GEO DataSets

(Submitter supplied) The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. Through isolating and characterizing a panel of novel human mAbs with binding to distinct AM OS motifs, we further defined the glycan epitope structures, identified a new epitope, and determined their differences among mycobacterial strains.

Organism:

synthetic construct; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL34369

11 Samples

Download data: GPR, XLSX

(Submitter supplied) The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. We here used synthetic AM oligosaccharide motifs to deplete sera from subjects along the spectrum of Mtb infection. more...

Organism:

Homo sapiens; synthetic construct

Type:

Protein profiling by protein array

Platform:

GPL34369

107 Samples

Download data: GPR, XLSX

(Submitter supplied) Purpose: There is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. more...

Organism:

Homo sapiens; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL34462

148 Samples

Download data: TXT

(Submitter supplied) High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. By using a protein microarray assaying more than 20,000 human proteins, we determined in this study the autoantibody profiles of highly myopic patiens and emmetropic controls.

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL33051

72 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Protein profiling by protein array; Expression profiling by array

Platforms:

GPL18573 GPL32055 GPL32054

300 Samples

Download data: BW, RCC, SF

(Submitter supplied) A 122-epigenetic gene signature distinguished low- versus high-risk early stage melanomas. We sought to validate the signature, examined clinical correlates in a cohort of primary melanomas of the skin, and studied the underlying transcriptomic aberrations and changes in chromatin in cell lines representing these two groups.

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL32054

15 Samples

Download data

(Submitter supplied) A total of 116 patients, 96 with treatment-naïve unresectable hepatocellular carcinoma (uHCC) and 20 chronic liver disease without any cancer, were analysed for 17 cytokines and chemokines from serum and analysed for oncological features.

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL34302

116 Samples

Download data: TXT

(Submitter supplied) DDX39 and DDX56 recombinant proteins were assayed using commercial protein microarrays in order to detect potential interaction partners.

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL27459

3 Samples

Download data: GPR

(Submitter supplied) We measued IgG autoantibodies associated with Connective Tissue Diseases (CTDs) and Anti-Cytokine Antibodies (ACA) in SLE and healthy controls who received the BNT162b2 vaccine.

Organism:

Escherichia coli; Spodoptera frugiperda; Bos taurus; Triticum aestivum; Capra hircus; Homo sapiens; Sus scrofa

Type:

Protein profiling by protein array

Platform:

GPL34257

102 Samples

Download data: TXT, XLSX

(Submitter supplied) We measued IgG autoantibodies associated with Connective Tissue Diseases (CTDs) and Anti-Cytokine Antibodies (ACA) in SLE and healthy controls who received the BNT162b2 vaccine.

Organism:

Escherichia coli; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL34255

113 Samples

Download data: TXT, XLSX

(Submitter supplied) The autoantibodies in serum (IgG antibody labeled with Cy3 and IgM antibody labeled with Cy5) were quantified by serum incubation human protein microarray, and the data of normal people and lung cancer patients were compared to find the predictive markers of autoantibodies in lung cancer

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platforms:

GPL29809 GPL29810

196 Samples

Download data: GPR

(Submitter supplied) Antibody recognition of Trypanosoma cruzi conserved proteins was assessed by evaluating pools of patient IgG samples on microarrays of 400,000 peptides covering these proteins as 15-mers with an overlap of 13 amino acids.

Organism:

Trypanosoma cruzi; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL33498

3 Samples

Download data: TXT

(Submitter supplied) We analyzed if LCN2 modulates the activity of phosphotyrosine kinases in LPS/IFNg-stimulated primary murine macrophages (BMDMs)

Organism:

Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL33127

10 Samples

Download data: TXT, XLSX

(Submitter supplied) To evaluate the short-term effect of elastase inhibition using telaprevir or sivelestat or DMSO on human islets

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL26730

24 Samples

Download data: XLSX

(Submitter supplied) Immune checkpoint inhibitors (ICIs) targeting PD-1/L1 have modest efficacy in hepatocellular carcinoma (HCC) as single agents, but combination regimens have demonstrated increased clinical benefit at the expense of treatment toxicities. Exposed phosphatidylserine suppresses the innate immune response in the tumor microenvironment (TME). Targeting phosphatidylserine does not induce tumor responses in the clinical setting when used as monotherapy or in combination with cytotoxic and targeted therapies, but may induce pro-inflammatory and –immune stimulating effects that enhance ICI activity. more...

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL33726

251 Samples

Download data: PNG, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Other

Platforms:

GPL30525 GPL30526

76 Samples

Download data

(Submitter supplied) We performed a targeted proteomics analysis of Cutaneous Lupus Erythematosus (CLE) patient blister biopsies and plasma using Olink Proteomics panels to validate the blister biopsy technique using previously identified biomarkers, to confirm protein-level expression of biomarkers previously identified at the RNA level, and to identify new biomarkers of disease.

Organism:

Homo sapiens

Type:

Other

Platform:

GPL30526

38 Samples

Download data: CSV

(Submitter supplied) We performed a targeted proteomics analysis of Cutaneous Lupus Erythematosus (CLE) patient blister biopsies and plasma using Olink Proteomics panels to validate the blister biopsy technique using previously identified biomarkers, to confirm protein-level expression of biomarkers previously identified at the RNA level, and to identify new biomarkers of disease.

Organism:

Homo sapiens

Type:

Other

Platform:

GPL30525

38 Samples

Download data: TXT

(Submitter supplied) Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disorder that may occur following an infection, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit a cohort of post-infectious ME/CFS (PI-ME/CFS) volunteers (n=17) with matched healthy controls (n=21) to conduct deep clinical and biological phenotyping using an extensive battery of tests. more...

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL28516

42 Samples

Download data: TXT

(Submitter supplied) In this experiment, we studied the effect of ICANS on microglial kinase signaling

Organism:

Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL33157

9 Samples

Download data: TXT