Alzheimer disease by 2-3 years.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19750560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results demonstrate that no association exists between apoB-100, apoE, and CYP7A1 polymorphisms and cholelithiasis in a Mexican population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20872969</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the involvement of inflammatory response in the pathogenic effect of the APOE epsilon-4 allele in AD, although their replication in larger samples is mandatory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19618379</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Midlife smoking was associated with an increased risk of dementia and Alzheimer&apos;s disease later in life only among those individuals carrying the APOE epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20847559</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20847553</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data show that APOE genotypes are not associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in either Germans or Italians</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20543710</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There are biological, psychological, and social variables associated with increased risk for cognitive impairment among individuals with the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20686979</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele was associated with increased risk for cognitive deficits, whereas the MBL2 O/O genotype was associated with increased risk for progressive cognitive decline in Chinese infected with HIV through contaminated blood products.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20442634</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A higher frequency of APOE4 in participants with amnestic mild cognitive impairment subtype suggested a greater risk of future AD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19449451</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20455863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results show that CVD increases the risk of AD in carriers (but not noncarriers) of the ApoE4 allele (hazard ratio 2.39, 95% confidence interval 1.15-4.96).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20473139</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data do not suggest an epsilon4 gene dose effect on the rate of hippocampal volume loss in healthy elderly subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20060049</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE Maebashi (Arg142-Leu144--&gt;0) is a common mutation in the Chinese population; not all carriers of both mutations have lipoprotein glomerulopathy although hyperlipidemia and high serum ApoE level may occur.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20090368</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study examines the association between APOE/C1/C4/C2 gene cluster variation using tagging single nucleotide polymorphisms and plasma lipid concentration along with risk of coronary heart disease in a prospective cohort.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20498921</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results lend mixed support for a link between past temperature and human APOE allele distribution and point to the need to develop better models of past climate in future analyses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20734437</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings demonstrate that APOE varepsilon4 genotype is predictive of increased general rates of decline with global measures of cognition and function most affected.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20813342</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings highlight the value of genetic and volumetric MRI information as predictors of functional decline, and thus disease progression, in cognition diosorder.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20813341</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive P300 potentials were significantly decreased in amplitude and delayed in latency for Apolipoprotein E epsilon4 carriers as compared to non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18976833</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE*E4 allele was significantly associated with reduced test scores for Adult Verbal Learning Test, particularly on the memory and learning sub domains, in persons older than 50 years of age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19004527</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The work was aimed to study blood lipid spectrum in 133 patients with cholelithiasis and 159 with gallbladder cholesterosis as well as apoE genotypes in 49 and 36 respectively.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20919569</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19554612</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20431431</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20889503</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 protects shanty town children against heavy diarrhea outcomes, and among those with heavy diarrhea it protects against the long-term cognitive sequelae of the condition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20401432</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings provide further support of the negative impact of the epsilon4 allele in cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20678545</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A slower rate of hippocampal atrophy in normal APOE2 carriers is consistent with the lower risk of Alzheimer disease in these individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20980669</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dysregulation of genes such as CES1 and APOE seems to be associated with some physiopathological markers of insulin resistance and cardiovascular risk factors in obesity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20975297</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>overexpression of DDAH1 reduces plaque formation in ApoE(-/-) mice by lowering ADMA</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20348244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>role of ApoE isoforms on the peripheral clearance of Abeta from the blood may impact on clearance from the brain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20555142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Stroke patients carrying the APOE-epsilon4 allele more often suffered a lacunar infarction than non-carriers. The APOE-epsilon4 allele had no effect on cognitive functioning during the follow-up.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20606435</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20714348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.20714348</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>it appears that the ApoE epsilon4 allele mainly promotes neuronal dysfunction rather than aggravates neurovascular dysfunction</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20430978</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The deleterious effects of beta-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume. APOE epsilon4 carriers are more likely to have higher Abeta load than non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20739349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20679343</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>25</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic variation of apoE does not contribute to the lipid abnormalities secondary to childhood minimal change nephrotic syndrome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19241136</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ectopic expression of the ApoE2 resulted in poor recovery of infectious hepatitis C virus, whereas the expression of ApoE3 and ApoE4 rescued the production of infectious virus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20826689</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study findings did not confirm that epsilon polymorphism of the apolipoprotein E gene is a risk factor of ischemic stroke in children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20682199</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the specific apoE-NS5A interaction is required for assembly of infectious HCV</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20719944</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE epsilon4 isoform is a genetic factor that might influence the age at onset of temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20554432</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the frequency of apolipoprotein genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20739760</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data confirmed genetic associations for Alzheimer&apos;s disease with APOE, CLU, PICALM and CR1 SNPs.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20534741</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The concomitant presences of two alleles of the BCHE-K and APOE-epsilon 4 in increasing the risk of coronary artery disease (CAD) or diabetes in type 2 diabetes mellitus (T2DM) patients with or without CAD and CAD patients without T2DM.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19685167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that apolipoproteins e4 allele affects neuropsychological performance and illness morbidity in sporadic Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20145290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>17</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among middle-aged carriers of APOE epsilon4 allele, parental dementia and Alzheimer disease were associated with poor verbal and visuospatial memory and higher brain atrophy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20007524</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20644276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found significant interactions between the presence of the apoE4 allele and the top sex-specific quartile of the stroke risk profile and their effects on verbal memory</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20471857</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apo E4 allele may serve as an independent genetic marker predicting severity of coronary artery disease (CAD). Other CAD risk factors may accelerate the process of pathogenesis. The apo E2 allele may play a protective role.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20552590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>57</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Apo E genotype, e3/4 was the most frequent in both the childhood obesity patient and control groups. And there was a significance between the Apo E genotypes with low density lipoprotein and total cholesterol levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20373846</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 carriers are at higher risk of cardiac death in community-based Australian type 2 diabetic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20693183</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E4 codon 112C point mutation is, by itself, not associated with an elevated risk of recurrent pregnancy loss, but rather codon 112C in association with codon 158C is a risk factor for recurrent pregnancy loss.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20175773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that hypertension is directly related to tau pathology in APOE epsilon4 homozygous carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20413898</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effect of apolipoprotein (apo) E genotype on apoB-100 metabolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20413671</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Enhanced functional connectivity of the medial temporal lobes with the posterior cingulate in young adult epsilon4 carriers suggests that APOE may be expressed early in brain regions known to be involved in Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19744893</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE epsilon4 carriers may be more vulnerable to environmental factors, and thus, lifestyle interventions may greatly modify dementia risk, particularly among the genetically susceptible individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18318693</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results indicated that AD cases with capillary CAA differ significantly from other AD cases both genetically and morphologically, thereby pointing to a specific capillary CAA-related and APOE epsilon4-associated subtype of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20535486</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20534961</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>risk reduction of statins for Alzheimer&apos;s disease varies by age but not presence of apolipoprotein E (APOE) epsilon4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20533968</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association between plasma levels of C-reactive protein and the APOE genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20074603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>E2 allele of ApoE seems to be a moderate risk factor for T2DM. Meta-regression analysis provided some weak evidence that the risk conferred by E2 allele is mediated through altering serum lipid levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20381392</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>abnormally high activation in fronto-temporal brain areas are present in both younger and older APOEepsilon4 carriers confronted with a working memory task when compared to non-APOEepsilon4 carriers, an effect which diminishes with age</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20502990</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Being an APOE epsilon4/CHRNA4 TT carrier was associated with slower and less efficient performance, and with steeper decline in speed tasks and in delayed recall.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20331911</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we have examined the effect of the epsilon4 allele on cognition in AD, and found the epsilon4 allele to be associated with faster decline in general, and to be associated with lower baseline scores in one trial.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19997085</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon3 allele was the most frequent in the evaluated population, both in the control group and in the dyslipidemic group, followed by the epsilon4 allele and the epsilon2 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20019593</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype seems to be associated with the trajectory of cognitive recovery after traumatic brain injury, but does not play a determinant role in the efficacy of memory rehabilitation in this population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20377344</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The authors present a literature review exploring the possible association between APOE epsilon4 and cognitive dysfunction in multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20463109</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>After every meal, VLDL fluidity is increased causing apoE4 into a more expanded conformation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19965582</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mutations not associated with spontaneous cervical artery dissection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20446941</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Performance in the novel-image-novel-location object recognition test and e predictors of study dropout in a longitudinal study design of non-demented human &quot;super agers&quot;.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20044903</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>role of ApoE in the localization and intracellular trafficking of lipoprotein and glutamate receptors reveals a mechanism by which ApoE4 may accelerate onset of dementia and neuronal degeneration by impairing the maintenance of synaptic stability</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20547867</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study does not support the current contention that the presence of APOE e4 allele should have a significant negative effect on the outcome after traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20508347</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the epsilon4 allele of APOE may serve as a candidate modulation factor for the Rett syndrome phenotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20139413</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>not useful in predicting colorectal cancer risk in populations with high fat intake</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20308031</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>higher prevalence of the APOE epsilon2 genotype was found among those with cerebral palsy. The association of microcephaly and epilepsy with the epsilon4epsilon4 genotype and the association of macrocephaly with epsilon3 demand further investigation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20002130</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of this study suggested that the apoE4 mice are already stressed under nonstimulated conditions and that AT8 tau phosphorylation may contribute to their increased susceptibility to brain insults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20160452</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Memory performance correlated positively with hippocampal volume, but no structural differences were found in hippocampal or frontal volumes with respect to APOE 4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18760504</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele is associated with an increased risk of vascular dementia in a dose-dependent fashion and accounts for almost 20% of vascular dementia in the population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20375505</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The NEP and ApoE gene polymorphisms may be associated with sporadic Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20376800</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>convergent cognitive and neuroanatomic findings in individuals with a CSF molecular profile consistent with AD support the hypothesis that APOE genotype modulates the clinical phenotype of AD through influence on specific large-scale brain networks</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20479234</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism in the women with GSD did not differ from those registered in control group from women population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20469680</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A novel finding of our study is the possibility that APOE genotypes may modify the association between ALS and head injuries experienced during adulthood.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20129626</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We did not find an association between ApoE polymorphisms and cognitive performance in Spanish adolescents.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20223480</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found no consistent association between ApoE genotype and abdominal aortic aneurysm.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19818961</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>58</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>With publicly available genome-wide genotyping data, use of genotype imputation methods is becoming common; this study shows that such an analysis can miss strong genetic association signals, such as that of the apo-e gene in late-onset Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20529013</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E has roles in Guillain-Barre syndrome and experimental autoimmune neuritis [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20182542</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Frequent consumption of foods rich in polyunsaturated fat resulted in the beneficial effect of increasing HDL-C only in individuals who were not carriers of the E*4 allele of the APOE gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20091341</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study does not support a role for the APOE-epsilon4 allele in cognitive dysfunction in multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20479360</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>23</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Development of hypertriglyceridemia in inhabitants of the European North was observed at lower level of serum apolipoprotein-E in comparison with normolipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20432703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results showed a significant independent additive effect on TG levels of the LPL polymorphisms HindIII, S447X, D9N and N291S; the S19W and -1131T/C variants of APOA5, and the epsilon4 allele of APOE in our study population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20429872</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present results suggest that the ApoE gene plays a role in olfactory functioning that is independent of dementia conversion within 5 years.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18619712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene polymorphism affected profile of blood lipids and the effects were found in different sex and age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16335008</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest that ApoE genotype status is associated with macular pigment optical density.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20107178</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The A560T832/A560T832 and A560T832/A560G832 5&apos; APOE genotypes had a significantly higher cumulative incidence of IHD(172/1000) compared to the cumulative incidence of 70/1000 in the total sample of 3686 women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20160192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present data suggest that apoE produced by pericytes, rather than astrocyte-produced apoE, modulates Abeta cytotoxicity and Abeta removal near the vasculature in the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20034483</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene influences plasma lipoproteins; genetic association studies in Greek children reveal higher LDL cholesterol in APOE epsilon4 carriers compared to epsilon3/epsilon3 homozygotes &amp; epsilon2 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19403283</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Diagnostic effectiveness of molecular-genetic markers (polymorphisms in APOE, ACE (I/D) and MTHFR (C677T) genes)is not sufficient for evaluation of risk factors for cardiovascular diseases.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20229631</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that isoform difference in GAG binding of apoE may be physiologically significant such as in the retention of apoE-containing lipoproteins in the arterial wall.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18507396</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The identification of disulphide-linked apoE dimers in human cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20170526</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The allelic frequencies of apoE epsilon2, epsilon3 and epsilon4 were similar in dyslipidemic and normo-lipemic subjects, suggesting that apoE polymorphisms have no effect on plasma lipid-lipoprotein levels in dyslipidemic subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19819279</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cognitive decline after major noncardiac surgery is not associated with APOE4 genotype or plasma biomarker levels</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20216394</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 may affect neurobehavioral performance, particularly spatial memory, and antenatal health decades before any clinical expression of neurodegenerative processes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19952867</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele and problems meeting basic needs independently predicted cognitive decline</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19946803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The volumes of right medial frontal gyrus, left middle frontal gyrus and left inferior occipital gyrus were significantly smaller in RLOD patients with ApoE epsilon4 allele carriers as compared to ApoE epsilon4 allele noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19647324</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sequence alignments identify regions within ligand binding clusters of low density lipoprotein receptors (LDLR) potentially capable of binding ApoE. Avidity effects combined with this distinct recognition process likely govern the ApoE-LDLR interaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20030366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE but not ACE is associated with late-onset incident dementia in an aging population in England and Wales</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19939808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>17</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>healthy individuals the broad range of neurobiological mechanisms associated with APOE is consistent with effects on non-memory cognitive subsystems.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19879282</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19948975</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.19948975</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We confirm that APOE4 has a powerful dose-dependent effect on cerebral Abeta deposition with age, found CSF levels of tau increase as a function of age in cognitively normal older adults but are not affected by APOE genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20186853</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the APOE epsilon4 allele is associated with an increased risk of MCI and a more rapid rate of cognitive decline in old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19907191</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype may influence the topography of regional atrophy and cortical thinning in Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19940480</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>34</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results do not suggest any association between the presence of the ApoE epsilon-4 allele and the progression of disability in patients with multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20073019</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3/epsilon3 genotype, the APOE promoter polymorphisms -219G/T and +113G/C interact with smoking in modulating aortic atherosclerosis in middle-aged Finnish men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20031552</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The probability of chronic hepatitis B progression was higher, and that of loss of HBsAg was lower, among patients with the ApoE3 allelic variant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20029801</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>9</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Small lung volumes were prospectively associated with an increased risk for poor cognitive function and dementia in non-carriers of the APOE epsilon4 gene</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19907180</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphisms are not associated with reduction of serum lipids by soy or dietary fiber in hyperlipidemic Mexican subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19917453</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the epsilon4 allele increases the risk for CVE and cardiac death in patients with T2DM and ESRD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19628211</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association found between APOE epsilon4 allele and obstructive sleep apnea in published literature.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19928390</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study does not support the reported association between APOE and recurrent pregnancy loss.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19732892</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE-epsilon4 allele could be a risk factor for developing a severe form of psoriasis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19911187</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We aimed to compare the rate of cognitive decline in patients with early and late onset Alzheimer&apos;s disease (AD) and to investigate the potentially modifying influence of the apolipoprotein E (APOE) genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19335933</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>21</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19996253</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Macrophage scaventer receptor A is found to recognize exchangeable apolipoproteins (Apo)A-I and ApoE in both lipid-free and lipid-associated form, suggesting the shared amphipathic alpha-helix as a potential recognition motif.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19911804</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE and ACE genes might predispose individuals to health and functional status deterioration in old age, and their effect is additive.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19653879</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study is the first to establish the relationship between APOE epsilon4 and sporadic Alzheimer&apos;s disease in the Mongolian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19819468</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype was associated with changes in lipid and lipoprotein profiles in pregnant women</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19853876</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In relapse-remitting multiple sclerosis cognitive impairment was associated with higher subcortical damage and cortical atrophy but not with APOE-epsilon4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19965518</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Asian Indians with polymorphisms in APOE and angiotensin i converting enzyme have the highest occurence of metabolic abnormalities such as metabolic syndrome X.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19800705</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study and meta-analysis suggest an association between delirium and the APOE epsilon 4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19910874</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>35</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Propose that APOE could be an important modifier gene explaining heterogeneity in lipoprotein profiles observed among familial LCAT deficient patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19515369</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>13</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of apoE epsilon4-allele had a higher risk of coronary artery sclerosis with a significantly higher degree of coronary stenosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19733021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that APOE haplotypes were not significantly associated with disease status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19259132</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>gene polymorphism is associated with psoriasis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19499236</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>50</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest that recruitment of apoE by NS5A is important for viral assembly and release of infectious viral particles</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20014138</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>47</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphisms generate more than 10 percent of the interindividual difference of plasma cholesterol.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19691831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High density lipoproteins (HDL) apolipoproteins A-I, A-II and E have distinct intracellular and post-secretory pathways of hepatic lipidation and dimerization in the process of HDL formation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19635584</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism influences the short-term outcome of CSM patients after surgical decompressive and stabilizing therapy in the way that the presence of the APOE epsilon4 allele is an independent predictor for a no improvement.