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Amigo3 adhesion molecule with Ig like domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316003, updated on 11-Apr-2024

Summary

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Official Symbol
Amigo3provided by RGD
Official Full Name
adhesion molecule with Ig like domain 3provided by RGD
Primary source
RGD:631413
See related
Ensembl:ENSRNOG00000064183 AllianceGenome:RGD:631413
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of neuron projection development; and nervous system development. Predicted to be integral component of membrane. Biomarker of sciatic neuropathy. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Amigo3 in Genome Data Viewer
Location:
8q32
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117620499..117622025)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108741899..108743425)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116830773..116832299)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480233 Neighboring gene cadherin-related family member 4 Neighboring gene inositol hexakisphosphate kinase 1 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene macrophage stimulating 1 Neighboring gene acylaminoacyl-peptide hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury. Ahmed Z, et al. PLoS One, 2013. PMID 23613963, Free PMC Article
  2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula J, et al. J Cell Biol, 2003 Mar 17. PMID 12629050, Free PMC Article
  3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
amphoterin-induced protein 3
Names
AMIGO-3
alivin-3
amphoterin induced gene and ORF 3
transmembrane protein AMIGO3
NP_835280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178144.1 → NP_835280.1  amphoterin-induced protein 3 precursor

    See identical proteins and their annotated locations for NP_835280.1

    Status: PROVISIONAL

    Source sequence(s)
    AY237731
    UniProtKB/Swiss-Prot
    Q80ZD5
    UniProtKB/TrEMBL
    A6I331
    Related
    ENSRNOP00000081738.1, ENSRNOT00000118165.1
    Conserved Domains (4) summary
    sd00033
    Location:65 → 86
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:65 → 121
    LRR_8; Leucine rich repeat
    pfam13927
    Location:279 → 355
    Ig_3; Immunoglobulin domain
    cd00096
    Location:295 → 303
    Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117620499..117622025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZD5.1 GenPept UniProtKB/Swiss-Prot:Q80ZD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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