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Stk24 serine/threonine kinase 24 [ Mus musculus (house mouse) ]

Gene ID: 223255, updated on 12-May-2024

Summary

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Official Symbol
Stk24provided by MGI
Official Full Name
serine/threonine kinase 24provided by MGI
Primary source
MGI:MGI:2385007
See related
Ensembl:ENSMUSG00000063410 AllianceGenome:MGI:2385007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst3; MST-3; STE20; 1810013H02Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of axon regeneration; and response to hydrogen peroxide. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in Golgi membrane; cytosol; and nucleolus. Is expressed in brain. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 21.9), large intestine adult (RPKM 15.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 E5; 14 64.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121521599..121618269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121284187..121380496, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37701 Neighboring gene STARR-seq mESC enhancer starr_37702 Neighboring gene importin 5 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene STARR-seq mESC enhancer starr_37715 Neighboring gene STARR-seq mESC enhancer starr_37718 Neighboring gene STARR-positive B cell enhancer ABC_E1475 Neighboring gene STARR-positive B cell enhancer ABC_E478 Neighboring gene STARR-seq mESC enhancer starr_37728 Neighboring gene STARR-seq mESC enhancer starr_37729 Neighboring gene STARR-positive B cell enhancer ABC_E11584 Neighboring gene predicted gene, 33299 Neighboring gene STARR-seq mESC enhancer starr_37731 Neighboring gene solute carrier family 15 (oligopeptide transporter), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3. Liu Y, et al. J Biol Chem, 2022 May. PMID 35413286, Free PMC Article
  2. Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome. Qin Q, et al. Cell Rep, 2021 May 25. PMID 34038725
  3. MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake. Chan CH, et al. Int J Mol Sci, 2021 Jan 20. PMID 33498219, Free PMC Article
  4. MST3 is involved in ENaC-mediated hypertension. Lu TJ, et al. Am J Physiol Renal Physiol, 2019 Jul 1. PMID 30969802
  5. The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet. Iglesias C, et al. Diabetologia, 2017 Dec. PMID 28956081

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
    Title: Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
  2. Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
    Title: Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
  3. Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
    Title: Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
  4. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
    Title: Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
  5. Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
    Title: Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
  6. GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
    Title: GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
  7. STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
    Title: STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
  8. MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
    Title: MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
  9. MST3 protein coats lipid droplets in mouse liver cells from mice fed a high-fat diet. MST3 fully colocalized with ADRP, the main LD-coating protein in mouse liver. No MST3 protein was detected in the cytosolic fraction. High mRNA and protein expression of MST3 was also found in organs that do not accumulate significant amounts of intracellular LDs.
    Title: Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.
  10. results indicated that serine/threonine kinase 24 (MST3) maintained Na(+) homeostasis through epithelial Na(+) channel( ENaC) regulation
    Title: MST3 is involved in ENaC-mediated hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6330

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 24
Names
STE20-like kinase MST3
mammalian STE20-like protein kinase 3
mammalian sterile twenty 3 kinase
serine/threonine kinase 24 (STE20 homolog, yeast)
NP_663440.1
XP_006518981.1
XP_011243345.1
XP_017171477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145465.2 → NP_663440.1  serine/threonine-protein kinase 24

    See identical proteins and their annotated locations for NP_663440.1

    Status: VALIDATED

    Source sequence(s)
    AK154959, BE687884, BY730101
    Consensus CDS
    CCDS37016.1
    UniProtKB/Swiss-Prot
    Q99KH8
    UniProtKB/TrEMBL
    Q3U335, Q3U3T6
    Related
    ENSMUSP00000078746.8, ENSMUST00000079817.8
    Conserved Domains (2) summary
    smart00220
    Location:24 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:22 → 295
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    121521599..121618269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518918.3 → XP_006518981.1  serine/threonine-protein kinase 24 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 197
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011245043.4 → XP_011243345.1  serine/threonine-protein kinase 24 isoform X2

    UniProtKB/TrEMBL
    Q3U3T6
    Conserved Domains (1) summary
    cd06609
    Location:21 → 294
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

  3. XM_017315988.2 → XP_017171477.1  serine/threonine-protein kinase 24 isoform X1

    UniProtKB/TrEMBL
    Q3U3T6
    Conserved Domains (1) summary
    cd06609
    Location:34 → 307
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KH8.1 GenPept UniProtKB/Swiss-Prot:Q99KH8

Gene LinkOut

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