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19951017</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a role for the APOE gene in the diminished physiological complexity seen in elderly populations</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19890394</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 carriers and non-ApoE4 carriers with depression had lower Abeta42 and a higher Abeta40/Abeta42 ratio in plasma compared with non-ApoE4 carriers without depression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19812466</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was not a significant interaction for fitness x apoE4 genotype in early-stage Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19812458</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association and significant cumulative contribution of genotypes in myocardial perfusion with E4 allele having the strongest association followed by ACE D and ApoE g.-219T alleles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19713976</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4 allele is not consistently related to the outcomes of mild traumatic brain injury in children</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19645623</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE might also have a role in endometrioid endometrial cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19823059</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genetic polymorphism potentially influences susceptibility to schizophrenia and may be associated with aspects of its phenotypic expression, particularly gender, age of onset and family history of psychotic illness.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19752580</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19686716</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study showed that age-dependent effects of APOE4 on spine density in the cortex. The APOE4 TR mice had significantly reduced spine density at three independent time points compared with APOE3 TR mice and APOE2 targeted replacement mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19955384</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype prevalence was significantly greater in the amnestic and nonamnestic subtypes of mild cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19901172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Much of the association among family history of Alzheimer dementia, APOE epsilon4, and cognitive decline may be attributed to undetected incipient (latent) disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19901170</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon 4 allele is not associated with disease course and severity in multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19804477</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>From the logistic regression ananlsis of this stidy showed that the highest risk for was found for Alzheimer&apos;s disease individuals who co-inherited APOE epsilon4 allele, PRNP codon 129 homozygosity, PRND codon 174 Thr allele, and CYP46 rs754203 g allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19363267</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study investigated whether apoE variants influence the prevalence of cardiovascular risk factors (obesity, diabetes and dyslipidaemia), in patients receiving antipsychotic treatment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19541455</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele does not seem to be associated with increased risk of renal impairment in Chinese type 2 diabetic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18774543</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE2 allele is a possible genetic risk factor for all-cause ESRD in Caucasians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19565203</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that ApoE-Sendai mice, but not apoE KO mice, are a model for human lipoprotein glomerulopathy, and that apoE variants are essential to LPG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19459027</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon(4) allele is associated to a peculiar neuropsychiatric profile characterizing the onset and evolution of Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19590821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17553421</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.17553421</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>41</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that in African Americans, but not in Caucasians, apoC-I (but not apoE) genotypes were associated with variation in lipoprotein phenotypes, and in particular, the apoC-I H2-allele was associated with an anti-atherogenic pattern.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19252179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphism in apolipoprotein E gene was associated with renal cell carcinoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19808960</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a weak association between the APOE e4 allele and low-GFR cases and continuous GFR in non-Hispanic whites, and the APOE e2 allele and continuous GFR in non-Hispanic blacks, but no association with either measure of kidney function in Mexican Americans</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19852818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest it might be important to take into account WML severity when assessing the relationship between apolipoprotein E and dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19644067</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE-epsilon4 allele may have a role in poor odor identification ability and cognitive disorders in the aged</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19633944</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Surface plasmon resonance (SPR)was used to monitor in real time the reversible binding of apoE to human very low-density lipoprotein and high-density lipoprotein.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19209940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of the ApoE gene has a negative impact on cognitive performance, notably on episodic memory functions, in physically and mentally healthy aged persons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18615849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>presence of a particular APOE allele shows an increased risk for pulmonary tuberculosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19631387</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 allele is strongly associated with Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19262956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results define the LDL-R as a hepatitis C virus (HCV) co-receptor that supports viral entry and infectivity through interaction with apoE ligand present in an infectious HCV/lipoprotein complex comprising the virion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19751943</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study suggests the MTHFR 677 T allele and the APOE 4 allele may synergistically act to increase the risk of Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18258338</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest different roles for the APOE alleles in survival by gender in old age, taking into account the possible contribution of Alzheimer&apos;s disease, other dementias, ischemic heart- and cerebrovascular disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18237822</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Allelic and haplotypic heterogeneity of the APOE gene region does not influence multiple sclerosis disease course in a well-defined Australian multiple sclerosis cohort</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19786693</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19372276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that lower plasma apoE levels in middle age could be a risk factor for Alzheimer disease in old age, independent of APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19720974</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data of this study suggested that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19473356</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study found apolipoprotein E e4e4 genotype was more common in patients with Parkinson disease(7.4%)than healthy controls(1.4%);no significant associations between APOE genotype &amp; development &amp; progression of dementia or time to dementia were found</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19321880</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of one or two ApoE epsilon4 alleles may be a significant independent risk factor for cognitive impairment in the early phase after stroke</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19494491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19589783</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19018779</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We failed to replicate the original allelic association between ApoE epsilon4 allele and postictal confusion in our population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19375284</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>this study confirms the role of the rs449647 A/A genotype as risk factor for Alzheimer&apos;s disease in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19172988</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 allele is not strongly associated with a particular pattern of cognitive functioning in African Americans once they are diagnosed with Alzheimer Disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19668025</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele was associated with increased behavior problems, impaired social interactions, and restricted behavior patterns.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19564306</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>extended haplotype combinations, including the functional promoter SNP rs405509, is required in mediating age-related macular degeneration pathology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19384966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study provides insights into the genetic pathogenesis of AMD, and APOE has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19015224</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there are two major factors, intramolecular domain interaction and intermolecular dimerization, that cause ApoE3- and ApoE4-dependent lipid efflux from neural cells in culture</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19326444</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results indicate that common variation in the APOE gene affected both early and late event-related potentials components in healthy middle aged and old participants during an auditory three-stimulus oddball task</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19409447</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE evolution and very likely the evolution of other apolipoproteins are influenced by the feeding environment and diet of humans and various other species.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17265535</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study found no link between polymorphisms in APOE, p53, and p21 genes and primary open-angle glaucoma in Turkish patients,although a larger sample is required to elucidate the role of these polymorphisms in the pathogenesis and course of glaucoma</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19578553</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human immunodeficiency virus downregulates podocyte apoE expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19553347</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Sex and apoE genotype determine ApoE plasma levels but this effect is dependent on dietary fat.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19025720</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We conclude that APOE is a risk gene for amnestic mild cognitive impairment and that ACT and CHRNA7 may act in these patients as modifier genes for the time of progression to Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18078695</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant influence of epsilon4 on the symptoms of Alzheimer disease (AD) was detected: APOE&apos;s effect in AD may occur prior to clinical symptoms, or may simply be more subtle than these instruments can detect.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18083276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>review focused on the gender-related influence of Apo E polymorphism in respect to plasma lipid levels and the risk of coronary heart disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19429797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Adolescent girls with apolipoprotein epsilon3/3 and epsilon3/4 genotypes had higher total cholesterol and LDL-C and showed different patterns of change, compared to those with epsilon2/3 genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19524160</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lack of association between ApoE gene polymorphism and Type 2 diabetic nephropathy might be due to ethnic differences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19542737</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18609337</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant differences were found between the acute hypertriglyceridaemic pancreatitis cases and controls with severe hypertriglyceridaemia in terms of LPL activity and mass, hepatic lipase activity, CII and CIII mass, or apo E polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19534808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of the APOE*4 allele with lower levels of TC and LDL-C in the CRC group, different from that which occurs in the general population, suggests alterations in the lipid synthesis and metabolism pathways in CRC.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19377787</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Whether the rare mutation Arg136 --&gt; Cys in Apolipoprotein E is causal for the development of myocardial infarction needs to be further evaluated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19545491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer&apos;s disease (AD).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19679070</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>correlations between ApoE genotypes, protein expression and structural changes in diabetic nephropathy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19218599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>frequency of ApoE genotypes in normal Han Chinese populationand effects on lipid parameters were analyzed</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18600472</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the largest prospective cohort study to date, CHD risk was not associated with APOE genotype after controlling for a variety of cardiovascular risk factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19667307</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that Hpt might save the function of ApoA-I and ApoE for cholesterol esterification, a process contributing to cholesterol elimination from the brain.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19457062</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E2/E3/E4 analysis showed an inverse relationship with IPH when E2 plus E4 compared with E3</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18685811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data demonstrate an APOE-genotype (alleles APOE2, APOE3 and APOE4) and brain-region dependent genomic response to traumatic brain injury</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19409232</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Brain changes associated with Alzheimer disease may already begin developing early in middle age, especially among APOE epsilon 4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19557866</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study does not support previously reported associations between APOE genotype and susceptibility to, or cognitive decline in, Parkinson&apos;s disease (PD); an updated meta-analysis indicates any association with PD susceptibility is at most modest</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19308307</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is involed in carotid atherosclerotic lesions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18619685</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE epsilon4/epsilon4 genotype is a robust predictor of Alzheimer&apos;s disease and are also associated with a more rapid progression from mild cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19420940</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The observed frequency of the epsilon4 allele was 10%, but the correlation between the presence of epsilon4 and cognitive deficit in this population was not statistically significant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18641859</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggested that memory complaints are associated with markers of mental health and quality of life that are independent of possession of the APOE-epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19494432</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although APOE plays an important role in the aging process, the varepsilon2 and varepsilon4 alleles, based on these study results, do not have a direct link with the decline of physical function at different stages.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19570164</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impact of an ApoE-deficient diet on mice expressing human ApoE2, E3, or E4 allele demonstrates that E2 is more protective for dietary deficiency than murine ApoE or E3 and E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19457069</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18930458</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggesting that the apoe2/4 genotype might represent a genetic risk factor for primary progressive aphasia in women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19597098</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Case Report: ApoE alleles may have a significant association with aortic valve stenosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19304773</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of apolipoprotein B (apoB) and E (apoE) genetic polymorphisms (Xba I, EcoR I, Msp I, and Hha I) with parameters describing the serum lipid profiles in children undergoing primary nephrotic syndrome, was investigated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18512131</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A high-resolution NMR structure of the complete receptor-binding domain of human apolipoprotein E3 (apoE3-NT), is reported.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19307174</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there is no association between the ApolipoproteinE-epsilon4 allele and depression among those with Alzheimer disease or among cognitively intact elders</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19368858</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of APOE4 is associated with poor functional outcomes in humans after intracerebral hemorrhage. Our data suggest that the mechanism for this may be increased cerebral edema and not larger hematoma volume.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19251191</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>novel antioxidant role for apoE in adipose tissue</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19450584</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E polymorphisms modulate the risk of microsatellite stable and unstable colorectal cancer among high red meat consumers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19455140</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Gene-gene interaction analysis shows increase of the risk to develop Alzheimer&apos;s disease in subjects carrying both the at least one C allele and the APOE E4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19142571</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 genotype represents a risk factor for Alzheimer disease, and results in higher levels of Abeta plaque in APOE4-positive patients with AD compared to APOE4-negative patients with similar levels of cognitive impairment and brain atrophy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19339712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the -219G--&gt;T polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19056482</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17920160</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 may not by itself alter sterol or sphingolipid metabolism in the brain under normal conditions, but that other neuropathologic changes of Alzheimer&apos;s are required to unmask the effect of ApoE4, and to perturb sterol and sphingolipid biochemistry.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17888544</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A higher frequency of the ApoE4 allele in sCJD with a PFHD could be indicative of an additional risk factor in CJD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17822808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 was associated with increased odds of clinical AD, and its association with level of cognition was stronger. However, the use of quantitative measures of AD pathology markedly enhanced the association.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19398704</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>vascular risk factors diabetes and hypertension, a history of stroke itself, and APOE epsilon4 genotype independently contribute to cognitive decline in late middle age and early elderly years</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19362884</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19529002</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.19529002</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>33</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that the PPARgamma-LXR-apoE regulatory cascade could be an important molecular link for cross-talk between adipocyte triglyceride and cholesterol homeostasis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19218241</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the present study provides an excellent model in which the cognitive effects of APOE 4 in multiple sclerosis can be further studied.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19422789</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that APOE epsilon2 gene increases the risk of migraine, while APOE epsilon4 gene is protective against migraine and tension-type headache.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19184578</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms seem to have no prognostic value for outcome after SAH.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19199499</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>decrease in lipid accumulation in apoE-transfected cells was associated with a strong downregulation of PPARs gamma1 and gamma2 and stearoyl-CoA desaturase 1.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19130493</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study indicates apolipoprotein E(APOE) epsilon4 allele may be assoc&apos;d with primary open-angle glaucoma(POAG), while APOE epsilon3 may be protective for POAG. APOE polymorphisms may not be assoc&apos;d at all with primary angle-closure glaucoma(PACG)in Saudis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19421411</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE may play a role in extreme longevity and survival, taking into account AD, dementia and sex.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19405181</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19357304</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Understanding how apoE4 structure impacts neurodegeneration (Review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18948255</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE-e2 allele may be regarded as a neuroprotective factor in the development of neurodegenerative process in patients with amyotrophic lateral sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19365373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19266700</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study did not confirm associations between genetic polymorphisms of ABCA1 transporter, CETP and apoE and abnormal serum lipid profile during remission of nephrotic syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19341173</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the ApoE epsilon2 allele in this study is suggested to be protective against depressive symptoms in multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19244396</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon 4 genotype is associated with higher risk and and earlier onset of dementia in Alzheimer disease in persons with Down syndrome and early mortality in nondemented Down syndrome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18464295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>subgroup of elderly patients with depressive symptoms, cognitive impairment, and a high likelihood of experiencing thoughts of death or suicide may exist that may not be related to APOE-epsilon4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19307863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>cognitively healthy APOE epsilon4 carriers are more prone to develop Alzheimer&apos;s disease pathology with aging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19276554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE has an influence on nonverbal cognition in old age and interacts with childhood IQ to influence processing speed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19290744</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphisms of the ApoE gene could affect disease progression in preclinical Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18786162</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was a significant difference in apoE genotype frequency between normoweight coronary heart disease patients and healthy controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19368122</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significantly more AD subjects had apolipoprotein Eepsilon4 alleles than did controls (63% vs.10%).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19199875</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of the APOE-epsilon4 allele significantly enhanced the risk of cognitive decline associated with depressive symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19181718</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The genetic polymorphisms of the ApoE, genes were found to be significantly different (p&lt;0.05) between the uremic and non-uremic diabetes group</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19148546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19116453</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E4 and ACE Del/Del genotype combination substantially increase stroke risk, supporting the notion that interactions of multiple gene variants influence stroke pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18027070</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Different isoforms of apolipoprotein E (apoE)degrade beta-amyloid in the brain with different efficiency and clearance rates and explain, in part, the isoform-dependent effects of apoE in determining genetic risk for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19295164</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of ApoE epsilon4 allele evidenced steeper age-related increase in costs of Stroop color interference, but showed no negative effects on memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19210038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>One single nucleotide polymorphism of apolipoprotein E(rs769450) was significantly associated with age at natural menopause</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19058936</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lack of association between apolipoprotein E promoters in epsilon4 carriers and worsening on computed tomography in early stage of traumatic brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19066116</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No differences in genotypic distributions between the dementia in Parkinson&apos;s disease,Parkinson&apos;s disease and control</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18930114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene does not predispose carriers to depressive symptoms among healthy young adults. However, the promoter haplotype GC/TG may elevate the risk of depressive symptoms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18843194</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We were thus able to confirm the role of ApoE, IL-1alpha and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1beta and PDYN.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19066720</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE genotype (APOE epsilon2 or APOE epsilon4 alleles) and SNCA-REP1 polymorphism do not seem to influence olfaction in PD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19047559</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between vitamin B-12 and cognitive function was moderated by APOE epsilon4 status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19244370</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These preliminary results demonstrate that APOE epsilon4 is associated with an increased risk of postictal confusion in patients with medically intractable temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18672349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors for atherosclerotic infarct in E3 or E4 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18945448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggested that both apoE and apoCI on chromosome 19 were the susceptibility loci for coronary artery disease, their linkage disequilibrium should be responsible for the development of coronary artery disease .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15793777</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that variation in the MIP-1alpha and ApoE genes and their interaction may increase susceptibility to Ulcerative Colitis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18762952</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alteration in circulating apolipoprotein E3 isoforms is implicated in preeclampsia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18725658</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results revealed that either the frequency of genotype or that of allele of apoE gene polymorphism showed statistical difference between the ethnic populations in Yunnan, China.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15793794</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Clinical trial of gene-disease association. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19300863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.19300863</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>31</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data do not support an association between ApoE polymorphism and frailty.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18266965</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the oldest old, the presence of the APOE epsilon2 allele is associated with reduced risk of dementia, but increased Alzheimer&apos;s disease neuropathology.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19255410</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In old age, high serum calcium levels associate with worse cognitive function especially in APOE epsilon4 allele carriers, but not in carriers of the epsilon2 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19255409</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>HuGE review of gene-disease association and gene-environment interaction. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19238444</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.19238444</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>influence of APOE epsilon4 on the risk of Alzheimer&apos;s disease was independent of homocysteine, vitamin B12 levels and MTHFR status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19169966</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association of allele epsilon 2 of apoE gene with the maturation of HDL in type IV hyperlipidemia was noted in the study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15696494</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The slightly altered structural properties of apoE4-mut2 are associated with slightly reduced binding of this protein to TG-rich lipoprotein particles and milder hypertriglyceridemia as compared with WT apoE4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18959431</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These observations suggest that the preferential binding of apoE to oxidized phospholipid containing membrane may play a role in the anti-oxidative properties of apoE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19159618</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that Longevity was noted to be positively correlated with epsilon 2 and negatively correlated with epsilon 4 apoE genotypes in the Xinjiang Uighur people.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16086293</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant differences were observed for genotype and allele distributions of APOE epsilon2/epsilon3/epsilon4 polymorphism in patient with stroke in chinese.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18851860</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphsms may increase risk of myocardial infarct.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19217440</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings indicate that the effects of tamoxifen on plasma triglyceride levels in breast cancer patients are modified by APOE polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19103187</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Report the anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in apolipoprotein E2 (APOE2) knock-in mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18757293</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results show an role of apoE4 C-terminal segments in secondary structure stability and unfolding and suggest that interactions mediated by the C-terminal segments are important for the structural integrity and conformational changes of apoE4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18690708</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Dietary supplements were effective in both normal and mice expressing human ApoE4, one of the three major alleles of ApoE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17914184</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no convincing evidence that carriers of the APOE epsilon4-allele have a higher risk of delirium</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17728664</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the older white population, APOE epsilon2 and epsilon4 allele carriers were more likely to have arterio-venous nicking.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18079687</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this population of elderly women, although having at least one epsilon4 allele increased the chances of an earlier death, having dementia increased the risk of death regardless of APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19207139</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE single nucleotide polymorphisms were not associated with increased Common carotid intima-media thickness.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19148342</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genetic polymorphisms/intrauterine undernutrition interaction and hypercholesterolemia in children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18052682</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18708484</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18721259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Enhanced hippocampal connectivity with additional brain regions in APOE epsilon4 allele carriers during the performance of an associative memory task</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17560689</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show the modulating effects of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18839184</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>individuals showed Presenilin 1 polymorphism to be associated with Alzheimer&apos;s disease in an apolipoprotein E specific manner</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18957849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*4 allele is not assosiated with risk of development of the multiple sclerosis at ethnic Russians.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19140315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an association between apo E polymorphism and CETP activity and this association did not affect the relationship between apo E polymorphism and triglyceride and HDL cholesterol concentrations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19140312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The frequency of E4 allele as a genetic risk factor for some multifactorial diseases in the population of Southern Iran is in the lowest reported amounts in the world.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17594534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of an ApoE epsilon4 allele was associated with an increased frequency of coexistent LBD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18653200</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19086990</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE polymorphism was statistically significantly associated with non-alcoholic steatohepatitis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18465245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our observations suggest that elderly people in long-term care hospitals in Japan may be repeatedly infected with hMPV and that the ApoE-varepsilon4 allele might be one of the host factors related to hMPV susceptibility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19166449</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Demonstrated the existence of the synergistic effect between cigarett smoking and the contemporaneous carrier-state of APOE epsilon4 ellele which increased the risk of coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19157170</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings support the hypothesis that the ApoE genotype in mild cognitive impairment might be associated with structural changes typically found in the early stages of Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18843182</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE may have a role in muscular invasion of gastric cancer</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19020708</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no major influence of APOE epsilon4 on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon4 carriers was found (p=0.027). These data support APOE epsilon4 as a subordinate contributing factor in ALS.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18656208</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype influences chronic lymhocytic leukemia outcome and response to therapy, it does not alter susceptibility to developing this disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18784741</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19165527</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>20</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>28</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate that the APOE genotype may be a component in assessing the effectiveness of 17beta-estradiol&apos;s action and may impact the neuroprotective role of 17beta-estradiol hormone replacement therapy on brain function when the APOE4 gene is expressed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17553597</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Outcome demonstrated that patients with APOE epsilon4 had worse outcome vs. those lacking this allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19025529</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest a possible influence of APOE genotype on nitric oxide production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18846579</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The diagnostic performance of hsCRP in distinguishing 3-vessel coronary artery disease from less extensive forms of coronary atherosclerosis is more accurate in a group of subjects without the apoE epsilon4 allele than in patients with it.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18609102</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lower CRP in those with APOE4 may reflect immune effects of the APOE4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17540481</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study shows a significant increase in intracerebral hemorrhage in human apoE4 targeted replacement mice compared with apoE3 mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18755411</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Older age was associated with increased lateral temporal FDDNP binding. Carriers of APOE-4 demonstrated higher frontal FDDNP binding than noncarriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19124691</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE epsilon3/epsilon4 genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19000312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genome-wide association study reveals putative Alzheimer disease susceptibility loci in addition to APOE.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18976728</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes may be associated with the psychosocial and neurocognitive performance after spontaneous nonaneurysmal SAH, even in the absence of neurological impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19035714</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These observations suggest that there is an interactive effect between APOE and LIPC genotypes on plasma triglyceride levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18641720</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Adipo-inductive media or dexamethasone induced sustained secretion of apolipoprotein E in mesenchymal stromal cells and the duration of secretion was only limited by the length of time mesenchymal stromal cells could be sustained in culture.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18823563</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APO E polymorphism is associated with the development of traumatic brain injury -induced pituitary dysfunction</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18707245</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>article reviews the current understanding of the genetic susceptibility of traumatic brain injury (TBI) and the advancements regarding the impact of apolipoprotein E genotype on the severity and/or outcome following TBI [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18667124</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed that the frequency of APOE epsilon4 allele was significantly higher in the depressed vs non-depressed AD patients (72% and 58%, respectively).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18058831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the APOE epsilon4 allele is associated with impaired memory functioning in both middle-aged and old subjects with mild cognitive impairment, although the memory function affected varies with age</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18617739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Within the coding sequence of APOE we identified an enhancer for the E4 allele associated with Alzheimer&apos;s disease, but not E3. A SNP causing the E4/E3 amino acid substitution was responsible for these variations, and higher expression levels of E4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18718521</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E gene expression and protein concentration were higher in non-small cell lung cancer tissue than in adjacent non-cancer tissue; increase of apo E concentration in the cancer tissue correlated with the decrease of apo E protein in the serum</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18760194</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a low adiponectin state is associated with metabolic abnormalities in obese children, particularly depending on apolipoprotein E phenotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18753423</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In adjusted models, while a higher cortisol level was associated with worse cognitive scores, the slopes of the adverse relations were steeper in persons with at least one APOE-epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18593777</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype is not associated with prevalent hypertension in old age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18297189</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Overweight exhibited an inverse association with APOE4 and associated with decreased non-APOE4 Alzheimer&apos;s disease onset age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18189240</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data suggest that a cooperative mechanism involving APOE and APH-1b plays a role in the susceptibility to develop AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17466415</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that of four genes studied -- angiotensin-forming enzyme, PON1, PPAR-gamma, and APOE -- only PPAR-gamma and APOE showed an effect on fertility.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18443916</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18572260</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>falls with head injury without explicit traumatic brain injury in connection with the ApoE epsilon4 allele is associated with subsequent dementia among older adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18307571</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that Apo e4 exerts a regionally selective effect on CA3&amp;DG in normal aging and AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18534867</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18262228</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The linkage of Alzheimer&apos;s disease to chromosome 19 was well explained by APOE in the whole sample as well as in the UK and USA.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18161859</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The specific Apolipoprotein E allele showed higher levels of Matrix Metalloproteinase 9 in epsilon 2 carriers compared to the non- epsilon 2 carriers of the patient group and large artery atherosclerosis subgroup.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18094576</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE2/3 blacks may benefit more from aerobic fitness to reduce cardiovascular risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19013289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evidence of an effect of APOE status on the relationship between stress and cognitive functioning despite a number of differences in study design.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18981067</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The preferential interaction of the P. falciparum PFE1590w protein with the human ApoE epsilon3 and ApoE epsilon4 isoforms, but not the ApoE epsilon2 isoform, supports the hypothesis that ApoE genotype affects risk of malaria infection.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18937849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Children dying from identified causes have different APOE allele distributions from sudden infant death syndrome (SIDS) cases, but are similar to adults. Children dying from SIDS have an allele distribution comparable to healthy newborns.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18280677</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is not associated with the development of schizophrenia (OR 1.04, CI 95%=0.90-1.21, p=0.184) in the absence of heterogeneity (chi2=18.8, df=18, p=0.4).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18590026</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype is not associated with cerebral palsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18810496</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that the apolipoprotein E epsilon3/epsilon4 genotype is more frequently seen in the simple febrile than in the complicated febrile convulsion group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18805361</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>36</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APO E4 genotype and allele were found to be associated with asymptomatic obesity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18454345</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among plasma proteins, apoE is one of the preferred substrates of matrix metalloproteinase (MMP)-14, and also of MMP-7 and MMP-2, to a lesser extent.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18655030</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E promoter polymorphism is associated with ischemic stroke and intracranial atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18301447</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 is a very strong risk factor for Alzheimer&apos;s disease (AD) in the population of central Norway. The odds ratio for developing AD increases in individuals carrying the APOE4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18416843</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Preexisting cognitive impairment and postoperative cognitive dysfunction are not associated with APOE epsilon4 genotype, suggesting that cognitive impairment both before and after CABG may not be associated with degenerative cognitive decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18721571</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18702945</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A combined effect of APOE and IL1B allelic variants has been discovered indicating the increased risk of the disease development in the carriers of APOE*4 and IL1B*T/*T alleles (OR = 4.76).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18664147</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that the ApoE epsilon4 allele frequency is significantly higher in the Alzheimer&apos;s disease patients than in the non-Alzheimer dementia patients or in the control groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18555606</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>It is possible that APOE*E4 carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65-69 years of age</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18620605</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>&apos;Free&apos; copper (fC) levels were higher in Alzheimer patients and correlated with parietotemporal delta and alpha-1 activities. The correlation between fC and temporal alpha-1 activity was stronger in APOE-epsilon4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18486114</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among 100 stroke patients and 30 healthy subjects included in the study, most frequent Apo E genotype was epsilon3/3; polymorphisms were associated with lipid profiles and homocysteine levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18576210</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>cognitively intact carriers of APOE-4 show regionally specific thinning of the cortical ribbon compared to APOE-3 carriers</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18486492</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The objective of our study was thus to determine the allele, genotype, and haplotype frequencies at several single nucleotide polymorphisms (SNPs) in the region of ApoE and test their association with OSA status in children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17658295</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer&apos;s disease: no evidence of association in the Irish population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18057979</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced antioxidant defense enzymatic activity and increased SOD activity increases the risk of AD in individuals who carry the APOE-4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18505684</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4/epsilon4 genotype is associated with an accelerated disease course and especially progression to death compared with the APOE epsilon3/epsilon3 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18562290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE and ApoA1 gene variants may act synergistically to associate with risk and protection against coronary artery disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18398670</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18525129</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele was associated with differences in neurological recovery and longer rehabilitation LOS. Genetic factors may be among the determinants of outcome after SCI and warrant further study.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18581664</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>E2 might interact with other disease-related factors to accelerate the onset of coronary artery disease in some patients with systemic lupus erythematosus</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18443545</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results examine the frequency of apolipoprotein E4 in dementia with Lewy bodies.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18370334</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 status modifies the association between depressive symptoms and dementia in elderly men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18678795</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is no important association between carrying the apolipoprotein epsilon 4 allele and sustaining a concussion</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18614883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>our data suggest that the four analyzed genes do not play an important role in susceptibility to schizophrenia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18164902</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE4 allele and life-stress factors are associated with SRH, especially in women. Physical exercise is good for health, but benefits may be attenuated among APOE4 allele carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18365330</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic variation at the APOE is not a genetic factor related to the genetic susceptibility to coronary artery disease in Mexican individuals</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18298348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The V allele of the GSTP1 may be a risk factor for late-onset Alzheimer&apos;s disease, mainly in the presence of the apoE 4 allele, while the presence of GSTT1 may indicate protection against the disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18298341</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no association between macular degeneration and APOE polymorphism; A weak negative association between APOE4 and cataract and apolipoprotein E3 may be a protective factor against the loss of nerve fibres in the macular region</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18498549</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-epsilon4 was not associated with cognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18305286</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results suggest that recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18359298</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results describe an antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18382765</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced task-associated MTL activation that does not correlate with either visuospatial perspective or task performance suggests that MTL dysregulation occurs prior to clinical symptoms of dementia in APOE*4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17350142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene actions may be more significant as modulators of frailty than of longevity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18250093</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>increased prevalence of APOE epsilon4 in patients with mild cognitive impairment and subjective complaints</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18401171</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We conclude that APOE is influencing the risk of dementia in persons with DS.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17250929</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17250852</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of gallstones, a 1.8-fold risk of gallbladder cance, a 3.7-fold risk of bile duct cancer and a 4-fold risk of ampullary cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18296645</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival in Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18332630</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results compare the effect of apolipoprotein E gene polymorphism on serum lipid levels between the Chinese Guangxi Hei Yi Zhuang and Han populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18367629</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The data suggest that neurophysiological endophenotype of non-demented individuals at genetic risk for AD, characterized by increased excitability and dysfunction of deep brain and alpha rhythm-generating structures.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17293007</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 enhances attachment of C. pneumoniae elementary bodies, but not those of C. trachomatis, to target host cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17997273</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sporadic inclusion body myositis but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon2 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18060780</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with ApoE epsilon4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17932679</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present study suggest the possible influence of APOE on specific cognitive domains (orientation and language domains)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18242855</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results indicate that the C-terminal domain is organized differently in apoE3 and apoE4 so that apoE4 self-associates less and binds less than apoE3 to HDL surfaces.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18201068</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results partially support studies of older adults that suggest that increased cognitive asymmetries reflect risk for dementia and are associated with the APOE-epsilon 4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18235080</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hypertriglyceridemia is closely associated with APOE*2 allele and with an early onset of liver cirrhosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18241317</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>mRNA expression of ApoE in arterial walls was not different between the controls and cerebral aneurysms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18360691</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>amyloid beta peptide association compromises the fundamental lipoprotein binding function of apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18407659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18401023</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The environmental and life-style conditions of the Kola Sami could have influenced the population-specific frequencies of the AGXTProIILeu allele, and certain alleles of APOE and LCT genes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18468259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*2 (apolipoprotein E2) carriers showed a decreased risk of all-cause mortality and APOE*2 allele confers a lower risk of all-cause mortality only to normal weight individuals</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18163216</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We report the discovery of a genetic interaction between APOE and LHCGR alleles that is associated with a significantly decreased risk for Alzheimer&apos;s disease in males</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18439297</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE (arginine 150 proline) is a novel apoE variant that etiologically related to lipoprotein glomerulopathy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18046082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The researchers found an association the presence of the epsilon2allele and epsilon2epsilon3 genotype and a lower risk of myocardial infarction compared to the epsilon3epsilon3 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17433475</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this Brazilian population, the epsilon 4 allele in the apolipoprotein E (APOE) gene was associated with an increased risk for AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18317248</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>24</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon4 allele in healthy elderly was associated with increased subjective mental slowing after trihexyphenidyl anticholinergic challenge.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18239197</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Carriers of the epsilon 2 or epsilon 4 APOE allele has an increased risk of both incident and recurrent intracerebral hemorrhage (ICH), and both cortical and deep ICH; most risk estimates are higher in Asians than in Europeans.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18256366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The rate of brain atrophy in certain brain areas may be increased in APOE epsilon 4-positive subjects with mild cognitive impairment progressing to dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18322386</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The researchers found that APOE gene variations were slightly less significant than the Alu polymorphisms in assessing the genetic heterogeneity within the sampled Mediterranean populations</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18274923</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Inhibition of CETP reduced the VLDL apoE pool size (-28%) by increasing the VLDL apoE fractional catabolic rate (77%) and leaving the VLDL apoE production rate unchanged</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18033754</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>identified receptor-ligand genetic interactions between VLDLR 1226 and APOE genotype for predicting CAAD case status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18056683</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18205760</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphism and coffee drinking was associated with Parkinson&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18210157</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although the ApoE genotype distribution was not significantly different between gPD patients and controls, the protective E2 alleles were more frequent in controls than in patients without a PFH and even less frequent in those with a PFH.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18157657</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>As compared with E4-, E4+ subjects showed decreased CMRglc in AD-related brain regions and associated higher CSF IP, P-Tau, T-Tau, and P-Tau/Abeta42 levels (p&apos;s &lt; .05).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17720148</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18376061</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.18376061</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE isoforms have minimal impact on warfarin dose requirements in Asian patients, probably due to the low frequency of epsilon 4 allele-containing genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17995970</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17420762</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with the APOE-in4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-in4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17971433</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of the ApoE-epsilon4 allele modifies the relation between plasma homocysteine and cognitive performance</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18023533</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon2/3 genotype is a major contributor to ADL disability in common geriatric diseases, while providing protective effects for coronary heart disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18179501</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE expression modulates capase-3 activity, but this has no significant impact on sensitivity to apoptosis and only a moderate impact on basal cholesterol efflux.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18047842</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease structural and biochemical arteriolar abnormalities did not vary as a function of APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18258839</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>To evaluate a possible association between the epsilon polymorphism of the apolipoprotein E gene (apo E) and premature IHD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17975753</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon2 allele was in linkage disequilibrium with the -427C allele in atherosclerosis diseases, and the -219T allele was associated with the epsilon4 allele in the ischemia heart disease group.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18219091</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alzheimer&apos;s disease development is controlled not only by the apoE isoforms but also by the posttranslational modifications in apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18023277</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present results indicate that the most common ApoE phenotype in Greek demented patients is E3/3.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18041613</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>detected the carriers of the apolipoprotein E Arg136 --&gt; Cys mutation through the population screening</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18326082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 allele increases the risk of CSM in patients with chronic cervical spinal cord compression</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18317192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 is significantly associated with cognitive impairment in patients with multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17460153</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 may function to accelerate thinning in areas found to decline in aging (medial prefrontal and pericentral cortex).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17161508</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E polymorphism does not differentiate familial from sporadic Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17607431</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis and HuGE review of genotype prevalence, gene-disease association, gene-gene interaction, genetic testing, and healthcare-related. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15003956</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.15003956</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study of genotype prevalence, gene-disease association, and pharmacogenomic / toxicogenomic. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17995970</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>348.17995970</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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          <Pub_pmid>
