Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp1a1provided by RGD
Official Full Name: cytochrome P450, family 1, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:2458
See related: Ensembl:ENSRNOG00000019500 AllianceGenome:RGD:2458
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AHH; AHRR; CP11; CYP1; Cyp45c; P1-450; P450-C; P450DX; Cypc45c; P-450MC
Summary: Enables several functions, including flavonoid 3'-monooxygenase activity; heat shock protein binding activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease; pulmonary hypertension; and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 85.1), Lung (RPKM 59.1) and 2 other tissues See more
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (66991940..66998014)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58096021..58102130)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62472087..62478122)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression.
Title: Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression.
Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
Title: Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Title: Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system.
Title: Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system.
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Title: Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
CYP1A1 and CYP1B1 mRNA expression levels were significantly reduced from day 7 and 10, respectively. These results suggested that CpG island hypermethylation of the CYP1A1 and CYP1B1 promoters regulate the low expression of genes involved in the occurrence of isoniazidinduced liver injury
Title: Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
We showed that the enhanced activity of the CYP1A1 mutant towards TCDD was due to more efficient binding of the substrate in the active site even though the mutated site was over 2.5nm away from the catalytic center
Title: Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.
Data suggest that two inhibitors from grapefruit juice (naringenin and 6',7'-dihydroxybergamottin) block oxidation of 7-ethoxyresorufin via competitive binding to the active site of both human and rat CYP1A1.
Title: Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.
Hexachloronaphthalene was found to be a strong inducer of maternal and fetal CYP1A1 in liver and placenta.
Title: Developmental toxicity of hexachloronaphthalene in Wistar rats. A role of CYP1A1 expression.
drugs acting as D2-dopamine receptor antagonists can modify several hormone systems that regulate the expression of CYP1A1, CYP1A2 and CYP1B1, and may affect the toxicity and carcinogenicity outcome of numerous toxicants and pre-carcinogenic substances
Title: Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mgh7 (e-PCR)
- UniSTS:261148

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:461912

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:462979

RH94445 (e-PCR)
- UniSTS:119693

PMC15407P1 (e-PCR)
- UniSTS:271291

D8MGH7 (e-PCR)
- UniSTS:120531

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IDA Inferred from Direct Assay more info	PubMed
enables demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavonoid 3'-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
contributes_to oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on diphenols and related substances as donors	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables vitamin D 24-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 9-cis-retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within amine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in coumarin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dibenzo-p-dioxin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dibenzo-p-dioxin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dibenzo-p-dioxin metabolic process	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in flavonoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in insecticide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in nitric oxide metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in porphyrin-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(III) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nematode	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 1A1

Names: CYPIA1; P450MT2; P450form6; aryl hydrocarbon hydroxylase; cytochrome P1-450; cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450-C; cytochrome P450-P1; cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; xenobiotic monooxygenase

NP_036672.3

EC 1.14.14.1

EC 4.2.1.152

XP_006243212.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012540.3 → NP_036672.3 cytochrome P450 1A1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P00185

UniProtKB/TrEMBL

A6J4X3, Q80UE2

Conserved Domains (1) summary

cd20676
Location:74 → 509

CYP1A; cytochrome P450 family 1, subfamily A