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Tfrc transferrin receptor [ Mus musculus (house mouse) ]

Gene ID: 22042, updated on 28-May-2024

Summary

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Official Symbol
Tfrcprovided by MGI
Official Full Name
transferrin receptorprovided by MGI
Primary source
MGI:MGI:98822
See related
Ensembl:ENSMUSG00000022797 AllianceGenome:MGI:98822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik
Summary
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]
Expression
Biased expression in liver E14 (RPKM 131.4), liver E14.5 (RPKM 101.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Tfrc in Genome Data Viewer
Location:
16 B3; 16 23.06 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32427714..32451612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32608896..32632794)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40658 Neighboring gene zinc finger, DHHC domain containing 19 Neighboring gene STARR-seq mESC enhancer starr_40663 Neighboring gene STARR-seq mESC enhancer starr_40664 Neighboring gene STARR-seq mESC enhancer starr_40665 Neighboring gene SET domain containing 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7444 Neighboring gene STARR-seq mESC enhancer starr_40668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32651205-32651388 Neighboring gene STARR-seq mESC enhancer starr_40671 Neighboring gene tyrosine kinase, non-receptor, 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32668208-32668409 Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_40672 Neighboring gene predicted gene, 34766

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development. Cheli VT, et al. J Neurosci, 2023 May 17. PMID 36977582, Free PMC Article
  2. Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2. Wang X, et al. J Virol, 2023 Feb 28. PMID 36779763, Free PMC Article
  3. VHHs as tools for therapeutic protein delivery to the central nervous system. Wouters Y, et al. Fluids Barriers CNS, 2022 Oct 3. PMID 36192747, Free PMC Article
  4. Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Zhang Z, et al. Cell Metab, 2021 Aug 3. PMID 34174197, Free PMC Article
  5. Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis. Ding H, et al. J Cachexia Sarcopenia Muscle, 2021 Jun. PMID 33955709, Free PMC Article

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
    Title: METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
  2. Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
    Title: Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
  3. Transferrin receptor in primary and metastatic breast cancer: Evaluation of expression and experimental modulation to improve molecular targeting.
    Title: Transferrin receptor in primary and metastatic breast cancer: Evaluation of expression and experimental modulation to improve molecular targeting.
  4. Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice.
    Title: Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice.
  5. TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
    Title: TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
  6. Autophagy Suppresses Ferroptosis by Degrading TFR1 to Alleviate Cognitive Dysfunction in Mice with SAE.
    Title: Autophagy Suppresses Ferroptosis by Degrading TFR1 to Alleviate Cognitive Dysfunction in Mice with SAE.
  7. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
    Title: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
  8. NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.
    Title: NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.
  9. H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1.
    Title: H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1.
  10. Murine Placental Erythroid Cells Are Mainly Represented by CD45[+] Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
    Title: Murine Placental Erythroid Cells Are Mainly Represented by CD45(+) Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables transferrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferrin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to iron ion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone resorption IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HFE-transferrin receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transferrin receptor protein 1
Names
mammary tumor virus receptor 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357298.1 → NP_001344227.1  transferrin receptor protein 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC161755
    Consensus CDS
    CCDS28123.1
    UniProtKB/Swiss-Prot
    Q61560, Q62351
    UniProtKB/TrEMBL
    Q542D9
    Conserved Domains (3) summary
    cd02128
    Location:203 → 379
    PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
    pfam04253
    Location:645 → 749
    TFR_dimer; Transferrin receptor-like dimerisation domain
    cl14876
    Location:387 → 613
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. NM_011638.4 → NP_035768.1  transferrin receptor protein 1

    See identical proteins and their annotated locations for NP_035768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC054522, BF714992, BY101284
    Consensus CDS
    CCDS28123.1
    UniProtKB/Swiss-Prot
    Q61560, Q62351
    UniProtKB/TrEMBL
    Q542D9
    Related
    ENSMUSP00000023486.9, ENSMUST00000023486.15
    Conserved Domains (3) summary
    cd02128
    Location:203 → 379
    PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
    pfam04253
    Location:645 → 749
    TFR_dimer; Transferrin receptor-like dimerisation domain
    cl14876
    Location:387 → 613
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32427714..32451612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159875.1 → XP_036015768.1  transferrin receptor protein 1 isoform X1

    Conserved Domains (3) summary
    cl28883
    Location:1 → 95
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cd09848
    Location:103 → 329
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:356 → 469
    TFR_dimer; Transferrin receptor-like dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62351.1 GenPept UniProtKB/Swiss-Prot:Q62351

Gene LinkOut

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