Reg3a regenerating islet-derived 3 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg3aprovided by MGI
Official Full Name: regenerating islet-derived 3 alphaprovided by MGI
Primary source: MGI:MGI:109408
See related: Ensembl:ENSMUSG00000079516 AllianceGenome:MGI:109408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including identical protein binding activity; oligosaccharide binding activity; and peptidoglycan binding activity. Involved in negative regulation of keratinocyte differentiation; positive regulation of keratinocyte proliferation; and positive regulation of wound healing. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut and pancreas. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 62.2), duodenum adult (RPKM 50.2) and 1 other tissue See more
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Genomic context

Location:: 6 C3; 6 34.76 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (78357692..78360822)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (78380709..78383839)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

skin injury increases IL-36gamma via the activation of TLR3-SLUG-VDR axis and IL-36gamma induces REG3A to promote wound healing
Title: IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.
Reg3alpha is an extracellular matrix-targeted reactive oxygen species scavenger that binds the fibrin scaffold resulting from hepatocyte death during acute liver failure.
Title: The Reg3α (HIP/PAP) Lectin Suppresses Extracellular Oxidative Stress in a Murine Model of Acute Liver Failure.
Data show that regenerating islet-derived 3-alpha (REG3alpha) is a plasma biomarker of gastrointestinal tract graft-versus-host disease that can be combined with clinical stage and histologic grade to improve risk stratification of patients.
Title: Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.
Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.
Title: Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.
Reg3alpha stimulates beta-cell replication, by activating Akt kinase and increasing the levels of cyclin D1/CDK4.
Title: Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of keratinocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regenerating islet-derived protein 3-alpha

Names: REG-3-alpha; RegIII (alpha); generating islet-derived, mouse homolog 3 alpha; islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; reg III-alpha; regenerating islet-derived protein III-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011259.1 → NP_035389.1 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_035389.1

Status: PROVISIONAL

Source sequence(s)

D63358

Consensus CDS

CCDS20255.1

UniProtKB/Swiss-Prot

O09037

UniProtKB/TrEMBL

Q794C6, Q9CVF4

Related

ENSMUSP00000098829.2, ENSMUST00000101272.3

Conserved Domains (1) summary

cl02432
Location:40 → 173

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain