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asp Asp [ Human immunodeficiency virus 1 ]

Gene ID: 19424028, updated on 18-Aug-2023

Summary

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Gene symbol
asp
Gene description
Asp
Locus tag
HIV1gp10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human immunodeficiency virus 1
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:
NC_001802.1 (6919..7488, complement)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Vif Neighboring gene Vpr Neighboring gene Tat Neighboring gene Rev Neighboring gene Vpu Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Nef

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001802.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope. Affram Y, et al. J Virol, 2019 Nov 1. PMID 31434734, Free PMC Article
  2. The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly. Zapata JC, et al. Virology, 2017 Jun. PMID 28340355, Free PMC Article
  3. HIV-1 Antisense Protein of Different Clades Induces Autophagy and Associates with the Autophagy Factor p62. Liu Z, et al. J Virol, 2019 Jan 15. PMID 30404795, Free PMC Article
  4. Reviving an old HIV-1 gene: the HIV-1 antisense protein. Torresilla C, et al. Curr HIV Res, 2015. PMID 25439234
  5. Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy. Torresilla C, et al. J Virol, 2013 May. PMID 23427159, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIV-1 hydrophobic antisense protein (ASP) shows polarized subnuclear distribution, preferentially in areas with low content of suppressive epigenetic marks. ASP is an integral protein of the plasma membranes of chronically infected cells stimulated with PMA, and upon viral budding, ASP becomes a structural protein of the HIV-1 envelope.
    Title: The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope.
  2. Results show that multimerization of ASP and induced autophagy partly involve its amino end. ASP from various HIV-1 clades all induced autophagy, as determined by LC3-II levels and p62 degradation, although clade A ASP was less efficient. ASP co-localized and interacted with p62 through its PB1 domain supporting the idea that ASP is ubiquitinated, further contributing to its targeting toward degradation pathways.
    Title: HIV-1 Antisense Protein of Different Clades Induces Autophagy and Associates with the Autophagy Factor p62.
  3. ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly.
    Title: The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly.
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HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
beclin-1 isoform a BECN1 upregulates PubMed
C-C motif chemokine 4 precursor CCL4 induces release of PubMed
HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor HLA-A binds PubMed
HLA-A inhibited by PubMed
HLA-A inhibited by PubMed
major histocompatibility complex, class I, B precursor HLA-B binds PubMed
HLA-B inhibited by PubMed
HLA-B inhibited by PubMed
HLA class I histocompatibility antigen, C alpha chain precursor HLA-C inhibited by PubMed
HLA-C inhibited by PubMed
interferon gamma precursor IFNG enhances PubMed
IFNG upregulates PubMed
interleukin-2 precursor IL2 induces release of PubMed
microtubule-associated proteins 1A/1B light chain 3B MAP1LC3B interacts with PubMed
MAP1LC3B upregulates PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 interacts with PubMed
tumor necrosis factor TNF induces release of PubMed
TNF upregulated by PubMed
upstream stimulatory factor 1 isoform 1 USF1 interacts with PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
Asp

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 Reference assembly

    Range
    6919..7488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009028572.1 Asp [Human immunodeficiency virus 1]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    I3QK15, Q998Z9

Gene LinkOut

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