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      </Gene-commentary_refs>
      <Gene-commentary_source>
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      <Gene-commentary_create-date>
        <Date>
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            <Date-std>
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              <Date-std_day>13</Date-std_day>
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              <Date-std_minute>43</Date-std_minute>
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            <Date-std>
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              <Date-std_month>3</Date-std_month>
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      </Gene-commentary_update-date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17659264</PubMedId>
          </Pub_pmid>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
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        </Pub>
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      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E-epsilon 4 carriers had significantly lower levels of C-Reactive Protein yet significantly higher levels of Cytomegalovirus antibodies</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18171282</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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      </Gene-commentary_update-date>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review cites growing evidence of the effect of ApoE on modifying brain inflammatory responses and providing protection from excitotoxic injury, which may be central to its protective properties.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17716229</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
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    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>it is concluded that apoE enhances the capacity of PLTP to remodel HDL but reduces the ability of HDL to participate in PLTP-mediated phospholipid transfers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17921435</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Common APOE polymorphism does not seem to be an independent genetic determinant of carotid intima-media thickness, brachial flow-mediated dilatation or carotid artery compliance</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18159095</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>To investigate associations of APOE, APOE promoter (G-219T), and tau protein exon 6 polymorphisms (47 and 53) and a history of self-reported concussion in college athletes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18185033</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In both wild-type and human apoE knock-in mice, apoE-intron3 is found predominantly in cortical and hippocampal neurons by in situ hybridization.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18256266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE -491AA promoter in epsilon4 carriers is apt to the clinical deterioration and may contribute to the poor outcome after TBI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18159991</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The expression of apo C1 and apo E are closely associated with the susceptibility to the pathogenesis of atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17936795</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In female subjects (but not in male) an association between APOE polymorphism and TC was observed on the background of the common APOA5 haplotype (TT-1131/SerSer19).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17957227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 allele may be correlated with severe depression in the elderly through ways other than the &quot;vascular depression&quot; hypothesis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17911363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the effects of APOE alleles on gene expression in Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17822919</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>both diabetes and APOE epsilon4 increases the risk of dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18195144</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the apolipoprotein E epsilon2 allele is an important risk factors for neurodevelopmental dysfunction after repair of Tetralogy of Fallot</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18179924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) indicate that E(4) is associated with more-rapid cognitive decline and may, therefore, predispose to dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17979899</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Coronary function improves by 6 months of pravastatin therapy in subjects with the apoE epsilon3/3 genotype, but not in those with the epsilon4/3.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17852827</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The latitudinal distribution of the APOE epsilon3 and epsilon4 allele frequencies in the populations examined was comparable to the frequency distribution pattern of these alleles in other populations of Eurasia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18069348</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our results show a clear association of APOE with carotid intima-media thickness, even though publication bias means that this is overestimated by the published literature.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18063831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as Progression Index.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17883422</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>present study suggests that ApoE polymorphism significantly affects serum lipid profile in hemodialysis patients and epsilon4 allele carriers are more susceptible to have atherogenic lipid profile</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17763167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele is associated with hippocampal, amygdalar and entorhinal cortex atrophy; increased brain atrophy; increased white matter hyperintensity volumes; and altered cerebral blood flow and glucose metabolism patterns. [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17911980</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon4 allele of APOE is an independent risk factor for metabolic syndrome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17848120</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the effect of APOE gene variation on risk of AD and rate of cognitive decline and demonstrates that a single SNP captures all of the risk of developing AD but two SNPs in the regulatory region may affect the rate of cognitive decline in AD patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17613540</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene interacted with gender in predicting severity of acute neurological deficit and post-stroke mortality within the period up to 1 year after the IS.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17986098</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a probable association between epsilon3/epsilon4 genotype of apolipoprotein E and lacunar infarcts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18055294</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is required for HCV virion infectivity and production, suggesting that HCV virions are assembled as apoE-enriched lipoprotein particles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17913825</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>occurrence of the epsilon2 allele and epsilon2epsilon3 genotype may be protective against development of nonalcoholic fatty liver disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17431774</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17342071</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impairments in neuroplasticity induced by apoE4 following environmental stimulation cause accumulation of intraneuronal Abeta, suggesting that Abeta mediates the synergistic pathological effects of apoE4 and environmental stimulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17666042</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17689519</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Men with APOE Kyoto mutation are at increased risk for lipoprotein glomerulopathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18077821</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apo e4 allele is associated with impairment of endothelium-dependent arterial dilation in the relatively early stage of female type 2 diabetes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16337304</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E2 genotype may contribute a common phenotype of enhanced vascular instability that increases the risk of hemorrhagic outcome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17986934</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regulation of mouse and human APOE genes may be sufficiently unique to justify the use of both the human APOE promoter sequence in transgenic rodent models and non-rodent AD models for studying factors involved in AD pathogenesis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17854398</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>found a significant increase in the hazard of ischemic heart disease in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other risk factors, and structural isoform variations of the ApoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17535270</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results are consistent with a close coupling between release of 24S-hydroxycholesterol and apoE secretion under conditions with neuronal degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17822846</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>HBO2 therapy reduces cognitive sequelae after CO poisoning in the absence of the APOE 4 e4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17702967</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype was not associated with education and did not account for the relationship between education and dementia in a twin study</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17597169</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>among dyslipidemic patients, carriers of APOE*4 compared to homozygous carriers of APOE*3 had significantly higher levels of LDL cholesterol and apoB, but no relationship with CAD was found</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17985658</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 carrier status was associated with increased risk for early postoperative delirium; results suggest genetic predisposition plays a role &amp; may interact with anesthetic/surgical factors contributing to the development of early postoperative delirium</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17721242</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E gene mutations may not be the only etiology of lipoprotein glomerulopathy, and it is likely that other abnormalities could play a role in the pathogenesis of the disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17918142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The e4 allelic frequency was 8% in the nephropathy group versus 25.9% in the control group. Apo e3 allele and E3/3 genotype frequency were higher and E3/4 genotype was lower in the nephropathy group than in controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17481771</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The exact role of APOE in the pathophysiological process of Alzheimer disease still remains unknown; the APOE gene is the only gene so far recognized as a consistent genetic determinant of sporadic forms of AD [review].</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17659844</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>RLP-cholesterol is better associated with, APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17704619</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Expression of the hApoE transgene was not sufficient to correct hypercholesterolemia. However, lesion area at the brachiocephalic artery (BCA) was significantly reduced (-72%) in female hApoE transgenic mice on the LDLR-/- background.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17669363</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings challenge the commonly held notion that the presence of the APOE epsilon4 allele reduces onset age; findings indicate risk factors other than APOEe4 allele underlie the non-familial, early onset posterior hemisphere presentations of Alzheimer&apos;s.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17941342</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 carrier might be associated with the protection for the development of diabetic nephropathy in type 2 diabetic patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17624465</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We propose that the differential regulation of mortalin in AD and by the APOE genotype is a cellular defense mechanism responding to increases in oxidative stress.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17050040</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no association between APOE epsilon4 genotype and aluminum absorption</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17966072</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The genetic polymorphism of apoE has an independent negative impact on patient and graft survival in kidney transplantation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17889142</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis of the APOE4 allele in Down Syndrome and its possible role in unsuccessful ageing</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17559337</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The present prospective study indicates that the epsilon4 allele of the Apo E polymorphism is one of the prognostic risk factors involved in the development of diabetic nephropathy with type 2 diabetes mellitus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16933203</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>detection of fourth allele (epsilon3r) in a Caucasian patient with motor neuron disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17244188</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Availability of monomeric, biologically active, full-length apoE, allowing high quality NMR structural determination</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17715945</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Changes of HDL-cholesterol and apo-AI/apo-E mRNA ratio could be a good indicator of liver damage and/or hepatic functional recovery post-orthotopic liver transplantation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17696931</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17519358</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These observations may give insight into the etiology behind the increased risk for AD associated with the ApoE-epsilon4 allele and the pathogenesis of vascular Abeta deposition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17089130</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE2 allele was negatively associated with hypertriglyceridemia/hyperapobetalipoproteinemia in the absence of a deleterious LPL gene variant.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17848837</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The sexual abuse scale were negatively associated with memory performance. Furthermore, the epsilon4 allele of the apolipoprotein E gene interacted with sexual abuse scores to result in reduced memory test performance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17210134</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Prolonged exposure of older, nondemented individuals to stress in the presence of an epsilon4 allele leads to memory decline.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17544378</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was an effect of APOE epsilon4 on the object recognition and spatial navigation tests in healthy elderly persons, with non-epsilon4 carriers outperforming epsilon4 carriers, but not in the other cognitive tests</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17509769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a significant effect of the apoE genotype on total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)/Total cholesterol (TC) ratio, and triglycerides was observed in a rural South African population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17676504</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>approximately linear relationship of apoE genotype with LDL-C levels &amp; coronary heart disease risk; compared with individuals with epsilon3/epsilon3 genotype, epsilon2 carriers have lower risk &amp; epsilon4 carriers have a slightly higher risk [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17878422</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The epsilon2 allele of the apolipoprotein E gene may have a protective effect against some aging-associated diseases and mortality in oldrer individuals.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17767697</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the Ouro Preto, Brazil, admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17224996</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>applied a genetic-demographic approach to a dataset relevant to two genes, APOE and HSP70.1, previously shown to be related to longevity by the gene-frequency method</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16896546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Evidence from these analyses supports current literature refuting the notion of relatively poorer neuropsychological functioning associated with the APOE-epsilon4 genotype among young adult participants shortly following mild or moderate brain injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17287237</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review discusses the differential effects of human apoE isoforms on anxiety in adult mice lacking apoE and in probable Alzheimer&apos;s disease patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17710250</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Among older adults free of clinical cardiovascular disease, specific apo E alleles appear to confer positive associations of alcohol confer associations of alcohol consumption with IL-6 concentrations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17684217</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Macrophage secretion of apoE occurs via a PKA- and calcium-dependent pathway along the microtubule network.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17660382</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16959267</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The study suggests an association between the ApoE epsilon4 allele and the late-onset depression without cerebrovascular disorders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17337010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review analyses the influence of apo E polymorphism on blood lipids and coronary heart disease in respect to age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17224309</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE*E2 allele occurred with lower and the epsilon4 allele with higher total and LDL-chol.  In adulthood, apoE phenotype-related difference in HDL-chol, and the epsilon2 allele occurred with higher and the epsilon4 allele with lower apoA-I and HDL-chol.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17484618</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No main effect of APOE in an autism data set.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17621165</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The relationship between APOE genotype and mortality differs across population groups but shows little evidence of variation within groups.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17702883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The prevalence of E3/E3 was lower &amp; that of E4-containing phenotypes was higher in stroke patients. The prevalence of E4-containing phenotypes was significantly higher in ischemic vs hemorrhagic &amp; in small-vessel vs large-vessel stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17689412</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17709709</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In contrast to previous smaller studies, apoE polymorphisms were not associated with susceptibility to cholesterol gallstone disease in high-risk populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17384433</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The aim of this study was to establish the frequency of apoE genotypes in 744 Mongolian subjects and to compare the results with findings from other Asian populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17706019</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Possession of an epsilon 4 allele influences the likelihood of exhibiting an exaggerated pupil response and the absolute overall magnitude of the response. Allelic variability also correlated with cognitive impairments in memory and attention.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16764677</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4,4 is associated with thinning of the microvascular basement membrane in Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12417381</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE varepsilon 4 allele occurs frequently in late-onset Alzheimer disease and we have found similar association in cognitively impaired individuals without clinical cerebrovascular disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12417380</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE varepsilon 4 allele is a predisposing factor for Alzheimer disease, but not for cerebrovascular disease or vascular dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12417379</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE e4 allele was associated with a marked reduction in LDL peak particle size and an increased plasma concentration of small dense LDL.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12818414</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Association of plasma lipid levels with apolipoprotein E polymorphism in Type 2 diabetes; carriers have increased risk of NIDDM</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11879722</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE 2 allele was associated with significantly worse reexperiencing symptoms and impaired memory function subjects with combat-related posttraumatic stress disorder population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16387995</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>for E2/2 subjects, lipoproteins isolated in the LDL density range appear to be composed mainly of dense IDL remnants and some Lp(a). The apo E isoform also has a significant effect on LDL concentration in both homozygotes and heterozygotes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16740268</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE genotype was determined using the CardioVascular Disease (CVD) StripAssay. The prevalence of genotypes E3/3, E3/4, and E2/3 was found to be 69%, 26%, and 22%, respectively, and 0.6% for each of E2/4 and E4/4 genotypes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16817024</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype may influence the cognitive phenotype of PD, and specifically that absence of the epsilon4 allele is associated with working memory impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16769085</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An association with the epsilon4 allele in multiple sclerosis was evident in this study, but only in cases of severe cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17294608</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE domain structural requirements for the formation of SDS-stable complexes with beta-Amyloid(1-40)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12015813</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE is dysregulated in nephrotic syndrome with marked increment in serum. Glomerular apoE is down regulated in focal segmental glomerulosclerosis and may contribute to pathogenesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12631135</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is a minor association between BChE-K and early-onset coronary artery disease, especially in the presence of the APOE-epsilon 4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12074828</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cellular and secreted levels of apoE are reduced (15 and 30%, respectively, over a 24-h period) by addition of exogenous lactosyl ceramide (LacSer) to cultured macrophages, indicating a proatherogenic role for LacCer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11820771</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results of the present study offer new insight into how recognition memory is affected by Alzheimer disease , the epsilon4 allele, and the modality of the stimulus to be remembered.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15370375</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE epsilon4 allele is associated with chronic cerebral infarction detected at autopsy in older persons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15774818</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE2 allele increased in tardive dyskinesia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16261623</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15525904</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that, in addition to lipid content, the assembly state of apoE influences amyloid-beta peptide (Abeta)binding and receptor recognition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16401069</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOC3 polymorphisms were associated with lipid variables, but the magnitude of these associations was modulated by additional genetic, biologic and/or environmental factors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17367769</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>HFE and APOE genotypes are different between Alzheimer&apos;s disease patients, high cognitive impairment and low cognitive impairment controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12707938</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>sequence variation in the BACE1 or BACE 2 gene is not a significant risk factor for AD; but, a combination of a specific BACE1 allele and APOE epsilon 4 may increase the risk for Alzheimer disease over and above that attributed to APOE epsilon 4 alone.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12707937</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No differences in ApoE allele or genotype frequencies were observed between schizophrenic patients and controls, except for a possible association between male schizophrenic patients and the ApoE epsilon 2 epsilon 3 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12707932</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE increases the rate of HL-mediated phospholipid and triacylglycerol hydrolysis in rHDL</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15379569</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results indicate that, in fetus, the character and metabolism of HDL, especially of apo E-rich HDL cholesterol, are distinct from those in adults.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11882335</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The unfavorable effect of ApoE 4 genotype on lipoproteins is not altered by HRT, but ApoE 2 genotype modulates the HDL-ERT association in older women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11882334</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>compared with all the other APOE genotypes, those carrying the Leu28--&gt;Pro mutation were at a substantially higher risk of developing AD (OR=4.25; 95% CI=1.21-14.97).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12498968</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>variant frequencies of ICAM1, APOE, PPARA and PAI-1 genes in coronary artery disease patients and healthy blood donors; specific arrangement of polymorphic variants which differentiate both groups</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16043164</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE worked as LPL-inhibitor of the lipolysis activated by APOC2.  The binding density of APOE was less for small emulsion surfaces than for large ones.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12782148</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant association was detected between the APOE epsilon 4 allele and the rate of decline on measures of specific cognitive functions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15767511</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4 and Abeta1-42 may work in concert in neurons to increase lysosome formation while increasing the susceptibility of lysosomal membranes to disruption, release of lysosomal enzymes into the cytosol, and neuronal degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16298992</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Fasting lipids were measured by usual methods and Apo E genotype was established in French patients with type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16799405</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study reports that African American apo E2 carriers, compared with E3 or E4 carriers, had lower allele-specific apo[a] levels for large apo[a] sizes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17172560</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We found no significant difference in RNFL thickness at the optic disc in the different genotype carriers of the APOE and CHRNA4 genes, and thereby no evidence for increased loss of ganglion cells in the retina as an effect of these genes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17488453</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study suggests a role of the APOE gene in the etiology of aneurysmal subarachnoid hemorrhage</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17672902</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results demonstrate that apoE4-202 functions even in the presence of clearance-defective apoE2.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12576523</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE is not associated with the risk of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12815750</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant differences in allele or genotype frequency for APOE gene were detected between patients with myocardial infarction and healthy controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12535745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings indicate that residues Leu-261, Trp-264, Phe-265, Leu-268, and Val-269 of apoE are responsible for hypertriglyceridemia and also interfere with the formation of HDL</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15576362</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Review. Apo E, a multifunctional protein with central roles in lipid metabolism &amp; neurobiology, has 3 common isoforms with different effects on lipid homeostasis.  ApoE4 is associated with higher risk of Alzheimer disease &amp; neurodegenerative disorders.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16432152</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16520487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Involvemenet of this allele is still unknown, but increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16606914</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 2 may be a risk factor for early malaria infection</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12746397</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no significant difference when APOE and SCA2 allele frequencies of cases and controls were compared for multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15124760</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE4 allele is not a contributory factor to cholesterol gallstone formation, at least in the Japanese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12873586</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Medium-term survivors after redo CABG have a strong genetic predisposition unrelated to hypercholesterolemia or apoE genotype, leading to more severe coronary artery disease at earlier age.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16118069</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic factors, as Apo E genotypes, could allow the early identification of patients who are at a high risk for developing hyperlipidemia after sirolimus treatment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16378065</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele is associated with increased risk of obstructive sleep apnea/hypoxia, particularly in individuals under age 65, possibly by affecting brainstem degeneration or adipokine-related ventilatory drive.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15326239</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apoe4 affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 &gt; apoE3 = apoE2) and is detected in neurons and astrocytes in the peri-infarct area of genetically engineered mice.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12638732</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE polymorphism was associated with higher risk of MI in Russians and Tatars under 45.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12500534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>E2 allele seems to be a risk factor of frontotemporal dementia but is associated with the lowest risk in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12107813</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Accelerated memory decline in Alzheimer&apos;s disease with apolipoprotein epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12928512</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>carotid ultrasound results (intimal-medial thickness and stenosis) were related to three APOE genotypes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15258198</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that the apolipoprotein E4 (apoE4) isoform acts to aggravate delayed infarct expansion and peri-infarct reactive astrocytosis in genetically engineered apoE-knock-in mice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15181372</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo e iaoproteins might contribute to the pathology of alzheimer disease through several different mechanisms. (review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15181247</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with (review)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15181244</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Accounted for 15-60% of variability of plasma LDL cholesterol or apoB levels in familial hypobetalipoproteinemia(FHBL). The physiologic bases for the greater effects of apoE in FHBL remain to be determined.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15585207</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The -219G/T polymorphism may influence triacylglycerol-rich lipoprotein metabolism during the postprandial period</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12923233</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE may have a role along with HSV1 in dementia [review]</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15246985</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon2 carriers have an increased risk of intracerebral hemorrhage in brain arteriovenous malformations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16639317</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study provide indicates the influence of ApoE genotype on implicit learning even in healthy older individuals without cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16701920</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE allele carriers have differential cerebral blood flow immediately after injury that may affect outcomes in the traumatic brain injured population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16927707</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The low frequency of APOE*E4 homozygous individuals in the Italian population prevented verification that extensive metabolizers homozygous for E4 requre higher doses of warfarin.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16133550</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon4 allele has a negative effect on the course of MS, and increasing axonal damage may be an important mechanism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12533090</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Shows normal apoE expression. Neurobiology of human apoE isoforms can now be studied in both normal and post-injury state. All apoE regulatory sequences intact. May explain regional vulnerability of neuronal degeneration in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15026113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Epsilon 4 allele is more often associated with a lack of response to current antiepileptic drugs in complex partial seizurese.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16202217</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>investigated the effect of APO E gene polymorphism over lipid profile, macular toxicity and clinical manifestations in rheumatoid arthritis and systemic lupus erythematosus patients treated with chloroquine</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11922198</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, primary open-angle glaucoma and alzheimer disease, it does not involve APOE polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17524782</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Although the harmful effect of APOE4 on episodic memory was modest in women, the risk was found to occur in about 30%. APOE4 was observed to have a dramatic effect on episodic memory in men, but only in homozygotes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16595618</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 may act by a lower neuronal metabolism as a risk factor for cognitive impairment in normal aging and early prodromal AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14989602</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E genotype affected the increase in aerobic capacity produced by exercise training possibly via undefined effects on nerve and skeletal muscle function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14767871</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>possession of an epsilon4 allele does increase risk of Alzheimer&apos;s disease in persons with mild cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15804918</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Apo epsilon4 allele seems to predispose carriers with multiple sclerosis to a faster progression of disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16193886</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>association between ApoE polymorphism and specific components of visuospatial attention</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11949718</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12165926</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype and heterogeneity at the CETP gene locus have an interactive influence on plasma lipid and lipoprotein levels in children.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12669678</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In APOE epsilon 4 carriers in a Finnish population with Alzheimer&apos;s disease, HSPG2 A allele may possess an additive risk effect.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14625044</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphism of apolipoprotein E gene is associated with longevity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14743603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regulated expression of gene cluster in mascrophages</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12032151</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein e4 allele works through amyloid deposition and subsequent tangle formation to cause cognitive impairment</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16107349</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16399213</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significant interaction between cholesterol, APOE-epsilon4 and the risk of Alzheimer disease in the Yoruba.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16434658</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between variation in the APOE gene and plasma C-reactive protein was shown.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16511556</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our findings suggest that the APOE epsilon 4 allele confers a protective effect against NTG, whereas the APOE promoter polymorphisms do not contribute to POAG risk. However, the APOE -219G carriers tended to have later-onset POAG.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16778644</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results confirmed that the APOE4 allele occurs frequently in late onset Alzheimer&apos;s disease compared with normal controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17069783</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A monomeric APOE carboxyl-terminal domain was engineered and studied.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15109264</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE does not seem to be a risk factor for incident ischemic stroke</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16210555</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE promoter polymorphisms -219G/T and +113G/C as well as their haplotype are associated with longitudinal changes in LDL-C and total cholesterol concentrations in young Finnish males.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16528057</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The interaction was stronger in the middle-aged than in the older participants. There was a trend for individuals with combined APOE-epsilon4/CHRNA4 TT genotypes to show both lower white matter volume and slower overall RT on the attention task.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16869227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study confirmed the risk association between APOE epsilon 4 and AD. The observation that APOE epsilon 4 is associated with mixed dementia reflected the role of AD in the aetiopathogenesis of this condition.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12876259</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>To determine whether late cognitive decline after head injury is more prevalent among carriers of APOE epsilon 4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12876232</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE binds to the LDL receptor by interacting with more than one of the receptor ligand-binding repeats.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12036962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype was evaluated for an association between infant genetic variation and the risk for spina bifida cystica.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12397634</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In human brain, apoE4 dose correlates inversely with dendritic spine density of dentate gyrus neurons in the hippocampus of both Alzheimer&apos;s disease patients and aged normal controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14614898</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the ApoE E2 allele is a risk factor for the occurrence of type 2 diabetes mellitus in Chinese general population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14674716</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a family based study, the authors consistently found a significantly reduced transmission of allele 2 to newborns affected with intrauterine growth restriction (IUGR); in other words, allele 2 seems protective against IUGR.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12920078</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>possession of epsilon4 does not by itself confer an increased risk of cerebral amyloid angiopathy but may be associated with reduced longevity even in the absence of alzheimer&apos;s disease or cerebral haemorrhage</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12960780</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE deficiency results in: impaired catabolism of VLDL/chylomicron and their remnants; 2) an increased rate of catabolism of LDL apoB-100; 3) reduced VLDL apoB production; and 4) a delayed catabolism of Lp(a)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15102883</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>cell-surface heparan sulfate proteoglycan localizes apoE-enriched remnant lipoproteins to the vicinity of receptors by fast association and dissociation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15583000</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotypes strongly influenced cognitive function and decline in worman with cardiovascular disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15653176</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a looped-back model of apoE4 is proposed in lipid-bound state, including spherical lipoprotein particles, wherein residues Arg-61 and Glu-255 are proximal to one another</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15708851</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15964100</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>like the LDL receptor, LRP prefers lipid-bound forms of apoE, but in contrast to the LDL receptor, both LRP and the VLDL receptor recognize all apoE isoforms</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15863833</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11912196</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo epsilon4 allele ise predictor for stroke development.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12123486</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variability in apoE-related risk was found in both Alzheimers disease(AD) and non-AD cases, depending on the subgroup /Review/meta-analysis/</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12833577</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no evidence for an APOE allele effect on thyroid status in males.  There was no evidence for an APOE allele effect on hepatitis B virus status (HBV), or for an HBV status effect on thyroid status.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12833399</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E genotype influences lipid and lipoprotein levels in pregnant women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14687732</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*4, allele was associated with increased relative risk for elevated total cholesterol to high-density lipoprotein (HDL) ratios and low-density lipoprotein (LDL.  APOE*2 was associated with a lower relative risk for total cholesterol to HDL ratios.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15825968</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3/epsilon4 genotype in men and APOE epsilon2/epsilon3 in women are associated with increased 30-day mortality in stroke.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16131797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Haplotypes of the apo E gene are associated with lobar intracerebral hemorrhage</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16100021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We apply an extension to this framework to the original cohort of the Framingham Heart Study for measuring the effects of different Apo-E genotypes on the onset age of various cardiovascular disease events.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16161810</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE level in tumorous tissues is frequently elevated and may be a good histological marker for hepatocellular carcinoma .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16465366</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE affects the age of onset of Abeta deposition in amyloid precursor protein transgenic mice as well as the level, structure and anatomic distribution of brain Abeta deposits.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11950276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The antioxidant domain of apoE has been localized to its receptor-binding N-terminal domain; the basic amino acids in this domain are important for protecting low-density lipoproteins against lipid oxidation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15896001</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The increase in phospholipid transfer protein lipid transfer protein in type 2 diabetes is partly related to the changes in apolipoprotein E.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16389649</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic Parkinson disease in our samples, whereas the ACT gene signal peptide polymorphism might not</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11992569</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the response to plant stanol ester ingestion was not influenced by apolipoprotein E phenotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12093429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12742846</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that the apolipoprotein E receptor 2 binding domain of apolipoprotein E is in the 1-165 amino terminal region, whereas the carboxy terminal 230-299 region of apoE is required for efficient initial association with phospholipids.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12950167</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This review examines key scientific advances which focus on possible therapeutic strategies encompassing the use of apoE in the amelioration of atherosclerosis, based on its direct effects on the vascular wall.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12769659</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Analysis of transgenic mice overexpressing human apoE in the liver revealed that apoE was recruited from the circulation to the injured site of the carptod aartery wall.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15161645</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Epsilon3-haplotypes containing the promoter allele -219T were associated with reduced amyloid deposition and reduced risk of neuropathologically verified Alzheimer disease as compared to epsilon3-haplotypes containing -219G.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11920850</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This data confirm a specific effect caused by the presence and amount of ApoE epsilon4 allele and suggest that a susceptibility factor to AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15337270</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15337261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Mild cognitive impairment subjects with APOE epsilon4 had distinct cognitive &amp; imaging profiles, resembling early Alzheimer patients. APOE4 was associated with greater impairments in memory &amp; functional activities &amp; hippocampal atrophy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15557508</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>that the epsilon4 allele of apolipoprotein E and the -491A allele are over-represented among individuals who complain of memory difficulties.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12192621</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Chronic anxiety is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15377739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effects of APOE genotype on component processes of cognition in healthy, middle-aged adults is consistent with the emergence in adulthood of an APOE-epsilon4 cognitive phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15769204</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High-cholesterol subjects that are ApoE-epsilon4 carriers have significantly higher levels of lipid peroxidation as assessed by circulating F2-isoprostane levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16028714</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>only lipid-bound apoE promotes SR-BI-mediated cholesterol efflux and that the amino-terminal region of residues 1-165 of apoE is sufficient for both receptor binding and cholesterol efflux</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16185081</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein C-III and E polymorphisms and cardiovascular syndrome, hyperlipidemia, and insulin resistance in renal transplantation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12118856</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a magnetic resonance spectroscopy study of the non-demented elderly occipital cortex, levels of creatine correlate significantly with age and performance on the Mini-Mental State Examination test in APOE epsilon 4 carriers, but not in the non-carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12658375</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype distribution strongly influences serum APOE concentration, not suggesting, at present, a possible role as a biochemical marker for AD, but only as a putative longevity factor.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12657895</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the epsilon2 allele of the APOE polymorphism is a prognostic risk factor for both the onset and the progression of diabetic nephropathy in Japanese type 2 diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12882872</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In elderly subjects who carry an APOE epsilon 4 allele, plasma amyloid beta protein levels are positively associated with lacunar infarcts and white matter lesions, whereas in APOE epsilon 4 noncarriers no associations are observed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15048897</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Accelerated brain tissue loss and a higher proportion of lesions evolving into &quot;black holes&quot; therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in multiple sclerosis patients with APOE-epsilon 4.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15048896</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>involvement of ApoE in the hematogenous route of HSV-1 to the CNS</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12414984</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>6 hour postprandial triglyceride values were correlated with fasting triglyceride levels, which showed association with the apolipoprotein E4 allele</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12915220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we did not find APOE associated with ALS risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15657798</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Variant alleles of APOE and APOC3 contribute to an unfavorable lipid profile in patients with HIV, who are therefore at high risk for severe ritonavir-associated hypertriglyceridemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15809899</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ability of monocyte-derived macrophages (MDMs) in 42 patients with type 2 diabetes to secrete ApoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16005361</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>VR22 or a nearby gene influences susceptibility to Alzheimer&apos;s disease, and the effect is dependent on APOE status</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16199552</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon3epsilon4 and epsilon4 frequencies have a role in development of myocardial infarction in middle-aged people in Spain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16276010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data suggest that human apoE or fragments containing the receptor-binding domain may contribute to innate immunity to viral infection by direct disruption of viral particles and/or inhibition of viral attachment, thus reducing viral entry.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16388493</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regulation of APOE4 expression modulates risk for Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16314757</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The structural functional characteristics of two full-length and truncated apoE3 and apoE4 tailored to eliminate helix and domain interactions are reported.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16540478</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16524875</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE gene status (presence or absence of Apo E4) has minimal influence on lipid profile characteristics except for low density lipoprotein (LDL) in Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16611016</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphism is not positively associated with type 2 diabetes in an Indian population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16621107</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The frequency of ApoE epsilon4 allele carriers was significantly overrepresented in Alzheimer disease group compared with Vascular Dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16758323</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4+ (epsilon4+/epsilon4 + or epsilon4+/epsilon4-) genotype is more frequent in Alzheimer disease and Lewy body dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16956959</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>With respect to hippocampal neurons, the apolipoprotein E polymorphism does not modulate the original formation of dendrites in vivo, contrary to conclusions drawn from in vitro studies on neurite outgrowth.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17023092</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Individuals with a family history of AD and the APOE epsilon4 allele, additional genetic or environmental factors may accelerate the onset of dementia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17101827</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4, but not apoE3, in macrophages enhances atherosclerotic plaque development in an LDLr-dependent manner</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17234631</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE-epsilon4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17283313</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in old age, in non-epsilon2-allele carriers, high plasma apoE levels are associated with cognitive impairments, independent of genotype, cardiovascular risk factors, and stroke</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17460173</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in old age, except for epsilon2-allele carriers, high plasma apoE levels are associated with a higher risk of stroke, independent of APOE genotype, plasma levels of lipids, and other cardiovascular risk factors</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17460172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>degree of linkage disequilibrium for a comprehensive set of 50 SNPs in and surrounding APOE using a substantial Caucasian sample of 1100 chromosomes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17434289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17562993</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This protein protects PC12 rat cells against the cytotoxicity of APP.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12128082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Longitudinal analysis of several components of memory over a 2-year interval showed a significant Age-by-APOE interaction reflecting a decline in new learning for the &gt; or =60 epsilon4+ group only.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12928055</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data may support the importance of Apo E 4 allele in determining postmenopausal spine bone mass.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12841538</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no relation between APOE gene polymorphisms and Japanese patients with multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12926843</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no association of the ApoE genotype with multiple sclerosis disease susceptibility nor clinical and MRI measures could be identified.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15222690</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE epsilon4 allele was not related to the disease course of multiple sclerosis or the ApoE epsilon2 to the intensity of demyelination on MRI</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15222689</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>role in amyloid foundation but not amyloid growth in vitro; is a risk factor for AD not due to a pathological gain of function of apoE4 but to a loss of protective function of apoE3</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12000192</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism is associated with age of onset in schizophrenia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15221639</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Thus, the present study provides evidence that the efficiency of intestinal absorption and synthesis of cholesterol in humans are not related to the apoE phenotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12518038</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE may play a role in invasiveness of human prostate cancer</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12632068</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE-epsilon 4 and butyrylcholinesterase-K variant alleles act synergistically to increase the risk of late-onset Alzheimer&apos;s disease, particularly in age group &lt;75 years in Tehran, Iran.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15519745</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>New role of apoE in cancer as apoE expression is important for the proliferation and survival in apoE-expressing ovarian cancer cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15665311</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12461692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The microenvironments of all 12 lysine residues in intact apoE3 were determined and their relative contributions to heparin binding were examined.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12588864</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In addition to the APOE epsilon2/epsilon3/epsilon4 polymorphism, the promoter polymorphisms -219G/T and +113G/C as well as their haplotype modulate lipid and lipoprotein concentrations in middle-aged Finnish men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15721023</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genotype of apo E in diabetic patients did not differ with healthy; E2/3 and E3/4 genotypes tend to have higher levels of triglyceride and cholesterol respectively.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15936467</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients who possess the apoE3/4 genotype had significantly faster rates of progression of renal failure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16113584</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regulates mesangial cell proliferation by inhibiting or reducing proliferation induced by apo B, implying that apo E has protective effect on kidney, and increasing proliferation under certain conditions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16179831</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Neuropsychiatric Inventory symptom-endophenotype-genotype relationships, and taking into account possible confounds by latent variable models, APOE genotype did not correlate with any endophenotype in Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16257094</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Unspecified factor embodied in first-degree family history of Alheimer disease is influencing the expression of APOE4 on brain function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16738250</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LRP binds and endocytoses Abeta42 both directly and via apoE but endocytosed Abeta42 is not completely degraded and accumulates in intraneuronal lysosomes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17012232</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data suggest a role of vascular wall apoE3 to balance the intracellular redox state in injured endothelial cells via NO-dependent pathways</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17138935</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an association of APOE promoter polymorphisms (A-491T, T-427C) with an ischaemic stroke is shown in individuals of Yakut ethnicity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17328917</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>study confirmed the association between APOE-epsilon4 and white matter hyperintensity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17376122</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In females, epsilon4 homozygosity confers a risk of shingles and also of infectious mononucleois, and the APOE-epsilon4 allele is protective against post-herpetic neuralgia whereas APOE-epsilon3 allele is a risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17356546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults; detailed cognitive characterization is necessary to interpret the relationship between cognition and brain structure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17389798</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Higher APOE epsilon4 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects, while no differences were found between VaD patients and subjects with NoCI; lower APOE epsilon3 allele frequency was observed in AD patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17374951</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Angiotensin I converting enzyme and APOE4 polymorphisms are risk factors in late onset Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17401152</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 allele is more frequent in children with obstructive sleep apnea and particularly in those who develop cognitive dysfunction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17636061</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The findings of this study are unique in that they address not only the relationship between APOE 4 allele presence and outcome from severe TBI, but also describe differences in trajectory of recovery by APOE 4 allele presence.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17518534</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Accumulation of potentially pathogenic C-terminal-truncated fragments of apoE depends on the isoform and cellular source. Neuron-specific cleavage of apoE4 is associated with increased tau phosphorylation and may play a role in Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15014128</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PON2*S and apoE4 alleles have interactive effect on the development of the two most common forms of dementias AD and VD, and further support the hypothesis that cardiovascular factors contribute to the development of AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11803456</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>in individuals with age-associated memory impairment APOE E4 allele carriers performed worse on memory; this effect was only observed in females</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11884660</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE2, apoE3, and apoE4 are equally effective in inhibiting aortic smooth muscle cell migration toward platelet-derived growth factor, while apoE3 and apoE2 isoforms are preferred to apoE4 for inhibiting PDGF-stimulated smooth muscle cell proliferation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12269825</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12205649</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E gene polymorphism has a role in hypercholesterolemia and type 2 diabetes, and affects glomerular filtration rate</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12595762</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the ApoE4 genotype group, low LDL cholesterol was associated with good performance in the mental arithmetic test, whereas for those without ApoE4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12886039</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that ApoE epsilon4 plays no significant role in the development of ICVD and VaD, but that ApoE epsilon2 has a protective effect with regard to the development of ICVD and VaD for Taiwan Chinese below the age of 65.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15084782</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is no linkage between Apo E polymorphism and autism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14755445</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ABCA1 is essential for the biogenesis of high density-sized lipoprotein containing only apoE particles in vivo</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14754908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>combined frequency of the apoE alleles in the Malays, Chinese and Indians in Malaysia was 0.058, 0.829 and 0.114 for epsilon2, epsilon3 and epsilon4, respectively</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14734213</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In our cohort, the APOE genotype does not constitute a risk factor for developing POAG (primary open-angle glaucoma).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14769603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results indicate that adipose tissue expression of apolipoprotein E is modulated by physiologic regulators of insulin sensitivity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15339912</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A peptide derived from the low density lipoprotein receptor-binding domain of apoE mediates an efficient, energy-dependent translocation of liposomes across the membrane of primary rat brain capillary endothelial cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15697227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was no association between the APOE genotype and the cognitive change caused by electroconvulsive therapy in major depressive disorder population as a whole</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15791170</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12799433</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a study comparing brains from Alzheimer&apos;s patients and controls, it was found that hippocampal apolipoprotein D level depends on Braak stage and APOE genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14596852</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the presence of apoE2/3 genotype, high HDL-cholesterol levels and the absence of apoE3/3 genotype can be regarded as risk factors for superficial fungal disease, especially dermatophytosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15227722</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Early recognition of severe hypertriglyceridemia in pregnancy may be caused by heterozygosity of this protein.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16142021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE gene polymorphism is associated with OAG in the Japanese population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16110302</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE polymorphisms for predicting dyslipidemia in the population at large.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16317171</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphism is related to coronary disease in the Chinese Han population, with smoking and alcohol drinking increasing the genetic predisposition to disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16459141</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein e genotype modifies the phenotype of Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16401755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4 appears to modulate APP processing and Abeta production through both the low-density lipoprotein receptor-related protein pathway and domain interaction</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16344478</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE allele is not associated with cognitive impairment in normal aging</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12112161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a less organized structure in the C-terminal domain of apoE4 leads to the higher affinity for lipid as compared to apoE3, contributing to its preferential association with VLDL</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12917433</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE molecules are folded into helical hairpins with the binding region for the low density lipoprotein receptor at the apex of each molecule</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16278220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE gene polymorphism as a risk factor for the severity of macular edema in Type 2 diabetes mexican patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11910554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hyperlipidemia in APOE*3 Leiden transgenic mice resulted in a significant increase in accelerated atherosclerosis in vein grafts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12364385</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE inhibits cell migration via cAMP-dependent protein kinase A activation as a consequence of its binding to LRP-1</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12857755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis of a novel, ABCA-1-independent, positive feedback pathway for stimulation of potentially anti-atherogenic apoE secretion by alpha-helix-containing molecules including apoA-I and apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15066991</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE*4 allele has an age-dependent association with atherosclerosis, increasing susceptibility among young to middle age Argentine males</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16201140</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16116137</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Hepatic lipase promoter SNPs are associated with increased HDL cholesterol and, paradoxically, an increased risk of IHD after adjustment for HDL cholesterol, and particularly in individuals with apolipoprotein E epsilon43 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12798568</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms do not contribute substantially to the risk of holoprosencephaly</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11857554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12213863</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>differences in binding capacity of apolipoprotein E3 and E4 isoforms to lipid emulsions</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12444983</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>data indicated that upstream-stimulatory-factor (USF) might be involved in the basal transcriptional machinery of apolipoprotein E by binding to a non-canonical E-box motif within the proximal promoter</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12444925</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our data do not support the hypothesis that the ApoE*4 risk allele is associated with BMD, increased bone loss, or an increased risk of osteoporotic fractures</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15312249</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms of ApoE, independent of gender or other known factors, may affect serum creatinine levels and predict glomerular filtration rate in healthy persons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15187200</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Ethnic differences and alterations of serum apoE levels significantly modify the relationship between apoE gene polymorphism and serum lipid variability.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15487712</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E epsilon4 haplotype is a predictor for recurrence in ischemic cerebrovascular disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12480082</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo E polymorphism was not found to be associated with maximal oxygen uptake (Vo(2max)) levels either in the sedentary state nor the Vo(2max) response to exercise training</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14681851</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12143056</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effects of the apolipoprotein E (ApoE) genotype and gender on the response to donepezil treatment in Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12142731</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphism is associated with neurodegenerative diseases, notably Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12604387</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Presence of TNFB*A329G polymorphism in addition to APOE*E4 variant is associated with significantly higher releases of interleukin 8 and tumor necrosis factor alpha, prolonged intubation, and increased transfusion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15224026</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>impaired recycling of apoE4 could interfere with intracellular cholesterol transport and contribute to the pathophysiological lipoprotein profile observed in apoE4 homozygotes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15485881</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>role of alleles in dyslipemia and kidney transplantation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11959333</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE/epsilon 4 was associated with an increase of plasma lipid levels and with a decrease of systolic blood pressure.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12359980</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Changes in cerebrospinal fluid apoE concentration occur after traumatic brain injury and may be important in the response of the human brain to injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14588111</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In young adults, the APOE epsilon4 allele and cigarette smoking act synergistically, increasing an individual&apos;s propensity to have a cerebral ischemic event.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14726545</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the APOE4 allele may have a protective role in children with a history of heavy burdens of diarrhea in their first 2 y of life</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15611352</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon 4 carrier status by itself does not predict cognitive decline or conversion to Alzheimer&apos;s disease, indicating that APOE genotyping in patients with mild cognitive impairment may have limited clinical applicability for prediction of outcome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15956169</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE*E4 genotype status appears to have a greater deleterious effect on gross hippocampal pathology and memory performance in women than in men.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15956166</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Parkinson&apos;s disease patients who carry the APOE epsilon4 allele develop psychosis earlier.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16367893</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Individuals with an epsilon (epsilon)2 genotype of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to individuals with an epsilon4 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16453339</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our studies suggest that AEC I is not just a simple barrier for gas exchange, but a functional cell that protects alveolar epithelium from injury.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16497717</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE epsilon4 allele than in those without it</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16614010</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>AD patients who carry the ApoE epsilon4 allele are at greater risk than noncarriers for developing psychotic symptoms, particularly as the severity of their dementia progresses.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16841077</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17129575</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE polymorphism appears to be associated with variance of the lipoprotein phenotype in Chinese families with familial combined hyperlipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17127808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism in childhood nephrotic syndrome.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12042894</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The relationship between APOE genotype and its influence on memory performance following traumatic brain injury have been demonstrated.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11940706</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12198535</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>inheritance of the APOE epsilon4 allele is associated with increased risk of late posttraumatic seizures</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12810485</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The distributions of ApoE epsilon 2, epsilon 3 and epsilon 4 were similar in both clinical patient groups and in the non-diabetic group and unrelated to progression of disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12706318</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no significant differences were observed between the frequency of apolipoprotein E epsilon3/epsilon3 genotype and epsilon3/epsilon4 genotype in the control group compared to Alzheimer patients&apos; group</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14695944</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we have now investigated whether the different apolipoprotein E (APO E) genotypes, in pairwise combinations with the MTHFR 677TT or ACE D/D mutation, could lead to an increased risk of leukoaraiosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14763962</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha-helices in receptor-binding region and CT domain of apoE align perpendicular to the fatty acyl chains of the phospholipid bilayer and residues of helix 4 are arrayed in a positively charged, curved helical segment for receptor interaction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14739281</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association of APOE epsilon 4 allele with less favorable outcome in multiple sclerosis is reviewed.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15157846</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Both epsilon 4 allele and mutation -219G/T in the promoter are associated with early onset coronary heart disease in Finland.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11862316</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results examine the impact of apolipoprotein E genetic variation on fertility in two Ecuadorian populations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15220465</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results confirm the hypothesis that serum ApoE concentration is dependent on ApoE genotype, but do not support the view that it has to be considered a relevant biochemical marker for Alzheimer disease and vascular dementia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15375590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the ApoE epsilon4 allele carried a 19.0-fold risk for developing hallucinations and a 3.4-fold risk for delusions in Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15452311</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Family history of dementia is associated with an increased risk of dementia and Alzheimer&apos;s disease in a very old population, but only among APOE epsilon 4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15596614</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>a significant deficit in prospective memory for epsilon4 allele carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15656760</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a Caucasian population, APOE may have effects on BMD variation in males but not females.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15549644</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11836653</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We conclude that APOE allelic patterns in healthy Kuwaiti blood donors and a smaller group of patients with CH do not satisfactorily predict circulating blood levels of lipids and lipoproteins.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15573849</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this study, variations in the frequencies of the apo epsilon4 allele and the apo E3/E4 and E4/E4 genotypes were found in patients with NIDDM, GN and ADPKD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15841787</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15817610</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study shows similar ApoE-epsilon4 genotype and allele frequencies in patients with ischemic cerebrovascular diseases and in control subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16123547</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results showed a gene-gene interaction between the ApoE and the CETP loci in determining HDL-C concentrations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16426594</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer&apos;s disease with late onset.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16490049</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A meta-analysis of APOE genotypes does not support a role for APOE in multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16682670</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16796589</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE epsilon3/epsilon3 genotypes were significantly decreased in diabetic nephropathy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16813599</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Romany and Slovakian populations differ in ApoE genotype; no effect of ApoE polymorphism on lipid levels in Romany subjects was determined.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16848156</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There was a clear association between apolipoprotein E polymorphism on lipid-lowering response to treatment with atorvastatin and fenofibrate in patients with different types of dyslipidemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17056835</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The apoE4 allele influences osteocalcin gamma-carboxylation in hemodialysis patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17336705</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This multiplex PCR technique can be carried out in a single tube and can differentiate between the three polymorphic sites of this gene associated with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17378730</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The allele variability in the -516C/T polymorphism in the APOB gene promoter may partly explain the interindividual differences in postprandial lipemic response in healthy subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17393220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Healthy adult males carrying this genotype were used in the oral fat load experiments.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12226739</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE has a role in regulating cholesteryl ester uptake by binding to SR-BI in human cells</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12138091</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apo e4 allele is associated with impairment of endothelium-dependent arterial dilation in the early stage of Type 2 diabetes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12739024</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study found that APOE promoter polymorphisms and APOC1 insertion alleles were significantly associated with AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12962909</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data support the hypothesis that increased levels of apoE may be associated with the pathology of schizophrenia and that antipsychotic drugs decrease apoE levels as part of their therapeutic actions.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>13129656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>young adult epsilon4 carriers, at genetic risk for late-onset Alzheimer&apos;s dementia, had abnormally low rates of brain glucose metabolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14688411</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE 4 genotype was more frequent in AD (41.4%) than in controls and In AD patients, CYP46*C along with ApoE epsilon4 genotype were associated with a higher cognitive decline at 1-year follow-up.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15165699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results confirm that the apolipoprotein E epsilon 4 genotype is associated with Alzheimer&apos;s disease and its cognitive impairment pattern.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15152345</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These experiments demonstrate the roles of Chol and ApoE in the modulation of membrane insertion of APP.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15202933</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg136--&gt;Ser.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15641930</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E (apoE) polymorphisms were determined in 165 Saudis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15663009</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Findings suggest that the epsilon2/2, epsilon3/4, and epsilon4/4 genotypes have greater early mortality risks.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15935014</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>epsilon4 gene dose is correlated with lower cerebral metabolic rate for glucose in regions of the precuneus and the posterior cingulate, parietotemporal, and frontal cortex</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15932949</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16165272</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>no association seen between APOE genotype and time to psychosis in Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11936240</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoe4 allele frequency is increased in patients with the temporal variant of frontotemporal dementia compared to non-demented controls</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12023438</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Increased expression of neuronal apolipoprotein E in cerebral infarction.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12649507</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The effect of APOE genes on brain MRI measures were studied in subjects with age-associated memory impairment. No APOE effects were observed when analyses accounted for other potential confounding variables.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12736801</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>NMR structure of apolipoprotein E carboxyl-terminal domain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15213448</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apoE4 inhibits synaptic plasticity following environmental stimulation and that this effect is both isoform- and brain area-specific</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15760646</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>No association is observed between the APOE epsilon 4 allele and clinical characteristics of the multiple sclerosis study population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14504972</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results describe the relative roles of apolipoprotein E isoforms in low density lipoprotein receptor (LDLR)- and non-LDLR-mediated very low density lipoprotein (VLDL) clearance.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15450205</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE concentration in combination with the ApoE polymorphism significantly influences serum lipid parameters in hemodialysis patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15264189</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12637699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11992263</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Isoforms of apolipoprotein E modulate tissue plasminogen activator-induced clot lysis in an in vitro clot assay system.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12133811</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E expression increases in fibroblasts during apoptosis, growth arrest and mitosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14656220</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>gene polymorphism as a risk factor for cerebral amyloid angiopathy-related hemorrhage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11676291</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE polymorphisms in cerebral amyloid angiopathy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11676289</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Comparison of apoE epsilon genotypes in MS patients revealed no significant differences in frequencies between benign &amp; severe septiles. The risk conferred by epsilon4 rose upon comparison of carriage rates in more narrowly defined anti-podal quantiles.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11990879</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE isoproteins are inefficient at complexing with synthetic Alzheimer disease amyloid-beta protein in vitro.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12393935</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12754278</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The alleles of apoE appear to have a role in the etiology of AMD, with the epsilon4 allele being protective, whereas the epsilon2 allele appears to have a modifier effect by bringing forward the mean age of disease diagnosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15111582</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The association between the APOE-epsilon4 allele and a reduced risk of AMD (age-related macular degeneration) was established in a large cohort with sufficient statistical power.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15111581</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE stimulates protein kinase CK2 autophosphorylation, and this can promote phosphorylation of additional substrates such as tau.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15882073</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE4 does not have a role in development of cognition disorders post-stroke in patients with hypertension</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16051894</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Single nucleotide polymorphisms in the promoter of APOE modify the phenotype of open-angle glaucoma and result in increased optic-nerve damage.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12817590</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Discontinuation and poor adherence to therapy with statins is dependent on APO E genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12668918</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>e*2 allele seems to be associated with the lowest reproductive efficiency and the e*3 allele, with the highest</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14711551</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>single nucleotide polymorphism +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15455263</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In schizophrenia, there was increased apoE in BA9 and BA46. In bipolar I disorder, increased levels of the apolipoprotein were detected in the caudate putamen and BA9 with a decrease in apoE being measured in BA10.