Cd24 CD24 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25145, updated on 2-May-2024

Summary

Official Symbol: Cd24provided by RGD
Official Full Name: CD24 moleculeprovided by RGD
Primary source: RGD:2298
See related: AllianceGenome:RGD:2298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd24a
Summary: Predicted to enable several functions, including heat shock protein binding activity; protein kinase binding activity; and protein tyrosine kinase activator activity. Involved in immune response. Located in external side of plasma membrane. Is anchored component of external side of plasma membrane. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1098.2), Uterus (RPKM 704.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (48655549..48661786)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (47074353..47079662)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (48335540..48340847)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that Foxo1 overexpression in betacells was able to increase apoptosis by inhibiting CD24 expression. This study may provide an approach for the treatment and prevention of type 2 diabetes.
Title: Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24.
Here we show that Plasmodium berghei ANKA infection of young rats leads to the modulation of expression of CD24. Susceptibility to malaria infection seems to be mediated by the alteration of genes expressing CD24.
Title: Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.
CD24 and Sca-1 in the mammary glands were expressed at lower level in 6-week-old female rats than in 9-week-old female rats.
Title: [Expressions of Sca-1, CD24 and Muc1 in quiescent mammary glands of female rats].
Expression of Cd24 in the pineal gland is >10-fold higher at night, when it reaches levels that are 16-fold higher than median tissue expression.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Exhibits similar patterns of regulation during development and epileptogenesis
Title: Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.
CD24 was high in the nucleus pulposus of intervertebral discs and was detected in herniated nucleus pulposus tissue
Title: CD24 is expressed specifically in the nucleus pulposus of intervertebral discs.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94631 (e-PCR)
- UniSTS:119878

RH142320 (e-PCR)
- UniSTS:231567

BE116382 (e-PCR)
- UniSTS:248478

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor transport into membrane raft	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor transport into membrane raft	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of T cell homeostatic proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic mitochondrial changes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic nuclear changes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine receptor transport out of membrane raft	ISO Inferred from Sequence Orthology more info
involved_in chemokine receptor transport out of membrane raft	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glomerular parietal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glomerular parietal epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of integrin activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell homeostatic proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of erythrocyte aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of erythrocyte clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta3 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta3 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell homeostatic proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pre-B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in respiratory burst	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in response to molecule of bacterial origin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducer CD24

Names: CD24 antigen; HSA; heat-stable antigen; nectadrin heat stable antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.