mt-Co3 cytochrome c oxidase III, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Co3provided by MGI
Official Full Name: cytochrome c oxidase III, mitochondrialprovided by MGI
Primary source: MGI:MGI:102502
See related: AllianceGenome:MGI:102502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX3
Summary: Predicted to enable electron transfer activity and oxidoreduction-driven active transmembrane transporter activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and respiratory chain complex IV assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in MELAS syndrome. Orthologous to human MT-CO3 (mitochondrially encoded cytochrome c oxidase III). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (8607..9390)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (8607..9390)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ischemic stress in vivo and oxidative stress in vitro lead to upregulation of COX III, followed by downregulation of COX I expression, impaired COX oxidative activity, and increased apoptosis.
Title: Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH136459 (e-PCR)
- UniSTS:210445

RH125504 (e-PCR)
- UniSTS:162322

RH136484 (e-PCR)
- UniSTS:210468

mt-Co3 (e-PCR), detects polymorphism
- UniSTS:143918

mt-Nd3 (e-PCR), detects polymorphism
- UniSTS:143919

RH136229 (e-PCR)
- UniSTS:210223

RH136241 (e-PCR)
- UniSTS:210235

RH136529 (e-PCR)
- UniSTS:210511

RH136532 (e-PCR)
- UniSTS:210514

RH136545 (e-PCR)
- UniSTS:210527

RH136286 (e-PCR)
- UniSTS:210279

NoName (e-PCR)
- UniSTS:234087

NoName (e-PCR)
- UniSTS:234088

NoName (e-PCR)
- UniSTS:234091

NoName (e-PCR)
- UniSTS:234093

NoName (e-PCR)
- UniSTS:234094

NoName (e-PCR)
- UniSTS:234095

RH136564 (e-PCR)
- UniSTS:210544

RH136324 (e-PCR)
- UniSTS:210315

RH136327 (e-PCR)
- UniSTS:210317

RH136597 (e-PCR)
- UniSTS:210577

RH136345 (e-PCR)
- UniSTS:210335

RH136387 (e-PCR)
- UniSTS:210377

RH136391 (e-PCR)
- UniSTS:210381

RH136401 (e-PCR)
- UniSTS:210391

RH136408 (e-PCR)
- UniSTS:210398

RH136413 (e-PCR)
- UniSTS:210403

RH125483 (e-PCR)
- UniSTS:162302

Homology

Orthologs from OrthoDB

variation

Loc: 9348 replace = a

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info