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Rtn2 reticulon 2 (Z-band associated protein) [ Mus musculus (house mouse) ]

Gene ID: 20167, updated on 9-May-2024

Summary

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Official Symbol
Rtn2provided by MGI
Official Full Name
reticulon 2 (Z-band associated protein)provided by MGI
Primary source
MGI:MGI:107612
See related
Ensembl:ENSMUSG00000030401 AllianceGenome:MGI:107612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ms10p; NSPLI; Nspl1; MMS10-P
Summary
Acts upstream of or within gene expression; intracellular protein transmembrane transport; and regulation of glucose import. Located in several cellular components, including T-tubule; Z disc; and terminal cisterna. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to human RTN2 (reticulon 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 67.1), heart adult (RPKM 42.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Rtn2 in Genome Data Viewer
Location:
7 A3; 7 9.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19016549..19030089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19282624..19296164)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vasodilator-stimulated phosphoprotein Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Neighboring gene STARR-positive B cell enhancer ABC_E1082 Neighboring gene nuclear encoded tRNA selenocysteine 2 (anticodon TCA) Neighboring gene STARR-positive B cell enhancer ABC_E9021 Neighboring gene FBJ osteosarcoma oncogene B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nspl1, a new Z-band-associated protein. Geisler JG, et al. J Muscle Res Cell Motil, 1999 Oct. PMID 10672514
  2. Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Ikemoto T, et al. Diabetes, 2009 Dec. PMID 19720795, Free PMC Article
  3. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Geisler JG, et al. Mamm Genome, 1998 Apr. PMID 9530622
  4. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. Liu Y, et al. J Biol Chem, 2008 Mar 7. PMID 18096700, Free PMC Article
  5. Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex. Gwynn B, et al. Blood, 2004 Nov 15. PMID 15265785

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC35990

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gene expression IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in terminal cisterna IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reticulon-2
Names
NSP-like protein 1
NSP-like protein I
neuroendocrine-specific protein-like 1
neuroendocrine-specific protein-like I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025364.3 → NP_001020535.1  reticulon-2 isoform C

    See identical proteins and their annotated locations for NP_001020535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant B. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.
    Source sequence(s)
    AK144271, AK160500, W65979
    Consensus CDS
    CCDS39797.1
    UniProtKB/TrEMBL
    Q3TUZ6, Q6IM74
    Related
    ENSMUSP00000104108.4, ENSMUST00000108468.5
    Conserved Domains (1) summary
    pfam02453
    Location:5 → 169
    Reticulon; Reticulon

  2. NM_013648.6 → NP_038676.1  reticulon-2 isoform B

    See identical proteins and their annotated locations for NP_038676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    AK144271, AU066588, CJ176292
    Consensus CDS
    CCDS20896.1
    UniProtKB/Swiss-Prot
    O70620, O70622
    UniProtKB/TrEMBL
    Q6IM75
    Related
    ENSMUSP00000032559.10, ENSMUST00000032559.17
    Conserved Domains (2) summary
    pfam02453
    Location:272 → 436
    Reticulon; Reticulon
    pfam15552
    Location:106 → 248
    DUF4657; Domain of unknown function (DUF4657)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19016549..19030089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70622.1 GenPept UniProtKB/Swiss-Prot:O70622

Gene LinkOut

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