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BRCA1 BRCA1 DNA repair associated [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100986197, updated on 11-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
Ensembl:ENSPPAG00000030624
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 19 NC_073268.2 (21865798..21957438)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 17 NC_073266.1 (23755123..23836219)

Chromosome 19 - NC_073268.2Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC130540913 Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1 Neighboring gene interferon induced protein 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
BRCA1 homologue
breast cancer type 1 susceptibility protein homolog
NP_001288687.1
XP_034797073.2
XP_034797074.2
XP_034797075.2
XP_034797076.2
XP_054956824.2
XP_054956825.2
XP_054956826.2
XP_054956827.2
XP_054956828.2
XP_054956829.2
XP_054956830.2
XP_054956831.2
XP_054956832.2
XP_057156164.2
XP_057156165.2
XP_057156166.2
XP_057156167.2
XP_057156168.2
XP_057156169.2
XP_057156170.2
XP_057156171.2
XP_057156172.2
XP_057156173.2
XP_057156174.2
XP_057156175.2
XP_057156176.2
XP_057156177.2
XP_057156178.2
XP_057156179.2
XP_057156180.2
XP_057156181.2
XP_057156182.2
XP_057156183.2
XP_057156184.2
XP_057156185.2
XP_057156186.2
XP_063454662.1
XP_063454663.1
XP_063454664.1
XP_063454665.1
XP_063454666.1
XP_063454667.1
XP_063454668.1
XP_063454669.1
XP_063454670.1
XP_063454671.1
XP_063454672.1
XP_063454673.1
XP_063454674.1
XP_063454675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301758.1 → NP_001288687.1  breast cancer type 1 susceptibility protein

    See identical proteins and their annotated locations for NP_001288687.1

    Status: PROVISIONAL

    Source sequence(s)
    KM017616
    UniProtKB/TrEMBL
    A0A075VQZ2, A0A2R9AJD0
    Related
    ENSPPAP00000015729.1, ENSPPAT00000038420.1
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1839
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:345 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073268.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    21865798..21957438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_055100850.3 → XP_054956825.2  breast cancer type 1 susceptibility protein isoform X5

  2. XM_057300188.2 → XP_057156171.2  breast cancer type 1 susceptibility protein isoform X8

  3. XM_063598593.1 → XP_063454663.1  breast cancer type 1 susceptibility protein isoform X17

  4. XM_063598597.1 → XP_063454667.1  breast cancer type 1 susceptibility protein isoform X18

  5. XM_055100852.3 → XP_054956827.2  breast cancer type 1 susceptibility protein isoform X7

  6. XM_057300190.2 → XP_057156173.2  breast cancer type 1 susceptibility protein isoform X9

  7. XM_057300194.2 → XP_057156177.2  breast cancer type 1 susceptibility protein isoform X10

  8. XM_063598600.1 → XP_063454670.1  breast cancer type 1 susceptibility protein isoform X19

  9. XM_057300196.2 → XP_057156179.2  breast cancer type 1 susceptibility protein isoform X13

  10. XM_057300199.2 → XP_057156182.2  breast cancer type 1 susceptibility protein isoform X15

  11. XM_057300185.2 → XP_057156168.2  breast cancer type 1 susceptibility protein isoform X5

  12. XM_055100853.2 → XP_054956828.2  breast cancer type 1 susceptibility protein isoform X6

  13. XM_057300187.2 → XP_057156170.2  breast cancer type 1 susceptibility protein isoform X8

  14. XM_063598594.1 → XP_063454664.1  breast cancer type 1 susceptibility protein isoform X17

  15. XM_057300186.2 → XP_057156169.2  breast cancer type 1 susceptibility protein isoform X7

  16. XM_057300191.2 → XP_057156174.2  breast cancer type 1 susceptibility protein isoform X9

  17. XM_063598601.1 → XP_063454671.1  breast cancer type 1 susceptibility protein isoform X19

  18. XM_057300197.2 → XP_057156180.2  breast cancer type 1 susceptibility protein isoform X14

  19. XM_057300184.2 → XP_057156167.2  breast cancer type 1 susceptibility protein isoform X4

  20. XM_034941182.3 → XP_034797073.2  breast cancer type 1 susceptibility protein isoform X5

  21. XM_034941183.3 → XP_034797074.2  breast cancer type 1 susceptibility protein isoform X6

  22. XM_034941184.3 → XP_034797075.2  breast cancer type 1 susceptibility protein isoform X8

  23. XM_055100855.2 → XP_054956830.2  breast cancer type 1 susceptibility protein isoform X11

  24. XM_063598595.1 → XP_063454665.1  breast cancer type 1 susceptibility protein isoform X17

  25. XM_063598598.1 → XP_063454668.1  breast cancer type 1 susceptibility protein isoform X18

  26. XM_055100851.2 → XP_054956826.2  breast cancer type 1 susceptibility protein isoform X7

  27. XM_055100854.2 → XP_054956829.2  breast cancer type 1 susceptibility protein isoform X9

  28. XM_055100856.2 → XP_054956831.2  breast cancer type 1 susceptibility protein isoform X10

  29. XM_055100857.2 → XP_054956832.2  breast cancer type 1 susceptibility protein isoform X12

  30. XM_063598602.1 → XP_063454672.1  breast cancer type 1 susceptibility protein isoform X19

  31. XM_063598604.1 → XP_063454674.1  breast cancer type 1 susceptibility protein isoform X20

  32. XM_063598605.1 → XP_063454675.1  breast cancer type 1 susceptibility protein isoform X24

  33. XM_057300183.2 → XP_057156166.2  breast cancer type 1 susceptibility protein isoform X3

  34. XM_057300201.2 → XP_057156184.2  breast cancer type 1 susceptibility protein isoform X21

  35. XM_057300203.2 → XP_057156186.2  breast cancer type 1 susceptibility protein isoform X23

  36. XM_057300198.2 → XP_057156181.2  breast cancer type 1 susceptibility protein isoform X14

  37. XM_055100849.2 → XP_054956824.2  breast cancer type 1 susceptibility protein isoform X5

  38. XM_057300189.2 → XP_057156172.2  breast cancer type 1 susceptibility protein isoform X8

  39. XM_057300193.2 → XP_057156176.2  breast cancer type 1 susceptibility protein isoform X11

  40. XM_063598592.1 → XP_063454662.1  breast cancer type 1 susceptibility protein isoform X16

  41. XM_063598596.1 → XP_063454666.1  breast cancer type 1 susceptibility protein isoform X17

  42. XM_063598599.1 → XP_063454669.1  breast cancer type 1 susceptibility protein isoform X18

  43. XM_034941185.3 → XP_034797076.2  breast cancer type 1 susceptibility protein isoform X7

  44. XM_057300192.2 → XP_057156175.2  breast cancer type 1 susceptibility protein isoform X9

  45. XM_057300195.2 → XP_057156178.2  breast cancer type 1 susceptibility protein isoform X10

  46. XM_063598603.1 → XP_063454673.1  breast cancer type 1 susceptibility protein isoform X19

  47. XM_057300200.2 → XP_057156183.2  breast cancer type 1 susceptibility protein isoform X15

  48. XM_057300181.2 → XP_057156164.2  breast cancer type 1 susceptibility protein isoform X1

  49. XM_057300182.2 → XP_057156165.2  breast cancer type 1 susceptibility protein isoform X2

  50. XM_057300202.2 → XP_057156185.2  breast cancer type 1 susceptibility protein isoform X22

Nucleotide Protein
Heading Accession and Version

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