Mtmr4 myotubularin related protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtmr4provided by RGD
Official Full Name: myotubularin related protein 4provided by RGD
Primary source: RGD:1310306
See related: Ensembl:ENSRNOG00000007496 AllianceGenome:RGD:1310306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; and protein phosphatase binding activity. Involved in response to denervation involved in regulation of muscle adaptation. Predicted to be located in endosome. Predicted to be active in cytoplasm and membrane. Biomarker of muscular atrophy. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 186.2), Brain (RPKM 153.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (72890665..72913598)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (72393411..72416342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (74886600..74909532)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that MTMR4 expression was decreased in atrophying muscle.
Title: The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.

Submit: New GeneRIF Correction

General gene information

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Markers

BE105983 (e-PCR)
- UniSTS:245938

D10Chm73 (e-PCR)
- UniSTS:518142

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to denervation involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myotubularin-related protein 4

NP_001099297.4

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105827.4 → NP_001099297.4 myotubularin-related protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AT43, D3ZW40

Related

ENSRNOP00000009943.6, ENSRNOT00000009943.8

Conserved Domains (3) summary

cd13342
Location:23 → 136

PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15733
Location:1107 → 1166

FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins

pfam06602
Location:127 → 519

Myotub-related; Myotubularin-like phosphatase domain