Srm spermidine synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srmprovided by MGI
Official Full Name: spermidine synthaseprovided by MGI
Primary source: MGI:MGI:102690
See related: Ensembl:ENSMUSG00000006442 AllianceGenome:MGI:102690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SpdST; SpdSy
Summary: Predicted to enable protein homodimerization activity and spermidine synthase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and integumental system. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 69.9), limb E14.5 (RPKM 62.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.76 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148675970..148679076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148591513..148594619)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
results indicate that SpdS levels are not rate limiting in vivo for polyamine biosynthesis and are unlikely to exert significant regulatory effects on cellular polyamine content and function
Title: Characterization of transgenic mice with overexpression of spermidine synthase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Srm (e-PCR), detects polymorphism
- UniSTS:531490

RH124625 (e-PCR)
- UniSTS:161447

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables spermidine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables spermidine synthase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: spermidine synthase

Names: putrescine aminopropyltransferase

NP_033298.1

EC 2.5.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.