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15820227</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Relative bioavailability of natural to synthetic vitamin E in apoE4 males was close to the currently accepted biopotency ratio of 1.36:1</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15867282</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16511213</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the epsilon2 apolipoprotein E genotypes may have a role in inducing breast cancer in patients in pre-menopause</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16752225</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Intravenous administration of AAV2/7- and AAV2/8-apoE vectors effectively mediated robust and sustained hepatic-specific expression of apoE and completely prevented atherosclerosis at 1 year.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16763161</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE genotype is unlikely to have a clinically significant effect on warfarin dose requirements.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16847429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results indicate that cortical acetylcholineesterase activity is relatively well preserved in apolipoprotein E4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16996687</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17030756</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>analysis of the LDLR recognition properties of apoE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17079229</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17474819</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In the Stanislas Family Study, epsilon4 allele of the APOE gene was associated with lower hs-CRP concentration, but not with 5-year changes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17460724</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Cortical thickness of the left entorhinal region was thinner in epsilon4 carriers than in non-epsilon4 carriers and cortical thicknes with epsilon4 carriers having the thinnest cortex and epsilon2 carriers the thickest, with epsilon3 homozygotes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17509484</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17126308</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The contribution of the epsilon4 allele towards lowering CRP levels is independent and may be by a different mechanism than how statins affect inflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16445917</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>apolipoprotein E genotype is not shown to increase risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage in a meta-analysis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16385096</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>differential effects of apoE3 and apoE4 on HDL metabolism</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12401887</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>role of ApoE3 and ApoE4 isoforms in lipid release from astrocytes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12042316</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the -491AA APOE promoter genotype is associated with elevated brain apolipoprotein E levels, suggesting that the risk for AD may be modulated by the apoE protein level as well as by the apoE protein isoform.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12232782</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>neuronal expression of apoE is regulated by a diffusible factor or factors released from astrocytes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14585838</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Using human monocyte-derived macrophages (MDM), we show a significantly greater increase in NO production during immune activation in MDM from APOE4 AD patients compared to normal, age-matched individuals or to AD patients with an APOE 3/3 genotype.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14741429</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the increased risk of developing Alzheimer&apos;s disease and vascular dementia is similar among Asian Indians with ApoE epsilon4 compared with the Caucasian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14739533</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results indicate that oleic acid increases apolipoprotein E secretion from macrophages at a locus involving post-translational glycosylation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15131109</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E polymorphism in Northern Indian patients with coronary heart disease: phenotype distribution and relation to serum lipids and lipoproteins</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12030385</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of one or more epsilon4 alleles of ApoE is a significant predictor for the incidence of delusions in the course of Alzheimer disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11971084</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE does not play an important role in susceptibility to Parkinson&apos;s disease, but may play a role in dementia associated with Parkinson&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11863377</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE epsilon-4 allele seems to influence the risk of Alzheimer disease by a relatively selective effect on episodic memory.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12117364</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interactions with APOE genotype, cigarette smoking, and alcohol intake</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15060087</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The ApoE4 is strongly associated with reduced Abeta42 CSF levels in Alzheimer&apos;s disease pts &amp; controls. As no associations of APOE variants with other indexes of AD severity were seen, this may reflect fundamental ApoE involvement in Abeta metabolism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15184629</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15184605</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of 2 epsilon4 alleles is an important determinant of both plaques &amp; tangles. A putative protective role for the epsilon2 allele in AD may be mediated by reduced plaque burden.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15184600</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>After mild head injury, participants with at least one APOE epsilon4 allele had a significantly decreased performance on neuropsychological tests. APOE genotype may influence the outcome following an MHI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15184597</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Polymorphisms in the APOE promoter are found not to be risk factors for Alzheimer&apos;s disease nor are they associated with parenchymal or vascular accumulation of amyloid-beta protein.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15106838</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>phenotype is associated with glucose metabolism and cognitive function</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11903399</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is a higher prevalence of the apo E2 allele in patients with severe aortic valve stenosis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11903341</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings suggest that the increased brain inflammation in apoE4 mice is related to disregulation of NF-kappaB signaling pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15979312</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results show apoE co-localized with amyloid beta in amyloid plaques that lack immunoreactivity with antibodies to N-terminal epitopes of amyloid beta indicating that formation of apoE-amyloid beta complexes may conceal N-terminal epitopes of amyloid beta</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16195918</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data provide no evidence of a strong association between the APOE gene and early ARM (age-related maculopathy) in middle-aged persons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16406547</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is considerable effect of the choline acetyltransferase polymorphisms on Alzheimer&apos;s disease in Korean population and this effect is dependent on ApoE genotypes</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16480703</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In multiple sclerosis APOE epsilon4 polymorphism is not associated with a more severe clinical course and does not appear to influence recovery of exacerbations.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16459715</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>APOE HhaI polymorphism may not be associated with gallstone disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16631424</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the protective effect of apoE2 seen in African Americans could be explained by a favorable lipid profile in epsilon 2 carriers; in Caucasians, the absence of this protective effect could be due to the lack of effect of apoE2 on the lipid profile</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16888319</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There appears no interaction between cerebrovascular disease and APOE epsilon4 on cognitive decline in very old people</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16945218</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of the ApoE4 allele was significantly associated with a worse MMSE score evolution (P=0.04).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16953165</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17230455</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE elicits isoform-dependent effects on macrophage TNF-alpha and IL-6 expression as well as secretion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17353005</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These findings show that oxidation of chylomicron-remnant-like particles lowers their rate of uptake and induction of lipid accumulation in macrophages.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17540618</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the epsilon4 APOE allele may promote intima-media thickening, interacting with other factors contributing to Alzheimer disease development</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17539949</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17283328</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>findings suggest that the APOE4 carriers are particularly susceptible to the atherogenic effects of smoking; this interaction is particularly clear in hypertensive subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12473860</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patient with APOE4 allele has significant increased levels of excitatory amino acid in traumatic brain injury patient.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14501969</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2003</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Allele transmission in families with autism (apolipoprotein-E2)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15167692</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2005</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data provide a novel explanation for the apparent AD-protective effect of inheriting an epsilon2 APOE allele, and suggest that optimizing AT enrichment of CNS lipoproteins or devising APOAI mimetics may augment AT efficacy in treating AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15584908</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2005</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In a sample of mostly white, well-educated research participants with Alzheimer&apos;s disease, the APOE epsilon 4 allele was associated with shorter survival in men but not in women.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11940690</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2002</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>amyloidogenic effects of apoE4 are exacerbated by polymorphisms in the APOE promoter that enhance apoE production</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12471457</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2003</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An interaction between apoE3 and CNTF occurs with both delipidated apeE3 and apoE3 found within a lipoprotein particle in cerebrospinal fluid. This interaction potentiates the survival-promoting activity of CNTF for hippocampal neurons.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>9236223</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2003</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>15</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2003</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>20</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Patients with multiple sclerosis and allelic polymorphism of APOE epsilon 4 have a significantly higher progression index of disability and a worse ranked multiple sclerosis severity score than their non-epsilon 4 counterparts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11552016</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2001</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>18</Date-std_hour>
              <Date-std_minute>24</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2001</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>ApoE inhibits the depolymerization of beta 2-microglobulin-related amyloid fibrils at pH 7.5, possibly by binding directly to the surface of the fibrils and stabilizing the conformation of beta 2-microglobulin in the fibrils.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11456487</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2001</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2001</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>14</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_heading>HIV-1 protein interactions</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>23728617</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155807</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>vpr</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>28872817</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Vpr</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>apolipoprotein E isoform b precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2014</Date-std_year>
                  <Date-std_month>6</Date-std_month>
                  <Date-std_day>19</Date-std_day>
                  <Date-std_hour>16</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>18051367</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>16697650</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>11100124</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155871</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>tat</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9629358</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Tat</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>apolipoprotein E isoform b precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>30</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>43</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>HIV-1 gp120 causes increased neurotoxicity in human neuronal cultures with the ApoE4 allele</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>16697650</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155971</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>env</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>28876544</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Envelope surface glycoprotein gp120</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>apolipoprotein E isoform b precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2007</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>32</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>The antioxidant properties of human lipidated apoE3 protects neurons from Tat-induced toxicity</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15264223</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155871</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>tat</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9629358</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Tat</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>apolipoprotein E isoform b precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2006</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
                  <Date-std_minute>15</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_heading>Interactions</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>36774506</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>26263</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FBXO22</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117649</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>3</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Proximity Label-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>38280479</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10413</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>YAP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115684</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>42</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>35914814</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6285</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>S100B</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112193</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>41</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS; Protein-peptide; Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>32812023</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>8620924</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>7566652</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4137</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAPT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110308</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>24</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>13</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>36215168</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>136847</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>440730</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TRIM67</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>136847</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>46</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>36759834</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
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                    <Dbtag>
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                          <Object-id_id>106845</Object-id_id>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>43740568</Object-id_id>
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                  <Other-source_anchor>S</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4383848</Object-id_id>
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                <Date-std>
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            <Date>
              <Date_std>
                <Date-std>
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              <Pub_pmid>
                <PubMedId>36759834</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>35915083</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>59272</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>121864</Object-id_id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>16</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>6</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
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                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Proximity Label-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>36964488</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2308</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>FOXO1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108597</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
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                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>16</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2023</Date-std_year>
                  <Date-std_month>6</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
                  <Date-std_minute>0</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
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            <Pub>
              <Pub_pmid>
                <PubMedId>35944360</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>54764</Object-id_id>
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                      </Dbtag_tag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                        <Object-id>
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                <Date-std>
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                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2022</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
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              <Pub_pmid>
                <PubMedId>34941261</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>207</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106710</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2022</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
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            <Pub>
              <Pub_pmid>
                <PubMedId>29950521</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>22528093</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>10842709</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                  </Dbtag_tag>
                </Dbtag>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
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                  <Other-source_anchor>APP</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2022</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>29</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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              <Pub_pmid>
                <PubMedId>33961781</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>KLK10</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
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                <Date-std>
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                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
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          <Gene-commentary_comment>
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                    <Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>1088</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>CEACAM8</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                        <Object-id>
                          <Object-id_id>107514</Object-id_id>
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                      </Dbtag_tag>
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                <Date-std>
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            <Date>
              <Date_std>
                <Date-std>
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            <Pub>
              <Pub_pmid>
                <PubMedId>33961781</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
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            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
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                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>735</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>C9</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107196</Object-id_id>
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                      </Dbtag_tag>
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            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
                  <Date-std_year>2021</Date-std_year>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>7</Date-std_day>
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                  <Date-std_minute>33</Date-std_minute>
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        </Gene-commentary>
        <Gene-commentary>
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            <Pub>
              <Pub_pmid>
                <PubMedId>33961781</PubMedId>
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            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>344</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106841</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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                  <Date-std_hour>9</Date-std_hour>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2021</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
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                </Date-std>
              </Date_std>
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        </Gene-commentary>
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                <PubMedId>33022573</PubMedId>
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            </Pub>
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                <Dbtag>
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                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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          <Gene-commentary_comment>
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              <Gene-commentary_source>
                <Other-source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>11091</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_text>Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex</Gene-commentary_text>
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              <Pub_pmid>
                <PubMedId>31270237</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>28887769</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>6622</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
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                      </Dbtag_tag>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>9</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>31273033</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>3320</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>HSP90AA1</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                        <Object-id>
                          <Object-id_id>109552</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
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                <Date-std>
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                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2021</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>30</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>23134465</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                    <Dbtag>
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              <Gene-commentary_source>
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                    <Dbtag>
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            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Other-source>
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                    <Dbtag>
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            <Date>
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                <Date-std>
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                <PubMedId>11294867</PubMedId>
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            </Pub>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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            <Date>
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            <Date>
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                <Date-std>
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        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            </Pub>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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            <Date>
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                <Date-std>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                    <Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
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        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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          <Gene-commentary_comment>
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                    <Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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            <Date>
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                <Date-std>
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            <Date>
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                <Date-std>
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                  <Date-std_minute>55</Date-std_minute>
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                </Date-std>
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        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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          <Gene-commentary_comment>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                <Other-source>
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                    <Dbtag>
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                <Date-std>
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        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                <PubMedId>31536960</PubMedId>
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                    <Dbtag>
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              <Gene-commentary_source>
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                    <Dbtag>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                    <Dbtag>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9361</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LONP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114762</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8540</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AGPS</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114110</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8508</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NIPSNAP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114080</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7879</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RAB7A</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113624</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7415</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>VCP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113258</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7388</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>UQCRH</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113234</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7385</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>UQCRC2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113231</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7384</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>UQCRC1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113230</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7284</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TUFM</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113135</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7037</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TFRC</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112895</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5955</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RCN2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111888</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5447</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>POR</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111443</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5245</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PHB1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111264</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5162</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PDHB</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                <Date-std>
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                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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                      <Object-id_id>106845</Object-id_id>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5160</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>PDHA1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5033</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>P4HA1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                  <Other-source_anchor>OGDH</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>55</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                  <Other-source_anchor>NDUFS7</Other-source_anchor>
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                    <Dbtag>
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          <Gene-commentary_create-date>
            <Date>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>21</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>SFXN1</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                      </Dbtag_tag>
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                  </Other-source_src>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>21</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>BCKDHA</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                    <Dbtag>
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            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                  <Other-source_anchor>ATP5PO</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
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                  <Date-std_second>0</Date-std_second>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>ATP5F1C</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
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                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
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                </Date-std>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                  </Dbtag_tag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>ATP5F1B</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
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                </Date-std>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>1</Date-std_month>
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                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
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                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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          <Gene-commentary_source>
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                <Dbtag>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>ATP5F1A</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>1</Date-std_month>
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                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                    </Dbtag>
                  </Other-source_src>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
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                        </Object-id>
                      </Dbtag_tag>
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                  <Other-source_anchor>ATP2A2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
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              <Other-source_src>
                <Dbtag>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>ACTB</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
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            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>4728</Object-id_id>
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                      </Dbtag_tag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
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                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4723</Object-id_id>
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                      </Dbtag_tag>
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                  <Other-source_anchor>NDUFV1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110802</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4722</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NDUFS3</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NDUFS1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NDUFB8</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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              </Gene-commentary_source>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
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                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NDUFA8</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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              </Gene-commentary_source>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
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                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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                    </Dbtag>
                  </Other-source_src>
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            </Gene-commentary>
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              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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                  <Other-source_anchor>HMOX2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
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                  <Date-std_second>0</Date-std_second>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
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                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
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                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
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            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                    <Dbtag>
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            <Date>
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          <Gene-commentary_update-date>
            <Date>
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                  <Date-std_minute>25</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
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            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                      </Dbtag_tag>
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                    <Dbtag>
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            <Date>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_minute>25</Date-std_minute>
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              </Date_std>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
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            </Pub>
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                <Dbtag>
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          <Gene-commentary_comment>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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                <Dbtag>
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                    <Dbtag>
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                      <Dbtag_tag>
                        <Object-id>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Date-std>
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                <Date-std>
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                    <Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Other-source>
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                    <Dbtag>
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                <Date-std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>1</Date-std_month>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
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        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>31536960</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                    </Dbtag>
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            </Gene-commentary>
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          <Gene-commentary_create-date>
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              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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          <Gene-commentary_update-date>
            <Date>
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                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>25</Date-std_minute>
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          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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              <Pub_pmid>
                <PubMedId>29872149</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
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                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
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              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
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                <PubMedId>27477018</PubMedId>
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            </Pub>
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                <Dbtag>
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                    <Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
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            <Date>
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            <Date>
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                <Date-std>
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                  <Date-std_hour>12</Date-std_hour>
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                <PubMedId>29969578</PubMedId>
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                <Dbtag>
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                  </Dbtag_tag>
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                    <Dbtag>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
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                <Dbtag>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
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                      </Dbtag_tag>
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                  <Other-source_anchor>CD81</Other-source_anchor>
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                <Other-source>
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            <Date>
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                <Date-std>
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                          <Object-id_id>112122</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6201</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
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                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6132</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RPL8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112052</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6128</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RPL6</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112048</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
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          <Gene-commentary_source>
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                <Dbtag>
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                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6124</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RPL4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112044</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5093</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PCBP1</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111126</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3312</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HSPA8</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109544</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1499</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CTNNB1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107880</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1213</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CLTC</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107623</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>27684187</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>71</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ACTG1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106586</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3445</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IFNA8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109668</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2017</Date-std_year>
                  <Date-std_month>6</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>26</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>26496610</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>16818</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Lck</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>201120</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>2</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>23</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Biochemical Activity</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15654758</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3931</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LCAT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110123</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>40</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21988832</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>55738</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ARFGAP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>120856</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>36</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15174051</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>213</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ALB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106715</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>36</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90580</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TIMM29</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>124736</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>84171</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LOXL4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>123925</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>84106</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PRAM1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>123894</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>58526</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MID1IP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>121846</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>56172</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ANKH</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>121103</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>54850</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FBXL12</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>120200</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>53822</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FXYD7</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119795</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51295</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ECSIT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119446</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>27250</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PDCD4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>118098</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>24138</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IFIT5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117289</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22983</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAST1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116632</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22905</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>EPN2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116569</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22874</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PLEKHA6</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116541</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Two-hybrid</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>11140</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDC37</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116312</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9922</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IQSEC1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115250</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7301</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TYRO3</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113152</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7001</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PRDX2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112860</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6767</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ST13</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6009</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RHEB</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111941</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5663</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PSEN1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111642</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5654</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HTRA1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111635</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5110</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PCMT1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111141</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>148156</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ZNF558</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>127124</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4846</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NOS3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110909</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3437</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IFIT3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109660</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2639</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>GCDH</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108909</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2290</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FOXG1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108580</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2193</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FARSA</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108487</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1994</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ELAVL1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108309</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1562</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CYP2C18</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107938</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1558</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CYP2C8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107936</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Biochemical Activity</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15882073</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1457</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CSNK2A1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107841</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>348</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APOE</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Reconstituted Complex; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>9831625</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>A2M</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>140545</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RNF32</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>126622</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21289314</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>56086</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Set</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>207808</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12950167</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>8626535</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7804</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113579</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>2779654</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4035</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110215</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12036962</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3949</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LDLR</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>126073</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01130</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12950167</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>12167620</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7804</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>259016389</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q14114</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12138091</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>949</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SCARB1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>37999904</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q8WTV0</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11421580</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4036</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>160332309</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P98164</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12167620</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7436</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>VLDLR</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1730111</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P98155</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15146195</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5621</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PRNP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>130912</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P04156</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12810820</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5360</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PLTP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1709662</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P55058</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8620924</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4741</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NEFM</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>281185500</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P07197</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9512010</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>9147408</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>7566652</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4137</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAPT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>334302961</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P10636</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8624078</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4133</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAP2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>215274255</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P11137</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9236223</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1270</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CNTF</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116585</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P26441</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12057992</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1508</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CTSB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>68067549</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P07858</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11421580</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4035</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>317373384</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q07954</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9147408</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>7566652</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>348</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APOE</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10559559</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>351</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112927</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P05067</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9831625</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>A2M</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8063017</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00135</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>213</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ALB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02768</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8620924</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4741</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NEFM</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110818</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>14</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>7768901</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4036</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110216</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12810820</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106845</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5360</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PLTP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111374</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>4</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Apolipoprotein E binds to ciliary neurotrophic factor</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9236223</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BIND</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>17535</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BIND</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NP_000032.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1270</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CNTF</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4758020</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NP_000605.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>16</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>ApoE interacts with NS5A. This interaction was modeled on a demonstrated interaction between ApoE from an unspecified species and NS5A from Hepatitis C virus type 1b isolate Con1.</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15326295</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BIND</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>185110</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BIND</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NP_000032.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5420377</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CAB46677.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>51</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>ApoE interacts with NS5A. This interaction was modeled on a demonstrated interaction between ApoE from an unspecified species and NS5A from Hepatitis C virus type 1a isolate H77.</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15326295</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BIND</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>185107</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BIND</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4557325</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NP_000032.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>951475</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>POLY</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22129793</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NP_671491.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>16</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>51</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Markers (Sequence Tagged Sites/STS)</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>157196</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:433407</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>273705</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC99927P2</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>21058</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>D19S571</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>347ZE1</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>AFM347ze1</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>GDB:343627</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>HS347ZE1</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH31456</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH74439</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>SHGC-21102</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>stSG34744</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>W2760</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>157265</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:438097</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>34644</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>STS-N29699</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH39108</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>sts-N29699</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>154995</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:178385</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>64138</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>STS-K00396</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH39076</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>sts-K00396</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>154765</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:169570</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>154776</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:171177</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>155318</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:181631</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>272824</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC310963P1</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>272825</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC310963P2</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>272826</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC310963P3</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>272827</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC310963P4</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>155329</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:181693</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>72925</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>RH11470</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH1669</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>stSG94</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>270328</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>PMC117303P1</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>154875</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:177380</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>155901</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
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    <Xtra-Terms>
      <Xtra-Terms_tag>PROP</Xtra-Terms_tag>
      <Xtra-Terms_value>phenotype</Xtra-Terms_value>
    </Xtra-Terms>
  </Entrezgene_xtra-properties>
</Entrezgene>